TY  - JOUR
AU  - Katheder, NS
AU  - Khezri, R
AU  - O'Farrell, F
AU  - Schultz, SW
AU  - Jain, A
AU  - Rahman, MM
AU  - Schink, KO
AU  - Theodossiou, TA
AU  - Johansen, T
AU  - Juhász, Gábor
AU  - Bilder, D
AU  - Brech, A
AU  - Stenmark, H
AU  - Rusten, TE
TI  - Microenvironmental autophagy promotes tumour growth
JF  - NATURE
J2  - NATURE
VL  - 541
PY  - 2017
IS  - 7637
SP  - 417
EP  - 420
PG  - 4
SN  - 0028-0836
DO  - 10.1038/nature20815
UR  - https://m2.mtmt.hu/api/publication/3171474
ID  - 3171474
AB  - As malignant tumours develop, they interact intimately with their microenvironment and can activate autophagy, a catabolic process which provides nutrients during starvation. How tumours regulate autophagy in vivo and whether autophagy affects tumour growth is controversial. Here we demonstrate, using a well characterized Drosophila melanogaster malignant tumour model, that non-cell-autonomous autophagy is induced both in the tumour microenvironment and systemically in distant tissues. Tumour growth can be pharmacologically restrained using autophagy inhibitors, and early-stage tumour growth and invasion are genetically dependent on autophagy within the local tumour microenvironment. Induction of autophagy is mediated by Drosophila tumour necrosis factor and interleukin-6-like signalling from metabolically stressed tumour cells, whereas tumour growth depends on active amino acid transport. We show that dormant growth-impaired tumours from autophagy-deficient animals reactivate tumorous growth when transplanted into autophagy-proficient hosts. We conclude that transformed cells engage surrounding normal cells as active and essential microenvironmental contributors to early tumour growth through nutrient-generating autophagy.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kurucz, Judit Éva
AU  - Váczi, Balázs
AU  - Márkus, Róbert
AU  - Laurinyecz, Barbara
AU  - Vilmos, Péter
AU  - Zsámboki, János
AU  - Csorba, Kinga
AU  - Gateff, E
AU  - Hultmark, D
AU  - Andó, István
TI  - Definition of Drosophila hemocyte subsets by cell-type specific antigens
JF  - ACTA BIOLOGICA HUNGARICA (1983-2018)
J2  - ACTA BIOL HUNG
VL  - 58
PY  - 2007
IS  - Suppl. 1
SP  - 95
EP  - 111
PG  - 17
SN  - 0236-5383
DO  - 10.1556/ABiol.58.2007.Suppl.8
UR  - https://m2.mtmt.hu/api/publication/1915261
ID  - 1915261
AB  - We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. Oil the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmalocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged ill four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocyles.
LA  - English
DB  - MTMT
ER  -