TY  - JOUR
AU  - Klivényi, Péter
AU  - Kékesi, Adrienna Katalin
AU  - Hartai, ZS
AU  - Juhász, Gábor Dénes
AU  - Vécsei, László
TI  - Effect of MPTP on the brain amino acid concentrations
JF  - MOVEMENT DISORDERS
J2  - MOVEMENT DISORD
VL  - 21
PY  - 2006
IS  - Suppl. 13
SP  - S68
EP  - S68
PG  - 1
SN  - 0885-3185
UR  - https://m2.mtmt.hu/api/publication/1235938
ID  - 1235938
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Lukács, Anita
AU  - Szabó, Andrea
AU  - Vezér, Tünde
AU  - Papp, András
TI  - The acute effects of 3-nitropropionic acid on the behavior and spontaneous cortical electrical activity of rats
JF  - ACTA NEUROBIOLOGIAE EXPERIMENTALIS
J2  - ACTA NEUROBIOL EXP
VL  - 66
PY  - 2006
IS  - 3
SP  - 227
EP  - 233
PG  - 7
SN  - 0065-1400
UR  - https://m2.mtmt.hu/api/publication/1294676
ID  - 1294676
AB  - In this study, the acute effects of 3-nitropropionic acid was investigated on open field and startle behavior of rats, and on their cortical electrical activity. Spontaneous locomotor activity, acoustic startle response, and pre-pulse inhibition of acoustic startle were measured in male Wistar rats (10 weeks old, 180-200g body weight) after a single dose of 10 or 20 mg/kg i.p. 3-nitropropionic acid. After the behavioral tests, the rats were anaesthetized, and spontaneous cortical electrical activity was recorded. The vertical, horizontal and local open field performance showed dose-dependent deterioration in the rats treated with 3-nitropropionic acid. The number of “noise-positive” startle responses showed non-significant changes, but the inhibition by pre-pulse was significantly reduced in the high dose animals. High dose also increased the proportion of low-frequencies in the cortical activity. Three-nitropropionic acid, known primarily to act in repeated doses (e.g., in animal models of Huntington’s disease) had also some clear-cut acute effects on behavioral and electrophysiological parameters of the treated rats.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Klivényi, Péter
AU  - Kékesi, Adrienna Katalin
AU  - Hartai, Z
AU  - Juhász, Gábor Dénes
AU  - Vécsei, László
TI  - Effects of mitochondrial toxins on the brain amino acid concentrations
JF  - NEUROCHEMICAL RESEARCH
J2  - NEUROCHEM RES
VL  - 30
PY  - 2005
IS  - 11
SP  - 1421
EP  - 1427
PG  - 7
SN  - 0364-3190
DO  - 10.1007/s11064-005-8512-x
UR  - https://m2.mtmt.hu/api/publication/1032192
ID  - 1032192
N1  - Cited By :9            
            Export Date: 7 November 2023            
            CODEN: NERED            
            Correspondence Address: Vecsei, L.; Department of Neurology, P.O.B. 427, H-6701, Szeged, Hungary; email: vecsei@nepsy.szote.u-szeged.hu            
            Chemicals/CAS: 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine, 28289-54-5; 3 nitropropionic acid, 504-88-1; adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5; amino acid, 65072-01-7; neurotoxin, 39386-17-9; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 28289-54-5; 3-nitropropionic acid, 504-88-1; Amino Acids; Neurotoxins; Nitro Compounds; Propionic Acids            
            Funding details: Hungarian Science Foundation, ETT 010/2003, F043306, RET-NORT 08/2004            
            Funding text 1: This work was supported by grants from the Hungarian Science Foundation (F043306), Bolyai János Research Fellowship, MediChem I. 8, AgyProt 1/4, ETT 010/2003, OM Bio-00100/2002 and RET-NORT 08/2004. We thank David Durham from England for his linguistic corrections.
AB  - In the pathogenesis of Parkinson's disease and Huntington's disease excitotoxicity may play an important role. The common toxin model for Parkinson's disease is MPTP, while for Huntington's disease it is 3-NP. These toxins inhibit the mitochondrial respiratory chain, resulting in an energy deficit. In the central nervous system, the amino acids act as neurotransmitters and neuromodulators. The energy deficit caused by these neurotoxins may alter the concentrations of amino acids. Thus, it can be claimed that the aminoacidergic neurotransmission can be changed by neurotoxins. To test this hypothesis we studied the amino acid concentrations in different brain regions following MPTP or 3-NP administration. The two toxins were found to produce similar changes. We detected marked decreases in most of the amino acid concentrations in the striatum and in the cortex, while the levels in the cerebellum increased significantly. The decreased amino acid levels can be explained by the reduced levels of ATP produced by these neurotoxins. In the cerebellum, where there is no detectable ATP loss, the elevated amino acid levels may reflect a compensation of the altered neurotransmission.
LA  - English
DB  - MTMT
ER  -