@article{MTMT:1429600, title = {Endocrine factors in the hypothalamic regulation of food intake in females: a review of the physiological roles and interactions of ghrelin, leptin, thyroid hormones, oestrogen and insulin}, url = {https://m2.mtmt.hu/api/publication/1429600}, author = {Somogyi, Virág and Győrffy, Andrea and Scalise, TJ and Kiss, Dávid Sándor and Goszleth, Gréta and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila}, doi = {10.1017/S0954422411000035}, journal-iso = {NUTR RES REV}, journal = {NUTRITION RESEARCH REVIEWS}, volume = {24}, unique-id = {1429600}, issn = {0954-4224}, abstract = {Controlling energy homeostasis involves modulating the desire to eat and regulating energy expenditure. The controlling machinery includes a complex interplay of hormones secreted at various peripheral endocrine endpoints, such as the gastrointestinal tract, the adipose tissue, thyroid gland and thyroid hormone-exporting organs, the ovary and the pancreas, and, last but not least, the brain itself. The peripheral hormones that are the focus of the present review (ghrelin, leptin, thyroid hormones, oestrogen and insulin) play integrated regulatory roles in and provide feedback information on the nutritional and energetic status of the body. As peripheral signals, these hormones modulate central pathways in the brain, including the hypothalamus, to influence food intake, energy expenditure and to maintain energy homeostasis. Since the growth of the literature on the role of various hormones in the regulation of energy homeostasis shows a remarkable and dynamic expansion, it is now becoming increasingly difficult to understand the individual and interactive roles of hormonal mechanisms in their true complexity. Therefore, our goal is to review, in the context of general physiology, the roles of the five best-known peripheral trophic hormones (ghrelin, leptin, thyroid hormones, oestrogen and insulin, respectively) and discuss their interactions in the hypothalamic regulation of food intake.}, year = {2011}, eissn = {1475-2700}, pages = {132-154}, orcid-numbers = {Győrffy, Andrea/0000-0001-7110-1464} } @article{MTMT:1423390, title = {Thermoregulation, energy balance, regulatory peptides: recent developments.}, url = {https://m2.mtmt.hu/api/publication/1423390}, author = {Székely, Miklós and Pétervári, Erika and Balaskó, Márta}, doi = {10.2741/S116}, journal-iso = {FRONT BIOSCI SCHOL ED}, journal = {FRONTIERS IN BIOSCIENCE (SCHOLAR EDITION)}, volume = {2}, unique-id = {1423390}, issn = {1945-0516}, abstract = {Energy balance of the body is determined mainly by the function of various hypothalamic and brainstem nuclei, according to a complex interaction between the regulation of body temperature (actual metabolic rate vs. heat loss) and regulation of body weight (metabolic rate vs. food intake). The direct effect of central anabolic neuropeptides (neuropeptide Y, orexins, melanin concentrating hormone, etc.) is to enhance food intake and suppress metabolic rate with a tendency to cause hypothermia, while central catabolic neuropeptides (melanocortins, corticotropin releasing factor, cocaine-amphetamine regulated peptide, etc.) suppress food intake and enhance energy expenditure with a tendency to induce hyperthermia. Many other neuropeptides are neither clearly anabolic, nor clearly catabolic, but still influence these complex hypothalamic/brainstem functions. Some peripheral peptides (e.g. leptin, insulin, ghrelin) acting at either peripheral or cerebral sites also contribute to the regulation of energy balance. The prevailing thermoregulatory status, the substances or neural signals representing actual feeding vs. established nutritional states, and the aging process may modify the expression and/or activity of peripheral and central peptides and peptide receptors.}, keywords = {Animals; Female; Male; Humans; signal transduction; Aging/physiology; Insulin/physiology; Energy Metabolism/*physiology; Eating/physiology; Pituitary Hormones/physiology; Peptides/*physiology; Neuropeptides/physiology; Melanocortins/physiology; Melanins/physiology; Leptin/physiology; Intracellular Signaling Peptides and Proteins/physiology; Hypothalamic Hormones/physiology; Ghrelin/physiology; Cholecystokinin/physiology; Body Weight/physiology; Body Temperature Regulation/*physiology; Adiponectin/physiology}, year = {2010}, eissn = {1945-0524}, pages = {1009-1046}, orcid-numbers = {Pétervári, Erika/0000-0002-3673-8491} }