@article{MTMT:1626916,
	title = {Endomorphin synthesis in rat brain from intracerebroventricularly injected [H-3]-Tyr-Pro: A possible biosynthetic route for endomorphins},
	url = {https://m2.mtmt.hu/api/publication/1626916},
	author = {Rónai, András and Szemenyei, Erzsébet and Kató, Erzsébet and Kocsis, László and Orosz, György and Al-Khrasani, Mahmoud and Tóth, Géza},
	doi = {10.1016/j.regpep.2005.12.004},
	journal-iso = {REGUL PEPTIDES},
	journal = {REGULATORY PEPTIDES},
	volume = {134},
	unique-id = {1626916},
	issn = {0167-0115},
	abstract = {in spite of concentrated efforts, the biosynthetic route of mu-opioid receptor agonist brain tetrapeptide endomorphins (Tyr-Pro-Trp-Phe-NH2 and Tyr-Pro-Phe-Phe-NH2), discovered in 1997, is still obscure. We report presently that 30 min after intracerebroventricular injection of 20 or 200 mu Ci [H-3]Tyr-Pro (49.9 Ci mmol(-1)) the incorporated radioactivity was found in endomorphin-related tetra- and tripeptides in rat brain extracts. As detected by the combination of HPLC with radiodetection, a peak corresponding to endomorphin-2-OH could be identified in two of four extracts of "20 mu Ci" series. Radioactive peaks in position of Tyr, Tyr-Pro, Tyr-Pro-Phe or Tyr-Pro-Trp appeared regularly in both series and also in the "tetrapeptide cluster" constituted by endomorphins and their free carboxylic forms. In one of the four extracts in the "200 mu Ci" series a robust active peak in the position of endomorphin 2 could be detected. Intracerebroventricularly injected 100 mmol, but not 10 or 1000 nmol cold Tyr-Pro (devoid of opioid activity in vitro), caused a naloxone-reversible prolongation of tail-flick latency in rats, peaking between 15 and 30 min. We suggest that Tyr-Pro may serve as a biosynthetic precursor to endomorphin synthesis. (C) 2006 Elsevier B.V. All rights reserved.},
	keywords = {HPLC; CELLS; LOCALIZATION; IMMUNOREACTIVITY; SPINAL-CORD; PAIN; ANALGESIA; DEGRADATION; MU-OPIOID RECEPTOR; DIPEPTIDYL-PEPTIDASE IV; ALPHA-AMIDATING MONOOXYGENASE; radiodetection; Tyr-Pro substrate; endomorphin de novo biosynthesis},
	year = {2006},
	eissn = {1873-1686},
	pages = {54-60},
	orcid-numbers = {Kató, Erzsébet/0000-0001-5786-0405; Al-Khrasani, Mahmoud/0000-0001-8488-3266}
}

@article{MTMT:1117747,
	title = {Conformational analysis of endomorphin-1 by molecular dynamics methods},
	url = {https://m2.mtmt.hu/api/publication/1117747},
	author = {Leitgeb, Balázs and Szekeres, András and Tóth, Géza},
	doi = {10.1034/j.1399-3011.2003.00084.x},
	journal-iso = {J PEPT RES},
	journal = {JOURNAL OF PEPTIDE RESEARCH},
	volume = {62},
	unique-id = {1117747},
	issn = {1397-002X},
	year = {2003},
	eissn = {1399-3011},
	pages = {145-157},
	orcid-numbers = {Szekeres, András/0000-0003-1651-4623}
}

@article{MTMT:1912835,
	title = {Conformational analysis of endomorphin-2 by molecular dynamics methods},
	url = {https://m2.mtmt.hu/api/publication/1912835},
	author = {Leitgeb, Balázs and Ötvös, Ferenc and Tóth, Géza},
	doi = {10.1002/bip.10333},
	journal-iso = {BIOPOLYMERS},
	journal = {BIOPOLYMERS},
	volume = {68},
	unique-id = {1912835},
	issn = {0006-3525},
	year = {2003},
	eissn = {1097-0282},
	pages = {497-511}
}