@article{MTMT:3045263,
	title = {The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/3045263},
	author = {Kari, Beáta and Csordás, Gábor and Honti, Viktor and Cinege, Gyöngyi Ilona and Williams, MJ and Andó, István and Kurucz, Judit Éva},
	doi = {10.1371/journal.pone.0150910},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {11},
	unique-id = {3045263},
	issn = {1932-6203},
	abstract = {Drosophila is an extremely useful model organism for understanding how innate immune mechanisms defend against microbes and parasitoids. Large foreign objects trigger a potent cellular immune response in Drosophila larva. In the case of endoparasitoid wasp eggs, this response includes hemocyte proliferation, lamellocyte differentiation and eventual encapsulation of the egg. The encapsulation reaction involves the attachment and spreading of hemocytes around the egg, which requires cytoskeletal rearrangements, changes in adhesion properties and cell shape, as well as melanization of the capsule. Guanine nucleotide metabolism has an essential role in the regulation of pathways necessary for this encapsulation response. Here, we show that the Drosophila inosine 5'-monophosphate dehydrogenase (IMPDH), encoded by raspberry (ras), is centrally important for a proper cellular immune response against eggs from the parasitoid wasp Leptopilina boulardi. Notably, hemocyte attachment to the egg and subsequent melanization of the capsule are deficient in hypomorphic ras mutant larvae, which results in a compromised cellular immune response and increased survival of the parasitoid.},
	keywords = {PHAGOCYTOSIS; INHIBITORS; ACTIVATION; SCREEN; RHO; Hematopoiesis; INOSINE MONOPHOSPHATE DEHYDROGENASE; Parasitoids; SMALL GTPASES; LEPTOPILINA-BOULARDI},
	year = {2016},
	eissn = {1932-6203},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:2853633,
	title = {The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster.},
	url = {https://m2.mtmt.hu/api/publication/2853633},
	author = {Bretscher, AJ and Honti, Viktor and Binggeli, O and Burri, O and Poidevin, M and Kurucz, Judit Éva and Zsámboki, János and Andó, István and Lemaitre, B},
	doi = {10.1242/bio.201410595},
	journal-iso = {BIOL OPEN},
	journal = {BIOLOGY OPEN},
	volume = {4},
	unique-id = {2853633},
	issn = {2046-6390},
	abstract = {Eater is an EGF-like repeat transmembrane receptor of the Nimrod family and is expressed in Drosophila hemocytes. Eater was initially identified for its role in phagocytosis of both Gram-positive and Gram-negative bacteria. We have deleted eater and show that it appears to be required for efficient phagocytosis of Gram-positive but not Gram-negative bacteria. However, the most striking phenotype of eater deficient larvae is the near absence of sessile hemocytes, both plasmatocyte and crystal cell types. The eater deletion is the first loss of function mutation identified that causes absence of the sessile hemocyte state. Our study shows that Eater is required cell-autonomously in plasmatocytes for sessility. However, the presence of crystal cells in the sessile compartment requires Eater in plasmatocytes. We also show that eater deficient hemocytes exhibit a cell adhesion defect. Collectively, our data uncovers a new requirement of Eater in enabling hemocyte attachment at the sessile compartment and points to a possible role of Nimrod family members in hemocyte adhesion.},
	year = {2015},
	eissn = {2046-6390},
	pages = {355-363},
	orcid-numbers = {Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1920757,
	title = {Sessile hemocytes as a hematopoietic compartment in drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/1920757},
	author = {Márkus, Róbert and Laurinyecz, Barbara and Kurucz, Judit Éva and Honti, Viktor and Bajusz, Izabella and Sipos, Botond and Somogyi, Kálmán and Kronhamn, J and Hultmark, D and Andó, István},
	doi = {10.1073/pnas.0801766106},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {106},
	unique-id = {1920757},
	issn = {0027-8424},
	year = {2009},
	eissn = {1091-6490},
	pages = {4805-4809},
	orcid-numbers = {Laurinyecz, Barbara/0000-0003-0620-2239; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1915261,
	title = {Definition of Drosophila hemocyte subsets by cell-type specific antigens},
	url = {https://m2.mtmt.hu/api/publication/1915261},
	author = {Kurucz, Judit Éva and Váczi, Balázs and Márkus, Róbert and Laurinyecz, Barbara and Vilmos, Péter and Zsámboki, János and Csorba, Kinga and Gateff, E and Hultmark, D and Andó, István},
	doi = {10.1556/ABiol.58.2007.Suppl.8},
	journal-iso = {ACTA BIOL HUNG},
	journal = {ACTA BIOLOGICA HUNGARICA (1983-2018)},
	volume = {58},
	unique-id = {1915261},
	issn = {0236-5383},
	abstract = {We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. Oil the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmalocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged ill four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocyles.},
	year = {2007},
	eissn = {1588-256X},
	pages = {95-111},
	orcid-numbers = {Laurinyecz, Barbara/0000-0003-0620-2239; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:2505827,
	title = {A model of bacterial intestinal infections in Drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/2505827},
	author = {Nehme, NT and Liegeois, S and Kele, Beatrix and Giammarinaro, P and Pradel, E and Hoffmann, JA and Ewbank, JJ and Ferrandon, D},
	doi = {10.1371/journal.ppat.0030173},
	journal-iso = {PLOS PATHOG},
	journal = {PLOS PATHOGENS},
	volume = {3},
	unique-id = {2505827},
	issn = {1553-7366},
	abstract = {Serratia marcescens is an entomopathogenic bacterium that opportunistically infects a wide range of hosts, including humans. In a model of septic injury, if directly introduced into the body cavity of Drosophila, this pathogen is insensitive to the host's systemic immune response and kills flies in a day. We find that S. marcescens resistance to the Drosophila immune deficiency (imd)-mediated humoral response requires the bacterial lipopolysaccharide O-antigen. If ingested by Drosophila, bacteria cross the gut and penetrate the body cavity. During this passage, the bacteria can be observed within the cells of the intestinal epithelium. In such an oral infection model, the flies succumb to infection only after 6 days. We demonstrate that two complementary host defense mechanisms act together against such food-borne infection: an antimicrobial response in the intestine that is regulated by the imd pathway and phagocytosis by hemocytes of bacteria that have escaped into the hemolymph. Interestingly, bacteria present in the hemolymph elicit a systemic immune response only when phagocytosis is blocked. Our observations support a model wherein peptidoglycan fragments released during bacterial growth activate the imd pathway and do not back a proposed role for phagocytosis in the immune activation of the fat body. Thanks to the genetic tools available in both host and pathogen, the molecular dissection of the interactions between S. marcescens and Drosophila will provide a useful paradigm for deciphering intestinal pathogenesis.},
	keywords = {Animals; PHAGOCYTOSIS; IMMUNOREACTIVITY; immunohistochemistry; ARTICLE; Pathogenesis; Bacteria (microorganisms); Microscopy, Fluorescence; nonhuman; animal tissue; animal model; Microscopy, Electron, Transmission; reverse transcriptase polymerase chain reaction; Drosophila melanogaster; *Disease Models, Animal; humoral immunity; disease model; blood cell; defense mechanism; Serratia marcescens; bacterial growth; Antibiotic resistance; opportunistic infection; bacteriophage; Intestines/*microbiology; Host-Pathogen Interactions/*physiology; intestine infection; Serratia marcescens/immunology/*pathogenicity; Serratia Infections/immunology/*physiopathology; Hemolymph/microbiology; Drosophila/immunology/*microbiology; entomopathogenic bacterium},
	year = {2007},
	eissn = {1553-7374}
}

@article{MTMT:1786592,
	title = {Expression pattern of Filamin-240 in Drosophila blood cells},
	url = {https://m2.mtmt.hu/api/publication/1786592},
	author = {Rus, Florentina and Kurucz, Judit Éva and Márkus, Róbert and Sinenko, SA and Laurinyecz, Barbara and Pataki, Andrea Csilla and Gausz, János and Hegedűs, Zoltán and Udvardy, Andor and Hultmark, D and Andó, István},
	doi = {10.1016/j.modgep.2006.03.005},
	journal-iso = {GENE EXPR PATTERNS},
	journal = {GENE EXPRESSION PATTERNS},
	volume = {6},
	unique-id = {1786592},
	issn = {1567-133X},
	keywords = {Animals; Female; TISSUE DISTRIBUTION; PHENOTYPE; PROTEIN ISOFORMS; ARTICLE; DROSOPHILA; HEMOCYTES; Cell Differentiation; priority journal; controlled study; nonhuman; animal tissue; animal cell; larva; Protein Binding; immune system; Western blotting; Animals, Genetically Modified; Gene Expression Profiling; PROTEIN FUNCTION; unclassified drug; protein expression; DNA, Complementary; Blood cells; encapsulation; in vivo study; blood cell; protein domain; TRANSGENE; immunofluorescence test; HOMOZYGOSITY; FILAMIN; protein motif; MUTANT; Contractile proteins; Microfilament Proteins; Vespoidea; Leptopilina boulardi; Wasps; larval development; insect development; filamin 240; Lamellocyte; Immune induction; Hemocyte; Blood cell development; Actin network},
	year = {2006},
	eissn = {1872-7298},
	pages = {928-934},
	orcid-numbers = {Laurinyecz, Barbara/0000-0003-0620-2239; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1913892,
	title = {Sterile wounding is a minimal and sufficient trigger for a cellular immune response in Drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/1913892},
	author = {Márkus, Róbert and Kurucz, Judit Éva and Rus, Florentina and Andó, István},
	doi = {10.1016/j.imlet.2005.03.021},
	journal-iso = {IMMUNOL LETT},
	journal = {IMMUNOLOGY LETTERS},
	volume = {101},
	unique-id = {1913892},
	issn = {0165-2478},
	year = {2005},
	eissn = {1879-0542},
	pages = {108-111},
	orcid-numbers = {Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1913536,
	title = {A directed screen for genes involved in Drosophila blood cell activation},
	url = {https://m2.mtmt.hu/api/publication/1913536},
	author = {Zettervall, CJ and Anderl, I and Williams, MJ and Palmer, R and Kurucz, Judit Éva and Andó, István and Hultmark, D},
	doi = {10.1073/pnas.0403789101},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {101},
	unique-id = {1913536},
	issn = {0027-8424},
	year = {2004},
	eissn = {1091-6490},
	pages = {14192-14197},
	orcid-numbers = {Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1912851,
	title = {Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila},
	url = {https://m2.mtmt.hu/api/publication/1912851},
	author = {Kurucz, Judit Éva and Zettervall, CJ and Sinka, Rita and Vilmos, Péter and Pivarcsi, A and Ekengren, S and Hegedűs, Zoltán and Andó, István and Hultmark, D},
	doi = {10.1073/pnas.0436940100},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {100},
	unique-id = {1912851},
	issn = {0027-8424},
	year = {2003},
	eissn = {1091-6490},
	pages = {2622-2627},
	orcid-numbers = {Sinka, Rita/0000-0003-4040-4184; Andó, István/0000-0002-4648-9396}
}