TY - JOUR AU - Váradi, Judit AU - Lekli, István AU - Juhász, Béla AU - Bácskay, Ildikó AU - Szabo, G AU - Gesztelyi, Rudolf AU - Szendrei, L AU - Varga, E AU - Bak, István AU - Foresti, R AU - Motterlini, R AU - Tósaki, Árpád TI - Beneficial effects of carbon monoxide-releasing molecules on post-ischemic myocardial recovery JF - LIFE SCIENCES J2 - LIFE SCI VL - 80 PY - 2007 IS - 17 SP - 1619 EP - 1626 PG - 8 SN - 0024-3205 DO - 10.1016/j.lfs.2007.01.047 UR - https://m2.mtmt.hu/api/publication/1191398 ID - 1191398 LA - English DB - MTMT ER - TY - JOUR AU - Bak, István AU - Váradi, Judit AU - Nagy, N AU - Vecsernyés, Miklós AU - Tósaki, Árpád TI - The role of exogenous carbon monoxide in the recovery of postischemic cardiac function in buffer perfused isolated rat hearts JF - CELLULAR AND MOLECULAR BIOLOGY J2 - CELL MOL BIOL VL - 51 PY - 2005 IS - 5 SP - 453 EP - 459 PG - 7 SN - 0145-5680 DO - 10.1170/T650 UR - https://m2.mtmt.hu/api/publication/1164838 ID - 1164838 AB - Isolated rat hearts were perfused for 10 min with oxygenated buffer and equilibrated with carbon monoxide (CO) of 0.001% and 0.01% before the induction of 30 min global ischemia followed by 120 min of reperfusion. These concentrations of CO significantly improved the post-ischemic recovery of coronary flow (CF), aortic flow (AF), and left ventricular developed pressure (LVDP). The improvement in recovery reflected in the reduction of infarct size and the incidence of reperfusion-induced ventricular fibrillation (VF). Thus, hearts subjected to 0.001% and 0.01% of CO exposure via the perfusion buffer, infarct size was reduced from the CO-free control value of 39% +/- 5% to 21% +/- 3% (*p < 0.05) and 18% +/- 4% (*p < 0.05), respectively. In the presence of 0.001% and 0.01% CO, the incidence of VF was also reduced from its control value of 92% to 17% (*p < 0.05) and 17% (*p < 0.05), respectively. Increasing the CO exposure to 0.1% in the buffer, all hearts showed VF combined with ventricular tachycardia or bradycardia and various rhythm disturbances indicating the direct toxic effects of CO on the myocardium. The results show that cardioprotective concentrations (0.01% and 0.001%) of exogenous CO related to an increase in cGMP levels and guanylate cyclase activities. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Márta Éva AU - Gallyas, Éva AU - Bak, István AU - Rakotovao, A AU - Boucher, F AU - DeLeiris, J AU - Nagy, N AU - Varga, E AU - Tósaki, Árpád TI - Heme oxygenase-1 related carbon monoxide and flavonoids in ischemic/reperfused rat retina JF - INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE J2 - INVEST OPHTH VIS SCI VL - 45 PY - 2004 IS - 10 SP - 3727 EP - 3732 PG - 6 SN - 0146-0404 DO - 10.1167/iovs.03-1324 UR - https://m2.mtmt.hu/api/publication/1163880 ID - 1163880 LA - English DB - MTMT ER - TY - JOUR AU - Bak, István AU - Szendrei, L AU - Turóczi, Tibor AU - Papp, Gábor Csaba AU - Joó, Ferenc AU - Das, DK AU - de Leiris, J AU - Der, P AU - Juhász, Béla AU - Varga, E AU - Bácskay, Ildikó AU - Balla, József AU - Kovács, Péter AU - Tósaki, Árpád TI - Heme oxygenase-1 related carbon monoxide production and ventricular fibrillation in isolated ischemic/reperfused mouse myocardium JF - FASEB JOURNAL J2 - FASEB J VL - 17 PY - 2003 IS - 14 SP - 2133 EP - 2135 PG - 3 SN - 0892-6638 DO - 10.1096/fj.03-0032fje UR - https://m2.mtmt.hu/api/publication/1195197 ID - 1195197 N1 - WoS-ban hibás kötetszám! LA - English DB - MTMT ER - TY - JOUR AU - Bak, István AU - Papp, Gábor Csaba AU - Turóczi, Tibor AU - Varga, E AU - Szendrei, L AU - Vecsernyés, Miklós AU - Joó, Ferenc AU - Tósaki, Árpád TI - The Role of Heme Oxygenase-related Carbon Monoxide and Ventricular Fibrillation in Ischemic/Reperfused Hearts JF - FREE RADICAL BIOLOGY AND MEDICINE J2 - FREE RADICAL BIO MED VL - 33 PY - 2002 IS - 5 SP - 639 EP - 648 PG - 10 SN - 0891-5849 DO - 10.1016/S0891-5849(02)00913-9 UR - https://m2.mtmt.hu/api/publication/1031393 ID - 1031393 AB - Reperfusion-induced ventricular fibrillation (VF) and heme oxygenase (HO)-related carbon monoxide (CO) production in isolated ischemic/reperfused rat hearts were studied by gas chromatography. Hearts were subjected to 30 min ischemia followed by 2 h reperfusion, and the expression of HO-1 mRNA (about 4-fold) was observed in ischemic/reperfused-nonfibrillated hearts. In fibrillated hearts, the reduction (about 75%) in HO-1 mRNA expression was detected. These changes in HO-1 mRNA expression were reflected in tissue CO production. Thus, in the absence of VF, CO production was increased about 3.5-fold, while in the presence of VF, CO production was under the detectable level in comparison with the control group. Our results suggest that the stimulation of HO-1 mRNA expression may lead to the prevention of reperfusion VF via an increase in endogenous CO production. To prove this, hearts were treated with 1 muM of N-tert-butyl-alpha-phenylnitrone (PBN) as an inducer of HO-1. PBN treatment resulted in about 20 times increase in HO-1 mRNA expression, and even a higher production rate in endogenous CO. HO protein level and enzyme activity followed the same pattern, as it was observed in HO-1 mRNA expression, in fibrillated and nonfibrillated myocardium. Five mM/1 of zinc-protoporphyrin IX (ZnPPIX) significantly blocked HO enzyme activity and increased the incidence of VF, therefore the application of ZnPPIX led to a significant reduction in HO-I mRNA and protein expression. Our data provide direct evidence of an inverse relationship between the development of reperfusion-induced VF and endogenous CO production. Thus, interventions that are able to increase tissue CO content may prevent the development of reperfusion-induced VF. LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Csaba AU - Varga, E AU - Kovács, Péter AU - Ferdinandy, Péter AU - Blasig, I E AU - Szilvássy, Zoltán AU - Tósaki, Árpád TI - Heme oxygenase and cardiac function in ischemic/reperfused rat hearts JF - FREE RADICAL BIOLOGY AND MEDICINE J2 - FREE RADICAL BIO MED VL - 27 PY - 1999 IS - 1-2 SP - 119 EP - 126 PG - 8 SN - 0891-5849 DO - 10.1016/S0891-5849(99)00077-5 UR - https://m2.mtmt.hu/api/publication/1300007 ID - 1300007 LA - English DB - MTMT ER -