TY - JOUR AU - Szöllősi, Attila AU - Hoschke, Ágoston AU - Rezessyné, Szabó Judit AU - Bujna, Erika AU - Kun, Szilárd AU - Nguyen, Duc Quang TI - Formation of novel hydrogel bio-anode by immobilization of biocatalyst in alginate/polyaniline/titanium-dioxide/graphite composites and its electrical performance JF - CHEMOSPHERE J2 - CHEMOSPHERE VL - 174 PY - 2017 IS - - SP - 58 EP - 65 PG - 8 SN - 0045-6535 DO - 10.1016/j.chemosphere.2017.01.095 UR - https://m2.mtmt.hu/api/publication/3183293 ID - 3183293 AB - A new bio-anode containing gel-entrapped bacteria in alginate/polyaniline/TiO2/graphite composites was constructed and electrically investigated. Alginate as dopant and template as well as entrapped gel was used for immobilization of microorganism cells. Increase of polyaniline concentration resulted an increase in the conductivity in gels. Addition of 0.01 and 0.02 g/mL polyaniline caused 6- fold and 10-fold higher conductivity, respectively. Furthermore, addition of 0.05 g/mL graphite powder caused 10-fold higher conductivity and 4- fold higher power density, respectively. The combination of polyaniline and graphite resulted 105-fold higher conductivity and 7-fold higher power-density output. Optimized concentrations of polyaniline and graphite powder were determined to be 0.02 g/mL and 0.05 g/mL, respectively. Modified hydrogel anode was successfully used in microbial fuel cell systems both in semi- and continuous operations modes. In semi-continuous mode, about 7.88 W/m3 power density was obtained after 13 h of fermentation. The glucose consumption rate was calculated to be about 7 mg glucose/h/1.2·107 CFU immobilized cells. Similar power density was observed in the continuous operation mode of the microbial fuel cell, and it was operated stably for more than 7 days. Our results are very promising for development of an improved microbial fuel cell with new type of bio-anode that have higher power density and can operate for long term. LA - English DB - MTMT ER - TY - JOUR AU - Dombovári, Balázs Gábor AU - Fiáth, Richárd AU - Kerekes, Bálint Péter AU - Tóth, Emília AU - Wittner, Lucia AU - Horváth, Domonkos AU - Seidl, K AU - Herwik, S AU - Torfs, T AU - Paul, O AU - Ruther, P AU - Neves, H AU - Ulbert, István TI - In vivo validation of the electronic depth control probes JF - BIOMEDIZINISCHE TECHNIK J2 - BIOMED TECH VL - 59 PY - 2014 IS - 4 SP - 283 EP - 289 PG - 7 SN - 0013-5585 DO - 10.1515/bmt-2012-0102 UR - https://m2.mtmt.hu/api/publication/2444026 ID - 2444026 N1 - Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg, Germany IMEC, Leuven, Belgium Department of Engineering Sciences, Uppsala University, Uppsala, Sweden Cited By :7 Export Date: 28 May 2020 CODEN: BMZTA Correspondence Address: Ulbert, I.; Faculty of Information Technology, Pázmány Péter Catholic UniversityHungary Funding text 1: Acknowledgments: NeuroProbes EU FP6, ANR/NKTH Neurogen, ANR/NKTH Multisca, OTKA 81357, OTKA PD77864, TÁMOP-4.2.1.B-11/2/KMR-2011-0002, Bolyai Research Fellowship. AB - Abstract In this article, we evaluated the electrophysiological performance of a novel, high-complexity silicon probe array. This brain-implantable probe implements a dynamically reconfigurable voltage-recording device, coordinating large numbers of electronically switchable recording sites, referred to as electronic depth control (EDC). Our results show the potential of the EDC devices to record good-quality local field potentials, and single- and multiple-unit activities in cortical regions during pharmacologically induced cortical slow wave activity in an animal model. LA - English DB - MTMT ER - TY - JOUR AU - Torfs, T AU - Aarts, A A A AU - Erismis, M A AU - Aslam, J AU - Yazicioglu, R F AU - Seidl, K AU - Herwik, S AU - Ulbert, István AU - Dombovári, Balázs Gábor AU - Fiáth, Richárd AU - Kerekes, Bálint Péter AU - Puers, R AU - Paul, O AU - Ruther, P AU - Van, Hoof C AU - Neves, H P TI - Two-dimensional multi-channel neural probes with electronic depth control JF - IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS J2 - IEEE T BIOMED CIRC S VL - 5 PY - 2011 IS - 5 SP - 403 EP - 412 PG - 10 SN - 1932-4545 DO - 10.1109/TBCAS.2011.2162840 UR - https://m2.mtmt.hu/api/publication/1815161 ID - 1815161 N1 - Funding Agency and Grant Number: European Commission [IST-027017]; OTKA [81357]; NKTH/ANR Neurogen Funding text: Manuscript received February 18, 2011; revised May 20, 2011; accepted July 11, 2011. Date of publication August 30, 2011; date of current version October 26, 2011. This work was supported in part by the European Commission under the Sixth Framework Program in the NeuroProbes Project (IST-027017) and by OTKA 81357 and NKTH/ANR Neurogen. This paper was recommended by Associate Editor Julius Georgiou. AB - This paper presents multi-electrode arrays for in vivo neural recording applications incorporating the principle of electronic depth control (EDC), i.e., the electronic selection of recording sites along slender probe shafts independently for multiple channels. Two-dimensional (2D) arrays were realized using a commercial 0.5-μm complementary-metal-oxide-semiconductor (CMOS) process for the EDC circuits combined with post-CMOS micromachining to pattern the comb-like probes and the corresponding electrode metallization. A dedicated CMOS integrated front-end circuit was developed for pre-amplification and multiplexing of the neural signals recorded using these probes. 2D arrays with IrOx metal finish showed electrode impedances of 300 kΩ on average with a standard deviation of 175 kΩ. In vivo tests demonstrated the capability to simultaneously record multi-unit activity in addition to local field potentials on each of the available output channels using the electronic depth control circuitry, and to finely adjust the position of the recording sites along the probe shaft for an optimal signal-to-noise ratio. In addition, this depth control concept has been demonstrated in the electronic steering of electrodes selected simultaneously within thalamic sites in the rat. By enabling the selection and thus position fine-tuning of the individual recording sites after implantation, this new device significantly increases the amount of useful information that can be obtained from a single recording experiment. © 2011 IEEE. LA - English DB - MTMT ER - TY - JOUR AU - Grand, László AU - Wittner, Lucia AU - Herwik, S AU - Gothelid, E AU - Ruther, P AU - Oscarsson, S AU - Neves, H AU - Dombovári, Balázs Gábor AU - Csercsa, Richárd AU - Karmos, György AU - Ulbert, István TI - Short and long term biocompatibility of NeuroProbes silicon probes. JF - JOURNAL OF NEUROSCIENCE METHODS J2 - J NEUROSCI METH VL - 189 PY - 2010 IS - 2 SP - 216 EP - 229 PG - 14 SN - 0165-0270 DO - 10.1016/j.jneumeth.2010.04.009 UR - https://m2.mtmt.hu/api/publication/1341714 ID - 1341714 N1 - CI: Copyright (c) 2010. Published by Elsevier B.V. Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary Péter Pázmány Catholic University, Faculty of Information Technology, Budapest, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Department of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg, Germany Department of Physics and Astronomy, Uppsala University, Uppsala, Sweden Interuniversity Microelectronics Centre (IMEC), Leuven, Belgium Cited By :35 Export Date: 28 May 2020 CODEN: JNMED Correspondence Address: Ulbert, I.; Institute for Psychology, Hungarian Academy of Sciences, 1068 Budapest, Szondi u. 83-85, Hungary; email: ulbert@cogpsyphy.hu Chemicals/CAS: dexamethasone, 50-02-2; dextran, 87915-38-6, 9014-78-2; hyaluronic acid, 31799-91-4, 9004-61-9, 9067-32-7; silicon, 7440-21-3; Biocompatible Materials; Dexamethasone, 50-02-2; Dextrans, 9004-54-0; Hyaluronic Acid, 9004-61-9; Silicon Compounds; Biocompatible Materials; Dexamethasone; Dextrans; Hyaluronic Acid; Silicon Compounds Funding details: IP IST-027017 Funding details: K81357 Funding text 1: We wish to thank Ms K. Iványi, K. Lengyel, E. Simon, K. Faddi, Mr P. Kottra and Gy. Goda for excellent technical assistance. This study was supported by the Hungarian Government OTKA K81357 grant and Bolyai János Research Fellowship grant and European Union NeuroProbes EU IP IST-027017 grant. AB - Brain implants provide exceptional tools to understand and restore cerebral functions. The utility of these devices depends crucially on their biocompatibility and long term viability. We addressed these points by implanting non-functional, NeuroProbes silicon probes, without or with hyaluronic acid (Hya), dextran (Dex), dexamethasone (DexM), Hya+DexM coating, into rat neocortex. Light and transmission electron microscopy were used to investigate neuronal survival and glial response. The surface of explanted probes was examined in the scanning electron microscope. We show that blood vessel disruption during implantation could induce considerable tissue damage. If, however, probes could be inserted without major bleeding, light microscopical evidence of damage to surrounding neocortical tissue was much reduced. At distances less than 100mum from the probe track a considerable neuron loss ( approximately 40%) occurred at short survival times, while the neuronal numbers recovered close to control levels at longer survival. Slight gliosis was observed at both short and long term survivals. Electron microscopy showed neuronal cell bodies and synapses close (<10mum) to the probe track when bleeding could be avoided. The explanted probes were usually partly covered by tissue residue containing cells with different morphology. Our data suggest that NeuroProbes silicon probes are highly biocompatible. If major blood vessel disruption can be avoided, the low neuronal cell loss and gliosis should provide good recording and stimulating results with future functional probes. We found that different bioactive molecule coatings had small differential effects on neural cell numbers and gliosis, with optimal results achieved using the DexM coated probes. LA - English DB - MTMT ER - TY - JOUR AU - Csicsvari, J AU - Henze, DA AU - Jamieson, B AU - Harris, KD AU - Sirota, A AU - Barthó, Péter AU - Wise, KD AU - Buzsáki, György TI - Massively parallel recording of unit and local field potentials with silicon-based electrodes JF - JOURNAL OF NEUROPHYSIOLOGY J2 - J NEUROPHYSIOL VL - 90 PY - 2003 SP - 1314 EP - 1323 PG - 10 SN - 0022-3077 DO - 10.1152/jn.00116.2003 UR - https://m2.mtmt.hu/api/publication/109455 ID - 109455 LA - English DB - MTMT ER -