TY - JOUR AU - Bretscher, AJ AU - Honti, Viktor AU - Binggeli, O AU - Burri, O AU - Poidevin, M AU - Kurucz, Judit Éva AU - Zsámboki, János AU - Andó, István AU - Lemaitre, B TI - The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster. JF - BIOLOGY OPEN J2 - BIOL OPEN VL - 4 PY - 2015 IS - 3 SP - 355 EP - 363 PG - 9 SN - 2046-6390 DO - 10.1242/bio.201410595 UR - https://m2.mtmt.hu/api/publication/2853633 ID - 2853633 AB - Eater is an EGF-like repeat transmembrane receptor of the Nimrod family and is expressed in Drosophila hemocytes. Eater was initially identified for its role in phagocytosis of both Gram-positive and Gram-negative bacteria. We have deleted eater and show that it appears to be required for efficient phagocytosis of Gram-positive but not Gram-negative bacteria. However, the most striking phenotype of eater deficient larvae is the near absence of sessile hemocytes, both plasmatocyte and crystal cell types. The eater deletion is the first loss of function mutation identified that causes absence of the sessile hemocyte state. Our study shows that Eater is required cell-autonomously in plasmatocytes for sessility. However, the presence of crystal cells in the sessile compartment requires Eater in plasmatocytes. We also show that eater deficient hemocytes exhibit a cell adhesion defect. Collectively, our data uncovers a new requirement of Eater in enabling hemocyte attachment at the sessile compartment and points to a possible role of Nimrod family members in hemocyte adhesion. LA - English DB - MTMT ER - TY - JOUR AU - Honti, Viktor AU - Csordás, Gábor AU - Kurucz, Judit Éva AU - Márkus, Róbert AU - Andó, István TI - The cell-mediated immunity of Drosophila melanogaster: Hemocyte lineages, immune compartments, microanatomy and regulation. JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 42 PY - 2014 IS - 1 SP - 47 EP - 56 PG - 10 SN - 0145-305X DO - 10.1016/j.dci.2013.06.005 UR - https://m2.mtmt.hu/api/publication/2372553 ID - 2372553 N1 - Cited By :124 Export Date: 19 January 2022 CODEN: DCIMD Correspondence Address: Andó, I.; Institute of Genetics Biological Research Centre of the Hungarian Academy of Sciences, P.O. Box 521, Szeged H-6701, Hungary; email: ando.istvan@brc.mta.hu AB - In the animal kingdom, innate immunity is the first line of defense against invading pathogens. The dangers of microbial and parasitic attacks are countered by similar mechanisms, involving the prototypes of the cell-mediated immune responses, the phagocytosis and encapsulation. Work on Drosophila has played an important role in promoting an understanding of the basic mechanisms of phylogenetically conserved modules of innate immunity. The aim of this review is to survey the developments in the identification and functional definition of immune cell types and the immunological compartments of Drosophila melanogaster. We focus on the molecular and developmental aspects of the blood cell types and compartments, as well as the dynamics of blood cell development and the immune response. Further advances in the characterization of the innate immune mechanisms in Drosophila will provide basic clues to the understanding of the importance of the evolutionary conserved mechanisms of innate immune defenses in the animal kingdom. LA - English DB - MTMT ER - TY - JOUR AU - Honti, Viktor AU - Csordás, Gábor AU - Márkus, Róbert AU - Kurucz, Judit Éva AU - Jankovics, Ferenc AU - Andó, István TI - Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in drosophila melanogaster JF - MOLECULAR IMMUNOLOGY J2 - MOL IMMUNOL VL - 47 PY - 2010 IS - 11-12 SP - 1997 EP - 2004 PG - 8 SN - 0161-5890 DO - 10.1016/j.molimm.2010.04.017 UR - https://m2.mtmt.hu/api/publication/1921048 ID - 1921048 N1 - Cited By :83 Export Date: 19 January 2022 CODEN: IMCHA Correspondence Address: Andó, I.; Institute of Genetics, Temesvári krt. 62, 6726 Szeged, Csongrád, Hungary; email: ando@brc.hu LA - English DB - MTMT ER - TY - JOUR AU - Márkus, Róbert AU - Laurinyecz, Barbara AU - Kurucz, Judit Éva AU - Honti, Viktor AU - Bajusz, Izabella AU - Sipos, Botond AU - Somogyi, Kálmán AU - Kronhamn, J AU - Hultmark, D AU - Andó, István TI - Sessile hemocytes as a hematopoietic compartment in drosophila melanogaster JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 106 PY - 2009 IS - 12 SP - 4805 EP - 4809 PG - 5 SN - 0027-8424 DO - 10.1073/pnas.0801766106 UR - https://m2.mtmt.hu/api/publication/1920757 ID - 1920757 N1 - Cited By :174 Export Date: 30 June 2022 CODEN: PNASA LA - English DB - MTMT ER - TY - JOUR AU - Kurucz, Judit Éva AU - Váczi, Balázs AU - Márkus, Róbert AU - Laurinyecz, Barbara AU - Vilmos, Péter AU - Zsámboki, János AU - Csorba, Kinga AU - Gateff, E AU - Hultmark, D AU - Andó, István TI - Definition of Drosophila hemocyte subsets by cell-type specific antigens JF - ACTA BIOLOGICA HUNGARICA (1983-2018) J2 - ACTA BIOL HUNG VL - 58 PY - 2007 IS - Suppl. 1 SP - 95 EP - 111 PG - 17 SN - 0236-5383 DO - 10.1556/ABiol.58.2007.Suppl.8 UR - https://m2.mtmt.hu/api/publication/1915261 ID - 1915261 AB - We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. Oil the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmalocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged ill four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocyles. LA - English DB - MTMT ER - TY - JOUR AU - Zettervall, CJ AU - Anderl, I AU - Williams, MJ AU - Palmer, R AU - Kurucz, Judit Éva AU - Andó, István AU - Hultmark, D TI - A directed screen for genes involved in Drosophila blood cell activation JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 101 PY - 2004 IS - 39 SP - 14192 EP - 14197 PG - 6 SN - 0027-8424 DO - 10.1073/pnas.0403789101 UR - https://m2.mtmt.hu/api/publication/1913536 ID - 1913536 LA - English DB - MTMT ER - TY - JOUR AU - Asha, H AU - Nagy, István AU - Kovacs, G AU - Stetson, D AU - Andó, István AU - Dearolf, CR TI - Analysis of Ras-induced overproliferation in Drosophila hemocytes JF - GENETICS J2 - GENETICS VL - 163 PY - 2003 SP - 203 EP - 215 PG - 13 SN - 0016-6731 UR - https://m2.mtmt.hu/api/publication/1912854 ID - 1912854 LA - English DB - MTMT ER -