@article{MTMT:1110809, title = {How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology.}, url = {https://m2.mtmt.hu/api/publication/1110809}, author = {Paulus, WJ and Tschöpe, C and Sanderson, JE and Rusconi, C and Flachskampf, FA and Rademakers, FE and Marino, P and Smiseth, OA and De Keulenaer, G and Leite-Moreira, AF and Borbély, Attila and Édes, István and Handoko, ML and Heymans, S and Pezzali, N and Pieske, B and Dickstein, K and Fraser, AG and Brutsaert, DL}, doi = {10.1093/eurheartj/ehm037}, journal-iso = {EUR HEART J}, journal = {EUROPEAN HEART JOURNAL}, volume = {28}, unique-id = {1110809}, issn = {0195-668X}, year = {2007}, eissn = {1522-9645}, pages = {2539-2550} } @article{MTMT:1082212, title = {National registry of patients with juvenile idiopathic inflammatory myopathies in Hungary—Clinical characteristics and disease course of 44 patients with juvenile dermatomyositis}, url = {https://m2.mtmt.hu/api/publication/1082212}, author = {Constantin, Tamás and Ponyi, Andrea and Orbán, Ilonka and Molnár, K and Dérfalvi, Beáta and Dicső, F and Kálovics, Tamás and Müller, Judit and Garami, Miklós and Sallai, Ágnes and Balogh, Zsolt and Szalai, Zsuzsanna Zsófia and Fekete, György and Dankó, Katalin}, doi = {10.1080/08916930600622819}, journal-iso = {AUTOIMMUNITY}, journal = {AUTOIMMUNITY}, volume = {39}, unique-id = {1082212}, issn = {0891-6934}, abstract = {Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune diseases characterized by chronic muscle inflammation resulting in progressive weakness and frequent involvement of internal organs, mainly the pulmonary, gastrointestinal and cardiac systems which considerably contribute to the morbidity and mortality of the IIMs. Aim of this study was to present clinical characteristics, disease course, frequency of relapses and survival in patients with juvenile dermatomyositis (DM). A national registry of patients with juvenile IIMs was elaborated by the authors in Hungary. We have summarized data of the register according to signs and symptoms, disease course, frequency of relapses and survival of patients with juvenile IIM. Analysis was performed using data of 44 patients with juvenile DM diagnosed between 1976 and 2004 according to Bohan and Peter's criteria. Survival probability was calculated by Kaplan-Meier method. Data of patients with juvenile DM were compared with data of 66 patients with adult DM. The most frequent cutaneous features were facial erythema and heliotrope rash. Extramuscular and extraskeletal manifestations of the disease were more frequent in adult patients. The most common extramuscular feature was arthralgia in both groups of patients with juvenile or adult DM. Cardiac manifestation of the disease was not observed in juvenile patients. Respiratory muscle involvement and interstitial lung disease (ILD) were more frequent among adult DM patients than cardiac manifestation of the myositis. In view of the disease course, the authors found that frequency of polycyclic and monophasic subtypes of the disease were mainly similar. The hazard of relapse was found higher during the first year after the remission. None of the juvenile patients died. Among adult patients four disease- specific deaths occurred. There was no correlation between relapse free survival and initial therapeutic regimen. Many of our patients had polycyclic or chronic disease. As relapses can occur after a prolonged disease-free interval, patients should be followed up for at least 2 years. Although we found favourable survival probability, further investigations are needed to assess functional outcome.}, year = {2006}, eissn = {1607-842X}, pages = {223-232}, orcid-numbers = {Constantin, Tamás/0000-0002-0146-3045; Ponyi, Andrea/0000-0001-9518-3193; Dérfalvi, Beáta/0000-0001-9208-312X; Müller, Judit/0000-0002-0488-7759; Garami, Miklós/0000-0003-4298-2746; Sallai, Ágnes/0000-0001-5470-7165; Fekete, György/0000-0002-5312-2541} } @article{MTMT:1394488, title = {Autonomic dysfunction in systemic sclerosis: time and frequency domain 24 hour heart rate variability analysis.}, url = {https://m2.mtmt.hu/api/publication/1394488}, author = {Ferri, C and Emdin, M and Giuggioli, D and Carpeggiani, C and Maielli, M and Varga, Albert and Michelassi, C and Pasero, G and L, Abbate A}, doi = {10.1093/rheumatology/36.6.669}, journal-iso = {BRIT J RHEUMATOL}, journal = {BRITISH JOURNAL OF RHEUMATOLOGY}, volume = {36}, unique-id = {1394488}, issn = {0263-7103}, abstract = {To evaluate the autonomic nervous control of the heart in patients with systemic sclerosis (SSc), spontaneous heart rate variability was investigated by means of time-domain and spectrum analysis of 24 h ECG ambulatory recordings in 30 SSc patients (four males, aged 45.2 +/- 9 yr, mean +/- S.D., range 27-60) and 30 age-matched healthy subjects. A significantly higher heart rate (P < 0.01) and lower circadian and spectral indices of heart rate variability (P < 0.01) were observed in SSc patients, compared with controls. A predictive value of age (P = 0.002), tachycardia (P = 0.002), circadian heart rate variability (P = 0.0025) and spectral power values (P = 0.005) for patient mortality was found. Moreover, the relative risk of death was higher (P = 0.05) in older subjects with circulating anti-Scl70. These abnormalities, detectable by a feasible, non-invasive diagnostic approach, indicate the presence of autonomic cardiac neuropathy in SSc patients.}, keywords = {Adult; Female; Middle Aged; Male; Humans; Regression Analysis; Time Factors; Activities of Daily Living; Echocardiography; Biological Markers; Tachycardia/*etiology/ultrasonography; Scleroderma, Systemic/*complications; Electrocardiography, Ambulatory; Autonomic Nervous System Diseases/*etiology/ultrasonography}, year = {1997}, pages = {669-676}, orcid-numbers = {Varga, Albert/0000-0002-8879-3927} }