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sclerosis (SSc) has been criticised. METHODS: Three investigators assigned an activity score on a 0-10 scale for 97 clinical charts. The median score served as gold standard. Two other investigators labelled the disease as inactive/moderately active or active/very active. Univariate-multivariate linear regression analyses were used to define variables predicting the 'gold standard', their weight and derive an activity index. The cut-off point of the index best separating active/very active from inactive/moderately active disease was identified by a receiver-operating curve analysis. The index was validated on a second set of 60 charts assessed by three different investigators on a 0-10 scale and defined as inactive/moderately active or active/very active by other two investigators. One hundred and twenty-three were investigated for changes over time in the index and their relationships with those in the summed Medsger severity score (MSS). RESULTS: A weighted 10-point activity index was identified and validated: Delta-skin=1.5 (Delta=patient assessed worsening during the previous month), modified Rodnan skin score (mRss) >18=1.5, digital ulcers=1.5, tendon friction rubs=2.25, C-reactive protein >1 mg/dL=2.25 and diffusing capacity of the lung for CO (DLCO) % predicted <70%=1.0. A cut-off >/=2.5 was found to identify patients with active disease. Changes in the index paralleled those of MSS (p=0.0001). CONCLUSIONS: A preliminarily revised SSc activity index has been developed and validated, providing a valuable tool for clinical practice and observational studies.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2016, "packet" : "517364", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "PAY", "oaCheckDate" : "2024-02-18", "oaFree" : false, "citationCount" : 128, "citationCountUnpublished" : 0, "citationCountWoOther" : 128, "independentCitCountWoOther" : 101, "nationalOriginCitationCount" : 6, "foreignEditionCitationCount" : 128, "doiCitationCount" : 118, "wosCitationCount" : 123, "scopusCitationCount" : 119, "wosScopusCitationCount" : 128, "wosScopusCitationCountWoOther" : 128, "wosScopusIndependentCitationCount" : 101, "wosScopusIndependentCitationCountWoOther" : 101, "independentCitationCount" : 101, "selfCitationCount" : 27, "unhandledCitationCount" : 0, "citingPubCount" : 128, "independentCitingPubCount" : 101, "citingPubCountWoOther" : 128, "independentCitingPubCountWoOther" : 101, "unhandledCitingPubCount" : 0, "citedPubCount" : 9, "citedCount" : 9, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10682583, "link" : "/api/sjrrating/10682583", "label" : "sjr:D1 (2017) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) ANNALS OF THE RHEUMATIC DISEASES 0003-4967 1468-2060", "listPos" : 5, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1301, "link" : "/api/classificationexternal/1301", "label" : "Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)", "published" : true, "oldId" : 1301, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "hasCitationDuplums" : false, "userChangeableUntil" : "2017-02-05T10:00:37.000+0000", "publishDate" : "2016-09-19T07:42:08.000+0000", "directInstitutesForSort" : "Reumatológiai és Immunológiai Klinika (PTE / ÁOK)", "ownerAuthorCount" : 2, "ownerInstituteCount" : 10, "directInstituteCount" : 1, "authorCount" : 23, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/3113748", "label" : "Valentini G et al. 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