TY - JOUR AU - Pásztiné Gere, Erzsébet AU - Jakus, Judit TI - The effect of N-acetylcysteine on amphetamine-mediated dopamine release in rat brain striatal slices by ion-pair reversed-phase high performance liquid chromatography JF - BIOMEDICAL CHROMATOGRAPHY J2 - BIOMED CHROMATOGR VL - 23 PY - 2009 IS - 6 SP - 658 EP - 664 PG - 7 SN - 0269-3879 DO - 10.1002/bmc.1171 UR - https://m2.mtmt.hu/api/publication/113092 ID - 113092 N1 - [038/2009] MTA KK LA - English DB - MTMT ER - TY - JOUR AU - Halmos, G AU - Horváth, Tamás AU - Polony, Gábor AU - Fekete, Ádám AU - Kittel, Ágnes AU - Vizi, E. Szilveszter AU - van der Laan, BF AU - Zelles, Tibor AU - Lendvai, Balázs TI - The role of N-methyl-d-aspartate receptors and nitric oxide in cochlear dopamine release JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 154 PY - 2008 IS - 2 SP - 796 EP - 803 PG - 8 SN - 0306-4522 DO - 10.1016/j.neuroscience.2008.03.071 UR - https://m2.mtmt.hu/api/publication/109991 ID - 109991 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u. 43, H-1083 Budapest, Hungary Department of Otolaryngology, University Medical Center, Groningen, Netherlands Cited By :11 Export Date: 1 February 2023 CODEN: NRSCD Correspondence Address: Lendvai, B.; Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary; email: lendvai@koki.hu AB - Dopamine (DA) released from lateral olivocochlear (LOC) terminals may have a neuroprotective effect in the cochlea. To explore the role of N-methyl-d-aspartate (NMDA) receptors and nitric oxide (NO) in the modulation of a cochlear DA release, we measured the release of [(3)H]DA from isolated mouse cochlea in response to the application of NMDA. NMDA at 100 muM significantly increased the electrical-field stimulation-evoked and resting release of DA from the cochlea. The NO donor sodium nitroprusside enhanced the basal outflow of DA but failed to influence the evoked release. The administration of the nitric oxide synthase inhibitor N(omega)-nitro-l-arginine methyl ester (l-NAME) alone was ineffective, but it significantly inhibited the initial phase of the NMDA-induced elevation of DA outflow, which suggested the role of NO in the NMDA-induced DA release. The DA uptake inhibitor nomifensine increased the electrically evoked release of DA. Nomifensine failed to change the effect of NMDA on the resting or electrically-evoked DA release, which suggested that the uptake mechanism does not play a role in NMDA-evoked and NO-mediated DA release. In summary, we provide evidence that NO can modulate the release of DA from the cochlea following NMDA receptor activation, but does not affect the uptake of DA. LA - English DB - MTMT ER - TY - JOUR AU - Kiss, János AU - Zsilla, Gabriella AU - Vizi, E. Szilveszter TI - Inhibitory effect of nitric oxide on dopamine transporters: interneuronal communication without receptors JF - NEUROCHEMISTRY INTERNATIONAL J2 - NEUROCHEM INT VL - 45 PY - 2004 SP - 485 EP - 489 PG - 5 SN - 0197-0186 DO - 10.1016/j.neuint.2003.11.004 UR - https://m2.mtmt.hu/api/publication/109442 ID - 109442 N1 - Cited By :91 Export Date: 22 June 2023 CODEN: NEUID Correspondence Address: Kiss, J.P.; Department of Pharmacology, P.O. Box 67, Budapest H-1450, Hungary; email: kiss-j@koki.hu Chemicals/CAS: n(g) nitroarginine methyl ester, 50903-99-6; nitric oxide, 10102-43-9; nitroprusside sodium, 14402-89-2, 15078-28-1; tritium, 10028-17-8; Dopamine Plasma Membrane Transport Proteins; Dopamine, 51-61-6; Enzyme Inhibitors; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester, 50903-99-6; Nitric Oxide Donors; Nitric Oxide Synthase Type I, EC 1.14.13.39; Nitric Oxide Synthase, EC 1.14.13.39; Nitric Oxide, 10102-43-9; Nitroprusside, 15078-28-1; Nos1 protein, rat, EC 1.14.13.39 Funding details: ICA1-CT-2000-70004 Funding details: Egészségügyi Tudományos Tanács, ETT, 476/2003 Funding details: Philip Morris International, PMI Funding details: Hungarian Scientific Research Fund, OTKA, T 032789, TS 40736 Funding text 1: This work was supported by grants from the Hungarian Research Fund (T 032789, TS 40736), from the Hungarian Medical Research Council (476/2003), and from EU Framework Programme 5, Centre of Excellence grant (ICA1-CT-2000-70004). Research described in this article was supported in part by Philip Morris USA Inc. LA - English DB - MTMT ER - TY - JOUR AU - Kiss, János AU - Vizi, E. Szilveszter TI - Nitric oxide: a novel link between synaptic and nonsynaptic transmission JF - TRENDS IN NEUROSCIENCES J2 - TRENDS NEUROSCI VL - 24 PY - 2001 SP - 211 EP - 215 PG - 5 SN - 0166-2236 DO - 10.1016/S0166-2236(00)01745-8 UR - https://m2.mtmt.hu/api/publication/109049 ID - 109049 N1 - Cited By :290 Export Date: 11 August 2019 CODEN: TNSCD Correspondence Address: Kiss, J.P.; Dept. Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, H-1450 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: Biogenic Monoamines; Carrier Proteins; Glutamic Acid, 56-86-0; Nitric Oxide Synthase Type I, EC 1.14.13.39; Nitric Oxide Synthase, EC 1.14.13.39; Nitric Oxide, 10102-43-9; NOS1 protein, human, EC 1.14.13.39; Nos1 protein, rat, EC 1.14.13.39; Receptors, N-Methyl-D-Aspartate Funding details: Hungarian Scientific Research Fund Funding details: T032789, T029859, Funding text 1: This work was supported by grants from the Hungarian Research Fund (OTKA T029859, T032789). J.P.K. is a Janos Bolyai Research Fellow. Cited By :295 Export Date: 19 April 2020 CODEN: TNSCD Correspondence Address: Kiss, J.P.; Dept. Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, H-1450 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: Biogenic Monoamines; Carrier Proteins; Glutamic Acid, 56-86-0; Nitric Oxide Synthase Type I, EC 1.14.13.39; Nitric Oxide Synthase, EC 1.14.13.39; Nitric Oxide, 10102-43-9; NOS1 protein, human, EC 1.14.13.39; Nos1 protein, rat, EC 1.14.13.39; Receptors, N-Methyl-D-Aspartate Funding details: Hungarian Scientific Research Fund, OTKA Funding details: Hungarian Scientific Research Fund, OTKA, T029859, T032789 Funding text 1: This work was supported by grants from the Hungarian Research Fund (OTKA T029859, T032789). J.P.K. is a Janos Bolyai Research Fellow. Cited By :295 Export Date: 20 April 2020 CODEN: TNSCD Correspondence Address: Kiss, J.P.; Dept. Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, H-1450 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: Biogenic Monoamines; Carrier Proteins; Glutamic Acid, 56-86-0; Nitric Oxide Synthase Type I, EC 1.14.13.39; Nitric Oxide Synthase, EC 1.14.13.39; Nitric Oxide, 10102-43-9; NOS1 protein, human, EC 1.14.13.39; Nos1 protein, rat, EC 1.14.13.39; Receptors, N-Methyl-D-Aspartate Funding details: Hungarian Scientific Research Fund, OTKA Funding details: Hungarian Scientific Research Fund, OTKA, T029859, T032789 Funding text 1: This work was supported by grants from the Hungarian Research Fund (OTKA T029859, T032789). J.P.K. is a Janos Bolyai Research Fellow. LA - English DB - MTMT ER -