TY  - JOUR
AU  - Zsarnovszky, Attila
AU  - Kiss, Dávid Sándor
AU  - Jócsák, Gergely
AU  - Németh, Gábor László
AU  - Tóth, István
AU  - Horváth, Tamás
TI  - Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum
JF  - FRONTIERS IN NEUROENDOCRINOLOGY
J2  - FRONT NEUROENDOCRIN
VL  - 48
PY  - 2018
IS  - SI
SP  - 23
EP  - 36
PG  - 14
SN  - 0091-3022
DO  - 10.1016/j.yfrne.2017.10.001
UR  - https://m2.mtmt.hu/api/publication/3278620
ID  - 3278620
AB  - Although the effects of phytoestrogens on brain function is widely unknown, they are often regarded as "natural" and thus as harmless. However, the effects of phytoestrogens or environmental pollutants on brain function is underestimated. Estrogen (17beta-estradiol, E2) and thyroid hormones (THs) play pivoltal roles in brain development. In the mature brain, these hormones regulate metabolism on cellular and organismal levels. Thus, E2 and THs do not only regulate the energy metabolism of the entire organism, but simultaneously also regulate important homeostatic parameters of neurons and glia in the CNS. It is, therefore, obvious that the mechanisms through which these hormones exert their effects are pleiotropic and include both intra- and intercellular actions. These hormonal mechanisms are versatile, and the experimental investigation of simultaneous hormone-induced mechanisms is technically challanging. In addition, the normal physiological settings of metabolic parameters depend on a plethora of interactions of the steroid hormones. In this review, we discuss conceptual and experimental aspects of the gonadal and thyroid hormones as they relate to in vitro models of the cerebellum.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kehler, J
AU  - Tolkunova, E
AU  - Koschorz, B
AU  - Pesce, M
AU  - Gentile, L
AU  - Boiani, M
AU  - Lomeli, H
AU  - Nagy, András
AU  - McLaughlin, KJ
AU  - Scholer, HR
AU  - Tomilin, A
TI  - Oct4 is required for primordial germ cell survival
JF  - EMBO REPORTS
J2  - EMBO REP
VL  - 5
PY  - 2004
IS  - 11
SP  - 1078
EP  - 1083
PG  - 6
SN  - 1469-221X
DO  - 10.1038/sj.embor.7400279
UR  - https://m2.mtmt.hu/api/publication/2941366
ID  - 2941366
N1  - : Alexey/C-3361-2014; Boiani, Michele/
AB  - Previous studies have shown that Oct4 has an essential role in maintaining pluripotency of cells of the inner cell mass (ICM) and embryonic stem cells. However, Oct4 null homozygous embryos die around the time of implantation, thus precluding further analysis of gene function during development. We have used the conditional Cre/loxP gene targeting strategy to assess Oct4 function in primordial germ cells (PGCs). Loss of Oct4 function leads to apoptosis of PGCs rather than to differentiation into a trophectodermal lineage, as has been described for Oct4-deficient ICM cells. These new results suggest a previously unknown function of Oct4 in maintaining viability of mammalian germline.
LA  - English
DB  - MTMT
ER  -