TY - JOUR AU - Fabian, E AU - Poloskey, P AU - Kosa, L AU - Elmadfa, I AU - Réthy, Lajos Attila TI - Activities of Antioxidant Enzymes in Relation to Oxidative and Nitrosative Challenges in Childhood Asthma JF - JOURNAL OF ASTHMA J2 - J ASTHMA VL - 48 PY - 2011 IS - 4 SP - 351 EP - 357 PG - 7 SN - 0277-0903 DO - 10.3109/02770903.2011.560319 UR - https://m2.mtmt.hu/api/publication/2141063 ID - 2141063 AB - Background. This study aimed to investigate the relationship between antioxidant enzyme activities, extent of airway inflammation, and systemic oxidative stress in children suffering from atopic asthma. Methods. A total of 35 asthmatic (AG) and 21 healthy children (CG) participated in this study. The volume of fractionated exhaled NO (FE(NO)) was measured with the NIOX test system. The activities of the erythrocyte antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and the total antioxidant capacity (TAC) were determined photometrically. Plasma interleukin (IL)-6 was measured using ELISA; malondialdehyde (MDA) levels were analyzed using HPLC. Results. Compared to healthy controls, asthmatic children exhaled a significantly (p < .001) higher mean volume of FE(NO), had significantly reduced plasma concentrations of TAC (p = .006), and significantly enhanced levels of MDA (p < .001) and IL-6 (p = .012). SOD (p = .027), CAT (p < .001), and GSH-Px (p = .005) were significantly less active in the asthma group and significantly negatively associated with FE(NO) (SOD/FE(NO) : p = .017; CAT/FE(NO) : p = .008; GSH-Px/FE(NO) : p = .001); the oxidative stress marker MDA showed such correlations in both investigated groups (SOD/MDA: AG: p = .001, CG: p = .381; CAT/MDA: AG: p = .003, CG: p = .020; GSH-Px/MDA: AG:p = .006, CG: p = .011). Furthermore, there was a significant (p < .01) positive correlation between MDA/FE(NO) and MDA/IL-6 observed in both groups. Conclusions. These results indicate that inflammation of the bronchial tree, reflected by increased NO formation in the airways and enhanced systemic oxidative stress, is related to an alteration of antioxidant enzyme activities in childhood asthma. Modulating the activity of antioxidant enzymes may therefore have beneficial effects on pulmonary and systemic antioxidant defense mechanisms and could reduce airway inflammation and oxidative stress in asthmatics. LA - English DB - MTMT ER - TY - JOUR AU - Haines, David AU - Varga, Balázs AU - Bak, István AU - Juhász, Béla AU - Mahmoud, FF AU - Kalantari, H AU - Gesztelyi, Rudolf AU - Lekli, István AU - Czompa, Attila AU - Tósaki, Árpád TI - Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in Suppression of respiratory inflammation: a comparison with ibuprofen JF - PHYTOTHERAPY RESEARCH J2 - PHYTOTHER RES VL - 25 PY - 2011 IS - 1 SP - 128 EP - 136 PG - 9 SN - 0951-418X DO - 10.1002/ptr.3160 UR - https://m2.mtmt.hu/api/publication/1359105 ID - 1359105 LA - English DB - MTMT ER - TY - JOUR AU - Halasz, A AU - Cserháti, Endre AU - Magyar, Pál AU - Kovács, Margit AU - Cseh, Károly TI - Role of tnf-alpha and its 55 and 75 kda receptors in bronchial hyperreactivity JF - RESPIRATORY MEDICINE J2 - RESP MED VL - 96 PY - 2002 IS - 4 SP - 262 EP - 267 PG - 6 SN - 0954-6111 DO - 10.1053/rmed.2001.1256 UR - https://m2.mtmt.hu/api/publication/1247245 ID - 1247245 N1 - ISI:000175123200009 LA - English DB - MTMT ER -