@article{MTMT:1921818,
	title = {Integrin beta nu-mediated Phagocytosis of Apoptotic Cells in Drosophila Embryos},
	url = {https://m2.mtmt.hu/api/publication/1921818},
	author = {Nagaosa, K and Okada, R and Nonaka, S and Takeuchi, K and Fujita, Y and Miyasaka, T and Manaka, J and Andó, István and Nakanishi, Y},
	doi = {10.1074/jbc.M110.204503},
	journal-iso = {J BIOL CHEM},
	journal = {JOURNAL OF BIOLOGICAL CHEMISTRY},
	volume = {286},
	unique-id = {1921818},
	issn = {0021-9258},
	abstract = {To identify molecules that play roles in the clearance of apoptotic cells by Drosophila phagocytes, we examined a series of monoclonal antibodies raised against larval hemocytes for effects on phagocytosis in vitro. One antibody that inhibited phagocytosis recognized terribly reduced optic lobes (Trol), a core protein of the perlecan-type proteoglycan, and the level of phagocytosis in embryos of a Trol-lacking fly line was lower than in a control line. The treatment of a hemocyte cell line with a recombinant Trol protein containing the amino acid sequence RGD augmented the phosphorylation of focal adhesion kinase, a hallmark of integrin activation. A loss of integrin beta nu, one of the two beta subunits of Drosophila integrin, brought about a reduction in the level of apoptotic cell clearance in embryos. The presence of integrin beta nu at the surface of embryonic hemocytes was confirmed, and forced expression of integrin beta nu in hemocytes of an integrin beta nu-lacking fly line recovered the defective phenotype of phagocytosis. Finally, the level of phagocytosis in a fly line that lacks both integrin beta nu and Draper, another receptor required for the phagocytosis of apoptotic cells, was lower than that in a fly line lacking either protein. We suggest that integrin beta nu serves as a phagocytosis receptor responsible for the clearance of apoptotic cells in Drosophila, independent of Draper.},
	year = {2011},
	eissn = {1083-351X},
	pages = {25770-25777},
	orcid-numbers = {Andó, István/0000-0002-4648-9396}
}

@article{MTMT:1915261,
	title = {Definition of Drosophila hemocyte subsets by cell-type specific antigens},
	url = {https://m2.mtmt.hu/api/publication/1915261},
	author = {Kurucz, Judit Éva and Váczi, Balázs and Márkus, Róbert and Laurinyecz, Barbara and Vilmos, Péter and Zsámboki, János and Csorba, Kinga and Gateff, E and Hultmark, D and Andó, István},
	doi = {10.1556/ABiol.58.2007.Suppl.8},
	journal-iso = {ACTA BIOL HUNG},
	journal = {ACTA BIOLOGICA HUNGARICA (1983-2018)},
	volume = {58},
	unique-id = {1915261},
	issn = {0236-5383},
	abstract = {We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. Oil the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmalocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged ill four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocyles.},
	year = {2007},
	eissn = {1588-256X},
	pages = {95-111},
	orcid-numbers = {Laurinyecz, Barbara/0000-0003-0620-2239; Andó, István/0000-0002-4648-9396}
}