TY - JOUR AU - Zaborszky, László AU - Csordas, A AU - Mosca, K AU - Kim, J AU - Gielow, MR AU - Vadasz, C AU - Nádasdy, Zoltán TI - Neurons in the basal forebrain project to the cortex in a complex topographic organization that reflects corticocortical connectivity patterns: an experimental study based on retrograde tracing and 3D reconstruction. JF - CEREBRAL CORTEX J2 - CEREB CORTEX VL - 25 PY - 2015 IS - 1 SP - 118 EP - 137 PG - 20 SN - 1047-3211 DO - 10.1093/cercor/bht210 UR - https://m2.mtmt.hu/api/publication/2830558 ID - 2830558 AB - The most prominent feature of the Basal Forebrain (BF) is the collection of large cortically projecting neurons (basal nucleus of Meynert) that serve as the primary source of cholinergic input to the entire cortical mantle. Despite its broad involvement in cortical activation, attention, and memory, the functional details of the BF are not well understood due to the anatomical complexity of the region. This study tested the hypothesis that basalocortical connections reflect cortical connectivity patterns. Distinct retrograde tracers were deposited into various frontal and posterior cortical areas, and retrogradely labeled cholinergic and noncholinergic neurons were mapped in the BF. Concurrently, we mapped retrogradely labeled cells in posterior cortical areas that project to various frontal areas, and all cell populations were combined in the same coordinate system. Our studies suggest that the cholinergic and noncholinergic projections to the neocortex are not diffuse, but instead, are organized into segregated or overlapping pools of projection neurons. The extent of overlap between BF populations projecting to the cortex depends on the degree of connectivity between the cortical targets of these projection populations. We suggest that the organization of projections from the BF may enable parallel modulation of multiple groupings of interconnected yet nonadjacent cortical areas. LA - English DB - MTMT ER - TY - JOUR AU - Pi, HJ AU - Hangya, Balázs AU - Kvitsiani, D AU - Sanders, JI AU - Huang, ZJ AU - Kepecs, A TI - Cortical interneurons that specialize in disinhibitory control. JF - NATURE J2 - NATURE VL - 503 PY - 2013 IS - 7477 SP - 521 EP - 524 PG - 4 SN - 0028-0836 DO - 10.1038/nature12676 UR - https://m2.mtmt.hu/api/publication/2480038 ID - 2480038 AB - In the mammalian cerebral cortex the diversity of interneuronal subtypes underlies a division of labour subserving distinct modes of inhibitory control. A unique mode of inhibitory control may be provided by inhibitory neurons that specifically suppress the firing of other inhibitory neurons. Such disinhibition could lead to the selective amplification of local processing and serve the important computational functions of gating and gain modulation. Although several interneuron populations are known to target other interneurons to varying degrees, little is known about interneurons specializing in disinhibition and their in vivo function. Here we show that a class of interneurons that express vasoactive intestinal polypeptide (VIP) mediates disinhibitory control in multiple areas of neocortex and is recruited by reinforcement signals. By combining optogenetic activation with single-cell recordings, we examined the functional role of VIP interneurons in awake mice, and investigated the underlying circuit mechanisms in vitro in auditory and medial prefrontal cortices. We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively. During the performance of an auditory discrimination task, reinforcement signals (reward and punishment) strongly and uniformly activated VIP neurons in auditory cortex, and in turn VIP recruitment increased the gain of a functional subpopulation of principal neurons. These results reveal a specific cell type and microcircuit underlying disinhibitory control in cortex and demonstrate that it is activated under specific behavioural conditions. LA - English DB - MTMT ER - TY - CHAP AU - Zaborszky, László AU - van den Pol, A AU - Gyengesi, E ED - Watson, C ED - Paxinos, G ED - Puelles, L TI - The Basal Forebrain Cholinergic Projection System in Mice T2 - The Mouse Nervous System PB - Academic Press CY - San Diego, California SN - 0080919189 PY - 2012 SP - 684 EP - 718 PG - 35 DO - 10.1016/B978-0-12-369497-3.10028-7 UR - https://m2.mtmt.hu/api/publication/2830797 ID - 2830797 LA - English DB - MTMT ER - TY - JOUR AU - Duque, A AU - Balatoni, B AU - Détári, László AU - Zaborszky, László TI - EEG correlation of the discharge properties of identified neurons in the basal forebrain. JF - JOURNAL OF NEUROPHYSIOLOGY J2 - J NEUROPHYSIOL VL - 84 PY - 2000 IS - 3 SP - 1627 EP - 1635 PG - 9 SN - 0022-3077 DO - 10.1152/jn.2000.84.3.1627 UR - https://m2.mtmt.hu/api/publication/1300395 ID - 1300395 N1 - GR: NS23945/NS/NINDS NIH HHS/United States GR: S06GM08223/GM/NIGMS NIH HHS/United States AB - The basal forebrain (BF) is a heterogeneous structure located in the ventral aspect of the cerebral hemispheres. It contains cholinergic as well as different types of noncholinergic corticopetal neurons and interneurons, including GABAergic and peptidergic cells. The BF constitutes an extrathalamic route to the cortex, and its activity is associated with an increase in cortical release of the neurotransmitter acetylcholine, concomitant with electroencephalographic (EEG) low-voltage fast activity (LVFA). However, the specific role of the different BF cell types has largely remained unknown due to the lack of chemical identification of the recorded neurons. Here we show that the firing rate of immunocytochemically identified cholinergic and parvalbumin-containing neurons increase during cortical LVFA. In contrast, increased neuropeptide Y neuron firing is accompanied by cortical slow waves. Our results, furthermore, indicate that BF neurons posses a distinct temporal relationship to different EEG patterns and suggest a more dynamic interplay within BF as well as between BF and cortical circuitries than previously proposed. LA - English DB - MTMT ER - TY - JOUR AU - Freund, Tamás AU - Gulyás, Attila TI - GABAergic interneurons containing calbindin D28k or somatostatin are major targets of GABAergic basal forebrain afferents in the rat neocortex JF - JOURNAL OF COMPARATIVE NEUROLOGY J2 - J COMP NEUROL VL - 314 PY - 1991 IS - 1 SP - 187 EP - 199 PG - 13 SN - 0021-9967 DO - 10.1002/cne.903140117 UR - https://m2.mtmt.hu/api/publication/107243 ID - 107243 N1 - Cited By :127 Export Date: 21 August 2019 Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O. Box 67, Budapest, H-1450, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; calbindin; Calcium-Binding Protein, Vitamin D-Dependent; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Phytohemagglutinins; Somatostatin, 51110-01-1 Cited By :129 Export Date: 28 May 2020 Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O. Box 67, Budapest, H-1450, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; calbindin; Calcium-Binding Protein, Vitamin D-Dependent; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Phytohemagglutinins; Somatostatin, 51110-01-1 Cited By :129 Export Date: 6 April 2021 Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O. Box 67, Budapest, H-1450, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; calbindin; Calcium-Binding Protein, Vitamin D-Dependent; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Phytohemagglutinins; Somatostatin, 51110-01-1 LA - English DB - MTMT ER -