TY  - JOUR
AU  - Mendler, Luca
AU  - Braun, T
AU  - Muller, S
TI  - The Ubiquitin-Like SUMO System and Heart Function: From Development to Disease
JF  - CIRCULATION RESEARCH
J2  - CIRC RES
VL  - 118
PY  - 2016
IS  - 1
SP  - 132
EP  - 144
PG  - 13
SN  - 0009-7330
DO  - 10.1161/CIRCRESAHA.115.307730
UR  - https://m2.mtmt.hu/api/publication/3054968
ID  - 3054968
AB  - SUMOylation is a ubiquitin-related transient posttranslational modification pathway catalyzing the conjugation of small ubiquitin-like modifier (SUMO) proteins (SUMO1, SUMO2, and SUMO3) to lysine residues of proteins. SUMOylation targets a wide variety of cellular regulators and thereby affects a multitude of different cellular processes. SUMO/sentrin-specific proteases are able to remove SUMOs from targets, contributing to a tight control of SUMOylated proteins. Genetic and cell biological experiments indicate a critical role of balanced SUMOylation/deSUMOylation for proper cardiac development, metabolism, and stress adaptation. Here, we review the current knowledge about SUMOylation/deSUMOylation in the heart and provide an integrated picture of cardiac functions of the SUMO system under physiologic or pathologic conditions. We also describe potential therapeutic approaches targeting the SUMO machinery to combat heart disease.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kehler, L
AU  - Biró, Orsolya
AU  - Lázár, Levente
AU  - Rigó, János
AU  - Nagy, Bálint
TI  - Elevated hsa-miR-99a levels in maternal plasma may indicate congenital heart defects
JF  - BIOMEDICAL REPORTS
J2  - BIOMEDICAL REPORTS
VL  - 3
PY  - 2015
IS  - 6
SP  - 869
EP  - 873
PG  - 5
SN  - 2049-9434
DO  - 10.3892/br.2015.510
UR  - https://m2.mtmt.hu/api/publication/2959181
ID  - 2959181
LA  - English
DB  - MTMT
ER  -