@article{MTMT:2853633,
	title = {The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster.},
	url = {https://m2.mtmt.hu/api/publication/2853633},
	author = {Bretscher, AJ and Honti, Viktor and Binggeli, O and Burri, O and Poidevin, M and Kurucz, Judit Éva and Zsámboki, János and Andó, István and Lemaitre, B},
	doi = {10.1242/bio.201410595},
	journal-iso = {BIOL OPEN},
	journal = {BIOLOGY OPEN},
	volume = {4},
	unique-id = {2853633},
	issn = {2046-6390},
	abstract = {Eater is an EGF-like repeat transmembrane receptor of the Nimrod family and is expressed in Drosophila hemocytes. Eater was initially identified for its role in phagocytosis of both Gram-positive and Gram-negative bacteria. We have deleted eater and show that it appears to be required for efficient phagocytosis of Gram-positive but not Gram-negative bacteria. However, the most striking phenotype of eater deficient larvae is the near absence of sessile hemocytes, both plasmatocyte and crystal cell types. The eater deletion is the first loss of function mutation identified that causes absence of the sessile hemocyte state. Our study shows that Eater is required cell-autonomously in plasmatocytes for sessility. However, the presence of crystal cells in the sessile compartment requires Eater in plasmatocytes. We also show that eater deficient hemocytes exhibit a cell adhesion defect. Collectively, our data uncovers a new requirement of Eater in enabling hemocyte attachment at the sessile compartment and points to a possible role of Nimrod family members in hemocyte adhesion.},
	year = {2015},
	eissn = {2046-6390},
	pages = {355-363},
	orcid-numbers = {Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1921818,
	title = {Integrin beta nu-mediated Phagocytosis of Apoptotic Cells in Drosophila Embryos},
	url = {https://m2.mtmt.hu/api/publication/1921818},
	author = {Nagaosa, K and Okada, R and Nonaka, S and Takeuchi, K and Fujita, Y and Miyasaka, T and Manaka, J and Andó, István and Nakanishi, Y},
	doi = {10.1074/jbc.M110.204503},
	journal-iso = {J BIOL CHEM},
	journal = {JOURNAL OF BIOLOGICAL CHEMISTRY},
	volume = {286},
	unique-id = {1921818},
	issn = {0021-9258},
	abstract = {To identify molecules that play roles in the clearance of apoptotic cells by Drosophila phagocytes, we examined a series of monoclonal antibodies raised against larval hemocytes for effects on phagocytosis in vitro. One antibody that inhibited phagocytosis recognized terribly reduced optic lobes (Trol), a core protein of the perlecan-type proteoglycan, and the level of phagocytosis in embryos of a Trol-lacking fly line was lower than in a control line. The treatment of a hemocyte cell line with a recombinant Trol protein containing the amino acid sequence RGD augmented the phosphorylation of focal adhesion kinase, a hallmark of integrin activation. A loss of integrin beta nu, one of the two beta subunits of Drosophila integrin, brought about a reduction in the level of apoptotic cell clearance in embryos. The presence of integrin beta nu at the surface of embryonic hemocytes was confirmed, and forced expression of integrin beta nu in hemocytes of an integrin beta nu-lacking fly line recovered the defective phenotype of phagocytosis. Finally, the level of phagocytosis in a fly line that lacks both integrin beta nu and Draper, another receptor required for the phagocytosis of apoptotic cells, was lower than that in a fly line lacking either protein. We suggest that integrin beta nu serves as a phagocytosis receptor responsible for the clearance of apoptotic cells in Drosophila, independent of Draper.},
	year = {2011},
	eissn = {1083-351X},
	pages = {25770-25777},
	orcid-numbers = {Andó, István/0000-0002-4648-9396}
}

@article{MTMT:2246800,
	title = {A novel role of the glial fate determinant glial cells missing in hematopoiesis},
	url = {https://m2.mtmt.hu/api/publication/2246800},
	author = {Jacques, C and Soustelle, L and Nagy, István and Diebold, C and Giangrande, A},
	doi = {10.1387/ijdb.082726cj},
	journal-iso = {INT J DEV BIOL},
	journal = {INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY},
	volume = {53},
	unique-id = {2246800},
	issn = {0214-6282},
	abstract = {Glial cell deficient/Glial cells missing (Glide/Gcm) transcription factor is expressed in all glial precursors of the Drosophila embryo. Gcm is necessary and sufficient to induce glial differentiation but also plays a role in other cell types, by interacting with specific factors. To find potential partners of Gcm which trigger these other pathways, we performed a yeast two-hybrid screen and identified dpias, a gene involved in post-embryonic hematopoiesis. dpias larvae show melanotic tumors due to excess of lamellocytes, a hemocyte lineage that is involved in non-self recognition. We here show that blocking Gcm activity also triggers melanotic tumors and that gcm interacts genetically with dpias. Moreover, the members of the Janus Kinase (JAK)/ Signal Transducer and Activator of Transcription (STAT) pathway, which are known for their role in the vertebrate and invertebrate immune system and are required for dpias-dependent tumor formation, act downstream of Gcm. Altogether, this study identifies an unpredicted role of Gcm, dictated by its cofactor dpias, allowing Gcm to act in a specific pathway. Together with the recent finding that glia act as scavengers during development and in pathological conditions, our data open new perspectives onto the cellular and molecular pathways involved in non-self recognition within and outside the nervous system.},
	year = {2009},
	eissn = {1696-3547},
	pages = {1013-1022}
}

@article{MTMT:1920757,
	title = {Sessile hemocytes as a hematopoietic compartment in drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/1920757},
	author = {Márkus, Róbert and Laurinyecz, Barbara and Kurucz, Judit Éva and Honti, Viktor and Bajusz, Izabella and Sipos, Botond and Somogyi, Kálmán and Kronhamn, J and Hultmark, D and Andó, István},
	doi = {10.1073/pnas.0801766106},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {106},
	unique-id = {1920757},
	issn = {0027-8424},
	year = {2009},
	eissn = {1091-6490},
	pages = {4805-4809},
	orcid-numbers = {Laurinyecz, Barbara/0000-0003-0620-2239; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1918046,
	title = {Evolution of Genes and Repeats in the Nimrod Superfamily},
	url = {https://m2.mtmt.hu/api/publication/1918046},
	author = {Somogyi, Kálmán and Sipos, Botond and Pénzes, Zsolt and Kurucz, Judit Éva and Zsámboki, János and Hultmark, D and Andó, István},
	doi = {10.1093/molbev/msn180},
	journal-iso = {MOL BIOL EVOL},
	journal = {MOLECULAR BIOLOGY AND EVOLUTION},
	volume = {25},
	unique-id = {1918046},
	issn = {0737-4038},
	abstract = {The recently identified Nimrod superfamily is characterized by the presence of a special type of EGF repeat, the NIM repeat, located right after a typical CCXGY/W amino acid motif. On the basis of structural features, nimrod genes can be divided into three types. The proteins encoded by Draper-type genes have an EMI domain at the N-terminal part and only one copy of the NIM motif, followed by a variable number of EGF-like repeats. The products of Nimrod B-type and Nimrod C-type genes (including the eater gene) have different kinds of N-terminal domains, and lack EGF-like repeats but contain a variable number of NIM repeats. Draper and Nimrod C-type (but not Nimrod B-type) proteins carry a transmembrane domain. Several members of the superfamily were claimed to function as receptors in phagocytosis and/or binding of bacteria, which indicates an important role in the cellular immunity and the elimination of apoptotic cells. In this paper, the evolution of the Nimrod superfamily is studied with various methods on the level of genes and repeats. A hypothesis is presented in which the NIM repeat, along with the EMI domain, emerged by structural reorganizations at the end of an EGF-like repeat chain, suggesting a mechanism for the formation of novel types of repeats. The analyses revealed diverse evolutionary patterns in the sequences containing multiple NIM repeats. Although in the Nimrod B and Nimrod C proteins show characteristics of independent evolution, many internal NIM repeats in Eater sequences seem to have undergone concerted evolution. An analysis of the nimrod genes has been performed using phylogenetic and other methods and an evolutionary scenario of the origin and diversification of the Nimrod superfamily is proposed. Our study presents an intriguing example how the evolution of multigene families may contribute to the complexity of the innate immune response.},
	year = {2008},
	eissn = {1537-1719},
	pages = {2337-2347},
	orcid-numbers = {Pénzes, Zsolt/0000-0003-0447-5997; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1915261,
	title = {Definition of Drosophila hemocyte subsets by cell-type specific antigens},
	url = {https://m2.mtmt.hu/api/publication/1915261},
	author = {Kurucz, Judit Éva and Váczi, Balázs and Márkus, Róbert and Laurinyecz, Barbara and Vilmos, Péter and Zsámboki, János and Csorba, Kinga and Gateff, E and Hultmark, D and Andó, István},
	doi = {10.1556/ABiol.58.2007.Suppl.8},
	journal-iso = {ACTA BIOL HUNG},
	journal = {ACTA BIOLOGICA HUNGARICA (1983-2018)},
	volume = {58},
	unique-id = {1915261},
	issn = {0236-5383},
	abstract = {We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. Oil the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmalocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged ill four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocyles.},
	year = {2007},
	eissn = {1588-256X},
	pages = {95-111},
	orcid-numbers = {Laurinyecz, Barbara/0000-0003-0620-2239; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1915010,
	title = {Nimrod, a Putative Phagocytosis Receptor With Egf Repeats in Drosophila Plasmatocytes},
	url = {https://m2.mtmt.hu/api/publication/1915010},
	author = {Kurucz, Judit Éva and Márkus, Róbert and Zsámboki, János and Medzihradszky F., Katalin and Darula, Zsuzsanna and Vilmos, Péter and Udvardy, Andor and Krausz, Ildikó and Lukacsovich, Tamás and Gateff, E and Zettervall, CJ and Hultmark, D and Andó, István},
	doi = {10.1016/j.cub.2007.02.041},
	journal-iso = {CURR BIOL},
	journal = {CURRENT BIOLOGY},
	volume = {17},
	unique-id = {1915010},
	issn = {0960-9822},
	year = {2007},
	eissn = {1879-0445},
	pages = {649-654},
	orcid-numbers = {Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1913892,
	title = {Sterile wounding is a minimal and sufficient trigger for a cellular immune response in Drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/1913892},
	author = {Márkus, Róbert and Kurucz, Judit Éva and Rus, Florentina and Andó, István},
	doi = {10.1016/j.imlet.2005.03.021},
	journal-iso = {IMMUNOL LETT},
	journal = {IMMUNOLOGY LETTERS},
	volume = {101},
	unique-id = {1913892},
	issn = {0165-2478},
	year = {2005},
	eissn = {1879-0542},
	pages = {108-111},
	orcid-numbers = {Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1913536,
	title = {A directed screen for genes involved in Drosophila blood cell activation},
	url = {https://m2.mtmt.hu/api/publication/1913536},
	author = {Zettervall, CJ and Anderl, I and Williams, MJ and Palmer, R and Kurucz, Judit Éva and Andó, István and Hultmark, D},
	doi = {10.1073/pnas.0403789101},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {101},
	unique-id = {1913536},
	issn = {0027-8424},
	year = {2004},
	eissn = {1091-6490},
	pages = {14192-14197},
	orcid-numbers = {Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1912851,
	title = {Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila},
	url = {https://m2.mtmt.hu/api/publication/1912851},
	author = {Kurucz, Judit Éva and Zettervall, CJ and Sinka, Rita and Vilmos, Péter and Pivarcsi, A and Ekengren, S and Hegedűs, Zoltán and Andó, István and Hultmark, D},
	doi = {10.1073/pnas.0436940100},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {100},
	unique-id = {1912851},
	issn = {0027-8424},
	year = {2003},
	eissn = {1091-6490},
	pages = {2622-2627},
	orcid-numbers = {Sinka, Rita/0000-0003-4040-4184; Andó, István/0000-0002-4648-9396}
}