@article{MTMT:2270900,
	title = {Redox-regulating sirtuins in aging, caloric restriction, and exercise},
	url = {https://m2.mtmt.hu/api/publication/2270900},
	author = {Radák, Zsolt and Koltai, Erika and Taylor, AW and Higuchi, M and Kumagai, S and Ohno, H and Goto, S and Boldogh, I},
	doi = {10.1016/j.freeradbiomed.2013.01.004},
	journal-iso = {FREE RADICAL BIO MED},
	journal = {FREE RADICAL BIOLOGY AND MEDICINE},
	volume = {58},
	unique-id = {2270900},
	issn = {0891-5849},
	year = {2013},
	eissn = {1873-4596},
	pages = {87-97},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804; Koltai, Erika/0000-0002-1370-2955}
}

@article{MTMT:1769020,
	title = {Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA},
	url = {https://m2.mtmt.hu/api/publication/1769020},
	author = {Radák, Zsolt and Zhao, Z and Goto, S and Koltai, Erika},
	doi = {10.1016/j.mam.2011.10.010},
	journal-iso = {MOL ASPECTS MED},
	journal = {MOLECULAR ASPECTS OF MEDICINE},
	volume = {32},
	unique-id = {1769020},
	issn = {0098-2997},
	abstract = {Lipids, proteins and DNA in the central nervous system have a high sensitivity to oxidative stress. Reactive oxygen species (ROS)-induced damage increases with aging, especially in the last quarter of the life span. The so called base level of oxidative modification of lipids could be important to cell signaling, and membrane remodeling, but the ROS-mediated post translation modifications of proteins could be important to the homeostasis of protein turnover. Low levels of 8-oxo-7,8-dihydroguanine (8-oxoG) might be necessary for transcription. A high level of accumulation of lipid peroxidation, oxidative protein damage or 8-oxoG, on the other hand, accelerates the progress of aging and neurodegenerative diseases. Therefore, agents that induce the activity of repair enzymes, such as Ca(2(+))-independent phospholipase A(2) (iPLA(2)beta), methionine sulfoxide reductase, and 8-oxoguanine DNA glycosylase, or the activity of enzymes that could prevent the accumulation of oxidized, toxic proteins, such as proteasome, Lon protease, neprilysin or insulin degrading enzyme, may act as potential therapeutic tools to slow the aging process and the progress of neurodegenerative diseases.},
	year = {2011},
	eissn = {1872-9452},
	pages = {305-315},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804; Koltai, Erika/0000-0002-1370-2955}
}

@article{MTMT:1303984,
	title = {Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats},
	url = {https://m2.mtmt.hu/api/publication/1303984},
	author = {Koltai, Erika and Szabo, Z and Atalay, M and Boldogh, I and Naito, H and Goto, S and Nyakas, Csaba and Radák, Zsolt},
	doi = {10.1016/j.mad.2009.11.002},
	journal-iso = {MECH AGEING DEV},
	journal = {MECHANISMS OF AGEING AND DEVELOPMENT},
	volume = {131},
	unique-id = {1303984},
	issn = {0047-6374},
	abstract = {Silent information regulators are potent NAD<sup>+</sup>-dependent protein deacetylases, which have been shown to regulate gene silencing, muscle differentiation and DNA damage repair. Here, changes in the level and activity of sirtuin 1 (SIRT1) in response to exercise in groups of young and old rats were studied. There was an age-related increase in SIRT1 level, while exercise training significantly increased the relative activity of SIRT1. A strong inverse correlation was found between the nuclear activity of SIRT1 and the level of acetylated proteins. Exercise training induced SIRT1 activity due to the positive effect of exercise on the activity of nicotinamide phosphoribosyltransferase (NAMPT) and thereby the production of sirtuin-fueling NAD<sup>+</sup>. Exercise training normalized the age-associated shift in redox balance, since exercised animals had significantly lower levels of carbonylated proteins, expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. The age-associated increase in the level of SIRT6 was attenuated by exercise training. On the other hand, aging did not significantly increase the level of DNA damage, which was in line with the activity of 8-oxoguanine DNA glycosylase, while exercise training increased the level of this enzyme. Regular exercise decelerates the deleterious effects of the aging process via SIRT1-dependent pathways through the stimulation of NAD<sup>+</sup> biosynthesis by NAMPT. © 2009 Elsevier Ireland Ltd. All rights reserved.},
	year = {2010},
	eissn = {1872-6216},
	pages = {21-28},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Nyakas, Csaba/0000-0003-3756-0186; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:1303998,
	title = {Hormetic effects of regular exercise in aging: Correlation with oxidative stress},
	url = {https://m2.mtmt.hu/api/publication/1303998},
	author = {Goto, S and Naito, H and Kaneko, T and Chung, H and Radák, Zsolt},
	doi = {10.1139/H07-092},
	journal-iso = {APPL PHYSIOL NUTR ME},
	journal = {APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION},
	volume = {32},
	unique-id = {1303998},
	issn = {1715-5312},
	abstract = {To explore mechanisms of the beneficial consequences of regular exercise, we studied the effects of regular swimming and treadmill exercise on oxidative stress in the brain and liver of rats. Protein carbonyl was significantly reduced and the activity of proteasome was upregulated in the brain extracts of young and middle-aged animals after 9 weeks of swimming training. Furthermore, their cognitive functions were significantly improved. In separate experiments, the activation of transcription nuclear factor κB was attenuated in the liver of old rats after 8 weeks of regular treadmill exercise and the DNA binding activity of glucocorticoid receptor reduced with age was restored, suggesting that inflammatory reactions are alleviated by the regimen. This was accompanied by upregulation of the glutathione level and reduced reactive oxygen species generation. Similar training reduced the 8-oxodeoxyguanosine content in the nuclear and mitochondrial DNA of the liver of old rats. Thus, these findings, together with reports of other investigators, suggest that moderate regular exercise attenuates oxidative stress. The mild oxidative stress possibly elicited by regular exercise appears to manifest a hormesis-like effect in nonmuscular tissues, constituting beneficial mechanisms of exercise by adaptively upregulating various antioxidant mechanisms, including antioxidative and repair-degradation enzymes for damaged molecules. Importantly, the adaptation induced by regular exercise was effective even if initiated late in life. © 2007 NRC Canada.},
	year = {2007},
	eissn = {1715-5320},
	pages = {948-953},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:1304008,
	title = {Exercise and hormesis: Oxidative stress-related adaptation for successful aging},
	url = {https://m2.mtmt.hu/api/publication/1304008},
	author = {Radák, Zsolt and Chung, H Y and Goto, S},
	doi = {10.1007/s10522-004-7386-7},
	journal-iso = {BIOGERONTOLOGY},
	journal = {BIOGERONTOLOGY},
	volume = {6},
	unique-id = {1304008},
	issn = {1389-5729},
	abstract = {The hormesis theory purports that biological systems respond with a bell-shaped curve to exposure to chemicals, toxins, and radiation. Here we extend the hormesis theory to include reactive oxygen species (ROS). We further suggest that the beneficial effects of regular exercise are partly based on the ROS generating capability of exercise, which is in the stimulation range of ROS production. Therefore, we suggest that exercise-induced ROS production plays a role in the induction of antioxidants, DNA repair and protein degrading enzymes, resulting in decreases in the incidence of oxidative stress-related diseases and retardation of the aging process. © Springer 2005.},
	year = {2005},
	eissn = {1573-6768},
	pages = {71-75},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:1304010,
	title = {Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise},
	url = {https://m2.mtmt.hu/api/publication/1304010},
	author = {Radák, Zsolt and Chung, H Y and Naito, H and Takahashi, R and Jung, K J and Kim, H J and Goto, S},
	doi = {10.1096/fj.03-0509fje},
	journal-iso = {FASEB J},
	journal = {FASEB JOURNAL},
	volume = {18},
	unique-id = {1304010},
	issn = {0892-6638},
	abstract = {The combined effects of aging and regular physical exercise was investigated on the production of reactive oxygen species (ROS), lipid peroxidation, glutathione status, and the activity of nuclear factor-kappaB (NF-kappaB) in rat liver. A group of 24 male F344 rats was divided into the following categories: adult control (18 months), adult exercised (18 months), and aged control (28 months) and aged exercised (28 months). The ROS formation increased as a function of age and exercise training decreased the rate of ROS formation in the two age groups. Significant positive correlation was found between ROS production and lipid peroxidation (LIPOX). The reduced glutathione (GSH) level was higher and the oxidized glutathione (GSSG) level lower in exercised groups compared with the sedentary controls (P<0.05). An age-associated increase in NF-kappaB activity was attenuated by the regular exercise. The content of p50 and p65 subunits of NF-kappaB increased with age and decreased with exercise training. The content of inhibitory factor-kappaB was inversely related to NF-kappaB activation. Regular exercise-induced adaptive responses, including attenuation of an increase in ROS production, LIPOX level, NF-kappaB activation, and reduced GSH/GSSG ratio, appear to be capable, even in old age, of reducing increases in inflammatory and other detrimental consequences that are often associated with advancing age.},
	year = {2004},
	eissn = {1530-6860},
	pages = {749-750},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:1304017,
	title = {Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle},
	url = {https://m2.mtmt.hu/api/publication/1304017},
	author = {Radák, Zsolt and Naito, H and Kaneko, T and Tahara, S and Nakamoto, H and Takahashi, R and Cardozo-Pelaez, F and Goto, S},
	doi = {10.1007/s00424-002-0918-6},
	journal-iso = {PFLUG ARCH EUR J PHY},
	journal = {PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY},
	volume = {445},
	unique-id = {1304017},
	issn = {0031-6768},
	abstract = {Regular physical exercise retards a number of age-associated disorders, in spite of the paradox that free radical generation is significantly enhanced with exercise. Eight weeks of treadmill running resulted in nearly a 40% increase in maximal oxygen uptake in both middle-aged (20-month-old) and aged (30-month-old) rats. The age-associated increase in 8-hydroxy-2′-deoxyguanosine (8-OHdG) content was significantly attenuated in gastrocnemius muscle by exercise. The 8-OHdG repair, as measured by the excision of <sup>32</sup>P-labeled damaged oligonucleotide, increased in muscle of exercising animals. The reactive carbonyl derivatives (RCD) of proteins did not increase with aging. However, when the muscle homogenate was exposed to a mixture of 1 mM iron sulfate and 50 mM ascorbic acid, the muscle of old control animals accumulated more RCD than that of the trained or adult groups. The chymotrypsin-like activity of proteasome complex increased in muscle of old trained rats. We suggest that regular exercise-induced adaptation attenuates the age-associated increase in 8-OHdG levels, and increases the activity of DNA repair and resistance against oxidative stress in proteins.},
	year = {2002},
	eissn = {1432-2013},
	pages = {273-278},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804}
}