TY  - JOUR
AU  - Abtahian, F
AU  - Guerriero, A
AU  - Sebzda, E
AU  - Lu, MM
AU  - Zhou, R
AU  - Mócsai, Attila
AU  - Myers, EE
AU  - Huang, B
AU  - Jackson, DG
AU  - Ferrari, VA
AU  - Tybulewicz, V
AU  - Lowell, CA
AU  - Lepore, JJ
AU  - Koretzky, GA
AU  - Kahn, ML
TI  - Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk
JF  - SCIENCE
J2  - SCIENCE
VL  - 299
PY  - 2003
IS  - 5604
SP  - 247
EP  - 251
PG  - 5
SN  - 0036-8075
DO  - 10.1126/science.1079477
UR  - https://m2.mtmt.hu/api/publication/1344944
ID  - 1344944
AB  - Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also arose in wild-type mice reconstituted with SLP-76 deficient bone marrow. These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Elkjaer, Marie-Louise
AU  - Vajda, Zsolt
AU  - Nejsum, Lene N
AU  - Kwon, Tae-Hwan
AU  - Jensen, Uffe B
AU  - Mahmood, Reza Amiry-Moghaddam
AU  - Frokiaer, Jorgen
AU  - Nielsen, Soren
TI  - Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain.
JF  - BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
J2  - BIOCHEM BIOPH RES CO
VL  - 276
PY  - 2000
IS  - 3
SP  - 1118
EP  - 1128
PG  - 11
SN  - 0006-291X
DO  - 10.1006/bbrc.2000.3505
UR  - https://m2.mtmt.hu/api/publication/2164004
ID  - 2164004
LA  - English
DB  - MTMT
ER  -