TY - JOUR AU - Honti, Viktor AU - Csordás, Gábor AU - Kurucz, Judit Éva AU - Márkus, Róbert AU - Andó, István TI - The cell-mediated immunity of Drosophila melanogaster: Hemocyte lineages, immune compartments, microanatomy and regulation. JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 42 PY - 2014 IS - 1 SP - 47 EP - 56 PG - 10 SN - 0145-305X DO - 10.1016/j.dci.2013.06.005 UR - https://m2.mtmt.hu/api/publication/2372553 ID - 2372553 N1 - Cited By :124 Export Date: 19 January 2022 CODEN: DCIMD Correspondence Address: Andó, I.; Institute of Genetics Biological Research Centre of the Hungarian Academy of Sciences, P.O. Box 521, Szeged H-6701, Hungary; email: ando.istvan@brc.mta.hu AB - In the animal kingdom, innate immunity is the first line of defense against invading pathogens. The dangers of microbial and parasitic attacks are countered by similar mechanisms, involving the prototypes of the cell-mediated immune responses, the phagocytosis and encapsulation. Work on Drosophila has played an important role in promoting an understanding of the basic mechanisms of phylogenetically conserved modules of innate immunity. The aim of this review is to survey the developments in the identification and functional definition of immune cell types and the immunological compartments of Drosophila melanogaster. We focus on the molecular and developmental aspects of the blood cell types and compartments, as well as the dynamics of blood cell development and the immune response. Further advances in the characterization of the innate immune mechanisms in Drosophila will provide basic clues to the understanding of the importance of the evolutionary conserved mechanisms of innate immune defenses in the animal kingdom. LA - English DB - MTMT ER - TY - JOUR AU - Takáts, Szabolcs AU - Pircs, Karolina Milena AU - Nagy, Péter AU - Varga, Ágnes AU - Kárpáti, Manuéla AU - Hegedűs, Krisztina AU - Kramer, H AU - Kovács, Attila Lajos AU - Sass, Miklós AU - Juhász, Gábor TI - Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila JF - MOLECULAR BIOLOGY OF THE CELL J2 - MOL BIOL CELL VL - 25 PY - 2014 IS - 8 SP - 1338 EP - 1354 PG - 17 SN - 1059-1524 DO - 10.1091/mbc.E13-08-0449 UR - https://m2.mtmt.hu/api/publication/2527687 ID - 2527687 N1 - Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pazmany s. 1/C, H-1117 Budapest, Hungary Department of Neuroscience, Department of Cell Biology, University of Texas Southwestern Medical School, Dallas, TX, United States Cited By :138 Export Date: 4 May 2021 CODEN: MBCEE Correspondence Address: Juhász, G.; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pazmany s. 1/C, H-1117 Budapest, Hungary; email: szmrt@elte.hu LA - English DB - MTMT ER - TY - JOUR AU - Honti, Viktor AU - Csordás, Gábor AU - Márkus, Róbert AU - Kurucz, Judit Éva AU - Jankovics, Ferenc AU - Andó, István TI - Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in drosophila melanogaster JF - MOLECULAR IMMUNOLOGY J2 - MOL IMMUNOL VL - 47 PY - 2010 IS - 11-12 SP - 1997 EP - 2004 PG - 8 SN - 0161-5890 DO - 10.1016/j.molimm.2010.04.017 UR - https://m2.mtmt.hu/api/publication/1921048 ID - 1921048 N1 - Cited By :83 Export Date: 19 January 2022 CODEN: IMCHA Correspondence Address: Andó, I.; Institute of Genetics, Temesvári krt. 62, 6726 Szeged, Csongrád, Hungary; email: ando@brc.hu LA - English DB - MTMT ER - TY - JOUR AU - Pataki, Andrea Csilla AU - Matusek, Tamás AU - Kurucz, Judit Éva AU - Andó, István AU - Jenny, A AU - Mihály, József TI - Drosophila Rab23 Is Involved in the Regulation of the Number and Planar Polarization of the Adult Cuticular Hairs JF - GENETICS J2 - GENETICS VL - 184 PY - 2010 IS - 4 SP - 1051 EP - 1065 PG - 15 SN - 0016-6731 DO - 10.1534/genetics.109.112060 UR - https://m2.mtmt.hu/api/publication/1921070 ID - 1921070 N1 - Megjegyzés-22194237 DI: 10.1534/genetics.109.112060 LA - English DB - MTMT ER - TY - JOUR AU - Márkus, Róbert AU - Laurinyecz, Barbara AU - Kurucz, Judit Éva AU - Honti, Viktor AU - Bajusz, Izabella AU - Sipos, Botond AU - Somogyi, Kálmán AU - Kronhamn, J AU - Hultmark, D AU - Andó, István TI - Sessile hemocytes as a hematopoietic compartment in drosophila melanogaster JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 106 PY - 2009 IS - 12 SP - 4805 EP - 4809 PG - 5 SN - 0027-8424 DO - 10.1073/pnas.0801766106 UR - https://m2.mtmt.hu/api/publication/1920757 ID - 1920757 N1 - Cited By :174 Export Date: 30 June 2022 CODEN: PNASA LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Gábor AU - Hill, JH AU - Yan, Y AU - Sass, Miklós AU - Baehrecke, EH AU - Backer, JM AU - Neufeld, TP TI - The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. JF - JOURNAL OF CELL BIOLOGY J2 - J CELL BIOL VL - 181 PY - 2008 IS - 4 SP - 655 EP - 666 PG - 12 SN - 0021-9525 DO - 10.1083/jcb.200712051 UR - https://m2.mtmt.hu/api/publication/1131857 ID - 1131857 N1 - Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, United States Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, H-2120, Hungary Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, United States Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, United States Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, United States Cited By :264 Export Date: 21 September 2022 CODEN: JCLBA Correspondence Address: Neufeld, T. P.; Department of Genetics, Cell Biology, and Development, , Minneapolis, MN 55455, United States; email: neufe003@umn.edu AB - Degradation of cytoplasmic components by autophagy requires the class III phosphatidylinositol 3 (PI(3))-kinase Vps34, but the mechanisms by which this kinase and its lipid product PI(3) phosphate (PI(3)P) promote autophagy are unclear. In mammalian cells, Vps34, with the proautophagic tumor suppressors Beclin1/Atg6, Bif-1, and UVRAG, forms a multiprotein complex that initiates autophagosome formation. Distinct Vps34 complexes also regulate endocytic processes that are critical for late-stage autophagosome- lysosome fusion. In contrast, Vps34 may also transduce activating nutrient signals to mammalian target of rapamycin (TOR), a negative regulator of autophagy. To determine potential in vivo functions of Vps34, we generated mutations in the single Drosophila melanogaster Vps34 orthologue, causing cell- autonomous disruption of autophagosome/autolysosome formation in larval fat body cells. Endocytosis is also disrupted in Vps34(-/-) animals, but we demonstrate that this does not account for their autophagy defect. Unexpectedly, TOR signaling is unaffected in Vps34 mutants, indicating that Vps34 does not act upstream of TOR in this system. Instead, we show that TOR/Atg1 signaling regulates the starvation-induced recruitment of PI(3)P to nascent autophagosomes. Our results suggest that Vps34 is regulated by TOR-dependent nutrient signals directly at sites of autophagosome formation. LA - English DB - MTMT ER - TY - JOUR AU - Kurucz, Judit Éva AU - Váczi, Balázs AU - Márkus, Róbert AU - Laurinyecz, Barbara AU - Vilmos, Péter AU - Zsámboki, János AU - Csorba, Kinga AU - Gateff, E AU - Hultmark, D AU - Andó, István TI - Definition of Drosophila hemocyte subsets by cell-type specific antigens JF - ACTA BIOLOGICA HUNGARICA (1983-2018) J2 - ACTA BIOL HUNG VL - 58 PY - 2007 IS - Suppl. 1 SP - 95 EP - 111 PG - 17 SN - 0236-5383 DO - 10.1556/ABiol.58.2007.Suppl.8 UR - https://m2.mtmt.hu/api/publication/1915261 ID - 1915261 AB - We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. Oil the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmalocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged ill four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocyles. LA - English DB - MTMT ER - TY - JOUR AU - Kurucz, Judit Éva AU - Márkus, Róbert AU - Zsámboki, János AU - Medzihradszky F., Katalin AU - Darula, Zsuzsanna AU - Vilmos, Péter AU - Udvardy, Andor AU - Krausz, Ildikó AU - Lukacsovich, Tamás AU - Gateff, E AU - Zettervall, CJ AU - Hultmark, D AU - Andó, István TI - Nimrod, a Putative Phagocytosis Receptor With Egf Repeats in Drosophila Plasmatocytes JF - CURRENT BIOLOGY J2 - CURR BIOL VL - 17 PY - 2007 IS - 7 SP - 649 EP - 654 PG - 6 SN - 0960-9822 DO - 10.1016/j.cub.2007.02.041 UR - https://m2.mtmt.hu/api/publication/1915010 ID - 1915010 N1 - Megjegyzés-22232309 Z9: 60 DI: 10.1016/j.cub.2007.02.041 LA - English DB - MTMT ER - TY - JOUR AU - Ryder, E AU - Ashburner, M AU - Bautista, Llacer R AU - Drummond, J AU - Webster, J AU - Johnson, G AU - Morley, T AU - Chan, YS AU - Blows, F AU - Coulson, D AU - Reuter, G AU - Baisch, H AU - Apelt, C AU - Kauk, A AU - Rudolph, T AU - Kube, M AU - Klimm, KM AU - Nickel, C AU - Szidonya, János AU - Maróy, Péter AU - Pál, Margit AU - Rasmuson, Lestander A AU - Ekstrom, K AU - Stocker, H AU - Hugentobler, C AU - Hafen, E AU - Gubb, D AU - Pflugfelder, G AU - Dorner, C AU - Mechler, B AU - Schenkel, H AU - Marhold, J AU - Serras, F AU - Corominas, M AU - Punset, A AU - Roote, J AU - Russell, S TI - The Drosdel Deletion Collection: A Drosophila Genomewide Chromosomal Deficiency Resource JF - GENETICS J2 - GENETICS VL - 177 PY - 2007 IS - 1 SP - 615 EP - 629 PG - 15 SN - 0016-6731 DO - 10.1534/genetics.107.076216 UR - https://m2.mtmt.hu/api/publication/1915229 ID - 1915229 N1 - Megjegyzés-22232557 Z9: 53 DI: 10.1534/genetics.107.076216 AB - We describe a second-gene ration deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering similar to 77% of the Release 5.1 genome. Using a previously reported collection of FRT-bearing P-element insertions, we have generated 655 new deletions and verified a set of 209 deletion-bearing fly stocks. In addition to deletions, we demonstrate how the P elements may also be used to generate a set of custom inversions and duplications, particularly useful for balancing difficult regions of the genome carrying haplo-insufficient loci. We describe a simple computational resource that facilitates selection of appropriate elements for generating custom deletions. Finally, we provide a computational resource that facilitates selection of other mapped FRT-bearing elements that, when combined with the DrosDel collection, can theoretically generate over half a million precisely mapped deletions. LA - English DB - MTMT ER - TY - JOUR AU - Scott, RC AU - Juhász, Gábor AU - Neufeld, TP TI - Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death JF - CURRENT BIOLOGY J2 - CURR BIOL VL - 17 PY - 2007 SP - 1 EP - 11 PG - 11 SN - 0960-9822 DO - 10.1016/j.cub.2006.10.053 UR - https://m2.mtmt.hu/api/publication/1071529 ID - 1071529 N1 - Cited By :488 Export Date: 18 October 2022 CODEN: CUBLE Correspondence Address: Neufeld, T.P.; Department of Genetics, Cell Biology, and Development, , Minneapolis, MN 55455, United States; email: neufeld@ahc.umn.edu LA - English DB - MTMT ER - TY - JOUR AU - Vilmos, Péter AU - Nagy, István AU - Kurucz, Judit Éva AU - Hultmark, D AU - Gateff, E AU - Andó, István TI - A rapid rosetting method for separation of hemocyte sub-populations of Drosophila melanogaster JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 28 PY - 2004 IS - 6 SP - 555 EP - 563 PG - 9 SN - 0145-305X DO - 10.1016/j.dci.2003.10.001 UR - https://m2.mtmt.hu/api/publication/1951675 ID - 1951675 LA - English DB - MTMT ER - TY - JOUR AU - Zettervall, CJ AU - Anderl, I AU - Williams, MJ AU - Palmer, R AU - Kurucz, Judit Éva AU - Andó, István AU - Hultmark, D TI - A directed screen for genes involved in Drosophila blood cell activation JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 101 PY - 2004 IS - 39 SP - 14192 EP - 14197 PG - 6 SN - 0027-8424 DO - 10.1073/pnas.0403789101 UR - https://m2.mtmt.hu/api/publication/1913536 ID - 1913536 LA - English DB - MTMT ER - TY - JOUR AU - Asha, H AU - Nagy, István AU - Kovacs, G AU - Stetson, D AU - Andó, István AU - Dearolf, CR TI - Analysis of Ras-induced overproliferation in Drosophila hemocytes JF - GENETICS J2 - GENETICS VL - 163 PY - 2003 SP - 203 EP - 215 PG - 13 SN - 0016-6731 UR - https://m2.mtmt.hu/api/publication/1912854 ID - 1912854 LA - English DB - MTMT ER - TY - JOUR AU - Erdélyi, Miklós AU - Szabad, János TI - Isolation and characterization of dominant female sterile mutations of Drosophila melanogaster. I. Mutations on the third chromosome. JF - GENETICS J2 - GENETICS VL - 122 PY - 1989 IS - 1 SP - 111 EP - 127 PG - 17 SN - 0016-6731 DO - 10.1093/genetics/122.1.111 UR - https://m2.mtmt.hu/api/publication/1903641 ID - 1903641 N1 - Nincs jelölve levelező szerzőség a közleményen. (TP, SZTE admin5) LA - English DB - MTMT ER -