{ "labelLang" : "hun", "responseDate" : "2024-03-29 00:37", "paging" : { "last" : true, "first" : true, "totalPages" : 1, "totalElements" : 4, "totalUncutElements" : 4, "totalEstimatedElements" : 1, "size" : 100, "number" : 1, "numberOfElements" : 4, "sort" : [ { "direction" : "DESC", "property" : "publishedYear", "ascending" : false }, { "direction" : "ASC", "property" : "firstAuthor", "ascending" : true }, { "direction" : "ASC", "property" : "title", "ascending" : true } ] }, "content" : [ { "otype" : "JournalArticle", "mtid" : 3192921, "status" : "ADMIN_APPROVED", "published" : true, "comment" : "Megjegyzés-27145423\nMegjegyzés-27133549\nOA gold", "unhandledTickets" : 0, "oldTimestamp" : "2018-07-02T22:20:54.000+0000", "deleted" : false, "oldId" : 3192921, "lastRefresh" : "2024-02-18T18:07:15.447+0000", "lastModified" : "2023-05-30T12:55:55.597+0000", "created" : "2017-02-27T16:28:46.000+0000", "creator" : { "otype" : "Author", "mtid" : 10000089, "link" : "/api/author/10000089", "label" : "Varga Zoltán (Biofizika)", "familyName" : "Varga", "givenName" : "Zoltán", "published" : true, "oldId" : 10000089, "snippet" : true }, "lastDuplumOK" : "2022-02-22T14:34:10.037+0000", "lastDuplumSearch" : "2022-02-22T14:34:10.037+0000", "adminApproved" : "2018-01-26T13:26:02.000+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10014931, "link" : "/api/admin/10014931", "label" : "Farkas Andrea (MTMT Központ, admin)", "familyName" : "Farkas", "givenName" : "Andrea", "published" : true, "oldId" : 10014931, "snippet" : true }, "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Hsu, EJ", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 8894522, "link" : "/api/authorship/8894522", "label" : "Hsu, EJ", "listPosition" : 1, "share" : 0.16666667, "first" : true, "last" : false, "familyName" : "Hsu", "givenName" : "EJ", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25678342, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8894523, "link" : "/api/authorship/8894523", "label" : "Zhu, W", "listPosition" : 2, "share" : 0.16666667, "first" : false, "last" : false, "familyName" : "Zhu", "givenName" : "W", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25678341, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8894524, "link" : "/api/authorship/8894524", "label" : "Schubert, AR", "listPosition" : 3, "share" : 0.16666667, "first" : false, "last" : false, "familyName" : "Schubert", "givenName" : "AR", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25678340, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8894525, "link" : "/api/authorship/8894525", "label" : "Voelker, T", "listPosition" : 4, "share" : 0.16666667, "first" : false, "last" : false, "familyName" : "Voelker", "givenName" : "T", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25678339, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8894526, "link" : "/api/authorship/8894526", "label" : "Varga, Z [Varga, Zoltán (Biofizika), szerző] MTA-DE-NAP B Ioncsatorna Funkcionális Szerkezet... (DE / ÁOK)", "listPosition" : 5, "share" : 0.16666667, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10000089, "link" : "/api/author/10000089", "label" : "Varga Zoltán (Biofizika)", "familyName" : "Varga", "givenName" : "Zoltán", "published" : true, "oldId" : 10000089, "snippet" : true }, "familyName" : "Varga", "givenName" : "Z", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25678338, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 8894527, "link" : "/api/authorship/8894527", "label" : "Silva, JR", "listPosition" : 6, "share" : 0.16666667, "first" : false, "last" : true, "familyName" : "Silva", "givenName" : "JR", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 25678337, "snippet" : true } ], "title" : "Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains.", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 1180372, "link" : "/api/publicationidentifier/1180372", "label" : "DOI: 10.1085/jgp.201611678", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaFree" : false, "validState" : "NO", "idValue" : "10.1085/jgp.201611678", "realUrl" : "https://doi.org/10.1085/jgp.201611678", "published" : false, "oldId" : 1554123, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1180371, "link" : "/api/publicationidentifier/1180371", "label" : "WoS: 000395829800008", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "000395829800008", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000395829800008", "published" : false, "oldId" : 1708674, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16554140, "link" : "/api/publicationidentifier/16554140", "label" : "DEA: 242525", "source" : { "otype" : "PlainSource", "mtid" : 38, "link" : "/api/publicationsource/38", "label" : "DEA", "type" : { "otype" : "PublicationSourceType", "mtid" : 10007, "link" : "/api/publicationsourcetype/10007", "label" : "Repozitórium", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DEA", "linkPattern" : "http://hdl.handle.net/2437/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 38, "snippet" : true }, "oaType" : "GREEN", "oaFree" : true, "validState" : "IDENTICAL", "idValue" : "242525", "realUrl" : "http://hdl.handle.net/2437/242525", "published" : true, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 23798741, "link" : "/api/publicationidentifier/23798741", "label" : "Scopus: 85026821941", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85026821941", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85026821941", "published" : true, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 1180373, "link" : "/api/publicationidentifier/1180373", "label" : "PubMed: 28232510", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "oaFree" : false, "validState" : "NO", "idValue" : "28232510", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28232510&dopt=Abstract", "published" : false, "oldId" : 1554124, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 2517, "link" : "/api/journal/2517", "label" : "JOURNAL OF GENERAL PHYSIOLOGY 0022-1295 1540-7748", "pIssn" : "0022-1295", "eIssn" : "1540-7748", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 2517, "snippet" : true }, "volume" : "149", "issue" : "3", "firstPage" : "389", "lastPage" : "403", "firstPageOrInternalIdForSort" : "389", "pageLength" : 13, "publishedYear" : 2017, "abstractText" : "Functional eukaryotic voltage-gated Na+ (NaV) channels comprise four domains (DI-DIV), each containing six membrane-spanning segments (S1-S6). Voltage sensing is accomplished by the first four membrane-spanning segments (S1-S4), which together form a voltage-sensing domain (VSD). A critical NaV channel gating process, inactivation, has previously been linked to activation of the VSDs in DIII and DIV. Here, we probe this interaction by using voltage-clamp fluorometry to observe VSD kinetics in the presence of mutations at locations that have been shown to impair NaV channel inactivation. These locations include the DIII-DIV linker, the DIII S4-S5 linker, and the DIV S4-S5 linker. Our results show that, within the 10-ms timeframe of fast inactivation, the DIV-VSD is the primary regulator of inactivation. However, after longer 100-ms pulses, the DIII-DIV linker slows DIII-VSD deactivation, and the rate of DIII deactivation correlates strongly with the rate of recovery from inactivation. Our results imply that, over the course of an action potential, DIV-VSDs regulate the onset of fast inactivation while DIII-VSDs determine its recovery.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2017, "packet" : "Nav2017 (Varga Zoltán (Biofizika); 2017.02.27. 17:26:54)", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "GREEN", "oaCheckDate" : "2024-02-18", "oaFree" : true, "oaLink" : "http://hdl.handle.net/2437/242525", "citationCount" : 22, "citationCountUnpublished" : 0, "citationCountWoOther" : 22, "independentCitCountWoOther" : 9, "nationalOriginCitationCount" : 0, "foreignEditionCitationCount" : 22, "doiCitationCount" : 22, "wosCitationCount" : 22, "scopusCitationCount" : 17, "wosScopusCitationCount" : 22, "wosScopusCitationCountWoOther" : 22, "wosScopusIndependentCitationCount" : 9, "wosScopusIndependentCitationCountWoOther" : 9, "independentCitationCount" : 9, "selfCitationCount" : 13, "unhandledCitationCount" : 0, "citingPubCount" : 22, "independentCitingPubCount" : 9, "citingPubCountWoOther" : 22, "independentCitingPubCountWoOther" : 9, "unhandledCitingPubCount" : 0, "citedPubCount" : 3, "citedCount" : 3, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10722895, "link" : "/api/sjrrating/10722895", "label" : "sjr:D1 (2017) Scopus - Physiology JOURNAL OF GENERAL PHYSIOLOGY 0022-1295 1540-7748", "listPos" : 14, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1314, "link" : "/api/classificationexternal/1314", "label" : "Scopus - Physiology", "published" : true, "oldId" : 1314, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "hasCitationDuplums" : false, "userChangeableUntil" : "2018-01-26T13:26:02.000+0000", "publishDate" : "2017-03-02T12:25:57.000+0000", "directInstitutesForSort" : "Biofizikai és Sejtbiológiai Intézet (DE / ÁOK); MTA-DE-NAP B Ioncsatorna Funkcionális Szerkezet... (DE / ÁOK)", "ownerAuthorCount" : 1, "ownerInstituteCount" : 7, "directInstituteCount" : 2, "authorCount" : 6, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/3192921", "label" : "Hsu EJ et al. Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains.. (2017) JOURNAL OF GENERAL PHYSIOLOGY 0022-1295 1540-7748 149 3 389-403", "template" : "