@article{MTMT:3402940,
	title = {Carboxamido steroids inhibit the opening properties of Transient Receptor Potential ion channels by lipid raft modulation.},
	url = {https://m2.mtmt.hu/api/publication/3402940},
	author = {Sághy, Éva and Payrits, Maja and Biro-Suto, T and Skodáné Földes, Rita and Szánti-Pintér, Eszter and Erostyák, János and Makkai, Géza and Sétáló, György (ifj.) and Kollár, László and Kőszegi, Tamás and Jakabfi-Csepregi, Rita and Szolcsányi, János and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.1194/jlr.M084723},
	journal-iso = {J LIPID RES},
	journal = {JOURNAL OF LIPID RESEARCH},
	volume = {59},
	unique-id = {3402940},
	issn = {0022-2275},
	abstract = {Transient Receptor Potential (TRP) cation channels, like the TRP Vanilloid 1 and TRP Ankyrin 1 (TRPV1 and TRPA1) are expressed on primary sensory neurons. These thermosensor channels play role in pain processing. We provided evidence that lipid raft disruption influenced the TRP channel activation and a carboxamido-steroid compound (C1) inhibited TRPV1 activation. Therefore, our aim was to investigate whether this compound exerts its effect through lipid raft disruption and the steroid backbone (C3) or altered position of the carboxamido group (C2) influence the inhibitory action by measuring Ca2+-transients on isolated neurons and calcium-uptake on receptor-expressing CHO cells. Membrane cholesterol content was measured by filipin staining and membrane polarisation by fluorescence spectroscopy. Both the percentage of responsive cells and the magnitude of the intracellular Ca2+-enhancement evoked by the TRPV1 agonist capsaicin were significantly inhibited after C1 and C2 incubation, but not after C3 administration. C1 was able to reduce other TRP channel activation as well. The compounds induced cholesterol depletion in CHO cells, but only C1 induced changes in membrane polarisation. The inhibitory action of the compounds on TRP channel activation develops by lipid raft disruption, and the presence and the position of the carboxamido group is essential.},
	keywords = {CELL-LINE; ACTIVATION; NICOTINIC ACETYLCHOLINE-RECEPTOR; ROOT GANGLION NEURONS; LIPID RAFTS; steroid; transient receptor potential channel; TRPV1 receptor; sensory neuron; Cation channels; nerve terminal; TRIGEMINAL SENSORY NEURONS; ALPHA-SPINASTEROL; SCREEN REVEALS},
	year = {2018},
	eissn = {1539-7262},
	pages = {1851-1863},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461; Skodáné Földes, Rita/0000-0002-9810-1509; Szánti-Pintér, Eszter/0000-0001-8263-9884}
}

@article{MTMT:3272305,
	title = {Sterol Regulation of Voltage-Gated K+ Channels},
	url = {https://m2.mtmt.hu/api/publication/3272305},
	author = {Balajthy, András and Hajdu, Péter Béla and Panyi, György and Varga, Zoltán},
	doi = {10.1016/bs.ctm.2017.05.006},
	journal-iso = {CURR TOP MEMBR},
	journal = {CURRENT TOPICS IN MEMBRANES},
	volume = {80},
	unique-id = {3272305},
	issn = {1063-5823},
	year = {2017},
	pages = {255-292},
	orcid-numbers = {Panyi, György/0000-0001-6227-3301}
}

@article{MTMT:3245960,
	title = {The dipole potential correlates with lipid raft markers in the plasma membrane of living cells},
	url = {https://m2.mtmt.hu/api/publication/3245960},
	author = {Kovács, Tamás and Batta, Gyula Gábor (Ifj.) and Zákány, Florina and Szöllősi, János and Nagy, Péter},
	doi = {10.1194/jlr.M077339},
	journal-iso = {J LIPID RES},
	journal = {JOURNAL OF LIPID RESEARCH},
	volume = {58},
	unique-id = {3245960},
	issn = {0022-2275},
	year = {2017},
	eissn = {1539-7262},
	pages = {1681-1691},
	orcid-numbers = {Kovács, Tamás/0000-0002-1084-9847; Batta, Gyula Gábor (Ifj.)/0000-0001-8735-6920; Nagy, Péter/0000-0002-7466-805X}
}

@article{MTMT:3334522,
	title = {A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore},
	url = {https://m2.mtmt.hu/api/publication/3334522},
	author = {Tomczak, Adam P and Fernández-Trillo, Jorge and Bharill, Shashank and Papp, Ferenc and Panyi, György and Stühmer, Walter and Isacoff, Ehud Y and Pardo, Luis A},
	doi = {10.1085/jgp.201611742},
	journal-iso = {J GEN PHYSIOL},
	journal = {JOURNAL OF GENERAL PHYSIOLOGY},
	volume = {149},
	unique-id = {3334522},
	issn = {0022-1295},
	year = {2017},
	eissn = {1540-7748},
	pages = {577-593},
	orcid-numbers = {Panyi, György/0000-0001-6227-3301}
}

@article{MTMT:3099238,
	title = {7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome},
	url = {https://m2.mtmt.hu/api/publication/3099238},
	author = {Balajthy, András and Somodi, Sándor and Pethő, Z and Péter, Mária and Varga, Zoltán and P. Szabó, Gabriella and Paragh, György and Vigh, László and Panyi, György and Hajdu, Péter Béla},
	doi = {10.1007/s00424-016-1851-4},
	journal-iso = {PFLUG ARCH EUR J PHY},
	journal = {PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY},
	volume = {468},
	unique-id = {3099238},
	issn = {0031-6768},
	abstract = {In vitro manipulation of membrane sterol level affects the regulation of ion channels and consequently certain cellular functions; however, a comprehensive study that confirms the pathophysiological significance of these results is missing. The malfunction of 7-dehydrocholesterol (7DHC) reductase in Smith-Lemli-Opitz syndrome (SLOS) leads to the elevation of the 7-dehydrocholesterol level in the plasma membrane. T lymphocytes were isolated from SLOS patients to assess the effect of the in vivo altered membrane sterol composition on the operation of the voltage-gated Kv1.3 channel and the ion channel-dependent mitogenic responses. We found that the kinetic and equilibrium parameters of Kv1.3 activation changed in SLOS cells. Identical changes in Kv1.3 operation were observed when control/healthy T cells were loaded with 7DHC. Removal of the putative sterol binding sites on Kv1.3 resulted in a phenotype that was not influenced by the elevation in membrane sterol level. Functional assays exhibited impaired activation and proliferation rate of T cells probably partially due to the modified Kv1.3 operation. We concluded that the altered membrane sterol composition hindered the operation of Kv1.3 as well as the ion channel-controlled T cell functions. © 2016, Springer-Verlag Berlin Heidelberg.},
	keywords = {cholesterol; Kv1.3; 7-Dehydrocholesterol; Smith-Lemli-Opitz syndrome; Voltage-gated ion channel},
	year = {2016},
	eissn = {1432-2013},
	pages = {1403-1418},
	orcid-numbers = {Somodi, Sándor/0000-0002-3615-2300; Panyi, György/0000-0001-6227-3301}
}

@article{MTMT:3130199,
	title = {The dipole potential modifies the clustering and ligand binding affinity of ErbB proteins and their signaling efficiency},
	url = {https://m2.mtmt.hu/api/publication/3130199},
	author = {Kovács, Tamás and Batta, Gyula Gábor (Ifj.) and Hajdu, Tímea and Szabó, Ágnes Tímea and Váradi, Tímea Erzsébet and Zákány, Florina and Csomós, István and Szöllősi, János and Nagy, Péter},
	doi = {10.1038/srep35850},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {6},
	unique-id = {3130199},
	issn = {2045-2322},
	year = {2016},
	eissn = {2045-2322},
	orcid-numbers = {Batta, Gyula Gábor (Ifj.)/0000-0001-8735-6920; Váradi, Tímea Erzsébet/0000-0002-9824-5967; Nagy, Péter/0000-0002-7466-805X}
}

@article{MTMT:2017137,
	title = {Membrane microdomain patterns, calcium signaling and NFAT activation as an important axis in determining polarized Th cell function},
	url = {https://m2.mtmt.hu/api/publication/2017137},
	author = {Izsépi, Emese and Himer, L and Szilágyi, Orsolya and Hajdu, Péter Béla and Panyi, György and László, Glória and Matkó, János},
	doi = {10.1002/cyto.a.22234},
	journal-iso = {CYTOM PART A},
	journal = {CYTOMETRY PART A},
	volume = {83},
	unique-id = {2017137},
	issn = {1552-4922},
	keywords = {DIFFERENTIATION; RECEPTOR; POTASSIUM CHANNELS; KINASE; LYMPHOCYTES; ION CHANNELS; IMMUNOLOGICAL SYNAPSE; LIPID RAFTS; Th2 Cells; Th1 Cells; CUTTING EDGE; NFAT; Kv1.3; CD59; EFFECTOR FUNCTION; cell death sensitivity; cytokine profiles; differential Ca2+-signals; T cell polarization},
	year = {2013},
	eissn = {1552-4930},
	pages = {185-196},
	orcid-numbers = {Panyi, György/0000-0001-6227-3301}
}

@article{MTMT:2239256,
	title = {Analysis of the K+ current in human CD4+ T lymphocytes in hypercholesterolemic state},
	url = {https://m2.mtmt.hu/api/publication/2239256},
	author = {Somodi, Sándor and Balajthy, András and Szilágyi, Orsolya and Pethő, Zoltán Dénes and Harangi, Mariann and Paragh, György and Panyi, György and Hajdu, Péter Béla},
	doi = {10.1016/j.cellimm.2013.01.004},
	journal-iso = {CELL IMMUNOL},
	journal = {CELLULAR IMMUNOLOGY},
	volume = {281},
	unique-id = {2239256},
	issn = {0008-8749},
	abstract = {Atherosclerosis involves immune mechanisms: T lymphocytes are found in atherosclerotic plaques, suggesting their activation during atherogenesis. The predominant voltage-gated potassium channel of T cells, Kv1.3 is a key regulator of the Ca2+-dependent activation pathway. In the present experiments we studied the proliferation capacity and functional changes of Kv1.3 channels in T cells from healthy and hypercholestaeremic patients.By means of CFSE-assay (carboxyfluorescein succinimidyl ester) we showed that spontaneous activation rate of lymphocytes in hypercholesterolemia was elevated and the antiCD3/antiCD28 co-stimulation was less effective as compared to the healthy group. Using whole-cell patch-clamping we obtained that the activation and deactivation kinetics of Kv1.3 channels were faster in hypercholesterolemic state but no change in other parameters of Kv1.3 were found (inactivation kinetics, steady-state activation, expression level). We suppose that incorporation of oxLDL species via its raft-rupturing effect can modify proliferative rate of T cells as well as the gating of Kv1.3 channels. © 2013 Elsevier Inc.},
	keywords = {PROLIFERATION; cholesterol; T lymphocyte; Kv1.3},
	year = {2013},
	eissn = {1090-2163},
	pages = {20-26},
	orcid-numbers = {Somodi, Sándor/0000-0002-3615-2300; Panyi, György/0000-0001-6227-3301}
}

@article{MTMT:1075641,
	title = {Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells},
	url = {https://m2.mtmt.hu/api/publication/1075641},
	author = {Panyi, György and Vámosi, György and Bacsó, Zsolt and Bagdány, M and Bodnár, Andrea and Varga, Zoltán and Gáspár, Rezső and Mátyus, László and Damjanovich, Sándor},
	doi = {10.1073/pnas.0307421100},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {101},
	unique-id = {1075641},
	issn = {0027-8424},
	year = {2004},
	eissn = {1091-6490},
	pages = {1285-1290},
	orcid-numbers = {Panyi, György/0000-0001-6227-3301}
}

@article{MTMT:3335428,
	title = {Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells},
	url = {https://m2.mtmt.hu/api/publication/3335428},
	author = {Vámosi, György and Bacso, Z and Bodnár, Andrea and Bagdany, M and Varga, Z and Gaspar, R and Mátyus, László and Damjanovich, Sándor and Panyi, György},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {86},
	unique-id = {3335428},
	issn = {0006-3495},
	year = {2004},
	eissn = {1542-0086},
	pages = {540A-540A},
	orcid-numbers = {Panyi, György/0000-0001-6227-3301}
}

@article{MTMT:105647,
	title = {Cholesterol modifies the gating of Kv1.3 in human T lymphocytes},
	url = {https://m2.mtmt.hu/api/publication/105647},
	author = {Hajdu, Péter Béla and Varga, Zoltán and Pieri, C and Panyi, György and Gáspár, Rezső},
	doi = {10.1007/s00424-002-0974-y},
	journal-iso = {PFLUG ARCH EUR J PHY},
	journal = {PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY},
	volume = {445},
	unique-id = {105647},
	issn = {0031-6768},
	year = {2003},
	eissn = {1432-2013},
	pages = {674-682},
	orcid-numbers = {Panyi, György/0000-0001-6227-3301}
}