@article{MTMT:2476829,
	title = {Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR.},
	url = {https://m2.mtmt.hu/api/publication/2476829},
	author = {Kleinman, CL and Gerges, N and Papillon-Cavanagh, S and Sin-Chan, P and Pramatarova, A and Quang, DA and Adoue, V and Busche, S and Caron, M and Djambazian, H and Bemmo, A and Fontebasso, AM and Spence, T and Schwartzentruber, J and Albrecht, S and Hauser, Péter and Garami, Miklós and Klekner, Álmos and Bognár, László and Montes, JL and Staffa, A and Montpetit, A and Berube, P and Zakrzewska, M and Zakrzewski, K and Liberski, PP and Dong, Z and Siegel, PM and Duchaine, T and Perotti, C and Fleming, A and Faury, D and Remke, M and Gallo, M and Dirks, P and Taylor, MD and Sladek, R and Pastinen, T and Chan, JA and Huang, A and Majewski, J and Jabado, N},
	doi = {10.1038/ng.2849},
	journal-iso = {NAT GENET},
	journal = {NATURE GENETICS},
	volume = {46},
	unique-id = {2476829},
	issn = {1061-4036},
	abstract = {Embryonal tumors with multilayered rosettes (ETMRs) are rare, deadly pediatric brain tumors characterized by high-level amplification of the microRNA cluster C19MC. We performed integrated genetic and epigenetic analyses of 12 ETMR samples and identified, in all cases, C19MC fusions to TTYH1 driving expression of the microRNAs. ETMR tumors, cell lines and xenografts showed a specific DNA methylation pattern distinct from those of other tumors and normal tissues. We detected extreme overexpression of a previously uncharacterized isoform of DNMT3B originating at an alternative promoter that is active only in the first weeks of neural tube development. Transcriptional and immunohistochemical analyses suggest that C19MC-dependent DNMT3B deregulation is mediated by RBL2, a known repressor of DNMT3B. Transfection with individual C19MC microRNAs resulted in DNMT3B upregulation and RBL2 downregulation in cultured cells. Our data suggest a potential oncogenic re-engagement of an early developmental program in ETMR via epigenetic alteration mediated by an embryonic, brain-specific DNMT3B isoform.},
	year = {2014},
	eissn = {1546-1718},
	pages = {39-44},
	orcid-numbers = {Hauser, Péter/0000-0002-8307-8975; Garami, Miklós/0000-0003-4298-2746}
}

@article{MTMT:2437200,
	title = {Clinical Course of Central Neurocytoma with Malignant Transformation-An Indication for Craniospinal Irradiation},
	url = {https://m2.mtmt.hu/api/publication/2437200},
	author = {Mózes, Petra and Szántó, Erika and Tiszlavicz, László and Barzó, Pál and Cserháti, Adrienn and Fodor, Emese and Hideghéty, Katalin},
	doi = {10.1007/s12253-013-9697-y},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {20},
	unique-id = {2437200},
	issn = {1219-4956},
	abstract = {Central neurocytoma is generally considered to be a benign tumor and the literature suggests that a cure may be attained by surgery +/- adjuvant focal irradiation. However, there is a need for change in the therapeutic strategy for the subgroup of patients with aggressive central neurocytoma. An example case is presented and the literature on central neurocytoma cases with malignant features and dissemination via the cerebrospinal fluid is reviewed and the radiotherapeutic strategies available for central neurocytoma treatment is discussed. Nineteen cases including the present report with a malignant course and cerebrospinal fluid dissemination have been described to date, most of them involving an elevated MIB-1 labeling index. Our case exhibited atypical central neurocytoma with an initially elevated MIB-1 labeling index (25-30 %). The primary treatment included surgery and focal radiotherapy. Three years later the disease had disseminated throughout the craniospinal axis. A good tumor response and symptom relief were achieved with repeated radiation and temozolomide chemotherapy. Central neurocytoma with an initially high proliferation activity has a high tendency to spread via the cerebrospinal fluid. The chemo- and radiosensitivity of the tumor suggest a more aggressive adjuvant therapy approach. Cases with a potential for malignant transformation should be identified and treated appropriately, including irradiation of the entire neuroaxis and adjuvant chemotherapy may be considered.},
	year = {2014},
	eissn = {1532-2807},
	pages = {319-325},
	orcid-numbers = {Mózes, Petra/0000-0002-2411-7719; Tiszlavicz, László/0000-0003-1134-6587; Barzó, Pál/0000-0001-8717-748X; Hideghéty, Katalin/0000-0001-7080-2365}
}