{ "labelLang" : "eng", "responseDate" : "2024-03-28 15:48", "paging" : { "last" : true, "first" : true, "totalPages" : 1, "totalElements" : 7, "totalUncutElements" : 7, "totalEstimatedElements" : 1, "size" : 100, "number" : 1, "numberOfElements" : 7, "sort" : [ { "direction" : "DESC", "property" : "publishedYear", "ascending" : false }, { "direction" : "ASC", "property" : "firstAuthor", "ascending" : true }, { "direction" : "ASC", "property" : "title", "ascending" : true } ] }, "content" : [ { "otype" : "JournalArticle", "mtid" : 5175, "status" : "VALIDATED", "published" : true, "comment" : "Megjegyzés-21289832\nChemicals/CAS: Cross-Linking Reagents; Factor XIII, 9013-56-3; Factor XIIIa, EC 2.3.2.13; Glutaral, 111-30-8; Immune Sera", "unhandledTickets" : 0, "oldTimestamp" : "2017-07-17T06:59:52.000+0000", "deleted" : false, "oldId" : 5175, "lastRefresh" : "2024-02-13T08:12:37.077+0000", "lastModified" : "2019-09-03T08:13:48.397+0000", "created" : "2009-12-31T23:00:00.000+0000", "creator" : { "otype" : "Author", "mtid" : 1131057, "link" : "/api/author/1131057", "label" : "Róza Ádány (Népegészségügy, genetikai epidemiológia)", "familyName" : "Ádány", "givenName" : "Róza", "published" : true, "oldId" : 1131057, "snippet" : true }, "lastDuplumSearch" : "2023-12-05T10:52:09.396+0000", "adminApproved" : "2013-11-28T09:24:08.000+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10036814, "link" : "/api/admin/10036814", "label" : "Balázs Bor (DE 4-es admin)", "familyName" : "Bor", "givenName" : "Balázs", "published" : true, "oldId" : 10036814, "snippet" : true }, "validated" : "2019-09-03T08:16:37.560+0000", "validator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "import WoS (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Journal Article", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Article (Journal Article)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Journal Article", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Scientific", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "English", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Adany, R", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 21178, "link" : "/api/authorship/21178", "label" : "Adany, R [Ádány, Róza (Népegészségügy, g...), author] Department of Preventive Medicine (UD / FPH)", "listPosition" : 1, "share" : 0.14285715, "first" : true, "last" : false, "author" : { "otype" : "Author", "mtid" : 1131057, "link" : "/api/author/1131057", "label" : "Róza Ádány (Népegészségügy, genetikai epidemiológia)", "familyName" : "Ádány", "givenName" : "Róza", "published" : true, "oldId" : 1131057, "snippet" : true }, "familyName" : "Adany", "givenName" : "R", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 1131114, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 21179, "link" : "/api/authorship/21179", "label" : "Bardos, H [Bárdos, Helga (megelőző orvostan...), author] Department of Preventive Medicine (UD / FPH)", "listPosition" : 2, "share" : 0.14285715, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10031715, "link" : "/api/author/10031715", "label" : "Helga Bárdos (megelőző orvostan és népegészségtan)", "familyName" : "Bárdos", "givenName" : "Helga", "published" : true, "oldId" : 10031715, "snippet" : true }, "familyName" : "Bardos", "givenName" : "H", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 1131115, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 21180, "link" : "/api/authorship/21180", "label" : "Antal, M [Antal, Miklós (Neurobiológia), author] Department of Anatomy, Histology and Embryology (UD)", "listPosition" : 3, "share" : 0.14285715, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10004930, "link" : "/api/author/10004930", "label" : "Miklós Antal (Neurobiológia)", "familyName" : "Antal", "givenName" : "Miklós", "duplumRole" : "DUPLUM", "published" : true, "oldId" : 10004930, "snippet" : true }, "familyName" : "Antal", "givenName" : "M", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 1131116, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 21181, "link" : "/api/authorship/21181", "label" : "Modis, L [Módis, László (Kötőszövetbiológia), author] Department of Anatomy, Histology and Embryology (UD)", "listPosition" : 4, "share" : 0.14285715, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10005536, "link" : "/api/author/10005536", "label" : "László Módis (Kötőszövetbiológia)", "familyName" : "Módis", "givenName" : "László", "published" : true, "oldId" : 10005536, "snippet" : true }, "familyName" : "Modis", "givenName" : "L", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 1131117, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 21182, "link" : "/api/authorship/21182", "label" : "Sarvary, A [Sárváry, Attila (megelőző orvostan...), author]", "listPosition" : 5, "share" : 0.14285715, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10030902, "link" : "/api/author/10030902", "label" : "Attila Sárváry (megelőző orvostan és népegészségtan)", "familyName" : "Sárváry", "givenName" : "Attila", "published" : true, "oldId" : 10030902, "snippet" : true }, "familyName" : "Sarvary", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 1131118, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 21183, "link" : "/api/authorship/21183", "label" : "Szucs, S [Szűcs, Sándor (egészségtudományok), author] Department of Preventive Medicine (UD / FPH)", "listPosition" : 6, "share" : 0.14285715, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10038339, "link" : "/api/author/10038339", "label" : "Sándor Szűcs (egészségtudományok)", "familyName" : "Szűcs", "givenName" : "Sándor", "published" : true, "oldId" : 10038339, "snippet" : true }, "familyName" : "Szucs", "givenName" : "S", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 1131119, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 21184, "link" : "/api/authorship/21184", "label" : "Balogh, I", "listPosition" : 7, "share" : 0.14285715, "first" : false, "last" : true, "familyName" : "Balogh", "givenName" : "I", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 1131120, "snippet" : true } ], "title" : "Factor XIII of blood coagulation as a nuclear crosslinking enzyme", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 21116887, "link" : "/api/publicationidentifier/21116887", "label" : "DOI: 10.1055/s-0037-1615758", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.1055/s-0037-1615758", "realUrl" : "https://doi.org/10.1055/s-0037-1615758", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 13726, "link" : "/api/publicationidentifier/13726", "label" : "WoS: 000168788000017", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "000168788000017", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000168788000017", "published" : false, "oldId" : 1613176, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 13727, "link" : "/api/publicationidentifier/13727", "label" : "Scopus: 0035023993", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "0035023993", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0035023993", "published" : false, "oldId" : 1613175, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 13728, "link" : "/api/publicationidentifier/13728", "label" : "PubMed: 11372678", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "11372678", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11372678&dopt=Abstract", "published" : false, "oldId" : 1572, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 4273, "link" : "/api/journal/4273", "label" : "THROMBOSIS AND HAEMOSTASIS 0340-6245 2567-689X", "pIssn" : "0340-6245", "eIssn" : "2567-689X", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 4273, "snippet" : true }, "volume" : "85", "issue" : "5", "firstPage" : "845", "lastPage" : "851", "firstPageOrInternalIdForSort" : "845", "pageLength" : 7, "publishedYear" : 2001, "abstractText" : "Intracellular localization and distribution of Factor XIII subunit A (FXIIIA) was investigated in association with monocyte-macrophage differentiation in a long term culture of human monocytes by light- and electron microscopical as well as biochemical and immunobiochemical techniques. To allow the detection of FXIIIA in cells with well-preserved ultrustructure, immunosera against glutaraldehyde-derivatized recombinant FXIIIA were developed in rabbits, then characterized and used in this study. In the early phase of macrophage differentiation intranuclear accumulation of FXIIIA was detected as a transient phenomenon in cells of the 2nd day culture by optical sectioning with 0,7 microm steps in laser scanning confocal microscopy and immunoblotting technique. FXIIIA could be detected by immunoelectron microscopic postembedding staining over electrodense DNA-containing areas. Fluoresceinated monodansylcadaverine incorporation assay was used to demonstrate that FXIIIA is not only present in the nuclei, but also expresses its transglutaminase activity. Our finding of the nuclear accumulation of FXIIIA in differentiating human macrophages is also unique in that a blood clotting factor has, for the first time, been localized in nuclei and has been shown to be an intracellular crosslinking enzyme. The possible role of nuclear FXIIIA in association with cellular processes involving chromatin structure remodeling, such as cell death, cell differentiation or cellular proliferation requires further in-depth investigation.", "subjects" : [ { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Clinical medicine", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 65, "link" : "/api/keyword/65", "label" : "Humans", "published" : true, "oldId" : 65, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4007, "link" : "/api/keyword/4007", "label" : "Cell Differentiation", "published" : true, "oldId" : 4007, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4526, "link" : "/api/keyword/4526", "label" : "immunoblotting", "published" : true, "oldId" : 4526, "snippet" : true }, { "otype" : "Keyword", "mtid" : 7926, "link" : "/api/keyword/7926", "label" : "Microscopy, Immunoelectron", "published" : true, "oldId" : 7926, "snippet" : true }, { "otype" : "Keyword", "mtid" : 14602, "link" : "/api/keyword/14602", "label" : "Cross-Linking Reagents", "published" : true, "oldId" : 14602, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16473, "link" : "/api/keyword/16473", "label" : "Monocytes/cytology/ultrastructure", "published" : true, "oldId" : 16473, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16474, "link" : "/api/keyword/16474", "label" : "Macrophages/cytology/ultrastructure", "published" : true, "oldId" : 16474, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16475, "link" : "/api/keyword/16475", "label" : "Immune Sera/diagnostic use", "published" : true, "oldId" : 16475, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16476, "link" : "/api/keyword/16476", "label" : "Glutaral", "published" : true, "oldId" : 16476, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16477, "link" : "/api/keyword/16477", "label" : "Factor XIIIa/immunology/metabolism/physiology", "published" : true, "oldId" : 16477, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16478, "link" : "/api/keyword/16478", "label" : "Factor XIII/immunology/*metabolism/physiology", "published" : true, "oldId" : 16478, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16479, "link" : "/api/keyword/16479", "label" : "Cell Nucleus/*enzymology/metabolism", "published" : true, "oldId" : 16479, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16672, "link" : "/api/keyword/16672", "label" : "Microscopy, Confocal", "published" : true, "oldId" : 16672, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16698, "link" : "/api/keyword/16698", "label" : "Cell Culture Techniques", "published" : true, "oldId" : 16698, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2010, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-02-13", "oaFree" : false, "oaByAuthor" : { "otype" : "Author", "mtid" : 1131057, "link" : "/api/author/1131057", "label" : "Róza Ádány (Népegészségügy, genetikai epidemiológia)", "familyName" : "Ádány", "givenName" : "Róza", "published" : true, "oldId" : 1131057, "snippet" : true }, "citationCount" : 29, "citationCountUnpublished" : 0, "citationCountWoOther" : 29, "independentCitCountWoOther" : 22, "nationalOriginCitationCount" : 9, "foreignEditionCitationCount" : 29, "doiCitationCount" : 28, "wosCitationCount" : 29, "scopusCitationCount" : 28, "wosScopusCitationCount" : 29, "wosScopusCitationCountWoOther" : 29, "wosScopusIndependentCitationCount" : 22, "wosScopusIndependentCitationCountWoOther" : 22, "independentCitationCount" : 22, "selfCitationCount" : 7, "unhandledCitationCount" : 0, "citingPubCount" : 29, "independentCitingPubCount" : 22, "citingPubCountWoOther" : 29, "independentCitingPubCountWoOther" : 22, "unhandledCitingPubCount" : 0, "citedPubCount" : 18, "citedCount" : 18, "ratings" : [ { "otype" : "SjrRating", "mtid" : 6110965, "link" : "/api/sjrrating/6110965", "label" : "sjr:D1 (2001) Scopus - Hematology THROMBOSIS AND HAEMOSTASIS 0340-6245", "listPos" : 3, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2720, "link" : "/api/classificationexternal/2720", "label" : "Scopus - Hematology", "published" : true, "oldId" : 2720, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "oldId" : 6110965, "snippet" : true } ], "ratingsForSort" : "D1", "hasCitationDuplums" : false, "userChangeableUntil" : "2013-11-28T09:24:08.000+0000", "publishDate" : "2013-02-23T19:18:00.000+0000", "directInstitutesForSort" : "Anatómiai, Szövet- és Fejlődéstani Intézet (DE / ÁOK); Megelőző Orvostani Intézet (DE / NK)", "ownerAuthorCount" : 6, "ownerInstituteCount" : 30, "directInstituteCount" : 2, "authorCount" : 7, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/5175", "label" : "Adany R et al. Factor XIII of blood coagulation as a nuclear crosslinking enzyme. (2001) THROMBOSIS AND HAEMOSTASIS 0340-6245 2567-689X 85 5 845-851", "template" : "