TY - JOUR AU - Paulus, WJ AU - Tschöpe, C AU - Sanderson, JE AU - Rusconi, C AU - Flachskampf, FA AU - Rademakers, FE AU - Marino, P AU - Smiseth, OA AU - De Keulenaer, G AU - Leite-Moreira, AF AU - Borbély, Attila AU - Édes, István AU - Handoko, ML AU - Heymans, S AU - Pezzali, N AU - Pieske, B AU - Dickstein, K AU - Fraser, AG AU - Brutsaert, DL TI - How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. JF - EUROPEAN HEART JOURNAL J2 - EUR HEART J VL - 28 PY - 2007 IS - 20 SP - 2539 EP - 2550 PG - 12 SN - 0195-668X DO - 10.1093/eurheartj/ehm037 UR - https://m2.mtmt.hu/api/publication/1110809 ID - 1110809 N1 - Megjegyzés-21963362 Chemicals/CAS: natriuretic factor, 9088-07-7; Biological Markers; Natriuretic Peptides LA - English DB - MTMT ER - TY - JOUR AU - Constantin, Tamás AU - Ponyi, Andrea AU - Orbán, Ilonka AU - Molnár, K AU - Dérfalvi, Beáta AU - Dicső, F AU - Kálovics, Tamás AU - Müller, Judit AU - Garami, Miklós AU - Sallai, Ágnes AU - Balogh, Zsolt AU - Szalai, Zsuzsanna Zsófia AU - Fekete, György AU - Dankó, Katalin TI - National registry of patients with juvenile idiopathic inflammatory myopathies in Hungary—Clinical characteristics and disease course of 44 patients with juvenile dermatomyositis JF - AUTOIMMUNITY J2 - AUTOIMMUNITY VL - 39 PY - 2006 IS - 3 SP - 223 EP - 232 PG - 10 SN - 0891-6934 DO - 10.1080/08916930600622819 UR - https://m2.mtmt.hu/api/publication/1082212 ID - 1082212 N1 - Megjegyzés-23199368 N1 : Chemicals/CASazathioprine, 446-86-6; diltiazem, 33286-22-5, 42399-41-7; immunoglobulin, 9007-83-4; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; ritrosulfan, 4148-16-7; Glucocorticoids; Immunoglobulins, Intravenous; Immunosuppressive Agents AB - Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune diseases characterized by chronic muscle inflammation resulting in progressive weakness and frequent involvement of internal organs, mainly the pulmonary, gastrointestinal and cardiac systems which considerably contribute to the morbidity and mortality of the IIMs. Aim of this study was to present clinical characteristics, disease course, frequency of relapses and survival in patients with juvenile dermatomyositis (DM). A national registry of patients with juvenile IIMs was elaborated by the authors in Hungary. We have summarized data of the register according to signs and symptoms, disease course, frequency of relapses and survival of patients with juvenile IIM. Analysis was performed using data of 44 patients with juvenile DM diagnosed between 1976 and 2004 according to Bohan and Peter's criteria. Survival probability was calculated by Kaplan-Meier method. Data of patients with juvenile DM were compared with data of 66 patients with adult DM. The most frequent cutaneous features were facial erythema and heliotrope rash. Extramuscular and extraskeletal manifestations of the disease were more frequent in adult patients. The most common extramuscular feature was arthralgia in both groups of patients with juvenile or adult DM. Cardiac manifestation of the disease was not observed in juvenile patients. Respiratory muscle involvement and interstitial lung disease (ILD) were more frequent among adult DM patients than cardiac manifestation of the myositis. In view of the disease course, the authors found that frequency of polycyclic and monophasic subtypes of the disease were mainly similar. The hazard of relapse was found higher during the first year after the remission. None of the juvenile patients died. Among adult patients four disease- specific deaths occurred. There was no correlation between relapse free survival and initial therapeutic regimen. Many of our patients had polycyclic or chronic disease. As relapses can occur after a prolonged disease-free interval, patients should be followed up for at least 2 years. Although we found favourable survival probability, further investigations are needed to assess functional outcome. LA - English DB - MTMT ER - TY - JOUR AU - Ferri, C AU - Emdin, M AU - Giuggioli, D AU - Carpeggiani, C AU - Maielli, M AU - Varga, Albert AU - Michelassi, C AU - Pasero, G AU - L, Abbate A TI - Autonomic dysfunction in systemic sclerosis: time and frequency domain 24 hour heart rate variability analysis. JF - BRITISH JOURNAL OF RHEUMATOLOGY J2 - BRIT J RHEUMATOL VL - 36 PY - 1997 IS - 6 SP - 669 EP - 676 PG - 8 SN - 0263-7103 DO - 10.1093/rheumatology/36.6.669 UR - https://m2.mtmt.hu/api/publication/1394488 ID - 1394488 AB - To evaluate the autonomic nervous control of the heart in patients with systemic sclerosis (SSc), spontaneous heart rate variability was investigated by means of time-domain and spectrum analysis of 24 h ECG ambulatory recordings in 30 SSc patients (four males, aged 45.2 +/- 9 yr, mean +/- S.D., range 27-60) and 30 age-matched healthy subjects. A significantly higher heart rate (P < 0.01) and lower circadian and spectral indices of heart rate variability (P < 0.01) were observed in SSc patients, compared with controls. A predictive value of age (P = 0.002), tachycardia (P = 0.002), circadian heart rate variability (P = 0.0025) and spectral power values (P = 0.005) for patient mortality was found. Moreover, the relative risk of death was higher (P = 0.05) in older subjects with circulating anti-Scl70. These abnormalities, detectable by a feasible, non-invasive diagnostic approach, indicate the presence of autonomic cardiac neuropathy in SSc patients. LA - English DB - MTMT ER -