@article{MTMT:1191398,
	title = {Beneficial effects of carbon monoxide-releasing molecules on post-ischemic myocardial recovery},
	url = {https://m2.mtmt.hu/api/publication/1191398},
	author = {Váradi, Judit and Lekli, István and Juhász, Béla and Bácskay, Ildikó and Szabo, G and Gesztelyi, Rudolf and Szendrei, L and Varga, E and Bak, István and Foresti, R and Motterlini, R and Tósaki, Árpád},
	doi = {10.1016/j.lfs.2007.01.047},
	journal-iso = {LIFE SCI},
	journal = {LIFE SCIENCES},
	volume = {80},
	unique-id = {1191398},
	issn = {0024-3205},
	year = {2007},
	eissn = {1879-0631},
	pages = {1619-1626},
	orcid-numbers = {Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:1164838,
	title = {The role of exogenous carbon monoxide in the recovery of postischemic cardiac function in buffer perfused isolated rat hearts},
	url = {https://m2.mtmt.hu/api/publication/1164838},
	author = {Bak, István and Váradi, Judit and Nagy, N and Vecsernyés, Miklós and Tósaki, Árpád},
	doi = {10.1170/T650},
	journal-iso = {CELL MOL BIOL},
	journal = {CELLULAR AND MOLECULAR BIOLOGY},
	volume = {51},
	unique-id = {1164838},
	issn = {0145-5680},
	abstract = {Isolated rat hearts were perfused for 10 min with oxygenated buffer and equilibrated with carbon monoxide (CO) of 0.001% and 0.01% before the induction of 30 min global ischemia followed by 120 min of reperfusion. These concentrations of CO significantly improved the post-ischemic recovery of coronary flow (CF), aortic flow (AF), and left ventricular developed pressure (LVDP). The improvement in recovery reflected in the reduction of infarct size and the incidence of reperfusion-induced ventricular fibrillation (VF). Thus, hearts subjected to 0.001% and 0.01% of CO exposure via the perfusion buffer, infarct size was reduced from the CO-free control value of 39% +/- 5% to 21% +/- 3% (*p < 0.05) and 18% +/- 4% (*p < 0.05), respectively. In the presence of 0.001% and 0.01% CO, the incidence of VF was also reduced from its control value of 92% to 17% (*p < 0.05) and 17% (*p < 0.05), respectively. Increasing the CO exposure to 0.1% in the buffer, all hearts showed VF combined with ventricular tachycardia or bradycardia and various rhythm disturbances indicating the direct toxic effects of CO on the myocardium. The results show that cardioprotective concentrations (0.01% and 0.001%) of exogenous CO related to an increase in cGMP levels and guanylate cyclase activities.},
	year = {2005},
	eissn = {1165-158X},
	pages = {453-459}
}

@article{MTMT:1163880,
	title = {Heme oxygenase-1 related carbon monoxide and flavonoids in ischemic/reperfused rat retina},
	url = {https://m2.mtmt.hu/api/publication/1163880},
	author = {Szabó, Márta Éva and Gallyas, Éva and Bak, István and Rakotovao, A and Boucher, F and DeLeiris, J and Nagy, N and Varga, E and Tósaki, Árpád},
	doi = {10.1167/iovs.03-1324},
	journal-iso = {INVEST OPHTH VIS SCI},
	journal = {INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE},
	volume = {45},
	unique-id = {1163880},
	issn = {0146-0404},
	year = {2004},
	eissn = {1552-5783},
	pages = {3727-3732}
}

@article{MTMT:1195197,
	title = {Heme oxygenase-1 related carbon monoxide production and ventricular fibrillation in isolated ischemic/reperfused mouse myocardium},
	url = {https://m2.mtmt.hu/api/publication/1195197},
	author = {Bak, István and Szendrei, L and Turóczi, Tibor and Papp, Gábor Csaba and Joó, Ferenc and Das, DK and de Leiris, J and Der, P and Juhász, Béla and Varga, E and Bácskay, Ildikó and Balla, József and Kovács, Péter and Tósaki, Árpád},
	doi = {10.1096/fj.03-0032fje},
	journal-iso = {FASEB J},
	journal = {FASEB JOURNAL},
	volume = {17},
	unique-id = {1195197},
	issn = {0892-6638},
	year = {2003},
	eissn = {1530-6860},
	pages = {2133-2135}
}

@article{MTMT:1031393,
	title = {The Role of Heme Oxygenase-related Carbon Monoxide and Ventricular Fibrillation in Ischemic/Reperfused Hearts},
	url = {https://m2.mtmt.hu/api/publication/1031393},
	author = {Bak, István and Papp, Gábor Csaba and Turóczi, Tibor and Varga, E and Szendrei, L and Vecsernyés, Miklós and Joó, Ferenc and Tósaki, Árpád},
	doi = {10.1016/S0891-5849(02)00913-9},
	journal-iso = {FREE RADICAL BIO MED},
	journal = {FREE RADICAL BIOLOGY AND MEDICINE},
	volume = {33},
	unique-id = {1031393},
	issn = {0891-5849},
	abstract = {Reperfusion-induced ventricular fibrillation (VF) and heme oxygenase (HO)-related carbon monoxide (CO) production in isolated ischemic/reperfused rat hearts were studied by gas chromatography. Hearts were subjected to 30 min ischemia followed by 2 h reperfusion, and the expression of HO-1 mRNA (about 4-fold) was observed in ischemic/reperfused-nonfibrillated hearts. In fibrillated hearts, the reduction (about 75%) in HO-1 mRNA expression was detected. These changes in HO-1 mRNA expression were reflected in tissue CO production. Thus, in the absence of VF, CO production was increased about 3.5-fold, while in the presence of VF, CO production was under the detectable level in comparison with the control group. Our results suggest that the stimulation of HO-1 mRNA expression may lead to the prevention of reperfusion VF via an increase in endogenous CO production. To prove this, hearts were treated with 1 muM of N-tert-butyl-alpha-phenylnitrone (PBN) as an inducer of HO-1. PBN treatment resulted in about 20 times increase in HO-1 mRNA expression, and even a higher production rate in endogenous CO. HO protein level and enzyme activity followed the same pattern, as it was observed in HO-1 mRNA expression, in fibrillated and nonfibrillated myocardium. Five mM/1 of zinc-protoporphyrin IX (ZnPPIX) significantly blocked HO enzyme activity and increased the incidence of VF, therefore the application of ZnPPIX led to a significant reduction in HO-I mRNA and protein expression. Our data provide direct evidence of an inverse relationship between the development of reperfusion-induced VF and endogenous CO production. Thus, interventions that are able to increase tissue CO content may prevent the development of reperfusion-induced VF.},
	keywords = {Animals; Male; RATS; Rats, Sprague-Dawley; Time Factors; myocardium/metabolism; Free Radicals; Blotting, Western; Blotting, Northern; RNA/metabolism; RNA, Messenger/metabolism; Heart/*drug effects; Chromatography, Gas; Reperfusion Injury/*metabolism; Heme Oxygenase (Decyclizing)/*metabolism; Ventricular Fibrillation/*metabolism; Carbon Monoxide/*pharmacology},
	year = {2002},
	eissn = {1873-4596},
	pages = {639-648}
}

@article{MTMT:1300007,
	title = {Heme oxygenase and cardiac function in ischemic/reperfused rat hearts},
	url = {https://m2.mtmt.hu/api/publication/1300007},
	author = {Csonka, Csaba and Varga, E and Kovács, Péter and Ferdinandy, Péter and Blasig, I E and Szilvássy, Zoltán and Tósaki, Árpád},
	doi = {10.1016/S0891-5849(99)00077-5},
	journal-iso = {FREE RADICAL BIO MED},
	journal = {FREE RADICAL BIOLOGY AND MEDICINE},
	volume = {27},
	unique-id = {1300007},
	issn = {0891-5849},
	year = {1999},
	eissn = {1873-4596},
	pages = {119-126},
	orcid-numbers = {Csonka, Csaba/0000-0003-2532-6261; Ferdinandy, Péter/0000-0002-6424-6806}
}