TY - JOUR AU - Kehler, L AU - Biró, Orsolya AU - Lázár, Levente AU - Rigó, János AU - Nagy, Bálint TI - Elevated hsa-miR-99a levels in maternal plasma may indicate congenital heart defects JF - BIOMEDICAL REPORTS J2 - BIOMEDICAL REPORTS VL - 3 PY - 2015 IS - 6 SP - 869 EP - 873 PG - 5 SN - 2049-9434 DO - 10.3892/br.2015.510 UR - https://m2.mtmt.hu/api/publication/2959181 ID - 2959181 LA - English DB - MTMT ER - TY - JOUR AU - Csaky-Szunyogh, M AU - Vereczkey, Attila AU - Kosa, Z AU - Gerencsér, Balázs AU - Czeizel, Endre TI - Risk factors in the origin of congenital left-ventricular outflow-tract obstruction defects of the heart: a population-based case-control study. JF - PEDIATRIC CARDIOLOGY J2 - PEDIATR CARDIOL VL - 35 PY - 2014 IS - 1 SP - 108 EP - 120 PG - 13 SN - 0172-0643 DO - 10.1007/s00246-013-0749-6 UR - https://m2.mtmt.hu/api/publication/2555708 ID - 2555708 AB - The aim of our project was to study possible etiological factors in the origin of congenital heart defects (CHDs) because in the majority of patients the underlying causes are unclear. Cases with different CHD entities as homogeneously as possible were planned for evaluation in the population-based large data set of the Hungarian Case Control Surveillance of Congenital Abnormalities. Dead or surgically corrected 302 live-born cases with different types of left-ventricular outflow tract obstructive defects (LVOT, i.e., valvular aortic stenosis 76, hypoplastic left heart syndrome 76, coarctation of the aorta 113, and other congenital anomalies of aorta 32) were compared with 469 matched controls, 38,151 controls without any defects, and 20,750 malformed controls with other isolated defects. Medically recorded pregnancy complications and chronic diseases were evaluated based on prenatal maternity logbooks, whereas acute diseases, drug treatments, and folic acid/multivitamin supplementation were analyzed both on the basis of retrospective maternal information and medical records. The results of the study showed the role of maternal diabetes in the origin of LVOT in general, while panic disorder was associated with a higher risk of hypoplastic left heart syndrome and ampicillin treatment with a higher risk of coarctation of the aorta (COA). High doses of folic acid had a protective effect regarding the manifestation of LVOT, particularly COA. In conclusion, only a minor portion of causes was shown in our study; thus, further studies are needed to understand better the underlying causal factors in the origin of LVOT. LA - English DB - MTMT ER - TY - JOUR AU - Czeizel, Endre AU - M, Dobó AU - P, Vargha TI - Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows a reduction in certain congenital abnormities JF - BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY J2 - BIRTH DEFECTS RES A VL - 70 PY - 2004 IS - 11 SP - 853 EP - 861 PG - 9 SN - 1542-0752 DO - 10.1002/bdra.20086 UR - https://m2.mtmt.hu/api/publication/2784124 ID - 2784124 N1 - Megjegyzés-24739387 Megjegyzés-21733035 : FN Thomson Reuters Web of Knowledge LA - English DB - MTMT ER -