@article{MTMT:1671122,
	title = {Influence of process conditions on the mean size of PLGA nanoparticles},
	url = {https://m2.mtmt.hu/api/publication/1671122},
	author = {Feczkó, Tivadar and Tóth, Judit and Dósa, György and Gyenis, János},
	doi = {10.1016/j.cep.2011.05.006},
	journal-iso = {CHEM ENG PROCESS},
	journal = {CHEMICAL ENGINEERING AND PROCESSING},
	volume = {50},
	unique-id = {1671122},
	issn = {0255-2701},
	year = {2011},
	eissn = {1873-3204},
	pages = {846-853},
	orcid-numbers = {Dósa, György/0000-0002-4909-6694; Gyenis, János/0000-0001-5928-0535}
}

@article{MTMT:1671149,
	title = {Optimization of protein encapsulation in PLGA nanoparticles},
	url = {https://m2.mtmt.hu/api/publication/1671149},
	author = {Feczkó, Tivadar and Tóth, Judit and Dósa, György and Gyenis, János},
	doi = {10.1016/j.cep.2011.06.008},
	journal-iso = {CHEM ENG PROCESS},
	journal = {CHEMICAL ENGINEERING AND PROCESSING},
	volume = {50},
	unique-id = {1671149},
	issn = {0255-2701},
	year = {2011},
	eissn = {1873-3204},
	pages = {757-765},
	orcid-numbers = {Dósa, György/0000-0002-4909-6694; Gyenis, János/0000-0001-5928-0535}
}

@article{MTMT:1304247,
	title = {Three-step experimental design to determine the effect of process parameters on the size of chitosan microspheres},
	url = {https://m2.mtmt.hu/api/publication/1304247},
	author = {Biró, Emese and Szemesné Németh, Ágnes and Feczkó, Tivadar and Tóth, Judit and Sisak, C and Gyenis, János},
	doi = {10.1016/j.cep.2008.10.001},
	journal-iso = {CHEM ENG PROCESS},
	journal = {CHEMICAL ENGINEERING AND PROCESSING},
	volume = {48},
	unique-id = {1304247},
	issn = {0255-2701},
	abstract = {Investigation was carried out to elucidate the influence of process parameters on the mean particle size of chitosan microspheres produced by water-in-oil (w/o) emulsion crosslinking method. The aqueous chitosan solution was dispersed in the oil phase composed of 40% (v/v) sunflower oil and 60% (v/v) n-hexadecane in the presence of Tween 80 surfactant. The droplets were solidified and hardened by glutaraldehyde crosslinking agent. The particle size of the obtained microspheres was influenced by four independent process variables, such as stirring rate, and the concentrations of chitosan, Tween 80 and glutaraldehyde. To study these effects, 4-factorial 3-level Box-Behnken type experimental design and statistical analysis of the experimental results were carried out in three consecutive steps. First, the 4 independent factors at 3 levels were taken into consideration without repetitions, resulting in 27 scheduled experiments. Second, the design was completed by further experiments to check the effects of some of the variables at five levels both inside and outside the original factor intervals used in the first step. In addition, five repeated experiments at the central points of the four factors were also involved in the second step to determine the pure error. In order to elucidate the effects of process variables on the mean particle size, non-linear multidimensional regression was determined. Third, the less significant effects were neglected resulting in a simplified model equation that proved to be suitable for the prediction of the mean particle size as a function of the studied process parameters. (c) 2008 Elsevier B.V. All rights reserved.},
	year = {2009},
	eissn = {1873-3204},
	pages = {771-779},
	orcid-numbers = {Gyenis, János/0000-0001-5928-0535}
}

@article{MTMT:1157826,
	title = {Comparison of the preparation of PLGA-BSA nano- and microparticles by PVA, poloxamer and PVP},
	url = {https://m2.mtmt.hu/api/publication/1157826},
	author = {Feczkó, Tivadar and Tóth, Judit and Gyenis, János},
	doi = {10.1016/j.colsurfa.2007.07.011},
	journal-iso = {COLLOID SURFACE A},
	journal = {COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS},
	volume = {319},
	unique-id = {1157826},
	issn = {0927-7757},
	abstract = {The objective of our study was to prepare nano- and microparticles economically considering some practical parameters such as size and
		encapsulation efficiency as well as ability of particle recovery. Bovine serum albumin (BSA) model protein was encapsulated by poly(d,l-lactideco-
		glycolide) (PLGA) using a multiple water-in-oil-in-water emulsion-solvent evaporation technique. The effect of three surfactants: polyvinyl
		alcohol, poloxamer, and polyvinyl pyrrolidone, used in the outer water phase, on the properties of particles was investigated. The emulsifier/PLGA
		mass ratio played an important role in the preparation procedure of the particles. This ratio was found to be approximately 1 for polyvinyl alcohol
		(PVA) if the aim was to formulate nanoparticles with narrow size distribution (<220 nm), high yield and good encapsulation efficiency (>90%).
		Although, a ratio of 2:1 was sufficient to produce submicron particles by poloxamer with high yield, more than 70% and 90% encapsulation
		efficiency required minimum 4 and 10 emulsifier/PLGA mass ratio, respectively. Five times more PVA and 10 times more poloxamer than the
		PLGA mass were necessary to obtain nanoparticles which were easy to redisperse after centrifugation. Microparticles released more BSA than
		nanoparticles prepared by PVA, however, the situation was reverse with poloxamer. Microparticles formulated by polyvinyl pyrrolidone (PVP)
		showed the fastest in vitro release.},
	year = {2008},
	eissn = {1873-4359},
	pages = {188-195},
	orcid-numbers = {Gyenis, János/0000-0001-5928-0535}
}