TY  - JOUR
AU  - Mosaferi Ziaaldini, Mohammad
AU  - Koltai, Erika
AU  - Csende, Zsolt
AU  - Goto, Sataro
AU  - Boldogh, Istvan
AU  - Taylor, Albert W
AU  - Radák, Zsolt
TI  - Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats
JF  - EXPERIMENTAL GERONTOLOGY
J2  - EXP GERONTOL
VL  - 67
PY  - 2015
SP  - 9
EP  - 14
PG  - 6
SN  - 0531-5565
DO  - 10.1016/j.exger.2015.04.008
UR  - https://m2.mtmt.hu/api/publication/2883904
ID  - 2883904
AB  - Abstract Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.
LA  - English
DB  - MTMT
ER  -