TY - JOUR AU - Horváth, Iván AU - Németh, Ádám AU - Lenkey, Zsófia AU - Alessandri, N AU - Tufano, F AU - Kis, P AU - Gaszner, Balázs AU - Cziráki, Attila TI - Invasive validation of a new oscillometric device (Arteriograph) for measuring augmentation index, central blood pressure and aortic pulse wave velocity JF - JOURNAL OF HYPERTENSION J2 - J HYPERTENSION VL - 28 PY - 2010 IS - 10 SP - 2068 EP - 2075 PG - 8 SN - 0263-6352 DO - 10.1097/HJH.0b013e32833c8a1a UR - https://m2.mtmt.hu/api/publication/1463458 ID - 1463458 AB - Background The importance of measuring aortic pulse wave velocity (PWVao), aortic augmentation index (Aix) and central systolic blood pressure (SBPao) has been shown under different clinical conditions; however, information on these parameters is hard to obtain. The aim of this study was to evaluate the accuracy of a new, easily applicable oscillometric device (Arteriograph), determining these parameters simultaneously, against invasive measurements. Methods Aortic Aix, SBPao and PWVao were measured invasively during cardiac catheterization in 16, 55 and 22 cases, respectively, and compared with the values measured by the Arteriograph. Results We found strong correlation between the invasively measured aortic Aix and the oscillometrically measured brachial Aix on either beat-to-beat or mean value per patient basis (r=0.9, P<0.001; r=0.94, P<0.001), which allowed the noninvasive calculation of the aortic Aix without using generalized transfer function. Similarly strong correlation (r=0.95, P<0.001) was found between the invasively measured and the noninvasively calculated central SBPao; furthermore, the BHS assessment of the paired differences fulfilled the 'B' grading. The PWVao values measured invasively and by Arteriograph were 9.41 +/- 1.8 m/s and 9.46 +/- 1.8 m/s, respectively (mean +/- SD); furthermore, the Pearson's correlation was 0.91 (P<0.001). The limits of agreement were 11.4% for aortic Aix and 1.59 m/s for PWVao. Conclusion Aix, SBPao and PWVao, measured oscillometrically, showed strong correlation with the invasively obtained values. The observed limits of agreement are encouragingly low for accepting the method for clinical use. Our results suggest that the PWVao values, measured by Arteriograph, are close to the true aortic PWV, determined invasively. J Hypertens 28: 2068-2075 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. LA - English DB - MTMT ER - TY - JOUR AU - Fülesdi, Béla AU - Limburg, M AU - Oláh, László AU - Bereczki, Dániel AU - Csiba, László AU - Kollár, József TI - Lack of gender difference in acetazolamide-induced cerebral vasomotor reactivity in patients suffering from type-1 diabetes mellitus JF - ACTA DIABETOLOGICA J2 - ACTA DIABETOL VL - 38 PY - 2001 IS - 3 SP - 107 EP - 112 PG - 6 SN - 0940-5429 DO - 10.1007/s005920170006 UR - https://m2.mtmt.hu/api/publication/1052901 ID - 1052901 AB - The aim of the present work was to investigate the impact of gender on resting cerebral blood flow velocity and cerebrovascular reserve capacity among diabetic patients. Middle cerebral artery mean blood flow velocity (MCAV) was measured in 72 patients suffering from type 1 diabetes mellitus at rest and 5, 10, 15 and 20 min after intravenous administration of 1 g acetazolamide. Cerebrovascular reserve was calculated as the maximal percent increase in MCAV after acetazolamide. Resting MCAV and cerebrovascular reserve capacity were compared between males and females. Resting cerebral blood flow velocity was higher in diabetic females than in males (men, 55.0+/-17.0 cm/s; women, 64.4+/-12.6 cm/s, p=0.0094). Cerebrovascular reserve capacity was similar in diabetic women and men (men, 44.0%+/-18.6%; women, 52.6%+/-32.9%, p=0.17). Comparing MCAV and cerebrovascular reserve capacity among the diabetic subgroups with disease duration < or = 10 years and >10 years, we did not detect any differences between women and men. Duration of diabetes was an important factor in determining cerebrovascular reserve capacity in both sexes: long-term diabetic women and men showed lower CRC values than diabetics with < or = 10 years disease duration. Cerebrovascular reserve capacity is similar in diabetic women and men. Taking into consideration that cerebrovascular reserve is normally higher among women, our finding indicates a relatively more serious worsening of cerebral vasodilatory responses in women suffering from type 1 diabetes. LA - English DB - MTMT ER - TY - JOUR AU - Fülesdi, Béla AU - Limburg, M AU - Bereczki, Dániel AU - Káplár, Miklós AU - Molnár, Csilla AU - Kappelmayer, János AU - Neuwirth, G AU - Csiba, László TI - Cerebrovascular reactivity and reserve capacity in type II diabetes mellitus JF - JOURNAL OF DIABETES AND ITS COMPLICATIONS J2 - J DIABETES COMPLICAT VL - 13 PY - 1999 IS - 4 SP - 191 EP - 199 PG - 9 SN - 1056-8727 DO - 10.1016/S1056-8727(99)00044-6 UR - https://m2.mtmt.hu/api/publication/1052918 ID - 1052918 AB - The aim of the study was to test the hypothesis that cerebrovascular reserve capacity and cerebrovascular reactivity are impaired in patients suffering from non insulin-dependent diabetes mellitus. We also intended to investigate factors which may influence resting cerebral blood flow velocity and cerebrovascular reserve capacity. A total of 28 patients suffering from type II diabetes mellitus and 20 healthy control subjects were studied. Based on diabetes duration patients were divided into two groups: subjects with > 10 years and those with < or = 10 years disease duration. Middle cerebral artery mean blood flow velocities were measured at rest and after intravenous administration of 1g acetazolamide. Cerebrovascular reactivity and reserve capacity were calculated. Blood glucose, insulin, glycosylated hemoglobin, hemostatic factors (fibrinogen, alpha-2 macroglobulin and von Willebrand factor antigen) were determined. Cerebrovascular reactivity and reserve capacity values were compared between the two diabetic subgroups and controls. Correlations between laboratory parameters and cerebrovascular reserve were investigated by linear regression analysis. Resting cerebral blood flow velocity was similar in controls and in the two diabetic subgroups. Cerebrovascular reactivity was elevated for a shorter time in patients with > 10 years disease duration than in controls and short-term diabetic patients. Cerebrovascular reserve capacity was lower in the long-term diabetes group (means +/- SD: 39.6 +/- 20.7%) than in patients with < or = 10 years disease duration (63.3 +/- 17.4%, p < 0.02 after Bonferroni correction). Cerebrovascular reserve capacity was inversely related to the duration of the disease (R = 0.53, p < 0.003). None of the determined laboratory factors had any relation with resting cerebral blood flow and cerebrovascular reserve capacity. The vasodilatory ability of cerebral arterioles is diminished in long-standing type II diabetes mellitus. LA - English DB - MTMT ER - TY - JOUR AU - Ficzere, Andrea AU - Valikovics, Attila AU - Fülesdi, Béla AU - Juhasz, A AU - Czuriga, István AU - Csiba, László TI - Cerebrovascular reactivity in hypertensive patients: A transcranial Doppler study JF - JOURNAL OF CLINICAL ULTRASOUND J2 - J CLIN ULTRASOUND VL - 25 PY - 1997 IS - 7 SP - 383 EP - 389 PG - 7 SN - 0091-2751 DO - 10.1002/(SICI)1097-0096(199709)25:7<383::AID-JCU6>3.0.CO;2-6 UR - https://m2.mtmt.hu/api/publication/1052926 ID - 1052926 AB - PURPOSE: We studied the usefulness of transcranial Doppler sonography for assessing changes in vasoreactivity in patients with hypertension and the hemodynamic consequences of hypertension. METHODS: The study group comprised 25 patients with chronic severe hypertension and 25 age- and sex-matched healthy subjects. Cerebrovascular reserve capacity was assessed by transcranial Doppler recording of the blood flow velocity in both middle cerebral arteries before and 5, 10, 15, and 20 minutes after intravenous injection of 1 g of acetazolamide (Diamox). Blood pressure, blood gases, and other blood parameters were also measured before and after acetazolamide injection. The sizes of the left atrium, left ventricle, and aortic root were measured by echocardiography and correlated with the vasoreactivity after acetazolamide injection. RESULTS: After acetazolamide injection, no significant changes in blood pressure were observed in either group. The mean blood flow velocity in the middle cerebral arteries of hypertensive patients (60.8 +/- 2.6 cm/sec) was not significantly different from that of controls (58.8 +/- 1.9 cm/sec) before acetazolamide injection. Ten minutes after acetazolamide injection, the percentage change in blood flow velocity was significantly lower in the hypertensive group (36.2 +/- 4.5%) than in the controls (52.6 +/- 3.7%). A significant negative correlation (p < 0.05) between decreased vasoreactivity and increased size of the left atrium and aortic root was observed. CONCLUSIONS: Vasoreactivity decreases in hypertensive patients without neurologic deficits or computed tomography abnormalities. Enlargement of the left atrium correlates well with the severity of the impairment in vasoreactivity. Transcranial Doppler sonography can be a sensitive tool in the investigation of vascular impairment caused by hypertension and in the follow-up of hypertensive patients. LA - English DB - MTMT ER -