TY  - JOUR
AU  - Szarka, Nikolett
AU  - Pabbidi, MR
AU  - Amrein, Krisztina
AU  - Czeiter, Endre
AU  - Berta, Gergely
AU  - Pohóczky, Krisztina
AU  - Helyes, Zsuzsanna
AU  - Ungvári, Zoltán István
AU  - Koller, Ákos
AU  - Büki, András
AU  - Tóth, Péter József
TI  - Traumatic brain injury impairs myogenic constriction of cerebral arteries: role of mitochondria-derived H2O2 and TRPV4-dependent activation of BKCa channels
JF  - JOURNAL OF NEUROTRAUMA
J2  - J NEUROTRAUM
VL  - 35
PY  - 2018
IS  - 7
SP  - 930
EP  - 939
PG  - 10
SN  - 0897-7151
DO  - 10.1089/neu.2017.5056
UR  - https://m2.mtmt.hu/api/publication/3297273
ID  - 3297273
N1  - Cited By :21            
            Export Date: 16 January 2021            
            CODEN: JNEUE            
            Correspondence Address: Toth, P.; Cerebrovascular Laboratory, Department of Neurosurgery, Medical School University of Pecs, University of Pecs, 2 Ret Street, Hungary; email: peter-toth@ouhsc.edu            
            Chemicals/CAS: catalase, 9001-05-2; hydrogen peroxide, 7722-84-1; macrogol, 25322-68-3; paxilline, 57186-25-1
AB  - Traumatic brain injury (TBI) impairs autoregulation of cerebral blood flow, which contributes to the development of secondary brain injury increasing mortality of patients. Impairment of pressure-induced myogenic constriction of cerebral arteries plays a critical role in autoregulatory dysfunction; however, the underlying cellular and molecular mechanisms are not well understood. To determine the role of mitochondria-derived H2O2 and large-conductance calcium-activated potassium channels (BKCa) in myogenic autoregulatory dysfunction, middle cerebral arteries (MCAs) were isolated from rats with severe weight drop-impact acceleration brain injury (24 h post-impact). We found that post-TBI MCAs exhibited impaired myogenic constriction, which was restored by treatment with a mitochondria-targeted antioxidant (mitoTEMPO), by scavenging of H2O2 (PEG-catalase) and by blocking both BKCa channels (paxilline) and TRPV4 channels (HC067047). Further, exogenous administration of H2O2 elicited significant dilation of MCAs, which was inhibited by blocking either BKCa or TRPV4 channels. Vasodilation induced by the TRPV4 agonist GSK1016790A was inhibited by paxilline. In cultured vascular smooth muscle cells H2O2 activated BKCa currents, which were inhibited by blockade of TRPV4 channels. Collectively, our results suggest that after TBI excessive mitochondria-derived H2O2 activates BKCa channels via a TRPV4-dependent pathway in the vascular smooth muscle cells, which impairs pressure-induced constriction of cerebral arteries. Future studies should elucidate the therapeutic potential of pharmacological targeting of this pathway in TBI to restore autoregulatory function in order to prevent secondary brain damage and decrease mortality.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tarantini, Stefano
AU  - Valcarcel-Ares, NM
AU  - Yabluchanskiy, A
AU  - Fülöp, Gábor Áron
AU  - Hertelendy, Péter
AU  - Gautam, T
AU  - Farkas, Eszter
AU  - Perz, A
AU  - Rabinovitch, PS
AU  - Sonntag, WE
AU  - Csiszar, Anna
AU  - Ungvári, Zoltán István
TI  - Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice
JF  - AGING CELL
J2  - AGING CELL
VL  - 17
ET  - 0
PY  - 2018
IS  - 2
PG  - 12
SN  - 1474-9718
DO  - 10.1111/acel.12731
UR  - https://m2.mtmt.hu/api/publication/3367042
ID  - 3367042
N1  - Megosztott első szerzőség
Funding Agency and Grant Number: American Heart AssociationAmerican Heart Association; National Institute on AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01-AG055395, R01-AG047879, R01-AG038747]; National Institute of Neurological Disorders and StrokeUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01-NS056218, R01-NS100782]; National Center for Complementary and Alternative MedicineUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01-AT006526]; NIA-supported Geroscience Training Program in Oklahoma [T32AG052363]; NIA-supported Oklahoma Nathan Shock Center [3P30AG050911-02S1]; NIH-supported Oklahoma Shared Clinical and Translational Resources [U54GM104938]; College of Medicine Alumni Association; Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center [AG028718]; Oklahoma Center for the Advancement of Science and Technology; Reynolds Foundation; EUEuropean Union (EU) [EFOP-3.6.1-16-2016-00008]
            Funding text: American Heart Association; the National Institute on Aging, Grant/Award Number: R01-AG055395, R01-AG047879, R01-AG038747; the National Institute of Neurological Disorders and Stroke, Grant/Award Number: R01-NS056218, R01-NS100782; the National Center for Complementary and Alternative Medicine, Grant/Award Number: R01-AT006526; the NIA-supported Geroscience Training Program in Oklahoma, Grant/Award Number: T32AG052363; the NIA-supported Oklahoma Nathan Shock Center, Grant/Award Number: 3P30AG050911-02S1; NIH-supported Oklahoma Shared Clinical and Translational Resources, Grant/Award Number: U54GM104938; College of Medicine Alumni Association; Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center, Grant/Award Number: AG028718; the Oklahoma Center for the Advancement of Science and Technology; the Reynolds Foundation; EU-funded Hungarian, Grant/Award Number: EFOP-3.6.1-16-2016-00008
Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Translational Geroscience Laboratory, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary            
            Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary            
            Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States            
            Department of Pathology, University of Washington, Seattle, WA, United States            
            Cited By :46            
            Export Date: 26 October 2020            
            CODEN: ACGEC            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences CenterUnited States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: acetylcholine, 51-84-3, 60-31-1, 66-23-9; adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5; elamipretide, 736992-21-5; n(g) nitroarginine methyl ester, 50903-99-6; nitric oxide, 10102-43-9; nitroprusside sodium, 14402-89-2, 15078-28-1; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; Antioxidants; Peptides            
            Tradenames: bendavia; mtp 131; ss 31
Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Translational Geroscience Laboratory, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary            
            Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary            
            Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States            
            Department of Pathology, University of Washington, Seattle, WA, United States            
            Cited By :47            
            Export Date: 30 October 2020            
            CODEN: ACGEC            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences CenterUnited States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: acetylcholine, 51-84-3, 60-31-1, 66-23-9; adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5; elamipretide, 736992-21-5; n(g) nitroarginine methyl ester, 50903-99-6; nitric oxide, 10102-43-9; nitroprusside sodium, 14402-89-2, 15078-28-1; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; Antioxidants; Peptides            
            Tradenames: bendavia; mtp 131; ss 31
Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Translational Geroscience Laboratory, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary            
            Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary            
            Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States            
            Department of Pathology, University of Washington, Seattle, WA, United States            
            Cited By :47            
            Export Date: 1 November 2020            
            CODEN: ACGEC            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences CenterUnited States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: acetylcholine, 51-84-3, 60-31-1, 66-23-9; adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5; elamipretide, 736992-21-5; n(g) nitroarginine methyl ester, 50903-99-6; nitric oxide, 10102-43-9; nitroprusside sodium, 14402-89-2, 15078-28-1; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; Antioxidants; Peptides            
            Tradenames: bendavia; mtp 131; ss 31
Funding Agency and Grant Number: American Heart AssociationAmerican Heart Association; National Institute on AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01-AG055395, R01-AG047879, R01-AG038747]; National Institute of Neurological Disorders and StrokeUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01-NS056218, R01-NS100782]; National Center for Complementary and Alternative MedicineUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01-AT006526]; NIA-supported Geroscience Training Program in Oklahoma [T32AG052363]; NIA-supported Oklahoma Nathan Shock Center [3P30AG050911-02S1]; NIH-supported Oklahoma Shared Clinical and Translational Resources [U54GM104938]; College of Medicine Alumni Association; Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center [AG028718]; Oklahoma Center for the Advancement of Science and Technology; Reynolds Foundation; EUEuropean Union (EU) [EFOP-3.6.1-16-2016-00008]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS100782, R01NS100782, R01NS100782] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG055395, R01AG055395, R01AG055395, R01AG055395, R01AG047879, R01AG047879, R01AG047879, R01AG047879, R01AG047879] Funding Source: NIH RePORTER
            Funding text: American Heart Association; the National Institute on Aging, Grant/Award Number: R01-AG055395, R01-AG047879, R01-AG038747; the National Institute of Neurological Disorders and Stroke, Grant/Award Number: R01-NS056218, R01-NS100782; the National Center for Complementary and Alternative Medicine, Grant/Award Number: R01-AT006526; the NIA-supported Geroscience Training Program in Oklahoma, Grant/Award Number: T32AG052363; the NIA-supported Oklahoma Nathan Shock Center, Grant/Award Number: 3P30AG050911-02S1; NIH-supported Oklahoma Shared Clinical and Translational Resources, Grant/Award Number: U54GM104938; College of Medicine Alumni Association; Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center, Grant/Award Number: AG028718; the Oklahoma Center for the Advancement of Science and Technology; the Reynolds Foundation; EU-funded Hungarian, Grant/Award Number: EFOP-3.6.1-16-2016-00008
Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Translational Geroscience Laboratory, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary            
            Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary            
            Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States            
            Department of Pathology, University of Washington, Seattle, WA, United States            
            Cited By :53            
            Export Date: 11 January 2021            
            CODEN: ACGEC            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences CenterUnited States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: acetylcholine, 51-84-3, 60-31-1, 66-23-9; adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5; elamipretide, 736992-21-5; n(g) nitroarginine methyl ester, 50903-99-6; nitric oxide, 10102-43-9; nitroprusside sodium, 14402-89-2, 15078-28-1; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; Antioxidants; Peptides            
            Tradenames: bendavia; mtp 131; ss 31
Funding Agency and Grant Number: American Heart AssociationAmerican Heart Association; National Institute on AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01-AG055395, R01-AG047879, R01-AG038747]; National Institute of Neurological Disorders and StrokeUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01-NS056218, R01-NS100782]; National Center for Complementary and Alternative MedicineUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01-AT006526]; NIA-supported Geroscience Training Program in Oklahoma [T32AG052363]; NIA-supported Oklahoma Nathan Shock Center [3P30AG050911-02S1]; NIH-supported Oklahoma Shared Clinical and Translational Resources [U54GM104938]; College of Medicine Alumni Association; Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center [AG028718]; Oklahoma Center for the Advancement of Science and Technology; Reynolds Foundation; EUEuropean Union (EU) [EFOP-3.6.1-16-2016-00008]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS100782, R01NS100782, R01NS100782] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG055395, R01AG047879, R01AG047879, R01AG055395, R01AG047879, R01AG055395, R01AG047879, R01AG047879, R01AG055395] Funding Source: NIH RePORTER
            Funding text: American Heart Association; the National Institute on Aging, Grant/Award Number: R01-AG055395, R01-AG047879, R01-AG038747; the National Institute of Neurological Disorders and Stroke, Grant/Award Number: R01-NS056218, R01-NS100782; the National Center for Complementary and Alternative Medicine, Grant/Award Number: R01-AT006526; the NIA-supported Geroscience Training Program in Oklahoma, Grant/Award Number: T32AG052363; the NIA-supported Oklahoma Nathan Shock Center, Grant/Award Number: 3P30AG050911-02S1; NIH-supported Oklahoma Shared Clinical and Translational Resources, Grant/Award Number: U54GM104938; College of Medicine Alumni Association; Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center, Grant/Award Number: AG028718; the Oklahoma Center for the Advancement of Science and Technology; the Reynolds Foundation; EU-funded Hungarian, Grant/Award Number: EFOP-3.6.1-16-2016-00008
Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Translational Geroscience Laboratory, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary            
            Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary            
            Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States            
            Department of Pathology, University of Washington, Seattle, WA, United States            
            Cited By :54            
            Export Date: 28 January 2021            
            CODEN: ACGEC            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, United States; email: zoltan-ungvari@ouhsc.edu
Funding Agency and Grant Number: American Heart AssociationAmerican Heart Association; National Institute on AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01-AG055395, R01-AG047879, R01-AG038747]; National Institute of Neurological Disorders and StrokeUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01-NS056218, R01-NS100782]; National Center for Complementary and Alternative MedicineUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01-AT006526]; NIA-supported Geroscience Training Program in Oklahoma [T32AG052363]; NIA-supported Oklahoma Nathan Shock Center [3P30AG050911-02S1]; NIH-supported Oklahoma Shared Clinical and Translational Resources [U54GM104938]; College of Medicine Alumni Association; Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center [AG028718]; Oklahoma Center for the Advancement of Science and Technology; Reynolds Foundation; EUEuropean Commission [EFOP-3.6.1-16-2016-00008]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938, U54GM104938] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS100782, R01NS100782, R01NS100782] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG055395, R01AG055395, R01AG055395, R01AG047879, R01AG055395, R01AG047879, R01AG047879, R01AG047879, R01AG047879] Funding Source: NIH RePORTER
            Funding text: American Heart Association; the National Institute on Aging, Grant/Award Number: R01-AG055395, R01-AG047879, R01-AG038747; the National Institute of Neurological Disorders and Stroke, Grant/Award Number: R01-NS056218, R01-NS100782; the National Center for Complementary and Alternative Medicine, Grant/Award Number: R01-AT006526; the NIA-supported Geroscience Training Program in Oklahoma, Grant/Award Number: T32AG052363; the NIA-supported Oklahoma Nathan Shock Center, Grant/Award Number: 3P30AG050911-02S1; NIH-supported Oklahoma Shared Clinical and Translational Resources, Grant/Award Number: U54GM104938; College of Medicine Alumni Association; Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center, Grant/Award Number: AG028718; the Oklahoma Center for the Advancement of Science and Technology; the Reynolds Foundation; EU-funded Hungarian, Grant/Award Number: EFOP-3.6.1-16-2016-00008
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szarka, Nikolett
AU  - Amrein, Krisztina
AU  - Horváth, Péter
AU  - Ivic, Ivan
AU  - Czeiter, Endre
AU  - Büki, András
AU  - Koller, Ákos
AU  - Tóth, Péter József
TI  - HYPERTENSION-INDUCED ENHANCED MYOGENIC CONSTRICTION OF CEREBRAL ARTERIES IS PRESERVED AFTER TRAUMATIC BRAIN INJURY.
JF  - JOURNAL OF NEUROTRAUMA
J2  - J NEUROTRAUM
VL  - 34
PY  - 2017
IS  - 14
SP  - 2315
EP  - 2319
PG  - 5
SN  - 0897-7151
DO  - 10.1089/neu.2016.4962
UR  - https://m2.mtmt.hu/api/publication/3195505
ID  - 3195505
N1  - Export Date: 31 August 2020            
            CODEN: JNEUE
AB  - Traumatic brain injury (TBI) was shown to impair pressure-induced myogenic response of cerebral arteries, which is associated with vascular and neural dysfunction and increased mortality of TBI patients. Hypertension was shown to enhance myogenic tone of cerebral arteries via increased vascular production of 20-hydroxyeicosatrienoic acid (HETE). This adaptive mechanism protects brain tissue form pressure/volume overload, but it can also lead to increased susceptibility to cerebral ischemia. Although both effects may potentiate the detrimental vascular consequences of TBI, it is not known how hypertension modulates the effect of TBI on myogenic responses of cerebral vessels. We hypothesized that in hypertensive rats, the enhanced myogenic cerebrovascular response is preserved after TBI. Thus, we investigated the myogenic responses of isolated middle cerebral arteries (MCA) of normotensive and spontaneously hypertensive rats (SHR) after severe impact acceleration diffuse brain injury. TBI diminished myogenic constriction of MCAs isolated from normotensive rats, whereas the 20-HETE-mediated enhanced myogenic response of MCAs isolated from SHRs was not affected by TBI. These results suggest that the optimal cerebral perfusion pressure values and vascular signaling pathways can be different and thus should be targeted differently in normotensive and hypertensive patients following TBI.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tóth, Péter József
AU  - Szarka, Nikolett
AU  - Farkas, Eszter
AU  - Ezer, Erzsébet
AU  - Czeiter, Endre
AU  - Amrein, Krisztina
AU  - Ungvári, Zoltán István
AU  - Hartings, JA
AU  - Büki, András
AU  - Koller, Ákos
TI  - Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications
JF  - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY
J2  - AM J PHYSIOL HEART C
VL  - 311
PY  - 2016
IS  - 5
SP  - H1118
EP  - H1131
SN  - 0363-6135
DO  - 10.1152/ajpheart.00267.2016
UR  - https://m2.mtmt.hu/api/publication/3110623
ID  - 3110623
N1  - Export Date: 31 August 2020            
            CODEN: AJPPD
Export Date: 2 September 2020            
            CODEN: AJPPD
Department of Neurosurgery, University of Pecs, Pecs, Hungary            
            Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary            
            Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Department of Translational Medicine, University of Pecs, Pecs, Hungary            
            Faculty of Medicine and Faculty of Science and Informatics, Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary            
            MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary            
            Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States            
            Institute of Natural Sciences, University of Physical Education, Budapest, Hungary            
            Department of Physiology, New York Medical College, Valhalla, NY, United States            
            Cited By :32            
            Export Date: 16 January 2021            
            CODEN: AJPPD            
            Correspondence Address: Toth, P.; Reynolds Oklahoma Center on Aging, Dept. of Geriatric Medicine, Univ. of Oklahoma, Health Sciences Center, 975 NE 10th St., BRC 1311, United States; email: peter-toth@ouhsc.edu
Funding Agency and Grant Number: American Heart AssociationAmerican Heart Association; Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences [BO/00634/15]; Hungarian Brain Research Program [KTIA_13_NAP-A-I/13, KTIA_13_NAP-A-II/8]; National Center for Complementary and Alternative MedicineUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01-AT006526]; Marie Slodowska-Curie Actions SMARTER 7th Framework Program of the European Union [606998]; Hungarian Scientific Research FundOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K111923, K108444]; NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01AT006526, R01AT006526, R01AT006526] Funding Source: NIH RePORTER; NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01AT006526, R01AT006526] Funding Source: NIH RePORTER
            Funding text: This work was supported by grants from the American Heart Association (to P. Toth and Z. Ungvari), the Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00634/15 to P. Toth and E. Farkas), the Hungarian Brain Research Program (Grant No. KTIA_13_NAP-A-I/13 to E. Farkas and Grant No. KTIA_13_NAP-A-II/8 to P. Toth, E. Czeiter, and A. Buki), National Center for Complementary and Alternative Medicine (R01-AT006526 to Z. Ungvari), the Marie Slodowska-Curie Actions SMARTER 7th Framework Program of the European Union 606998 (to N. Szarka and A. Koller), and the Hungarian Scientific Research Fund (K111923 to E. Farkas and K108444 to A. Koller).
Department of Neurosurgery, University of Pecs, Pecs, Hungary            
            Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary            
            Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Department of Translational Medicine, University of Pecs, Pecs, Hungary            
            Faculty of Medicine and Faculty of Science and Informatics, Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary            
            MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary            
            Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States            
            Institute of Natural Sciences, University of Physical Education, Budapest, Hungary            
            Department of Physiology, New York Medical College, Valhalla, NY, United States            
            Cited By :32            
            Export Date: 28 January 2021            
            CODEN: AJPPD            
            Correspondence Address: Toth, P.; Reynolds Oklahoma Center on Aging, 975 NE 10th St., BRC 1311, United States; email: peter-toth@ouhsc.edu
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Springó, Zsolt
AU  - Tarantini, Stefano
AU  - Tóth, Péter József
AU  - Tucsek, Z
AU  - Koller, Ákos
AU  - Sonntag, WE
AU  - Csiszar, Anna
AU  - Ungvári, Zoltán István
TI  - Aging exacerbates pressure-induced mitochondrial oxidative stress in mouse cerebral arteries
JF  - JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
J2  - J GERONTOL A-BIOL MED SCI
VL  - 70
PY  - 2015
IS  - 11
SP  - 1355
EP  - 1359
PG  - 5
SN  - 1079-5006
DO  - 10.1093/gerona/glu244
UR  - https://m2.mtmt.hu/api/publication/2798902
ID  - 2798902
N1  - Megosztott első szerzőség
Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, Oklahoma City, OK 73104, United States            
            Department of Pathophysiology and Gerontology, Medical School, Szentágothai Research Center, University of Pecs, Hungary            
            Peggy and Charles Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, United States            
            Cited By :38            
            Export Date: 30 October 2020            
            CODEN: JGASF            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, United States            
            Chemicals/CAS: Reactive Oxygen Species
Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, Oklahoma City, OK 73104, United States            
            Department of Pathophysiology and Gerontology, Medical School, Szentágothai Research Center, University of Pecs, Hungary            
            Peggy and Charles Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, United States            
            Cited By :38            
            Export Date: 31 October 2020            
            CODEN: JGASF            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, United States            
            Chemicals/CAS: Reactive Oxygen Species
Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, Oklahoma City, OK 73104, United States            
            Department of Pathophysiology and Gerontology, Medical School, Szentágothai Research Center, University of Pecs, Hungary            
            Peggy and Charles Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, United States            
            Cited By :38            
            Export Date: 1 November 2020            
            CODEN: JGASF            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, United States            
            Chemicals/CAS: Reactive Oxygen Species
Funding Agency and Grant Number: American Heart AssociationAmerican Heart Association; Oklahoma Center for the Advancement of Science and Technology; Hungarian National Science Research Fund (OTKA)Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 108444]; grant: Developing Competitiveness of Universities in the South Transdanubian Region, "Identification of new bio-markers ..., " [SROP-4.2.2.A-11/1/KONV-2012-0017]; grant: "Complex examination of neuropeptides ... ," [SROP-4.2.2. A-11/1/KONV-2012-0024]; National Center for Complementary and Alternative MedicineUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01-AT006526]; National Institute on AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01-AG031085, R01-AG038747, R01-NS056218]; Ellison Medical FoundationLawrence Ellison Foundation; Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center [P30 AG028718]; European UnionEuropean Union (EU); State of Hungary; European Social Fund, "National Excellence Program" [TAMOP 4.2.4.A/2-11-1-2012-0001]
            Funding text: This work was supported by grants from the American Heart Association (to P.T., S.T., A.C., and Z.U.), the Oklahoma Center for the Advancement of Science and Technology (to A.C., Z.U., and W.E.S.), the Hungarian National Science Research Fund (OTKA) K 108444 and grants: Developing Competitiveness of Universities in the South Transdanubian Region, "Identification of new bio-markers ... ," SROP-4.2.2.A-11/1/KONV-2012-0017 and "Complex examination of neuropeptides ... ," SROP-4.2.2. A-11/1/KONV-2012-0024 to A. K., the National Center for Complementary and Alternative Medicine (R01-AT006526 to Z.U.), the National Institute on Aging (R01-AG031085 to A.C.; R01-AG038747 to W.E.S.; R01-NS056218 to A.C. and W.E.S.), the Ellison Medical Foundation (to W.E.S.), and the Arkansas Claude Pepper Older Americans Independence Center at University of Arkansas Medical Center (P30 AG028718 to A.C.). Z.S. is a Copastoeck Fellow supported by a fellowship from the European Union and the State of Hungary, cofinanced by the European Social Fund in the framework of TAMOP 4.2.4.A/2-11-1-2012-0001 "National Excellence Program."
Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, Oklahoma City, OK 73104, United States            
            Department of Pathophysiology and Gerontology, Medical School, Szentágothai Research Center, University of Pecs, Hungary            
            Peggy and Charles Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, United States            
            Cited By :38            
            Export Date: 2 November 2020            
            CODEN: JGASF            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, United States            
            Chemicals/CAS: Reactive Oxygen Species
Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, Oklahoma City, OK 73104, United States            
            Department of Pathophysiology and Gerontology, Medical School, Szentágothai Research Center, University of Pecs, Hungary            
            Peggy and Charles Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, United States            
            Cited By :38            
            Export Date: 4 November 2020            
            CODEN: JGASF            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, United States            
            Chemicals/CAS: Reactive Oxygen Species
Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, Oklahoma City, OK 73104, United States            
            Department of Pathophysiology and Gerontology, Medical School, Szentágothai Research Center, University of Pecs, Hungary            
            Peggy and Charles Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, United States            
            Cited By :38            
            Export Date: 6 November 2020            
            CODEN: JGASF            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, United States            
            Chemicals/CAS: Reactive Oxygen Species
Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, Oklahoma City, OK 73104, United States            
            Department of Pathophysiology and Gerontology, Medical School, Szentágothai Research Center, University of Pecs, Hungary            
            Peggy and Charles Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, United States            
            Cited By :38            
            Export Date: 13 January 2021            
            CODEN: JGASF            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, United States            
            Chemicals/CAS: Reactive Oxygen Species
Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma, Health Sciences Center, 975 N.E. 10th Street, BRC 1303, Oklahoma City, OK 73104, United States            
            Department of Pathophysiology and Gerontology, Medical School, Szentágothai Research Center, University of Pecs, Hungary            
            Peggy and Charles Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, United States            
            Cited By :39            
            Export Date: 8 February 2021            
            CODEN: JGASF            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, 975 N.E. 10th Street, BRC 1303, United States
AB  - Epidemiological studies demonstrate that in addition to the increased prevalence of hypertension in old patients, the deleterious cerebrovascular effects of hypertension ( including atherosclerosis, stroke, and vascular cognitive impairment) are also exacerbated in elderly individuals. The cellular mechanisms by which aging and hypertension interact to promote cerebrovascular pathologies are not well understood. To test the hypothesis that aging exacerbates high pressure-induced mitochondrial oxidative stress, we exposed isolated segments of the middle cerebral arteries of young ( 3 months) and aged ( 24 months) C57BL/6 mice to 60 or 140 mmHg intraluminal pressure and assessed changes in mitochondrial reactive oxygen species production using a mitochondria-targeted redox-sensitive fluorescent indicator dye ( MitoSox) by confocal microscopy. Perinuclear MitoSox fluorescence was significantly stronger in high pressure-exposed middle cerebral arteries compared with middle cerebral arteries of the same animals exposed to 60 mmHg, indicating that high pressure increases mitochondrial reactive oxygen species production in the smooth muscle cells of cerebral arteries. Comparison of young and aged middle cerebral arteries showed that aging exacerbates high pressure-induced mitochondrial reactive oxygen species production in cerebral arteries. We propose that increased mechanosensitive mitochondrial oxidative stress may potentially exacerbate cerebrovascular injury and vascular inflammation in aging.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tóth, Péter József
AU  - Tarantini, Stefano
AU  - Tucsek, Z
AU  - Ashpole, NM
AU  - Sosnowska, D
AU  - Gautam, T
AU  - Ballabh, P
AU  - Koller, Ákos
AU  - Sonntag, WE
AU  - Csiszar, Anna
AU  - Ungvári, Zoltán István
TI  - Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase
JF  - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY
J2  - AM J PHYSIOL HEART C
VL  - 306
PY  - 2014
IS  - 3
SP  - H299
EP  - H308
SN  - 0363-6135
DO  - 10.1152/ajpheart.00744.2013
UR  - https://m2.mtmt.hu/api/publication/2496231
ID  - 2496231
N1  - Funding Agency and Grant Number: American Heart AssociationAmerican Heart Association; American Federation for Aging Research; Oklahoma Center for the Advancement of Science and Technology; Hungarian National Science Research Fund (OTKA)Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 108444]; Developing Competitiveness of Universities in the South Transdanubian Region [SROP-4.2.2.A-11/1/KONV-2012-0017, SROP-4.2.2.A-11/1/KONV-2012-0024]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AG-031085, AT-006526, AG-038747, NS-056218, P01AG-11370]; Ellison Medical FoundationLawrence Ellison Foundation; NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01AT006526, R01AT006526, R01AT006526] Funding Source: NIH RePORTER; NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01AT006526, R01AT006526] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG026607, P01AG011370, R01AG038747, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, K08AG031085, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG038747, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG038747, P01AG011370, P01AG011370, P01AG011370, R01AG038747, P01AG011370, P01AG011370, R01AG026607, K08AG031085, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, K08AG031085, P01AG011370, P01AG011370, R01AG026607, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG026607, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG038747, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG026607, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370] Funding Source: NIH RePORTER
            Funding text: This work was supported by grants from the American Heart Association (to P. Toth, A. Csiszar, and Z. Ungvari), American Federation for Aging Research (to A. Csiszar), Oklahoma Center for the Advancement of Science and Technology (to A. Csiszar, Z. Ungvari, and W. E. Sonntag), Hungarian National Science Research Fund (OTKA) K 108444, Developing Competitiveness of Universities in the South Transdanubian Region, "Identification of new biomarkers . . .", SROP-4.2.2.A-11/1/KONV-2012-0017 and "Complex examination of neuropeptide . . ." SROP-4.2.2.A-11/1/KONV-2012-0024 (to A. Koller and Z. Ungvari), National Institutes of Health (AG-031085 to A. Csiszar; AT-006526 to Z. Ungvari; and AG-038747, NS-056218, and P01AG-11370 to W. E. Sonntag), and Ellison Medical Foundation (to W. E. Sonntag).
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Department of Pathophysiology, Gerontology and Szentagothai Research Center, University of Pecs, Pecs, Hungary            
            Department of Pediatrics, New York Medical College-Westchester Medical Center, Valhalla, NY, United States            
            Department of Anatomy and Cell Biology, New York Medical College-Westchester Medical Center, Valhalla, NY, United States            
            Department of Physiology, New York Medical College, Valhalla, NY, United States            
            Cited By :97            
            Export Date: 4 December 2020            
            CODEN: AJPPD            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Dept. of Geriatric Medicine, Univ. of Oklahoma Health Sciences Center, 975 NE 10th St., BRC 1311, Oklahoma City, OK 73104, United States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: 3 nitrotyrosine, 3604-79-3; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; resveratrol, 501-36-0; NADPH Oxidase; Reactive Oxygen Species; resveratrol; Stilbenes; Vasodilator Agents
Funding Agency and Grant Number: American Heart AssociationAmerican Heart Association; American Federation for Aging Research; Oklahoma Center for the Advancement of Science and Technology; Hungarian National Science Research Fund (OTKA)Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 108444]; Developing Competitiveness of Universities in the South Transdanubian Region [SROP-4.2.2.A-11/1/KONV-2012-0017, SROP-4.2.2.A-11/1/KONV-2012-0024]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AG-031085, AT-006526, AG-038747, NS-056218, P01AG-11370]; Ellison Medical FoundationLawrence Ellison Foundation; NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01AT006526, R01AT006526, R01AT006526] Funding Source: NIH RePORTER; NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Complementary & Alternative Medicine [R01AT006526, R01AT006526] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218, R01NS056218] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [P01AG011370, P01AG011370, R01AG038747, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG026607, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG038747, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG026607, P01AG011370, P01AG011370, P01AG011370, R01AG026607, P01AG011370, P01AG011370, P01AG011370, K08AG031085, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, K08AG031085, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG038747, P01AG011370, P01AG011370, K08AG031085, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, R01AG026607, R01AG026607, P01AG011370, P01AG011370, P01AG011370, R01AG038747, R01AG038747, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370, P01AG011370] Funding Source: NIH RePORTER
            Funding text: This work was supported by grants from the American Heart Association (to P. Toth, A. Csiszar, and Z. Ungvari), American Federation for Aging Research (to A. Csiszar), Oklahoma Center for the Advancement of Science and Technology (to A. Csiszar, Z. Ungvari, and W. E. Sonntag), Hungarian National Science Research Fund (OTKA) K 108444, Developing Competitiveness of Universities in the South Transdanubian Region, "Identification of new biomarkers . . .", SROP-4.2.2.A-11/1/KONV-2012-0017 and "Complex examination of neuropeptide . . ." SROP-4.2.2.A-11/1/KONV-2012-0024 (to A. Koller and Z. Ungvari), National Institutes of Health (AG-031085 to A. Csiszar; AT-006526 to Z. Ungvari; and AG-038747, NS-056218, and P01AG-11370 to W. E. Sonntag), and Ellison Medical Foundation (to W. E. Sonntag).
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Department of Pathophysiology, Gerontology and Szentagothai Research Center, University of Pecs, Pecs, Hungary            
            Department of Pediatrics, New York Medical College-Westchester Medical Center, Valhalla, NY, United States            
            Department of Anatomy and Cell Biology, New York Medical College-Westchester Medical Center, Valhalla, NY, United States            
            Department of Physiology, New York Medical College, Valhalla, NY, United States            
            Cited By :98            
            Export Date: 11 January 2021            
            CODEN: AJPPD            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Dept. of Geriatric Medicine, Univ. of Oklahoma Health Sciences Center, 975 NE 10th St., BRC 1311, Oklahoma City, OK 73104, United States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: 3 nitrotyrosine, 3604-79-3; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; resveratrol, 501-36-0; NADPH Oxidase; Reactive Oxygen Species; resveratrol; Stilbenes; Vasodilator Agents
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Department of Pathophysiology, Gerontology and Szentagothai Research Center, University of Pecs, Pecs, Hungary            
            Department of Pediatrics, New York Medical College-Westchester Medical Center, Valhalla, NY, United States            
            Department of Anatomy and Cell Biology, New York Medical College-Westchester Medical Center, Valhalla, NY, United States            
            Department of Physiology, New York Medical College, Valhalla, NY, United States            
            Cited By :98            
            Export Date: 13 January 2021            
            CODEN: AJPPD            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging, Dept. of Geriatric Medicine, Univ. of Oklahoma Health Sciences Center, 975 NE 10th St., BRC 1311, Oklahoma City, OK 73104, United States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: 3 nitrotyrosine, 3604-79-3; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; resveratrol, 501-36-0; NADPH Oxidase; Reactive Oxygen Species; resveratrol; Stilbenes; Vasodilator Agents
AB  - Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling is essential for the maintenance of normal neuronal function. Increased oxidative stress that occurs with aging was shown to impair neurovascular coupling, which likely contributes to a significant age-related decline in higher brain function, increasing the risk for vascular cognitive impairment (VCI). Resveratrol is a polyphenolic compound that exerts significant anti-aging protective effects in large vessels but its effects on the cerebromicrovasculature remain poorly defined. The present study was undertaken to investigate the capacity of resveratrol to improve neurovascular coupling in aging. In aged (24 months old) C57BL/6 mice L-NAME sensitive, NO-mediated CBF responses to whisker stimulation and to the endothelium-dependent dilator acethylcholine (ACh) were impaired as compared to those in young (3 months old) mice. Treatment of aged mice with resveratrol rescued neurovascular coupling and ACh-induced responses, which was associated with down-regulation of cortical expression of NADPH oxidase and decreased levels of biomarkers of oxidative/nitrative stress (3-nitrotyrosine, 8-isoprostanes). Resveratrol also attenuated age-related increases in ROS production in cultured cerebromicrovascular endothelial cells (DCF fluorescence, flow cytometry). In conclusion, treatment with resveratrol rescues cortical neurovascular coupling responses to increased neuronal activity in aged mice, likely by restoring cerebromicrovascular endothelial function via down-regulation of NADPH-oxidase derived ROS production. Beneficial cerebromicrovascular effects of resveratrol likely contribute to its protective effects on higher brain function in aging.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Dikalov, SI
AU  - Ungvári, Zoltán István
TI  - Role of mitochondrial oxidative stress in hypertension
JF  - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY
J2  - AM J PHYSIOL HEART C
VL  - 305
PY  - 2013
IS  - 10
SP  - H1417
EP  - H1427
SN  - 0363-6135
DO  - 10.1152/ajpheart.00089.2013
UR  - https://m2.mtmt.hu/api/publication/2528667
ID  - 2528667
N1  - Cited By :101            
            Export Date: 29 October 2020            
            CODEN: AJPPD            
            Correspondence Address: Dikalov, S. I.; Div. of Clinical Pharmacology, VUMC, 2200 Pierce Ave., PRB 554, Nashville, TN 37232-6600, United States; email: sergey.dikalov@vanderbilt.edu            
            Chemicals/CAS: aconitate hydratase, 9024-25-3; angiotensin II, 11128-99-7; glutaredoxin, 157514-02-8; glutathione, 70-18-8; glutathione peroxidase, 9013-66-5; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone), 9028-04-0; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; rotenone, 83-79-4; succinate dehydrogenase (ubiquinone), 9028-11-9; vasculotropin, 127464-60-2; Angiotensin II, 11128-99-7; Antihypertensive Agents; Antioxidants; NADPH Oxidase, 1.6.3.1; Reactive Oxygen Species
Cited By :101            
            Export Date: 30 October 2020            
            CODEN: AJPPD            
            Correspondence Address: Dikalov, S. I.; Div. of Clinical Pharmacology, VUMC, 2200 Pierce Ave., PRB 554, Nashville, TN 37232-6600, United States; email: sergey.dikalov@vanderbilt.edu            
            Chemicals/CAS: aconitate hydratase, 9024-25-3; angiotensin II, 11128-99-7; glutaredoxin, 157514-02-8; glutathione, 70-18-8; glutathione peroxidase, 9013-66-5; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone), 9028-04-0; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; rotenone, 83-79-4; succinate dehydrogenase (ubiquinone), 9028-11-9; vasculotropin, 127464-60-2; Angiotensin II, 11128-99-7; Antihypertensive Agents; Antioxidants; NADPH Oxidase, 1.6.3.1; Reactive Oxygen Species
Cited By :101            
            Export Date: 31 October 2020            
            CODEN: AJPPD            
            Correspondence Address: Dikalov, S. I.; Div. of Clinical Pharmacology, VUMC, 2200 Pierce Ave., PRB 554, Nashville, TN 37232-6600, United States; email: sergey.dikalov@vanderbilt.edu            
            Chemicals/CAS: aconitate hydratase, 9024-25-3; angiotensin II, 11128-99-7; glutaredoxin, 157514-02-8; glutathione, 70-18-8; glutathione peroxidase, 9013-66-5; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone), 9028-04-0; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; rotenone, 83-79-4; succinate dehydrogenase (ubiquinone), 9028-11-9; vasculotropin, 127464-60-2; Angiotensin II, 11128-99-7; Antihypertensive Agents; Antioxidants; NADPH Oxidase, 1.6.3.1; Reactive Oxygen Species
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Dai, DF
AU  - Rabinovitch, PS
AU  - Ungvári, Zoltán István
TI  - Mitochondria and Cardiovascular Aging
JF  - CIRCULATION RESEARCH
J2  - CIRC RES
VL  - 110
PY  - 2012
IS  - 8
SP  - 1109
EP  - 1124
PG  - 16
SN  - 0009-7330
DO  - 10.1161/CIRCRESAHA.111.246140
UR  - https://m2.mtmt.hu/api/publication/2528682
ID  - 2528682
N1  - Megjegyzés-22398168
WC: Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
: Disease
Export Date: 23 June 2020            
            CODEN: CIRUA
Department of Pathology, University of Washington, Seattle, WA, United States            
            Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States            
            Cited By :229            
            Export Date: 29 October 2020            
            CODEN: CIRUA            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: insulin, 9004-10-8; somatomedin C, 67763-96-6; Antioxidants
Department of Pathology, University of Washington, Seattle, WA, United States            
            Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States            
            Cited By :229            
            Export Date: 30 October 2020            
            CODEN: CIRUA            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: insulin, 9004-10-8; somatomedin C, 67763-96-6; Antioxidants
Funding Agency and Grant Number: American Diabetes AssociationAmerican Diabetes Association; Oklahoma Center for Advancement of Science and Technology; American Heart AssociationAmerican Heart Association; Ellison Medical FoundationLawrence Ellison Foundation; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AT006526, AG038747, AG11370, HL101186, AG013280, AG000751]
            Funding text: This work was supported by grants from the American Diabetes Association, the Oklahoma Center for the Advancement of Science and Technology, the American Heart Association, the Ellison Medical Foundation, and the National Institutes of Health (AT006526, AG038747, AG11370, HL101186, AG013280, AG000751).
Department of Pathology, University of Washington, Seattle, WA, United States            
            Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States            
            Cited By :229            
            Export Date: 31 October 2020            
            CODEN: CIRUA            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: insulin, 9004-10-8; somatomedin C, 67763-96-6; Antioxidants
Department of Pathology, University of Washington, Seattle, WA, United States            
            Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States            
            Cited By :229            
            Export Date: 4 November 2020            
            CODEN: CIRUA            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: insulin, 9004-10-8; somatomedin C, 67763-96-6; Antioxidants
Department of Pathology, University of Washington, Seattle, WA, United States            
            Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States            
            Cited By :235            
            Export Date: 11 January 2021            
            CODEN: CIRUA            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: insulin, 9004-10-8; somatomedin C, 67763-96-6; Antioxidants
Department of Pathology, University of Washington, Seattle, WA, United States            
            Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States            
            Cited By :235            
            Export Date: 13 January 2021            
            CODEN: CIRUA            
            Correspondence Address: Ungvari, Z.; Reynolds Oklahoma Center on Aging Donald W. Reynolds, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th Street, Oklahoma City, OK 73104, United States; email: zoltan-ungvari@ouhsc.edu            
            Chemicals/CAS: insulin, 9004-10-8; somatomedin C, 67763-96-6; Antioxidants
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Csiszar, Anna
AU  - Labinskyy, N
AU  - Perez, V
AU  - Recchia, FA
AU  - Podlutsky, A
AU  - Mukhopadhyay, P
AU  - Losonczy, György
AU  - Pacher, Pál
AU  - Austad, SN
AU  - Bartke, A
AU  - Ungvári, Zoltán István
TI  - Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice
JF  - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY
J2  - AM J PHYSIOL HEART C
VL  - 295
PY  - 2008
IS  - 5
SP  - H1882
EP  - H1894
SN  - 0363-6135
DO  - 10.1152/ajpheart.412.2008
UR  - https://m2.mtmt.hu/api/publication/1416573
ID  - 1416573
N1  - Megjegyzés-23693842
AB  - Csiszar A, Labinskyy N, Perez V, Recchia FA, Podlutsky A, Mukhopadhyay P, Losonczy G, Pacher P, Austad SN, Bartke A, Ungvari Z. Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol 295: H1882-H1894, 2008. First published August 29, 2008; doi:10.1152/ajpheart.412.2008. - Hypopituitary Ames dwarf mice have low circulating growth hormone (GH)/IGF-I levels, and they have extended longevity and exhibit many symptoms of delayed aging. To elucidate the vascular consequences of Ames dwarfism we compared endothelial O-2(center dot-) and H2O2 production, mitochondrial reactive oxygen species (ROS) generation, expression of antioxidant enzymes, and nitric oxide (NO) production in aortas of Ames dwarf and wild-type control mice. In Ames dwarf aortas endothelial O-2(center dot-) and H2O2 production and ROS generation by mitochondria were enhanced compared with those in vessels of wild-type mice. In Ames dwarf aortas there was a less abundant expression of Mn-SOD, Cu, Zn-SOD, glutathione peroxidase (GPx)-1, and endothelial nitric oxide synthase (eNOS). NO production and acetylcholine-induced relaxation were also decreased in aortas of Ames dwarf mice. In cultured wild-type mouse aortas and in human coronary arterial endothelial cells treatment with GH and IGF significantly reduced cellular O-2(center dot-) and H2O2 production and ROS generation by mitochondria and upregulated expression of Mn-SOD, Cu, Zn-SOD, GPx-1, and eNOS. Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hortobagyi, L
AU  - Kis, B
AU  - Hrabák, András
AU  - Horváth, Béla András
AU  - Huszty, Gergely
AU  - Schweer, H
AU  - Benyó, Balázs István
AU  - Sándor, Péter
AU  - Busija, DW
AU  - Benyó, Zoltán
TI  - Adaptation of the hypothalamic blood flow to chronic nitric oxide deficiency is independent of vasodilator prostanoids
JF  - BRAIN RESEARCH
J2  - BRAIN RES
VL  - 1131
PY  - 2007
SP  - 129
EP  - 137
PG  - 9
SN  - 0006-8993
DO  - 10.1016/j.brainres.2006.11.009
UR  - https://m2.mtmt.hu/api/publication/1151559
ID  - 1151559
LA  - English
DB  - MTMT
ER  -