@article{MTMT:2830558,
	title = {Neurons in the basal forebrain project to the cortex in a complex topographic organization that reflects corticocortical connectivity patterns: an experimental study based on retrograde tracing and 3D reconstruction.},
	url = {https://m2.mtmt.hu/api/publication/2830558},
	author = {Zaborszky, László and Csordas, A and Mosca, K and Kim, J and Gielow, MR and Vadasz, C and Nádasdy, Zoltán},
	doi = {10.1093/cercor/bht210},
	journal-iso = {CEREB CORTEX},
	journal = {CEREBRAL CORTEX},
	volume = {25},
	unique-id = {2830558},
	issn = {1047-3211},
	abstract = {The most prominent feature of the Basal Forebrain (BF) is the collection of large cortically projecting neurons (basal nucleus of Meynert) that serve as the primary source of cholinergic input to the entire cortical mantle. Despite its broad involvement in cortical activation, attention, and memory, the functional details of the BF are not well understood due to the anatomical complexity of the region. This study tested the hypothesis that basalocortical connections reflect cortical connectivity patterns. Distinct retrograde tracers were deposited into various frontal and posterior cortical areas, and retrogradely labeled cholinergic and noncholinergic neurons were mapped in the BF. Concurrently, we mapped retrogradely labeled cells in posterior cortical areas that project to various frontal areas, and all cell populations were combined in the same coordinate system. Our studies suggest that the cholinergic and noncholinergic projections to the neocortex are not diffuse, but instead, are organized into segregated or overlapping pools of projection neurons. The extent of overlap between BF populations projecting to the cortex depends on the degree of connectivity between the cortical targets of these projection populations. We suggest that the organization of projections from the BF may enable parallel modulation of multiple groupings of interconnected yet nonadjacent cortical areas.},
	year = {2015},
	eissn = {1460-2199},
	pages = {118-137},
	orcid-numbers = {Nádasdy, Zoltán/0000-0002-6515-9683}
}

@article{MTMT:2480038,
	title = {Cortical interneurons that specialize in disinhibitory control.},
	url = {https://m2.mtmt.hu/api/publication/2480038},
	author = {Pi, HJ and Hangya, Balázs and Kvitsiani, D and Sanders, JI and Huang, ZJ and Kepecs, A},
	doi = {10.1038/nature12676},
	journal-iso = {NATURE},
	journal = {NATURE},
	volume = {503},
	unique-id = {2480038},
	issn = {0028-0836},
	abstract = {In the mammalian cerebral cortex the diversity of interneuronal subtypes underlies a division of labour subserving distinct modes of inhibitory control. A unique mode of inhibitory control may be provided by inhibitory neurons that specifically suppress the firing of other inhibitory neurons. Such disinhibition could lead to the selective amplification of local processing and serve the important computational functions of gating and gain modulation. Although several interneuron populations are known to target other interneurons to varying degrees, little is known about interneurons specializing in disinhibition and their in vivo function. Here we show that a class of interneurons that express vasoactive intestinal polypeptide (VIP) mediates disinhibitory control in multiple areas of neocortex and is recruited by reinforcement signals. By combining optogenetic activation with single-cell recordings, we examined the functional role of VIP interneurons in awake mice, and investigated the underlying circuit mechanisms in vitro in auditory and medial prefrontal cortices. We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively. During the performance of an auditory discrimination task, reinforcement signals (reward and punishment) strongly and uniformly activated VIP neurons in auditory cortex, and in turn VIP recruitment increased the gain of a functional subpopulation of principal neurons. These results reveal a specific cell type and microcircuit underlying disinhibitory control in cortex and demonstrate that it is activated under specific behavioural conditions.},
	year = {2013},
	eissn = {1476-4687},
	pages = {521-524}
}

@{MTMT:2830797,
	title = {The Basal Forebrain Cholinergic Projection System in Mice},
	url = {https://m2.mtmt.hu/api/publication/2830797},
	author = {Zaborszky, László and van den Pol, A and Gyengesi, E},
	booktitle = {The Mouse Nervous System},
	doi = {10.1016/B978-0-12-369497-3.10028-7},
	unique-id = {2830797},
	year = {2012},
	pages = {684-718}
}

@article{MTMT:1300395,
	title = {EEG correlation of the discharge properties of identified neurons in the basal forebrain.},
	url = {https://m2.mtmt.hu/api/publication/1300395},
	author = {Duque, A and Balatoni, B and Détári, László and Zaborszky, László},
	doi = {10.1152/jn.2000.84.3.1627},
	journal-iso = {J NEUROPHYSIOL},
	journal = {JOURNAL OF NEUROPHYSIOLOGY},
	volume = {84},
	unique-id = {1300395},
	issn = {0022-3077},
	abstract = {The basal forebrain (BF) is a heterogeneous structure located in the ventral aspect of the cerebral hemispheres. It contains cholinergic as well as different types of noncholinergic corticopetal neurons and interneurons, including GABAergic and peptidergic cells. The BF constitutes an extrathalamic route to the cortex, and its activity is associated with an increase in cortical release of the neurotransmitter acetylcholine, concomitant with electroencephalographic (EEG) low-voltage fast activity (LVFA). However, the specific role of the different BF cell types has largely remained unknown due to the lack of chemical identification of the recorded neurons. Here we show that the firing rate of immunocytochemically identified cholinergic and parvalbumin-containing neurons increase during cortical LVFA. In contrast, increased neuropeptide Y neuron firing is accompanied by cortical slow waves. Our results, furthermore, indicate that BF neurons posses a distinct temporal relationship to different EEG patterns and suggest a more dynamic interplay within BF as well as between BF and cortical circuitries than previously proposed.},
	year = {2000},
	eissn = {1522-1598},
	pages = {1627-1635},
	orcid-numbers = {Détári, László/0000-0002-0630-8466}
}

@article{MTMT:107243,
	title = {GABAergic interneurons containing calbindin D28k or somatostatin are major targets of GABAergic basal forebrain afferents in the rat neocortex},
	url = {https://m2.mtmt.hu/api/publication/107243},
	author = {Freund, Tamás and Gulyás, Attila},
	doi = {10.1002/cne.903140117},
	journal-iso = {J COMP NEUROL},
	journal = {JOURNAL OF COMPARATIVE NEUROLOGY},
	volume = {314},
	unique-id = {107243},
	issn = {0021-9967},
	year = {1991},
	eissn = {1096-9861},
	pages = {187-199},
	orcid-numbers = {Gulyás, Attila/0000-0003-4961-636X}
}