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Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors
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Neuronal hyperexcitability is a phenomenon associated with early Alzheimer's disease. The underlying mechanism is considered to involve excessive activation of glutamate receptors; however, the exact molecular pathway remains to be determined. Extracellular recording from the CA1 of hippocampal slices is a long-standing standard for a range of studies both in basic research and in neuropharmacology. Evoked field potentials (fEPSPs) are regarded as the input, while spiking rate is regarded as the output of the neuronal network; however, the relationship between these two phenomena is not fully clear. We investigated the relationship between spontaneous spiking and evoked fEPSPs using mouse hippocampal slices. Blocking AMPA receptors (AMPARs) with CNQX abolished fEPSPs, but left firing rate unchanged. NMDA receptor (NMDAR) blockade with MK801 decreased neuronal spiking dose dependently without altering fEPSPs. Activating NMDARs by small concentration of NMDA induced a trend of increased firing. These results suggest that fEPSPs are mediated by synaptic activation of AMPARs, while spontaneous firing is regulated by the activation of extrasynaptic NMDARs. Synaptotoxic Abeta(1-42) increased firing activity without modifying evoked fEPSPs. This hyperexcitation was prevented by ifenprodil, an antagonist of the NR2B NMDARs. Overall, these results suggest that Abeta(1-42) induced neuronal overactivity is not dependent on AMPARs but requires NR2B.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10037419"> <a href="/gui2/?type=authors&mode=browse&sel=10037419" target="_blank">Varga, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10063613"> <a href="/gui2/?type=authors&mode=browse&sel=10063613" target="_blank">Juhasz, G</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10011919"> <a href="/gui2/?type=authors&mode=browse&sel=10011919" target="_blank">Bozso, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000481"> <a href="/gui2/?type=authors&mode=browse&sel=10000481" target="_blank">Penke, B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000567"> <a href="/gui2/?type=authors&mode=browse&sel=10000567" target="_blank">Fulop, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10027696"> <a href="/gui2/?type=authors&mode=browse&sel=10027696" target="_blank">Szegedi, V ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2755870" mtid="2755870" target="_blank">Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors</a></div> <div class="pub-info"> <span class="journal-title">NEURAL PLASTICITY</span> <span class="journal-volume">2014</span> <span class="page"> Paper: 584314 , 12 p. </span> <span class="year">(2014)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1155/2014/584314" target="_blank" href="https://doi.org/10.1155/2014/584314"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000344264700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000344264700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84925376428" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84925376428"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25276438" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25276438&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10503" target="_blank" href="http://publicatio.bibl.u-szeged.hu/10503"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:2755870 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 22</span> | Független: 21 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 22 | Scopus jelölt: 21 | WoS/Scopus jelölt: 22 | DOI jelölt: 22 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10037419"><a href="/gui2/?type=authors&mode=browse&sel=10037419" target="_blank">Varga E (<span class="authorship-author-name">Varga Edina</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ; <span class="author-name" mtid="10063613"><a href="/gui2/?type=authors&mode=browse&sel=10063613" target="_blank">Juhasz G (<span class="authorship-author-name">Juhász Gábor</span> <span class="authorAux-mtmt"> elektofiziológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ; <span class="author-name" mtid="10011919"><a href="/gui2/?type=authors&mode=browse&sel=10011919" target="_blank">Bozso Z (<span class="authorship-author-name">Bozsó Zsolt</span> <span class="authorAux-mtmt"> Peptidkémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ; <span class="author-name" mtid="10000481"><a href="/gui2/?type=authors&mode=browse&sel=10000481" target="_blank">Penke B (<span class="authorship-author-name">Penke Botond</span> <span class="authorAux-mtmt"> Neurodegeneráció, peptidkémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ; <span class="author-name" mtid="10000567"><a href="/gui2/?type=authors&mode=browse&sel=10000567" target="_blank">Fulop L (<span class="authorship-author-name">Fülöp Lívia</span> <span class="authorAux-mtmt"> Neurodegeneratív betegségekkel kapcsolatos gyóg...</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ; <span class="author-name" mtid="10027696"><a href="/gui2/?type=authors&mode=browse&sel=10027696" target="_blank">Szegedi V ✉ (<span class="authorship-author-name">Szegedi Viktor</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Biokémiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;2755870" target="_blank">Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors</a></div> <div> <span class="journal-title">NEURAL PLASTICITY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2090-5904">2090-5904</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1687-5443">1687-5443</a>)</span>: <span class="journal-volume">2014</span> <span class="page"> Paper 584314. 12 p. </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1155/2014/584314" target="_blank" href="https://doi.org/10.1155/2014/584314"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000344264700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000344264700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84925376428" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84925376428"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25276438" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25276438&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10503" target="_blank" href="http://publicatio.bibl.u-szeged.hu/10503"> SZTE Publicatio </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 22</span> | Független: 21 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 22 | Scopus jelölt: 21 | WoS/Scopus jelölt: 22 | DOI jelölt: 22 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2755870&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2755870</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 2755870</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2024.02.27. 22:36 Pécsi Éva (MTMT Közp 3, admin) </div> <div class="lockedBy">Ideiglenesen zárolva 2024.03.11. 18:47 Pécsi Éva (MTMT Közp 3, admin) </div> </div></div>
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APPROVED
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Cited By :52
Export Date: 12 March 2020
CODEN: NRSCD
Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B. 67, Budapest, H-1450, Hungary; email: freund@koki.hu
Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; gamma-Aminobutyric Acid, 56-12-2; HSP72 Heat-Shock Proteins; sodium-potassium chloride cotransporter 2 protein; Sodium-Potassium-Chloride Symporters
Funding details: Academy of Finland
Funding details: Howard Hughes Medical Institute, HHMI
Funding details: National Institutes of Health, NIH, NS30549
Funding details: Hungarian Scientific Research Fund, OTKA, T46820
Funding text 1: The excellent technical assistance of E. Simon and Gy Goda is also acknowledged. This study was supported by the Howard Hughes Medical Institute (T.F.F.), Szentágothai Knowledge Centre (T.F.F.), NIH, NS30549 (T.F.F.), OTKA T46820 (T.F.F.), and by the Academy of Finland (K.K., C.R.) E. P. is a grantee of the János Bólyai scholarship.
Cited By :52
Export Date: 24 May 2020
CODEN: NRSCD
Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B. 67, Budapest, H-1450, Hungary; email: freund@koki.hu
Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; gamma-Aminobutyric Acid, 56-12-2; HSP72 Heat-Shock Proteins; sodium-potassium chloride cotransporter 2 protein; Sodium-Potassium-Chloride Symporters
Funding details: Academy of Finland
Funding details: Howard Hughes Medical Institute, HHMI
Funding details: National Institutes of Health, NIH, NS30549
Funding details: Hungarian Scientific Research Fund, OTKA, T46820
Funding text 1: The excellent technical assistance of E. Simon and Gy Goda is also acknowledged. This study was supported by the Howard Hughes Medical Institute (T.F.F.), Szentágothai Knowledge Centre (T.F.F.), NIH, NS30549 (T.F.F.), OTKA T46820 (T.F.F.), and by the Academy of Finland (K.K., C.R.) E. P. is a grantee of the János Bólyai scholarship.
Cited By :52
Export Date: 28 May 2020
CODEN: NRSCD
Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B. 67, Budapest, H-1450, Hungary; email: freund@koki.hu
Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; gamma-Aminobutyric Acid, 56-12-2; HSP72 Heat-Shock Proteins; sodium-potassium chloride cotransporter 2 protein; Sodium-Potassium-Chloride Symporters
Funding details: Academy of Finland
Funding details: Howard Hughes Medical Institute, HHMI
Funding details: National Institutes of Health, NIH, NS30549
Funding details: Hungarian Scientific Research Fund, OTKA, T46820
Funding text 1: The excellent technical assistance of E. Simon and Gy Goda is also acknowledged. This study was supported by the Howard Hughes Medical Institute (T.F.F.), Szentágothai Knowledge Centre (T.F.F.), NIH, NS30549 (T.F.F.), OTKA T46820 (T.F.F.), and by the Academy of Finland (K.K., C.R.) E. P. is a grantee of the János Bólyai scholarship.
Cited By :54
Export Date: 30 December 2020
CODEN: NRSCD
Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B. 67, Budapest, H-1450, Hungary; email: freund@koki.hu
Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; gamma-Aminobutyric Acid, 56-12-2; HSP72 Heat-Shock Proteins; sodium-potassium chloride cotransporter 2 protein; Sodium-Potassium-Chloride Symporters
Funding details: Academy of Finland
Funding details: Howard Hughes Medical Institute, HHMI
Funding details: National Institutes of Health, NIH, NS30549
Funding details: Hungarian Scientific Research Fund, OTKA, T46820
Funding text 1: The excellent technical assistance of E. Simon and Gy Goda is also acknowledged. This study was supported by the Howard Hughes Medical Institute (T.F.F.), Szentágothai Knowledge Centre (T.F.F.), NIH, NS30549 (T.F.F.), OTKA T46820 (T.F.F.), and by the Academy of Finland (K.K., C.R.) E. P. is a grantee of the János Bólyai scholarship.
Cited By :55
Export Date: 1 April 2021
CODEN: NRSCD
Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O.B. 67, Budapest, H-1450, Hungary; email: freund@koki.hu
Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; gamma-Aminobutyric Acid, 56-12-2; HSP72 Heat-Shock Proteins; sodium-potassium chloride cotransporter 2 protein; Sodium-Potassium-Chloride Symporters
Funding details: National Institutes of Health, NIH
Funding details: Howard Hughes Medical Institute, HHMI
Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549
Funding details: Academy of Finland
Funding details: Hungarian Scientific Research Fund, OTKA, T46820
Funding text 1: The excellent technical assistance of E. Simon and Gy Goda is also acknowledged. This study was supported by the Howard Hughes Medical Institute (T.F.F.), Szentágothai Knowledge Centre (T.F.F.), NIH, NS30549 (T.F.F.), OTKA T46820 (T.F.F.), and by the Academy of Finland (K.K., C.R.) E. P. is a grantee of the János Bólyai scholarship.
Cited By :55
Export Date: 6 April 2021
CODEN: NRSCD
Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O.B. 67, Budapest, H-1450, Hungary; email: freund@koki.hu
Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; gamma-Aminobutyric Acid, 56-12-2; HSP72 Heat-Shock Proteins; sodium-potassium chloride cotransporter 2 protein; Sodium-Potassium-Chloride Symporters
Funding details: National Institutes of Health, NIH
Funding details: Howard Hughes Medical Institute, HHMI
Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549
Funding details: Academy of Finland
Funding details: Hungarian Scientific Research Fund, OTKA, T46820
Funding text 1: The excellent technical assistance of E. Simon and Gy Goda is also acknowledged. This study was supported by the Howard Hughes Medical Institute (T.F.F.), Szentágothai Knowledge Centre (T.F.F.), NIH, NS30549 (T.F.F.), OTKA T46820 (T.F.F.), and by the Academy of Finland (K.K., C.R.) E. P. is a grantee of the János Bólyai scholarship.
Cited By :55
Export Date: 20 April 2021
CODEN: NRSCD
Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O.B. 67, Budapest, H-1450, Hungary; email: freund@koki.hu
Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; gamma-Aminobutyric Acid, 56-12-2; HSP72 Heat-Shock Proteins; sodium-potassium chloride cotransporter 2 protein; Sodium-Potassium-Chloride Symporters
Funding details: National Institutes of Health, NIH
Funding details: Howard Hughes Medical Institute, HHMI
Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549
Funding details: Academy of Finland
Funding details: Hungarian Scientific Research Fund, OTKA, T46820
Funding text 1: The excellent technical assistance of E. Simon and Gy Goda is also acknowledged. This study was supported by the Howard Hughes Medical Institute (T.F.F.), Szentágothai Knowledge Centre (T.F.F.), NIH, NS30549 (T.F.F.), OTKA T46820 (T.F.F.), and by the Academy of Finland (K.K., C.R.) E. P. is a grantee of the János Bólyai scholarship.
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Cation chloride cotransporters have been reported to be expressed in neurons in the hippocampus and to regulate intracellular Cl(-) concentration. The neuron-specific K-Cl cotransporter 2 (KCC2) is necessary for maintaining the low intracellular chloride concentration required for the hyperpolarizing actions of GABA. In this study we examined the vulnerability of KCC2-containing neurons as well as the changes in the pattern of KCC2 distribution in the rat hippocampus following 15 min ischemia induced by four-vessel occlusion. Immunostaining for the 72 kDa heat shock protein (HSP-72) was used to investigate the extent of damage in neuronal populations previously shown to be vulnerable to ischemia. At 6-24 h after ischemia, when the pyramidal cells in the CA1 (subfield of cornu Ammonis) region showed no morphological signs of damage, a small rise of KCC2 immunoreactivity was already observed. After 2 days, when the CA1 pyramidal cells started to degenerate, a progressive downregulation of the KCC2 protein was visible. Interestingly, in the same areas, the parvalbumin containing interneurons showed no signs of ischemic damage, and KCC2 immunoreactivity was retained on their membrane surface. In CA1 pyramidal cells, the reduction in KCC2 expression may lead to an elevation of intracellular Cl(-) concentration, which causes a shift in equilibrium potential toward more positive levels. Consequently, the reduction of the inhibitory action of GABA through downregulation of KCC2 function may be involved in the pathomechanisms of delayed neuronal death in the CA1 subfield.
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :52
Export Date: 12 March 2020
CODEN: NRSCD
Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B. 67, Budapest, H-1450, Hungary; email: freund@koki.hu
Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 8...</pre>
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N1 Molecular Sequence Numbers: GENBANK: AA982489;
Megjegyzés-25140616
N1 Molecular Sequence Numbers: GENBANK: AA982489;
Department of Biosciences, University of Helsinki, Helsinki, FIN-00014, Finland
Institute of Biotechnology, University of Helsinki, Helsinki, FIN-00014, Finland
Department of Human Physiology, Univ. of California Sch. of Medicine, Davis, CA 95616, United States
Europ. Molecular Biology Laboratory, 00016 Monterotondo, Italy
Institute of Biotechnology, P.O. Box 56, University of Helsinki, FIN-00014, Finland
Chemical Research Center, H-1025 Budapest, Hungary
Cited By :336
Export Date: 12 March 2020
CODEN: JNRSD
Correspondence Address: Rivera, C.; Institute of Biotechnology, P.O. Box 56, University of Helsinki, FIN-00014, Finland; email: Claudio.Rivera@helsinki.fi
Molecular Sequence Numbers: GENBANK: AA982489;
Chemicals/CAS: brain derived neurotrophic factor, 218441-99-7; cyclic AMP responsive element binding protein binding protein, 190209-80-4; phospholipase C, 9001-86-9; potassium ion, 24203-36-9; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Brain-Derived Neurotrophic Factor; Chlorides; Cyclic AMP Response Element-Binding Protein; Magnesium, 7439-95-4; Phospholipase C gamma, EC 3.1.4.3; Phospholipase C, EC 3.1.4.3; potassium-chloride symporters; Receptor, trkB, EC 2.7.1.112; RNA, Messenger; Src homology 2 domain-containing, transforming protein 1; Symporters
Department of Biosciences, University of Helsinki, Helsinki, FIN-00014, Finland
Institute of Biotechnology, University of Helsinki, Helsinki, FIN-00014, Finland
Department of Human Physiology, Univ. of California Sch. of Medicine, Davis, CA 95616, United States
Europ. Molecular Biology Laboratory, 00016 Monterotondo, Italy
Institute of Biotechnology, P.O. Box 56, University of Helsinki, FIN-00014, Finland
Chemical Research Center, H-1025 Budapest, Hungary
Cited By :357
Export Date: 6 April 2021
CODEN: JNRSD
Correspondence Address: Rivera, C.; Institute of Biotechnology, P.O. Box 56, University of Helsinki, FIN-00014, Finland; email: Claudio.Rivera@helsinki.fi
Molecular Sequence Numbers: GENBANK: AA982489;
Chemicals/CAS: brain derived neurotrophic factor, 218441-99-7; cyclic AMP responsive element binding protein binding protein, 190209-80-4; phospholipase C, 9001-86-9; potassium ion, 24203-36-9
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GABA-mediated fast-hyperpolarizing inhibition depends on extrusion of chloride by the neuron-specific K-Cl cotransporter, KCC2. Here we show that sustained interictal-like activity in hippocampal slices downregulates KCC2 mRNA and protein expression in CA1 pyramidal neurons, which leads to a reduced capacity for neuronal Cl- extrusion. This effect is mediated by endogenous BDNF acting on tyrosine receptor kinase B (TrkB), with down-stream cascades involving both Shc/FRS-2 (src homology 2 domain containing transforming protein/FGF receptor substrate 2) and PLCgamma (phospholipase Cgamma)-cAMP response element-binding protein signaling. The plasmalemmal KCC2 has a very high rate of turnover, with a time frame that suggests a novel role for changes in KCC2 expression in diverse manifestations of neuronal plasticity. A downregulation of KCC2 may be a general early response involved in various kinds of neuronal trauma.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Rivera, C </span> <span class="author-type"> </span> ; <span class="author-name" > Voipio, J </span> <span class="author-type"> </span> ; <span class="author-name" > Thomas-Crusells, J </span> <span class="author-type"> </span> ; <span class="author-name" > Li, H </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10010485"> <a href="/gui2/?type=authors&mode=browse&sel=10010485" target="_blank">Emri, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Sipila, S </span> <span class="author-type"> </span> ; <span class="author-name" > Payne, JA </span> <span class="author-type"> </span> ; <span class="author-name" > Minichiello, L </span> <span class="author-type"> </span> ; <span class="author-name" > Saarma, M </span> <span class="author-type"> </span> ; <span class="author-name" > Kaila, K </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2287575" mtid="2287575" target="_blank">Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-volume">24</span> : <span class="journal-issue">19</span> <span class="page"> pp. 4683-4691. , 9 p. </span> <span class="year">(2004)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1523/JNEUROSCI.5265-03.2004" target="_blank" href="https://doi.org/10.1523/JNEUROSCI.5265-03.2004"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000221477200021" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000221477200021"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="2442707888" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-2442707888"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="15140939" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15140939&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:2287575 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 357</span> | Független: 328 | Függő: 29 | Nem jelölt: 0 | WoS jelölt: 357 | Scopus jelölt: 298 | WoS/Scopus jelölt: 357 | DOI jelölt: 353 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="lastModified">Utolsó módosítás: 2018.11.13. 11:23 Lantos Edit (2, 3 közp admin - INAKTÍV)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-25140151
N1 Molecular Sequence Numbers: GENBANK: AA982489;
Megjegyzés-25140616
N1 Molecular Sequence Numbers: GENBANK: AA982489;
Department of Biosciences, University of Helsinki, Helsinki, FIN-00014, Finland
Institute of Biotechnology, University of Helsinki, Helsinki, FIN-00014, Finland
Department of Human Physiology, Univ. of Califor...</pre>
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Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn of the spinal cord is a crucial substrate for chronic pain syndromes. However, the nature of the mechanisms that underlie such disinhibition has remained controversial. Here we present evidence for a novel mechanism of disinhibition following peripheral nerve injury. It involves a trans-synaptic reduction in the expression of the potassium-chloride exporter KCC2, and the consequent disruption of anion homeostasis in neurons of lamina I of the superficial dorsal horn, one of the main spinal nociceptive output pathways. In our experiments, the resulting shift in the transmembrane anion gradient caused normally inhibitory anionic synaptic currents to be excitatory, substantially driving up the net excitability of lamina I neurons. Local blockade or knock-down of the spinal KCC2 exporter in intact rats markedly reduced the nociceptive threshold, confirming that the reported disruption of anion homeostasis in lamina I neurons was sufficient to cause neuropathic pain.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Coull, JA </span> <span class="author-type"> </span> ; <span class="author-name" > Boudreau, D </span> <span class="author-type"> </span> ; <span class="author-name" > Bachand, K </span> <span class="author-type"> </span> ; <span class="author-name" > Prescott, SA </span> <span class="author-type"> </span> ; <span class="author-name" > Nault, F </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10009549"> <a href="/gui2/?type=authors&mode=browse&sel=10009549" target="_blank">Sik, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" > De Koninck, P </span> <span class="author-type"> </span> ; <span class="author-name" > De Koninck, Y ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;3301448" mtid="3301448" target="_blank">Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain.</a></div> <div class="pub-info"> <span class="journal-title">NATURE</span> <span class="journal-volume">424</span> : <span class="journal-issue">6951</span> <span class="page"> pp. 938-942. , 5 p. </span> <span class="year">(2003)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/nature01868" target="_blank" href="https://doi.org/10.1038/nature01868"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000184843600041" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000184843600041"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="6223715" target="_blank" href="https://www.researchgate.net/publication/6223715"> ResearchGate publ. </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0042860080" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0042860080"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="12931188" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12931188&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:3301448 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 867</span> | Független: 822 | Függő: 45 | Nem jelölt: 0 | WoS jelölt: 804 | Scopus jelölt: 848 | WoS/Scopus jelölt: 867 | DOI jelölt: 827 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;3301448" target="_blank">Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain.</a></div> <div> <span class="journal-title">NATURE</span>
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<span class="journal-volume">424</span> <span class="journal-issue">6951</span>
<span class="page">
pp 938-942
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PubMed
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<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 867</span>
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| Függő: 45
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 3301448</span>
| <span class="status-data status-VALIDATED"> Egyeztetett
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<span class="oldId">Régi azonosító: 3301448</span> |
Forrás Idéző
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| <span class="pub-category">Tudományos</span>
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<div class="lastModified">Utolsó módosítás: 2023.09.03. 07:41 Milánkovics Róbert (PTE ÁOK admin 4)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 27 January 2024; CODEN: NATUA</pre>
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Increased number of synaptic GABA~A receptors underlies potentiation at hippocampal inhibitory synapses
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Changes in synaptic efficacy are essential far neuronal development(1), learning and memory formation(2) and for pathological slates of neuronal excitability, including temporal-lobe epilepsy(3), At synapses, where there is a high probability of opening of postsynaptic receptors(4), all of which are occupied by the released transmitter(5-9), the most effective means of augmenting postsynaptic responses is to increase the number of receptors(2,10,11). Here we combine quantal analysis of evoked inhibitory postsynaptic currents with quantitative immunogold localization of synaptic GABA(A) receptors in hippocampal granule cells in order to clarify the basis of inhibitory synaptic plasticity induced by an experimental model of temporal-lobe epilepsy (a process known as kindling)(10). We find that the larger amplitude (66% increase) of elementary synaptic currents (quantal size) after kindling results directly from a 75% increase in the number of GABA(A) receptors at inhibitory synapses on somata and axon initial segments. Receptor density was up by 34-40% and the synaptic junctional area was expanded by 31%. Presynaptic boutons were enlarged, which may account for the 39% decrease in the average number of released transmitter packets (quantal content). Our findings establish the postsynaptic insertion of new GABA(A) receptors and the corresponding increase in postsynaptic responses augmenting the efficacy of mammalian inhibitory synapses.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10000499"> <a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10010484"> <a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hájos, N</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10032182"> <a href="/gui2/?type=authors&mode=browse&sel=10032182" target="_blank">Somogyi, P</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Mody, I ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;108650" mtid="108650" target="_blank">Increased number of synaptic GABA~A receptors underlies potentiation at hippocampal inhibitory synapses</a></div> <div class="pub-info"> <span class="journal-title">NATURE</span> <span class="journal-volume">395</span> : <span class="journal-issue">6698</span> <span class="page"> pp. 172-177. , 6 p. </span> <span class="year">(1998)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/25999" target="_blank" href="https://doi.org/10.1038/25999"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000075829900042" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000075829900042"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0032505048" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0032505048"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="9744275" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9744275&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:108650 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 422</span> | Független: 397 | Függő: 25 | Nem jelölt: 0 | WoS jelölt: 390 | Scopus jelölt: 412 | WoS/Scopus jelölt: 421 | DOI jelölt: 403 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> ; <span class="author-name" mtid="10010484"><a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hájos N (<span class="authorship-author-name">Hájos Norbert</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet</span> ; <span class="author-name" mtid="10032182"><a href="/gui2/?type=authors&mode=browse&sel=10032182" target="_blank">Somogyi P (<span class="authorship-author-name">Somogyi Péter Pál</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> ; <span class="author-name" >Mody I ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;108650" target="_blank">Increased number of synaptic GABA~A receptors underlies potentiation at hippocampal inhibitory synapses</a></div> <div> <span class="journal-title">NATURE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-0836">0028-0836</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1476-4687">1476-4687</a>)</span>: <span class="journal-volume">395</span> <span class="journal-issue">6698</span> <span class="page"> pp 172-177 </span> <span class="year">(1998)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/25999" target="_blank" href="https://doi.org/10.1038/25999"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000075829900042" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000075829900042"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0032505048" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0032505048"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="9744275" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9744275&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 422</span> | Független: 397 | Függő: 25 | Nem jelölt: 0 | WoS jelölt: 390 | Scopus jelölt: 412 | WoS/Scopus jelölt: 421 | DOI jelölt: 403 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;108650&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 108650</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 108650</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Institute of Neurological Disorders and Stroke(NINDS, R01NS036142) </div> <div class="lastModified">Utolsó módosítás: 2023.06.22. 12:00 Turek Márta (KOKI admin 4) </div> </div></div>
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Segregation of different GABA~A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells
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Two types of GABA(A) receptor-mediated inhibition (phasic and tonic) have been described in cerebellar granule cells, although these cells receive GABAergic input only from a single cell type, the Golgi cell. In adult rats, granule cells express six GABA(A) receptor subunits abundantly (alpha 1, alpha 6, beta 2, beta 3, gamma 2, and delta), which are coassembled into at least four to six distinct GABA(A) receptor subtypes. We tested whether a differential distribution of GABA(A) receptors on the surface of granule cells could play a role in the different forms of inhibition, assuming that phasic inhibition originates from the activation of synaptic receptors, whereas tonic inhibition is provided mainly by extrasynaptic receptors. The alpha 1, alpha 6, beta 2/3, and gamma 2 subunits have been found by immunogold localizations to be concentrated in GABAergic Golgi synapses and also are present in the extrasynaptic membrane at a lower concentration. In contrast, immunoparticles for the delta subunit could not be detected in synaptic junctions, although they were abundantly present in the extrasynaptic dendritic and somatic membranes. Gold particles for the alpha 6, gamma 2, and beta 2/3, but not the alpha 1 and delta, subunits also were concentrated in some glutamatergic mossy fiber synapses, where their colocalization with AMPA-type glutamate receptors was demonstrated. The exclusive extrasynaptic presence of the delta subunit-containing receptors, together with their kinetic properties, suggests that tonic inhibition could be mediated mainly by extrasynaptic alpha(6) beta(2/3)delta receptors, whereas phasic inhibition is attributable to the activation of synaptic alpha(1) beta(2/3)gamma(2), alpha(6) beta(2/3)gamma(2), and alpha(1) alpha(6) beta(2/3)gamma(2) receptors.
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Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
Medical Research Council, Anatomical Neuropharmacology Unit, University of Oxford, Oxford 0X1 3TH, United Kingdom
Cited By :369
Export Date: 3 August 2023
CODEN: NERNE
Correspondence Address: Nusser, Z.; Department of Pharmacology, , London WC1E 6BT, United Kingdom
Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; bicuculline methobromide, 66016-70-4; flurazepam, 1172-18-5, 17617-23-1; tetrodotoxin, 4368-28-9, 4664-41-9
Funding details: Howard Hughes Medical Institute, HHMI
Funding details: Wellcome Trust, WT
Funding details: Medical Research Council, MRC
Funding text 1: This work was supported by the Medical Research Council, the Wellcome Trust, the Howard Hughes Medical Institute (International Scholars Award to S. C.-C.), and a European Commission Shared Cost RTD Programme Grant (number BIO 4 CT96–0585). We are grateful to Werner Sieghart and Peter Somogyi for providing antibody P16 and antiserum GABA number 9, respectively. We would like to thank Brian Edmonds, Matthew Frerking, Michael Häusser, David Rossi, Angus Silver, and Peter Somogyi for valuable discussions and David Attwell, Stephen Brickley, Akiko Momiyama, Angus Silver, and Peter Somogyi for comments on the manuscript. We would also like to thank Stephen Traynelis and Ioana Vais for provision of software and Zahida Ahmad, Juliann Thomas, Paul Jays, and Frank Kennedy for technical assistance.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10000499"> <a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser*, Z ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Cull-Candy, S </span> <span class="author-type"> </span> ; <span class="author-name" > Farrant, M </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;108773" mtid="108773" target="_blank">Differences in synaptic GABA~A receptor number underlie variation in GABA mini amplitude</a></div> <div class="pub-info"> <span class="journal-title">NEURON</span> <span class="journal-volume">19</span> <span class="page"> pp. 697-709. , 13 p. </span> <span class="year">(1997)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/S0896-6273(00)80382-7" target="_blank" href="https://doi.org/10.1016/S0896-6273%2800%2980382-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1997XZ01600022" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1997XZ01600022"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0030922803" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0030922803"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="9331359" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9331359&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:108773 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 384</span> | Független: 362 | Függő: 22 | Nem jelölt: 0 | WoS jelölt: 369 | Scopus jelölt: 374 | WoS/Scopus jelölt: 383 | DOI jelölt: 376 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="lastModified">Utolsó módosítás: 2021.12.01. 10:32 Turek Márta (KOKI admin 4)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
Medical Research Council, Anatomical Neuropharmacology Unit, University of Oxford, Oxford 0X1 3TH, United Kingdom
Cited By :369
Export Date: 3 August 2023
CODEN: NERNE
Correspondence Address...</pre>
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10000499"> <a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser*, Z ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Sieghart, W </span> <span class="author-type"> </span> ; <span class="author-name" > Stephenson, FA </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10032182"> <a href="/gui2/?type=authors&mode=browse&sel=10032182" target="_blank">Somogyi, P<sup>**</sup></a> </span> <span class="author-type"> </span> ; <span class="author-name" > Sieghart, W </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;108778" mtid="108778" target="_blank">Theα6 subunit of the GABA~A receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-volume">16</span> : <span class="journal-issue">1</span> <span class="page"> pp. 103-114. , 12 p. </span> <span class="year">(1996)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1523/jneurosci.16-01-00103.1996" target="_blank" href="https://doi.org/10.1523/jneurosci.16-01-00103.1996"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1996TL99000012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1996TL99000012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0029670816" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0029670816"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="8613776" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8613776&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:108778 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 142</span> | Független: 114 | Függő: 28 | Nem jelölt: 0 | WoS jelölt: 118 | Scopus jelölt: 130 | WoS/Scopus jelölt: 135 | DOI jelölt: 126 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser* Z ✉ (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> ; <span class="author-name" >Sieghart W </span> ; <span class="author-name" >Stephenson FA </span> ; <span class="author-name" mtid="10032182"><a href="/gui2/?type=authors&mode=browse&sel=10032182" target="_blank">Somogyi P<sup>**</sup> (<span class="authorship-author-name">Somogyi Péter Pál</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> ; <span class="author-name" >Sieghart W </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;108778" target="_blank">Theα6 subunit of the GABA~A receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">1</span> <span class="page"> pp 103-114 </span> <span class="year">(1996)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1523/jneurosci.16-01-00103.1996" target="_blank" href="https://doi.org/10.1523/jneurosci.16-01-00103.1996"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1996TL99000012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1996TL99000012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0029670816" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0029670816"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="8613776" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8613776&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 142</span> | Független: 114 | Függő: 28 | Nem jelölt: 0 | WoS jelölt: 118 | Scopus jelölt: 130 | WoS/Scopus jelölt: 135 | DOI jelölt: 126 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;108778&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 108778</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 108778</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2021.12.01. 10:28 Turek Márta (KOKI admin 4) </div> </div></div>