@article{MTMT:3278620,
	title = {Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum},
	url = {https://m2.mtmt.hu/api/publication/3278620},
	author = {Zsarnovszky, Attila and Kiss, Dávid Sándor and Jócsák, Gergely and Németh, Gábor László and Tóth, István and Horváth, Tamás},
	doi = {10.1016/j.yfrne.2017.10.001},
	journal-iso = {FRONT NEUROENDOCRIN},
	journal = {FRONTIERS IN NEUROENDOCRINOLOGY},
	volume = {48},
	unique-id = {3278620},
	issn = {0091-3022},
	abstract = {Although the effects of phytoestrogens on brain function is widely unknown, they are often regarded as "natural" and thus as harmless. However, the effects of phytoestrogens or environmental pollutants on brain function is underestimated. Estrogen (17beta-estradiol, E2) and thyroid hormones (THs) play pivoltal roles in brain development. In the mature brain, these hormones regulate metabolism on cellular and organismal levels. Thus, E2 and THs do not only regulate the energy metabolism of the entire organism, but simultaneously also regulate important homeostatic parameters of neurons and glia in the CNS. It is, therefore, obvious that the mechanisms through which these hormones exert their effects are pleiotropic and include both intra- and intercellular actions. These hormonal mechanisms are versatile, and the experimental investigation of simultaneous hormone-induced mechanisms is technically challanging. In addition, the normal physiological settings of metabolic parameters depend on a plethora of interactions of the steroid hormones. In this review, we discuss conceptual and experimental aspects of the gonadal and thyroid hormones as they relate to in vitro models of the cerebellum.},
	year = {2018},
	eissn = {1095-6808},
	pages = {23-36},
	orcid-numbers = {Németh, Gábor László/0000-0003-1829-3457; Tóth, István/0000-0002-0168-4753}
}

@article{MTMT:2941366,
	title = {Oct4 is required for primordial germ cell survival},
	url = {https://m2.mtmt.hu/api/publication/2941366},
	author = {Kehler, J and Tolkunova, E and Koschorz, B and Pesce, M and Gentile, L and Boiani, M and Lomeli, H and Nagy, András and McLaughlin, KJ and Scholer, HR and Tomilin, A},
	doi = {10.1038/sj.embor.7400279},
	journal-iso = {EMBO REP},
	journal = {EMBO REPORTS},
	volume = {5},
	unique-id = {2941366},
	issn = {1469-221X},
	abstract = {Previous studies have shown that Oct4 has an essential role in maintaining pluripotency of cells of the inner cell mass (ICM) and embryonic stem cells. However, Oct4 null homozygous embryos die around the time of implantation, thus precluding further analysis of gene function during development. We have used the conditional Cre/loxP gene targeting strategy to assess Oct4 function in primordial germ cells (PGCs). Loss of Oct4 function leads to apoptosis of PGCs rather than to differentiation into a trophectodermal lineage, as has been described for Oct4-deficient ICM cells. These new results suggest a previously unknown function of Oct4 in maintaining viability of mammalian germline.},
	keywords = {EXPRESSION; GENE; APOPTOSIS; DIFFERENTIATION; TRANSCRIPTION FACTOR; STEM-CELLS; PROLIFERATION; MIGRATION; Mouse embryo; LINEAGES; MAMMALIAN EMBRYO; Cre/loxP; conditional gene targeting; primordial germ cells; Oct4 function},
	year = {2004},
	eissn = {1469-3178},
	pages = {1078-1083}
}