@article{MTMT:2141063,
	title = {Activities of Antioxidant Enzymes in Relation to Oxidative and Nitrosative Challenges in Childhood Asthma},
	url = {https://m2.mtmt.hu/api/publication/2141063},
	author = {Fabian, E and Poloskey, P and Kosa, L and Elmadfa, I and Réthy, Lajos Attila},
	doi = {10.3109/02770903.2011.560319},
	journal-iso = {J ASTHMA},
	journal = {JOURNAL OF ASTHMA},
	volume = {48},
	unique-id = {2141063},
	issn = {0277-0903},
	abstract = {Background. This study aimed to investigate the relationship between antioxidant enzyme activities, extent of airway inflammation, and systemic oxidative stress in children suffering from atopic asthma. Methods. A total of 35 asthmatic (AG) and 21 healthy children (CG) participated in this study. The volume of fractionated exhaled NO (FE(NO)) was measured with the NIOX test system. The activities of the erythrocyte antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and the total antioxidant capacity (TAC) were determined photometrically. Plasma interleukin (IL)-6 was measured using ELISA; malondialdehyde (MDA) levels were analyzed using HPLC. Results. Compared to healthy controls, asthmatic children exhaled a significantly (p < .001) higher mean volume of FE(NO), had significantly reduced plasma concentrations of TAC (p = .006), and significantly enhanced levels of MDA (p < .001) and IL-6 (p = .012). SOD (p = .027), CAT (p < .001), and GSH-Px (p = .005) were significantly less active in the asthma group and significantly negatively associated with FE(NO) (SOD/FE(NO) : p = .017; CAT/FE(NO) : p = .008; GSH-Px/FE(NO) : p = .001); the oxidative stress marker MDA showed such correlations in both investigated groups (SOD/MDA: AG: p = .001, CG: p = .381; CAT/MDA: AG: p = .003, CG: p = .020; GSH-Px/MDA: AG:p = .006, CG: p = .011). Furthermore, there was a significant (p < .01) positive correlation between MDA/FE(NO) and MDA/IL-6 observed in both groups. Conclusions. These results indicate that inflammation of the bronchial tree, reflected by increased NO formation in the airways and enhanced systemic oxidative stress, is related to an alteration of antioxidant enzyme activities in childhood asthma. Modulating the activity of antioxidant enzymes may therefore have beneficial effects on pulmonary and systemic antioxidant defense mechanisms and could reduce airway inflammation and oxidative stress in asthmatics.},
	keywords = {Inflammation; INHIBITION; SUPEROXIDE-DISMUTASE; ACTIVATION; STRESS; NF-KAPPA-B; T-CELLS; Lipid Peroxidation; Asthma; GUINEA-PIGS; antioxidant enzymes; airway hyperresponsiveness; nitrosative stress; Oxidant; Oxidative stress},
	year = {2011},
	pages = {351-357}
}

@article{MTMT:1359105,
	title = {Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in Suppression of respiratory inflammation: a comparison with ibuprofen},
	url = {https://m2.mtmt.hu/api/publication/1359105},
	author = {Haines, David and Varga, Balázs and Bak, István and Juhász, Béla and Mahmoud, FF and Kalantari, H and Gesztelyi, Rudolf and Lekli, István and Czompa, Attila and Tósaki, Árpád},
	doi = {10.1002/ptr.3160},
	journal-iso = {PHYTOTHER RES},
	journal = {PHYTOTHERAPY RESEARCH},
	volume = {25},
	unique-id = {1359105},
	issn = {0951-418X},
	year = {2011},
	eissn = {1099-1573},
	pages = {128-136},
	orcid-numbers = {Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:1247245,
	title = {Role of tnf-alpha and its 55 and 75 kda receptors in bronchial hyperreactivity},
	url = {https://m2.mtmt.hu/api/publication/1247245},
	author = {Halasz, A and Cserháti, Endre and Magyar, Pál and Kovács, Margit and Cseh, Károly},
	doi = {10.1053/rmed.2001.1256},
	journal-iso = {RESP MED},
	journal = {RESPIRATORY MEDICINE},
	volume = {96},
	unique-id = {1247245},
	issn = {0954-6111},
	year = {2002},
	eissn = {1532-3064},
	pages = {262-267},
	orcid-numbers = {Cserháti, Endre/0000-0003-4973-7145; Kovács, Margit/0000-0001-7092-5920}
}