TY - JOUR AU - Freund, Tamás TI - Interneuron diversity series: Rhythm and mood in perisomatic inhibition JF - TRENDS IN NEUROSCIENCES J2 - TRENDS NEUROSCI VL - 26 PY - 2003 SP - 489 EP - 495 PG - 7 SN - 0166-2236 DO - 10.1016/S0166-2236(03)00227-3 UR - https://m2.mtmt.hu/api/publication/109314 ID - 109314 N1 - Cited By :523 Export Date: 1 June 2023 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, PO Box 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; vasoactive intestinal polypeptide, 37221-79-7 Funding details: National Institutes of Health, NIH, MH 54671 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 Funding details: Hungarian Scientific Research Fund, OTKA, T 32251 Funding text 1: I am grateful to all members of my team for valuable contributions to the original studies that underlie this review, as well as for discussion and comments on the manuscript. The help of Gábor Nyiri, Ágnes Bodor and István Katona with the figures, and the assistance of Katalin Iványi and Katalin Lengyel in the preparation of the manuscript, is also acknowledged. My work is supported by the Howard Hughes Medical Institute (USA), NIH (MH 54671, NS30549), Philip Morris External Research Program and OTKA (T 32251) Hungary. LA - English DB - MTMT ER - TY - JOUR AU - Gulyás, Attila AU - Hájos, Norbert AU - Katona, István AU - Freund, Tamás TI - Interneurons are the local targets of hippocampal inhibitory cells which project to the medial septum JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 17 PY - 2003 SP - 1861 EP - 1872 PG - 12 SN - 0953-816X DO - 10.1046/j.1460-9568.2003.02630.x UR - https://m2.mtmt.hu/api/publication/109325 ID - 109325 N1 - Cited By :139 Export Date: 13 July 2023 CODEN: EJONE Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, P.O.Box 67, Budapest H-1450, Hungary; email: gulyas@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; somatostatin, 38916-34-6, 51110-01-1 LA - English DB - MTMT ER - TY - JOUR AU - Klausberger, T AU - Magill, PJ AU - Marton, LF AU - Roberts, JD AU - Cobden, PM AU - Buzsáki, György AU - Somogyi, Péter Pál TI - Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo. JF - NATURE J2 - NATURE VL - 421 PY - 2003 IS - 6925 SP - 844 EP - 848 PG - 5 SN - 0028-0836 DO - 10.1038/nature01374 UR - https://m2.mtmt.hu/api/publication/2138091 ID - 2138091 AB - Neural-network oscillations at distinct frequencies have been implicated in the encoding, consolidation and retrieval of information in the hippocampus. Some GABA (gamma-aminobutyric acid)-containing interneurons fire phase-locked to theta oscillations (4-8 Hz) or to sharp-wave-associated ripple oscillations (120-200 Hz), which represent different behavioural states. Interneurons also entrain pyramidal cells in vitro. The large diversity of interneurons poses the question of whether they have specific roles in shaping distinct network activities in vivo. Here we report that three distinct interneuron types--basket, axo-axonic and oriens-lacunosum-moleculare cells--visualized and defined by synaptic connectivity as well as by neurochemical markers, contribute differentially to theta and ripple oscillations in anaesthetized rats. The firing patterns of individual cells of the same class are remarkably stereotyped and provide unique signatures for each class. We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner. LA - English DB - MTMT ER - TY - JOUR AU - Nyíri, Gábor AU - Stephenson, FA AU - Freund, Tamás AU - Somogyi, Péter Pál TI - Large variability in synaptic N-methyl-D-aspartate receptor density on interneurons and a comparison with pyramidal-cell spines in the rat hippocampus JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 119 PY - 2003 SP - 347 EP - 363 PG - 17 SN - 0306-4522 DO - 10.1016/S0306-4522(03)00157-X UR - https://m2.mtmt.hu/api/publication/109324 ID - 109324 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, Budapest, H-1450, Hungary MRC Anat. Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom School of Pharmacy, Dept. of Pharmaceutical/Biol. Chem., University of London, London WC1N 1AX, United Kingdom Cited By :106 Export Date: 22 June 2023 CODEN: NRSCD Correspondence Address: Nyíri, G.; Institute of Experimental Medicine, PO Box 67, Budapest, H-1450, Hungary; email: nyiri@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1 Funding details: National Institutes of Health, NIH Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 Funding details: Hungarian Scientific Research Fund, OTKA, T032251 Funding text 1: We would like to thank the expert technical assistance of Philip Cobden, David Roberts, Paul Jays and Dr. László Márton. This work was supported by the Howard Hughes Medical Institute, National Institutes of Health (NIH) grant NS 30549 and OTKA grant T032251 (T.F.F.). LA - English DB - MTMT ER - TY - JOUR AU - Aradi, I AU - Santhakumar, V AU - Chen, K AU - Soltesz, Ivan TI - Postsynaptic effects of GABAergic synaptic diversity: regulation of neuronal excitability by changes in IPSC variance JF - NEUROPHARMACOLOGY J2 - NEUROPHARMACOLOGY VL - 43 PY - 2002 IS - 4 SP - 511 EP - 522 PG - 12 SN - 0028-3908 DO - 10.1016/S0028-3908(02)00167-3 UR - https://m2.mtmt.hu/api/publication/2941543 ID - 2941543 AB - GABAergic synaptic inputs to principal cells are heterogeneous in terms of their anatomical, molecular and physiological properties. Whether diversity in GABAergic synaptic inputs affects the efficacy of GABAergic inhibition is not understood. Here we show that alterations in the heterogeneity of IPSC populations arriving at single cells can significantly modify the effects of GABAergic inputs on neuronal excitability. The effects of IPSC diversity were examined in a computational model that incorporated experimentally measured values for spontaneous IPSCs and CA1 pyramidal cell electrophysiological properties. The simulations showed that increased variance in the conductance or decay of IPSCs could potently modulate the firing rate of the postsynaptic cells. The actual direction of the IPSC variance-induced modulation in postsynaptic cell discharges depended on the mean IPSC conductance and mean decay time constant around which the variance was introduced, as well as on the degree of depolarization and firing of the postsynaptic cell. Further analysis of the underlying mechanisms determined that these effects of IPSC variance on neuronal excitability were entirely predicted from the non-linear actions of IPSCs on action potential generation. The variance effects on neuronal excitability could be strong enough to overcome even large chances in mean IPSC conductance, demonstrating that increased mean synaptic conductance (or increased mean IPSC or IPSP) alone does not necessarily imply a more effective inhibition, a finding which has important implications for epilepsy research. These data show that the degree of heterogeneity of the GABAergic synaptic inputs to principal cells can powerfully modulate the efficacy of GABAergic inhibition. The results indicate the functional importance of the diversity of interneurons in cortical and hippocampal circuits, and suggest that plastic changes in GABAergic synaptic diversity may modulate neuronal excitability under both normal and pathological conditions. (C) 2002 Elsevier Science Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Losonczy, Attila AU - Zhang, L AU - Shigemoto, R AU - Somogyi, Péter Pál AU - Nusser, Zoltán TI - Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 542 PY - 2002 SP - 193 EP - 210 PG - 18 SN - 0022-3751 DO - 10.1113/jphysiol.2002.020024 UR - https://m2.mtmt.hu/api/publication/109138 ID - 109138 LA - English DB - MTMT ER - TY - JOUR AU - Ross, ST AU - Soltesz, Ivan TI - Long-term plasticity in interneurons of the dentate gyrus JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 98 PY - 2001 IS - 15 SP - 8874 EP - 8879 PG - 6 SN - 0027-8424 DO - 10.1073/pnas.141042398 UR - https://m2.mtmt.hu/api/publication/2941547 ID - 2941547 AB - Single interneurons influence thousands of postsynaptic principal cells, and the control of interneuronal excitability is an important regulator of the computational properties of the hippocampus. However, the mechanisms underlying long-term alterations in the input-output functions of interneurons are not fully understood. We report a mechanism of interneuronal plasticity that leads to the functional enhancement of the gain of glutamatergic inputs in the absence of long-term potentiation of the excitatory synaptic currents. Interneurons in the dentate gyrus exhibit a characteristic, limited (approximate to8 mV) depolarization of their resting membrane potential after high-frequency stimulation of the perforant path. The depolarization can be observed with either whole-cell or perforated patch electrodes, and it lasts in excess of 3 h. The long-term depolarization is specific to interneurons, because granule cells do not show it. The depolarization requires the activation of Ca2+-permeable alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and the rise of intracellular Ca2+, but not N-methyl-o-aspartate (NMDA) receptor activation. Data on the maintenance of the depolarization point to a major role for a long-term change in the rate of electrogenic Na+/K+-ATPase pump function in interneurons. As a result of the depolarization, interneurons after the tetanus respond with action potential discharges to previously subthreshold excitatory postsynaptic potentials (EPSPs), even though the EPSPs are not potentiated. These results demonstrate that the plastic nature of the interneuronal resting membrane potential underlies a unique form of long-term regulation of the gain of excitatory inputs to gamma -aminobutyric acid (CABA)ergic neurons. LA - English DB - MTMT ER - TY - JOUR AU - Maccaferri, G AU - Roberts, JD AU - Szűcs, Péter AU - Cottingham, CA AU - Somogyi, Péter Pál TI - Cell surface domain specific postsynaptic currents evoked by identified GABAergic neurones in rat hippocampus in vitro. JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 524 PY - 2000 IS - 1 SP - 91 EP - 116 PG - 26 SN - 0022-3751 DO - 10.1111/j.1469-7793.2000.t01-3-00091.x UR - https://m2.mtmt.hu/api/publication/2138095 ID - 2138095 N1 - Cited By :259 Export Date: 21 August 2019 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :261 Export Date: 6 March 2020 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :262 Export Date: 20 May 2020 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :262 Export Date: 24 May 2020 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :262 Export Date: 25 May 2020 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :270 Export Date: 23 March 2021 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :271 Export Date: 6 April 2021 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :271 Export Date: 13 April 2021 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 AB - 1. Inhibitory postsynaptic currents (IPSCs) evoked in CA1 pyramidal cells (n = 46) by identified interneurones (n = 43) located in str. oriens were recorded in order to compare their functional properties and to determine the effect of synapse location on the apparent IPSC kinetics as recorded using somatic voltage clamp at -70 mV and nearly symmetrical [Cl-]. 2. Five types of visualised presynaptic interneurone, oriens-lacunosum moleculare (O-LMC), basket (BC), axo-axonic (AAC), bistratified (BiC) and oriens-bistratified (O-BiC) cells, were distinguished by immunocytochemistry and/or synapse location using light and electron microscopy. 3. Somatostatin immunoreactive O-LMCs, innervating the most distal dendritic shafts and spines, evoked the smallest amplitude (26 +/- 10 pA, s.e.m., n = 8) and slowest IPSCs (10-90 % rise time, 6.2 +/- 0.6 ms; decay, 20.8 +/- 1.7 ms, n = 8), with no paired-pulse modulation of the second IPSC (93 +/- 4 %) at 100 ms interspike interval. In contrast, parvalbumin-positive AACs evoked larger amplitude (308 +/- 103 pA, n = 7) and kinetically faster (rise time, 0.8 +/- 0.1 ms; decay 11.2 +/- 0.9 ms, n = 7) IPSCs showing paired-pulse depression (to 68 +/- 5 %, n = 6). Parvalbumin- or CCK-positive BCs (n = 9) terminating on soma/dendrites, BiCs (n = 4) and O-BiCs (n = 7) innervating dendrites evoked IPSCs with intermediate kinetic parameters. The properties of IPSCs and sensitivity to bicuculline indicated that they were mediated by GABAA receptors. 4. In three cases, kinetically complex, multiphasic IPSCs, evoked by an action potential in the recorded basket cells, suggested that coupled interneurones, possibly through electrotonic junctions, converged on the same postsynaptic neurone. 5. The population of O-BiCs (4 of 4 somatostatin positive) characterised in this study had horizontal dendrites restricted to str. oriens/alveus and innervated stratum radiatum and oriens. Other BiCs had radial dendrites as described earlier. The parameters of IPSCs evoked by BiCs and O-BiCs showed the largest cell to cell variation, and a single interneurone could evoke both small and slow as well as large and relatively fast IPSCs. 6. The kinetic properties of the somatically recorded postsynaptic current are correlated with the innervated cell surface domain. A significant correlation of rise and decay times for the overall population of unitary IPSCs suggests that electrotonic filtering of distal responses is a major factor for the location and cell type specific differences of unitary IPSCs, but molecular heterogeneity of postsynaptic GABAA receptors may also contribute to the observed kinetic differences. Furthermore, domain specific differences in the short-term plasticity of the postsynaptic response indicate a differentiation of interneurones in activity-dependent responses. LA - English DB - MTMT ER - TY - JOUR AU - Arabadzisz, Dimitrula AU - Freund, Tamás TI - Changes in excitatory and inhibitory circuits of the rat hippocampus 12-14 months after complete forebrain ischemia JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 92 PY - 1999 IS - 1 SP - 27 EP - 45 PG - 19 SN - 0306-4522 DO - 10.1016/S0306-4522(98)00736-2 UR - https://m2.mtmt.hu/api/publication/108723 ID - 108723 N1 - Megjegyzés-27029511 Megjegyzés-21894842 Z9: 41 \n Cited By :50 \n Export Date: 13 November 2018 \n CODEN: NRSCD \n Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B.67, H-1450 Budapest, Hungary \n Funding details: T16942 \n Funding details: James S. McDonnell Foundation, JSMF \n Funding details: Howard Hughes Medical Institute, HHMI \n Funding details: National Institutes of Health, NIH, MH 54671 \n Funding text 1: The authors are grateful to Drs K. G. Baimbridge, J. H. Rogers, R. Shigemoto, and T. Görcs for the gifts of antisera against parvalbumin, calbindin, calretinin, substance P receptor and metabotropic glutamate receptor 1α, respectively. The contribution of Dr C. Dolorfo at earlier stages of the experiments, the helpful discussions of Dr Péter Rajna and the excellent technical assistance of Ms E. Borók and Mr Gy. Goda is also gratefully acknowledged. This study was supported by the Howard Hughes Medical Institute, the McDonnel Foundation, NIH (MH 54671), and OTKA Hungary (T16942). Cited By :51 Export Date: 21 August 2019 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B.67, H-1450 Budapest, Hungary Funding details: T16942 Funding details: James S. McDonnell Foundation Funding details: Howard Hughes Medical Institute Funding details: National Institutes of Health, MH 54671 Funding text 1: The authors are grateful to Drs K. G. Baimbridge, J. H. Rogers, R. Shigemoto, and T. Görcs for the gifts of antisera against parvalbumin, calbindin, calretinin, substance P receptor and metabotropic glutamate receptor 1α, respectively. The contribution of Dr C. Dolorfo at earlier stages of the experiments, the helpful discussions of Dr Péter Rajna and the excellent technical assistance of Ms E. Borók and Mr Gy. Goda is also gratefully acknowledged. This study was supported by the Howard Hughes Medical Institute, the McDonnel Foundation, NIH (MH 54671), and OTKA Hungary (T16942). Cited By :51 Export Date: 12 March 2020 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B.67, H-1450 Budapest, Hungary Funding details: Howard Hughes Medical Institute, HHMI Funding details: Hungarian Scientific Research Fund, OTKA, T16942 Funding details: National Institutes of Health, NIH, MH 54671 Funding text 1: The authors are grateful to Drs K. G. Baimbridge, J. H. Rogers, R. Shigemoto, and T. Görcs for the gifts of antisera against parvalbumin, calbindin, calretinin, substance P receptor and metabotropic glutamate receptor 1α, respectively. The contribution of Dr C. Dolorfo at earlier stages of the experiments, the helpful discussions of Dr Péter Rajna and the excellent technical assistance of Ms E. Borók and Mr Gy. Goda is also gratefully acknowledged. This study was supported by the Howard Hughes Medical Institute, the McDonnel Foundation, NIH (MH 54671), and OTKA Hungary (T16942). Cited By :51 Export Date: 20 May 2020 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B.67, H-1450 Budapest, Hungary Funding details: Howard Hughes Medical Institute, HHMI Funding details: Hungarian Scientific Research Fund, OTKA, T16942 Funding details: National Institutes of Health, NIH, MH 54671 Funding text 1: The authors are grateful to Drs K. G. Baimbridge, J. H. Rogers, R. Shigemoto, and T. Görcs for the gifts of antisera against parvalbumin, calbindin, calretinin, substance P receptor and metabotropic glutamate receptor 1α, respectively. The contribution of Dr C. Dolorfo at earlier stages of the experiments, the helpful discussions of Dr Péter Rajna and the excellent technical assistance of Ms E. Borók and Mr Gy. Goda is also gratefully acknowledged. This study was supported by the Howard Hughes Medical Institute, the McDonnel Foundation, NIH (MH 54671), and OTKA Hungary (T16942). Cited By :51 Export Date: 24 May 2020 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B.67, H-1450 Budapest, Hungary Funding details: Howard Hughes Medical Institute, HHMI Funding details: Hungarian Scientific Research Fund, OTKA, T16942 Funding details: National Institutes of Health, NIH, MH 54671 Funding text 1: The authors are grateful to Drs K. G. Baimbridge, J. H. Rogers, R. Shigemoto, and T. Görcs for the gifts of antisera against parvalbumin, calbindin, calretinin, substance P receptor and metabotropic glutamate receptor 1α, respectively. The contribution of Dr C. Dolorfo at earlier stages of the experiments, the helpful discussions of Dr Péter Rajna and the excellent technical assistance of Ms E. Borók and Mr Gy. Goda is also gratefully acknowledged. This study was supported by the Howard Hughes Medical Institute, the McDonnel Foundation, NIH (MH 54671), and OTKA Hungary (T16942). Cited By :51 Export Date: 25 May 2020 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B.67, H-1450 Budapest, Hungary Funding details: Howard Hughes Medical Institute, HHMI Funding details: Hungarian Scientific Research Fund, OTKA, T16942 Funding details: National Institutes of Health, NIH, MH 54671 Funding text 1: The authors are grateful to Drs K. G. Baimbridge, J. H. Rogers, R. Shigemoto, and T. Görcs for the gifts of antisera against parvalbumin, calbindin, calretinin, substance P receptor and metabotropic glutamate receptor 1α, respectively. The contribution of Dr C. Dolorfo at earlier stages of the experiments, the helpful discussions of Dr Péter Rajna and the excellent technical assistance of Ms E. Borók and Mr Gy. Goda is also gratefully acknowledged. This study was supported by the Howard Hughes Medical Institute, the McDonnel Foundation, NIH (MH 54671), and OTKA Hungary (T16942). Cited By :51 Export Date: 28 May 2020 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B.67, H-1450 Budapest, Hungary Funding details: Howard Hughes Medical Institute, HHMI Funding details: Hungarian Scientific Research Fund, OTKA, T16942 Funding details: National Institutes of Health, NIH, MH 54671 Funding text 1: The authors are grateful to Drs K. G. Baimbridge, J. H. Rogers, R. Shigemoto, and T. Görcs for the gifts of antisera against parvalbumin, calbindin, calretinin, substance P receptor and metabotropic glutamate receptor 1α, respectively. The contribution of Dr C. Dolorfo at earlier stages of the experiments, the helpful discussions of Dr Péter Rajna and the excellent technical assistance of Ms E. Borók and Mr Gy. Goda is also gratefully acknowledged. This study was supported by the Howard Hughes Medical Institute, the McDonnel Foundation, NIH (MH 54671), and OTKA Hungary (T16942). Cited By :52 Export Date: 23 March 2021 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O.B.67, H-1450 Budapest, Hungary Funding details: National Institutes of Health, NIH, MH 54671 Funding details: Howard Hughes Medical Institute, HHMI Funding details: Hungarian Scientific Research Fund, OTKA, T16942 Funding text 1: The authors are grateful to Drs K. G. Baimbridge, J. H. Rogers, R. Shigemoto, and T. Görcs for the gifts of antisera against parvalbumin, calbindin, calretinin, substance P receptor and metabotropic glutamate receptor 1α, respectively. The contribution of Dr C. Dolorfo at earlier stages of the experiments, the helpful discussions of Dr Péter Rajna and the excellent technical assistance of Ms E. Borók and Mr Gy. Goda is also gratefully acknowledged. This study was supported by the Howard Hughes Medical Institute, the McDonnel Foundation, NIH (MH 54671), and OTKA Hungary (T16942). Cited By :52 Export Date: 6 April 2021 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O.B.67, H-1450 Budapest, Hungary Funding details: National Institutes of Health, NIH, MH 54671 Funding details: Howard Hughes Medical Institute, HHMI Funding details: Hungarian Scientific Research Fund, OTKA, T16942 Funding text 1: The authors are grateful to Drs K. G. Baimbridge, J. H. Rogers, R. Shigemoto, and T. Görcs for the gifts of antisera against parvalbumin, calbindin, calretinin, substance P receptor and metabotropic glutamate receptor 1α, respectively. The contribution of Dr C. Dolorfo at earlier stages of the experiments, the helpful discussions of Dr Péter Rajna and the excellent technical assistance of Ms E. Borók and Mr Gy. Goda is also gratefully acknowledged. This study was supported by the Howard Hughes Medical Institute, the McDonnel Foundation, NIH (MH 54671), and OTKA Hungary (T16942). AB - Changes in interneuron distribution and excitatory connectivity have been investigated in animals which bad survived 12-14 months after complete forebrain ischemia, induced by four-vessel occlusion. Anterograde tracing with Phaseolus vulgaris leucoagglutinin revealed massive Schaffer collateral input even to those regions of the CA1 subfield where hardly any surviving pyramidal cells were found. Boutons of these Schaffer collaterals formed conventional synaptic contacts on dendritic spines and shafts, many of which likely belong to interneurons. Mossy fibres survived the ischemic challenge, however, large mossy terminals showed altered morphology, namely, the number of filopodiae on these terminals decreased significantly. The entorhinal input to the hippocampus did not show any morphological alterations. The distribution of interneurons was investigated by neurochemical markers known to label functionally distinct GABAergic cell populations. In the hilus, spiny interneurons showed a profound decrease in number. This phenomenon was not as obvious in CA3, but the spiny metabotropic glutamate receptor 1α- positive non-pyramidal cells, some of which contain calretinin or substance P receptor, disappeared from stratum lucidum of this area. In the CA1 region, somatostatin immunoreactivity disappeared from stratum oriens/lacunosum- moleculare-associated cells, while in metabotropic glutamate receptor 1α- stained sections these cells seemed unaffected in number. Other interneurons did not show an obvious decrease in number. In stratum radiatum of the CA1 subfield, some interneuron types had altered morphology: the substance P receptor-positive dendrites lost their characteristic radial orientation, and the metabotropic glutamate receptor 1α-expressing cells became extremely spiny. The loss of inhibitory interneurons at the first two stages of the trisynaptic loop coupled with a well-preserved excitatory connectivity among the subfields suggests that hyperexcitability in the surviving dentate gyms and CA3 may persist even a year after the ischemic impact. The dorsal CA1 region is lost; nevertheless hyperactivity, if it occurs, may have a route to leave the hippocampus via the longitudinally extensive axon collaterals of CA3 pyramidal cells, which may activate the subiculum and entorhinal cortex with a relay in the surviving ventral hippocampal CA1 region. LA - English DB - MTMT ER - TY - JOUR AU - Gulyás, Attila AU - Megías, M AU - Emri, Zsuzsa AU - Freund, Tamás TI - Total number and ratio of excitatory and inhibitory synapses converging onto single interneurons of different types in the CA1 area of the rat hippocampus JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 19 PY - 1999 SP - 10082 EP - 10097 PG - 16 SN - 0270-6474 DO - 10.1523/jneurosci.19-22-10082.1999 UR - https://m2.mtmt.hu/api/publication/108862 ID - 108862 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1450, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, P. O. Box 67, H-1450 Budapest, Hungary Cited By :383 Export Date: 1 August 2023 CODEN: JNRSD Correspondence Address: Gulyas, A.I.; Institute of Experimental Medicine, P.O. Box 67, H-1450 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; parvalbumin, 56094-12-3, 83667-75-8 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R37NS030549 LA - English DB - MTMT ER - TY - JOUR AU - Katona, István AU - Acsády, László AU - Freund, Tamás TI - Postsynaptic targets of somatostatin-immunoreactive interneurons in the rat hippocampus JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 88 PY - 1999 IS - 1 SP - 37 EP - 55 PG - 19 SN - 0306-4522 DO - 10.1016/S0306-4522(98)00302-9 UR - https://m2.mtmt.hu/api/publication/108648 ID - 108648 N1 - Cited By :169 Export Date: 22 June 2023 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O. Box 67, Budapest H-1450, Hungary Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2; Somatostatin, 51110-01-1 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute of Mental Health, NIMH, MH54671 Funding details: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, SNF Funding details: Hungarian Scientific Research Fund, OTKA, T16942 Funding text 1: We are grateful to Dr T. J. Görcs for antisera against somatostatin, vasoactive intestinal polypeptide and cholecystokinin, to Dr K. G. Baimbridge and to Dr J. H. Rogers for antisera against parvalbumin and calretinin, respectively, and to Dr P. Somogyi for antisera against GABA. The valuable discussions with Drs A. M. Thomson, Gy. Buzsáki, H. Markram and R. Miles concerning the activation of O-LM cells, and the time-course of back-propagating action potentials and disynaptic IPSPs are highly appreciated. The authors wish to thank for preparation of the colour figure Ms Á. L. Bodor. The excellent technical assistance of Mrs E. Borók, Mrs A. Zöldi Szabóné and Mr Gy. Goda is also acknowledged. This work was supported by the Howard Hughes Medical Institute, the Swiss National Science Foundation, NIMH (MH54671) and OTKA (T16942) Hungary. LA - English DB - MTMT ER - TY - JOUR AU - Rivera, C AU - Voipio, J AU - Payne, JA AU - Ruusuvuori, E AU - Lahtinen, H AU - Lamsa, Karri AU - Pirvola, U AU - Saarma, M AU - Kaila, K TI - The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. JF - NATURE J2 - NATURE VL - 397 PY - 1999 IS - 6716 SP - 251 EP - 255 PG - 5 SN - 0028-0836 DO - 10.1038/16697 UR - https://m2.mtmt.hu/api/publication/2966610 ID - 2966610 AB - GABA (gamma-aminobutyric acid) is the main inhibitory transmitter in the adult brain, and it exerts its fast hyperpolarizing effect through activation of anion (predominantly Cl-)-permeant GABA(A) receptors. However, during early neuronal development, GABA(A)-receptor-mediated responses are often depolarizing, which may be a key factor in the control of several Ca2+-dependent developmental phenomena, including neuronal proliferation, migration and targeting. To date, however, the molecular mechanism underlying this shift in neuronal electrophysiological phenotype is unknown. Here we show that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABA(A)-mediated responses from depolarizing to hyperpolarizing is coupled to a developmental induction of the expression of the neuronal (Cl-)-extruding K+/Cl- co-transporter, KCC2. Antisense oligonucleotide inhibition of KCC2 expression produces a marked positive shift in the reversal potential of GABAA responses in functionally mature hippocampal pyramidal neurons. These data support the conclusion that KCC2 is the main Cl- extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain. LA - English DB - MTMT ER - TY - JOUR AU - Parra, P AU - Gulyás, Attila AU - Miles, R TI - How many subtypes of inhibitory cells in the hippocampus? JF - NEURON J2 - NEURON VL - 20 PY - 1998 SP - 983 EP - 993 PG - 11 SN - 0896-6273 DO - 10.1016/S0896-6273(00)80479-1 UR - https://m2.mtmt.hu/api/publication/108447 ID - 108447 N1 - Lab. de Neurobiologie Cellulaire, Institut Pasteur, 25 rue de Dr Roux, 75724 Paris, France Institute of Experimental Medicine, Academy of Sciences, POB67, H-1450 Budapest, Hungary Cited By :290 Export Date: 18 April 2023 CODEN: NERNE Correspondence Address: Miles, R.; Lab. de Neurobiologie Cellulaire, 25 rue de Dr Roux, 75724 Paris, France Chemicals/CAS: muscarine, 300-54-9; noradrenalin, 1407-84-7, 51-41-2; serotonin, 50-67-9 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS) Funding details: Heising-Simons Foundation, HSF Funding details: Human Frontier Science Program, HFSP Funding details: Institut National de la Santé et de la Recherche Médicale, Inserm Funding details: Hungarian Scientific Research Fund, OTKA, T16942, T23261 Funding details: European Social Fund, ESF Funding text 1: We thank T. F. Freund, C. Sotelo, D. S. Faber, B. Barbour, and K. Toth for helpful comments. This work was supported by grants from the HFSP, ESF, NIH (MH54671), INSERM and MRT (France), HSF and OTKA (T16942 and T23261, Hungary), and Colciencias (Colombia). LA - English DB - MTMT ER - TY - JOUR AU - Reyes, A AU - Lujan, R AU - Rozov, A AU - Burnashev, N AU - Somogyi, Péter Pál AU - Sakmann, B TI - Target-cell-specific facilitation and depression in neocortical circuits. JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 1 PY - 1998 IS - 4 SP - 279 EP - 285 PG - 7 SN - 1097-6256 UR - https://m2.mtmt.hu/api/publication/2138098 ID - 2138098 N1 - Megjegyzés-22898736 Megjegyzés-21894849 Z9: 326 AB - In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortical layer 2/3. We induced repetitive action potentials in pyramidal cells and recorded the evoked unitary excitatory (E)PSPs in two classes of GABAergic neurons. We observed facilitation of EPSPs in bitufted GABAergic interneurons, many of which expressed somatostatin immunoreactivity. EPSPs recorded from multipolar interneurons, however, showed depression. Some of these neurons were immunopositive for parvalbumin. Unitary inhibitory (I)PSPs evoked by repetitive stimulation of a bitufted neuron also showed a less pronounced but significant difference between the two target neurons. Facilitation and depression involve presynaptic mechanisms, and because a single neuron can express both behaviors simultaneously, we infer that local differences in the molecular structure of presynaptic nerve terminals are induced by retrograde signals from different classes of target neurons. Because bitufted and multipolar neurons both formed reciprocal inhibitory connections with pyramidal cells, the results imply that the balance of activation between two recurrent inhibitory pathways in the neocortex depends on the frequency of action potentials in pyramidal cells. LA - English DB - MTMT ER - TY - JOUR AU - Vida, I AU - Halasy, Katalin AU - Szinyei, C AU - Somogyi, Péter Pál AU - Buhl, EH TI - Unitary IPSPs evoked by interneurons at the stratum radiatum stratum lacunosum-moleculare border in the CA1 area of the rat hippocampus in vitro JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 506 PY - 1998 IS - 3 SP - 755 EP - 773 PG - 19 SN - 0022-3751 DO - 10.1111/j.1469-7793.1998.755bv.x UR - https://m2.mtmt.hu/api/publication/1661006 ID - 1661006 N1 - Admin megjegyzés-10018711 #JournalID1# Name: J PHYSIOL LONDON ISSN: 0022-3751 #JournalID2# Megjegyzés-21894846 Z9: 102 MRC Anat. Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom Institute of Pharmacology, University Medical School of Pecs, H-7643 Pécs, Hungary Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary Department of Anatomy, University of Freiburg, 79001 Freiburg, Germany Cited By :135 Export Date: 21 August 2019 CODEN: JPHYA Correspondence Address: Buhl, E.H.; MRC Anatomical Neuropharmacol Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom; email: eberhard.buhl@pharmacology.oxford.ac.uk Chemicals/CAS: bicuculline, 485-49-4 MRC Anat. Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom Institute of Pharmacology, University Medical School of Pecs, H-7643 Pécs, Hungary Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary Department of Anatomy, University of Freiburg, 79001 Freiburg, Germany Cited By :139 Export Date: 24 May 2020 CODEN: JPHYA Correspondence Address: Buhl, E.H.; MRC Anatomical Neuropharmacol Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom; email: eberhard.buhl@pharmacology.oxford.ac.uk Chemicals/CAS: bicuculline, 485-49-4 MRC Anat. Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom Institute of Pharmacology, University Medical School of Pecs, H-7643 Pécs, Hungary Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary Department of Anatomy, University of Freiburg, 79001 Freiburg, Germany Cited By :139 Export Date: 25 May 2020 CODEN: JPHYA Correspondence Address: Buhl, E.H.; MRC Anatomical Neuropharmacol Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom; email: eberhard.buhl@pharmacology.oxford.ac.uk Chemicals/CAS: bicuculline, 485-49-4 MRC Anat. Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom Institute of Pharmacology, University Medical School of Pecs, H-7643 Pécs, Hungary Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary Department of Anatomy, University of Freiburg, 79001 Freiburg, Germany Cited By :146 Export Date: 1 January 2021 CODEN: JPHYA Correspondence Address: Buhl, E.H.; MRC Anatomical Neuropharmacol Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom; email: eberhard.buhl@pharmacology.oxford.ac.uk Chemicals/CAS: bicuculline, 485-49-4 MRC Anat. Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom Institute of Pharmacology, University Medical School of Pecs, H-7643 Pécs, Hungary Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary Department of Anatomy, University of Freiburg, 79001 Freiburg, Germany Cited By :147 Export Date: 23 March 2021 CODEN: JPHYA Correspondence Address: Buhl, E.H.; MRC Anatomical Neuropharmacol Unit, , Oxford OX1 3TH, United Kingdom; email: eberhard.buhl@pharmacology.oxford.ac.uk Chemicals/CAS: bicuculline, 485-49-4 MRC Anat. Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom Institute of Pharmacology, University Medical School of Pecs, H-7643 Pécs, Hungary Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary Department of Anatomy, University of Freiburg, 79001 Freiburg, Germany Cited By :147 Export Date: 6 April 2021 CODEN: JPHYA Correspondence Address: Buhl, E.H.; MRC Anatomical Neuropharmacol Unit, , Oxford OX1 3TH, United Kingdom; email: eberhard.buhl@pharmacology.oxford.ac.uk Chemicals/CAS: bicuculline, 485-49-4 MRC Anat. Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, United Kingdom Institute of Pharmacology, University Medical School of Pecs, H-7643 Pécs, Hungary Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary Department of Anatomy, University of Freiburg, 79001 Freiburg, Germany Cited By :147 Export Date: 7 April 2021 CODEN: JPHYA Correspondence Address: Buhl, E.H.; MRC Anatomical Neuropharmacol Unit, , Oxford OX1 3TH, United Kingdom; email: eberhard.buhl@pharmacology.oxford.ac.uk Chemicals/CAS: bicuculline, 485-49-4 AB - 1. Hippocampal non-principal neurons at the stratum radiatum-stratum lacunosum-moleculare border (R-LM interneurons) of the CA1 area may constitute several cell classes and have been implicated in the generation of GABAergic unitary IPSPs. Using biocytin filled electrodes we recorded R-LM interneurons intracellularly in vitro and determined their postsynaptic effects in concomitantly recorded pyramidal cells. 2. Light microscopic analysis revealed four populations of R-LM interneurons with distinct axons: (1) basket cells (n = 4) with axons predominantly ramifying in the pyramidal cell layer; (2) Schaffer collateral/commissural pathway-associated interneurons (n = 10) stratifying in stratum radiatum and, to a lesser extent, stratum oriens; (3) perforant pathway-associated interneurons (n = 6) innervating the perforant path termination zone in stratum lacunosum-moleculare of the CA1 area as well as equivalent portions of the dentate gyrus and subiculum; and (4) neurogliaform interneurons (n = 2) characterized by their dense, compact axonal and dendritic arbour. 3. Random electron microscopic sampling of synaptic targets revealed a preponderance of pyramidal neurons as postsynaptic elements. Basket cells had a synaptic target preference for somata and proximal dendrites, whereas the remainder of R-LM interneurons innervated dendritic shafts and spines. The axon of dendrite-targeting cells formed up to six putative contacts with individual postsynaptic pyramidal cells. 4. Anatomically recovered R-LM interneurons (n = 22) had a mean resting membrane potential of -56.7 +/- 3.6 mV, a membrane time constant of 12.9 +/- 7.7 ms and an input resistance of 86.4 +/- 29.2 M Ohm. Depolarizing current pulses generally elicited overshooting action potentials (70.8 +/- 6.9 mV) which had a mean duration, when measured at half-amplitude, of 0.7 +/- 0.1 ms. In response to prolonged (> 200 ms) depolarizing current pulses all R-LM interneurons displayed (a varying degree of) spike frequency adaptation. 5. Basket cells, Schaffer-associated and neurogliaform interneurons elicited small-amplitude (< 2 mV), short-latency IPSPs in postsynaptic pyramids (n = 5, 13 and 1, respectively). Those interactions in which an effect was elicited with the repetitive activation of the presynaptic neuron (n = 13) showed a substantial degree of postsynaptic response summation. Unitary IPSPs had fast kinetics and, whenever tested (n = 5; 1 basket cell and 4 Schaffer-associated interneurons), were abolished by the GABA(A) receptor antagonist bicuculline. 6. Thus, R-LM interneurons comprise several distinct populations which evoke fast GABA(A) receptor-mediated IPSPs. The domain-specific innervation of postsynaptic pyramidal cells suggests functionally diverse effects on the integration of afferent information in functionally non-equivalent compartments of pyramidal cells. LA - English DB - MTMT ER - TY - JOUR AU - Hájos, Norbert AU - Mody, I TI - Synaptic communication among hippocampal interneurons: Properties of spontaneous IPSCs in morphologically identified cells JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 17 PY - 1997 IS - 21 SP - 8427 EP - 8442 PG - 16 SN - 0270-6474 DO - 10.1523/jneurosci.17-21-08427.1997 UR - https://m2.mtmt.hu/api/publication/108671 ID - 108671 N1 - Cited By :95 Export Date: 21 August 2019 CODEN: JNRSD Correspondence Address: Mody, I.; Department of Neurology, Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, United States Chemicals/CAS: Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid, 56-12-2; Kynurenic Acid, 492-27-3; Receptors, GABA-A Cited By :98 Export Date: 24 May 2020 CODEN: JNRSD Correspondence Address: Mody, I.; Department of Neurology, Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, United States Chemicals/CAS: Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid, 56-12-2; Kynurenic Acid, 492-27-3; Receptors, GABA-A Cited By :101 Export Date: 23 March 2021 CODEN: JNRSD Correspondence Address: Mody, I.; Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095-1769, United States Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS027528, R37NS030549 Cited By :102 Export Date: 6 April 2021 CODEN: JNRSD Correspondence Address: Mody, I.; Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095-1769, United States Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS027528, R37NS030549 LA - English DB - MTMT ER - TY - JOUR AU - Freund, Tamás AU - Buzsáki, György TI - Interneurons of the hippocampus JF - HIPPOCAMPUS J2 - HIPPOCAMPUS VL - 6 PY - 1996 SP - 347 EP - 470 PG - 124 SN - 1050-9631 DO - 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I UR - https://m2.mtmt.hu/api/publication/107931 ID - 107931 LA - English DB - MTMT ER - TY - JOUR AU - Miles, R AU - Tóth, Katalin AU - Gulyás, Attila AU - Hájos, Norbert AU - Freund, Tamás TI - Differences between somatic and dendritic inhibition in the hippocampus JF - NEURON J2 - NEURON VL - 16 PY - 1996 IS - 4 SP - 815 EP - 823 PG - 9 SN - 0896-6273 DO - 10.1016/S0896-6273(00)80101-4 UR - https://m2.mtmt.hu/api/publication/107721 ID - 107721 N1 - Megjegyzés-25002645 Megjegyzés-21894988 Z9: 477 Lab. de Neurobiologie Cellulaire, Institut Pasteur, 25 rue de Dr. Roux, 75724 Paris, France Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest, Hungary Cited By :713 Export Date: 24 March 2021 CODEN: NERNE Correspondence Address: Miles, R.; Lab. de Neurobiologie Cellulaire, 25 rue de Dr. Roux, 75724 Paris, France Chemicals/CAS: biocytin, 576-19-2 Funding details: European Science Foundation, ESF Funding details: Human Frontier Science Program, HFSP Funding details: Hungarian Scientific Research Fund, OTKA, T5532 Funding text 1: Correspondence should be addressed to R. M. This work was supported by the Human Science Frontier Program, the European Science Foundation, the Ministére de la Recherche et de la Technologie, and OTKA (T5532) Hungary. We thank B. Barbour for helpful comments and E. Borók, I. Weisz, and G. Terstyánszky for excellent technical assistance. Lab. de Neurobiologie Cellulaire, Institut Pasteur, 25 rue de Dr. Roux, 75724 Paris, France Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest, Hungary Cited By :714 Export Date: 6 April 2021 CODEN: NERNE Correspondence Address: Miles, R.; Lab. de Neurobiologie Cellulaire, 25 rue de Dr. Roux, 75724 Paris, France Chemicals/CAS: biocytin, 576-19-2 Funding details: European Science Foundation, ESF Funding details: Human Frontier Science Program, HFSP Funding details: Hungarian Scientific Research Fund, OTKA, T5532 Funding text 1: Correspondence should be addressed to R. M. This work was supported by the Human Science Frontier Program, the European Science Foundation, the Ministére de la Recherche et de la Technologie, and OTKA (T5532) Hungary. We thank B. Barbour for helpful comments and E. Borók, I. Weisz, and G. Terstyánszky for excellent technical assistance. LA - English DB - MTMT ER - TY - JOUR AU - Blasco-Ibanez, Jose Miguel AU - Freund, Tamás TI - Synaptic input of horizontal interneurons in striatum oriens of the hippocampal CA1 subfield: Structural basis of feed-back activation JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 7 PY - 1995 SP - 2170 EP - 2180 PG - 11 SN - 0953-816X DO - 10.1111/j.1460-9568.1995.tb00638.x UR - https://m2.mtmt.hu/api/publication/107793 ID - 107793 N1 - Cited By :175 Export Date: 3 August 2023 Correspondence Address: Freund, T.F. Chemicals/CAS: Receptors, Metabotropic Glutamate LA - English DB - MTMT ER - TY - JOUR AU - COBB, SR AU - BUHL, EH AU - Halasy, Katalin AU - PAULSEN, O AU - Somogyi, Péter Pál TI - SYNCHRONIZATION OF NEURONAL-ACTIVITY IN HIPPOCAMPUS BY INDIVIDUAL GABAERGIC INTERNEURONS JF - NATURE J2 - NATURE VL - 378 PY - 1995 IS - 6552 SP - 75 EP - 78 PG - 4 SN - 0028-0836 DO - 10.1038/378075a0 UR - https://m2.mtmt.hu/api/publication/1661000 ID - 1661000 N1 - MRC Anatomical Neuropharmacology Unit, University Department of Pharmacology, Mansfield Road, Oxford, OX1 3TH, United Kingdom Department of Zoology & Cell Biology, Jozsef Attila University, Szeged, H-6722, Hungary Cited By :1114 Export Date: 6 April 2021 Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; gamma-Aminobutyric Acid, 56-12-2; Receptors, GABA-A AB - SYNCHRONIZATION Of neuronal activity is fundamental in the operation of cortical networks(1). With respect to an ongoing synchronized oscillation, the precise timing of action potentials is an attractive candidate mechanism for information coding(2-5) Networks of inhibitory interneurons have been proposed to have a role in entraining cortical, synchronized 40-Hz activity(6,7). Here we demonstrate that individual GABAergic interneurons(8) can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at theta frequencies (4-7 Hz). The efficiency of this entrainment is due to interaction of GABA(A)-receptor-mediated hyperpolarizing synaptic events with intrinsic oscillatory mechanisms tuned to this frequency range in pyramidal cells. Moreover, this GABAergic mechanism is sufficient to synchronize the firing of pyramidal cells. Thus, owing to the divergence of each GABAergic interneuron(9,10), more than a thousand pyramidal cells may share a common temporal reference established by an individual interneuron. LA - English DB - MTMT ER - TY - JOUR AU - BUHL, EH AU - Halasy, Katalin AU - Somogyi, Péter Pál TI - DIVERSE SOURCES OF HIPPOCAMPAL UNITARY INHIBITORY POSTSYNAPTIC POTENTIALS AND THE NUMBER OF SYNAPTIC RELEASE SITES JF - NATURE J2 - NATURE VL - 368 PY - 1994 IS - 6474 SP - 823 EP - 828 PG - 6 SN - 0028-0836 DO - 10.1038/368823a0 UR - https://m2.mtmt.hu/api/publication/1660995 ID - 1660995 N1 - Medical Research Council, Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford 0X1 3TH, United Kingdom Department of Zoology, Jozsef Attila University, Szeged, Hungary Cited By :569 Export Date: 6 April 2021 Correspondence Address: Buhl, E.H.; Medical Research Council, Mansfield Road, Oxford 0X1 3TH, United Kingdom Chemicals/CAS: Receptors, GABA-A AB - Dual intracellular recordings from microscopically identified neurons in the hippocampus reveal that the synaptic terminals of three morphologically distinct types of interneuron act through GABA(A) receptors. Each type of interneuron forms up to 12 synaptic contacts with a postsynaptic principal neuron, but each interneuron innervates a different domain of the surface of the postsynaptic neuron. Different kinetics of the postsynaptic effects, together with the strategic placement of synapses, indicate that these GABAergic interneurons serve distinct functions in the cortical network. LA - English DB - MTMT ER - TY - JOUR AU - Baude, A AU - Nusser, Zoltán AU - Roberts, JDB AU - Mulvihill, E AU - McIIhinney, RAJ AU - Somogyi, Péter Pál TI - The metabotropic glutamate receptor (mGluR1α) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction JF - NEURON J2 - NEURON VL - 11 PY - 1993 IS - 4 SP - 771 EP - 787 PG - 17 SN - 0896-6273 DO - 10.1016/0896-6273(93)90086-7 UR - https://m2.mtmt.hu/api/publication/108532 ID - 108532 AB - An antiserum to mGluR1α labeled a 160 kd protein in immunoblots of membranes derived from rat brain or cells transfected with mGluRlα. Immunoreactivity for mGluR1 a was present in discrete subpopulations of neurons. The GABAergic neurons of the cerebellar cortex were strongly immunoreactive; only some Golgi cells were immunonegative. Somatostatin/GABA-immunopositive cells in the neocortex and hippocampus were enriched in mGluR1α. The hippocampal cells had spiny dendrites that were precisely codistributed with the local axon collaterals of pyramidal and granule cells. Electron microscopic immunometal detection of mGluR1α showed a preferential localization at the periphery of the extensive postsynaptic densities of type 1 synapses in both the cerebellum and the hippocampus. The receptor was also present at sites in the dendritic and somatic membrane where synapses were not located. © 1993. LA - English DB - MTMT ER - TY - JOUR AU - Gulyás, Attila AU - Miles, R AU - Hájos, Norbert AU - Freund, Tamás TI - Precision and variability in postsynaptic target selection of inhibitory cells in the hippocampal CA3 region JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 5 PY - 1993 IS - 12 SP - 1729 EP - 1751 PG - 23 SN - 0953-816X DO - 10.1111/j.1460-9568.1993.tb00240.x UR - https://m2.mtmt.hu/api/publication/107599 ID - 107599 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, Budapest, H-1450, Hungary Laboratoire de Neurobiologie Cellulaire, Institut Pasteur, INSERM U261, 25 Rue de Dr Roux, Paris, 75264, France Cited By :180 Export Date: 6 April 2021 Correspondence Address: Freund, T.F. Chemicals/CAS: biocytin, 576-19-2; Lysine, 56-87-1 Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, Budapest, H-1450, Hungary Laboratoire de Neurobiologie Cellulaire, Institut Pasteur, INSERM U261, 25 Rue de Dr Roux, Paris, 75264, France Cited By :180 Export Date: 7 April 2021 Correspondence Address: Freund, T.F. Chemicals/CAS: biocytin, 576-19-2; Lysine, 56-87-1 LA - English DB - MTMT ER - TY - JOUR AU - Freund, Tamás AU - Ylinen, A AU - Miettinen, R AU - Pitkänen, A AU - Lahtinen, H AU - Baimbridge, KG AU - Riekkinen, PJ TI - Pattern of neuronal death in the rat hippocampus after status epilepticus. Relationship to calcium binding protein content and ischemic vulnerability JF - BRAIN RESEARCH BULLETIN J2 - BRAIN RES BULL VL - 28 PY - 1992 SP - 27 EP - 38 PG - 12 SN - 0361-9230 DO - 10.1016/0361-9230(92)90227-O UR - https://m2.mtmt.hu/api/publication/107244 ID - 107244 N1 - Department of Functional Neuroanatomy, Institute of Experimental Medicine Hungarian Academy of Sciences, P.O.B. 67, Budapest, H-1450, Hungary First Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary Departments of Neurology and Pathology, University of Kuopio, Kuopio, Finland Department of Physiology, University of British Columbia, Vancouver, Canada Cited By :163 Export Date: 6 April 2021 CODEN: BRBUD Correspondence Address: Freund, T.F.; Department of Functional Neuroanatomy, Institute of Experimental Medicine Hungarian Academy of Sciences, P.O.B. 67, Budapest, H-1450, Hungary Chemicals/CAS: calbindin; Calcium-Binding Protein, Vitamin D-Dependent; Calcium-Binding Proteins; Nerve Tissue Proteins; Parvalbumins; Somatostatin, 51110-01-1 LA - English DB - MTMT ER -