https://m2.mtmt.hu/hun2024-03-28 12:47truetrue111110011DESCpublishedYearfalseASCfirstAuthortrueASCtitletrueJournalArticle1176835VALIDATEDtrue02018-08-10T06:32:45.000+0000false11768352024-03-21T19:14:18.141+00002023-09-02T13:41:22.904+00002009-02-11T23:00:00.000+0000true10001849BódisJózsef
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Categorytrue1Bodis, JInfluence of melatonin on basal and gonadotropin-stimulated progesterone and estradiol secretion of cultured human granulosa cells and in the superfused granulosa cell system.truetrue
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REVIEWEDtruefalse10000787false10000787true0378-73461423-002XJournalFOREIGN52319820219852001The aim of this study was to explore the direct action of melatonin (Me) on basal
and gonadotropin-stimulated progesterone (PG) and estradiol (E2) secretion of
human granulosa cells (GCs) cultured in serum-free medium and in a superfused GC
system. Human GCs were isolated from preovulatory follicular fluid aspirated from
34 women undergoing in vitro fertilization at the University Women's Hospital of
Tubingen. PG and E2 production was measured in the presence and absence of Me,
propranolol, LH or FSH using radioimmunoassay. Statistical analysis of the data
was performed by ANOVA and Newman-Keuls test. Me stimulated E2 secretion in a
dose-dependent manner. Propranolol did not cause any change in E2 secretion, and
when given with Me, it only partially blocked but could not entirely prevent E2
output. There was no statistically significant effect of Me on PG production when
Me was administered at concentrations between 10(-4) and 10(-8) M. However, at
10(-3) M Me significantly suppressed PG output of granulosa cells. LH and FSH
significantly stimulated the secretion of both steroid hormones. Me significantly
reduced LH- and FSH-induced E2 secretion, as well as LH-stimulated PG output,
while it caused only a slight, yet significant decrease in PG secretion. In the
superfused GC system, FSH and LH resulted in a significant stimulatory effect on
PG release. Me did not modify the stimulatory effect of FSH on PG, while it
caused some delay in LH-stimulated PG release. Propranolol and Me had no
stimulatory effect on PG release. On the basis of our results we suggest that Me
has a direct modulatory effect on basal E2 and gonadotropin-stimulated E2 and PG
secretion of human GCs. The observed effect may play a physiological role in the
regulation of GC function during the menstrual cycle.2009truetruetruefalsefalseNONE2024-03-21falsetrue10045349FeketeRita
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10001849"> <a href="/gui2/?type=authors&mode=browse&sel=10001849" target="_blank">Bodis, J ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10015923"> <a href="/gui2/?type=authors&mode=browse&sel=10015923" target="_blank">Koppan, M</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10044260"> <a href="/gui2/?type=authors&mode=browse&sel=10044260" target="_blank">Kornya, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Tinneberg, HR </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10006857"> <a href="/gui2/?type=authors&mode=browse&sel=10006857" target="_blank">Torok, A</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1176835" mtid="1176835" target="_blank">Influence of melatonin on basal and gonadotropin-stimulated progesterone and estradiol secretion of cultured human granulosa cells and in the superfused granulosa cell system.</a></div> <div class="pub-info"> <span class="journal-title">GYNECOLOGIC AND OBSTETRIC INVESTIGATION</span> <span class="journal-volume">52</span> : <span class="journal-issue">3</span> <span class="page"> pp. 198-202. , 5 p. </span> <span class="year">(2001)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1159/000052973" target="_blank" href="https://doi.org/10.1159/000052973"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000171721200011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000171721200011"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0035741988" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0035741988"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="11598364" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11598364&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1176835 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 34</span> | Független: 29 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 24 | Scopus jelölt: 29 | WoS/Scopus jelölt: 29 | DOI jelölt: 23 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10001849"><a href="/gui2/?type=authors&mode=browse&sel=10001849" target="_blank">Bodis J ✉ (<span class="authorship-author-name">Bódis József</span> <span class="authorAux-mtmt"> Szülészet és nőgyógyászat</span>) </a> </span> ; <span class="author-name" mtid="10015923"><a href="/gui2/?type=authors&mode=browse&sel=10015923" target="_blank">Koppan M (<span class="authorship-author-name">Koppán Miklós</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> ; <span class="author-name" mtid="10044260"><a href="/gui2/?type=authors&mode=browse&sel=10044260" target="_blank">Kornya L (<span class="authorship-author-name">Kornya László</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, Klinikai onkológia, Kli...</span>) </a> </span> ; <span class="author-name" >Tinneberg HR </span> ; <span class="author-name" mtid="10006857"><a href="/gui2/?type=authors&mode=browse&sel=10006857" target="_blank">Torok A (<span class="authorship-author-name">Török Attila</span> <span class="authorAux-mtmt"> Reprodukciós endokrinológia</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;1176835" target="_blank">Influence of melatonin on basal and gonadotropin-stimulated progesterone and estradiol secretion of cultured human granulosa cells and in the superfused granulosa cell system.</a></div> <div> <span class="journal-title">GYNECOLOGIC AND OBSTETRIC INVESTIGATION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0378-7346">0378-7346</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1423-002X">1423-002X</a>)</span>: <span class="journal-volume">52</span> <span class="journal-issue">3</span> <span class="page"> pp 198-202 </span> <span class="year">(2001)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1159/000052973" target="_blank" href="https://doi.org/10.1159/000052973"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000171721200011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000171721200011"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0035741988" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0035741988"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="11598364" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11598364&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 34</span> | Független: 29 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 24 | Scopus jelölt: 29 | WoS/Scopus jelölt: 29 | DOI jelölt: 23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1176835&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1176835</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 1176835</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2023.09.02. 15:41 Milánkovics Róbert (PTE ÁOK admin 4) </div> </div></div>