TY  - JOUR
AU  - Hunyadi, Attila
AU  - Herke, I
AU  - Veres, Katalin
AU  - Erdei, Anna
AU  - Simon, András
AU  - Tóth, Gábor
TI  - Volatile Glycosides from the Leaves of Morus alba with a Potential Contribution to the Complex Anti-diabetic Activity
JF  - NATURAL PRODUCT COMMUNICATIONS
J2  - NAT PROD COMMUN
VL  - 9
PY  - 2014
IS  - 2
SP  - 145
EP  - 147
PG  - 3
SN  - 1934-578X
DO  - 10.1177/1934578x1400900201
UR  - https://m2.mtmt.hu/api/publication/2512463
ID  - 2512463
N1  - Funding Agency and Grant Number: Hungarian National Research Fund [OTKA PD75383]; European Union; European Social Fund [TAMOP- 4.2.2/B-10/1-2010-0012, TAMOP-4.2.2A-11/1/KONV-2012-0035]
            Funding text: This work was supported by the Hungarian National Research Fund (OTKA PD75383). The authors acknowledge grants from the European Union co-funded by the European Social Fund (TAMOP- 4.2.2/B-10/1-2010-0012, and TAMOP-4.2.2A-11/1/KONV-2012-0035).
AB  - The leaves and root bark of Morus alba, the white mulberry tree, 
are well-known traditional medicines for the treatment of type 
II diabetes. Several different
types of constituents have been suggested to be responsible for 
the anti-diabetic activity of mulberry drugs, such as 
iminosugars, flavonoids and other phenolic
compounds, glycopeptides and ecdysteroids. Our group recently 
suggested that a volatile-oil like fraction of the hot water 
extract of M. alba leaves, containing
several phenyl-propane derivatives, can increase the glucose 
consumption of adipocytes. Here we report the isolation of three 
glycosylated volatile constituents
from mulberry leaves, two megastigmane derivatives along with 
the β-D-glucoside of eugenol. Furthermore, a commercially 
available mixture of probiotic
bacteria was assessed to study the effect of the intestinal 
flora on the megastigmane derivatives. Significant amounts of 
the aglycons of both compounds were
liberated, suggesting that these compounds can be metabolized in 
the large intestines and absorbed without the sugar moiety after 
the consumption of a
traditional mulberry tea. Based on literature data, both the 
glycosides and their aglycons have a potential contribution to 
the beneficial effects of mulberry
leaves in type 2 diabetes.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hunyadi, Attila
AU  - Veres, Katalin
AU  - Dankó, Balázs Ödön
AU  - Kele, Zoltán
AU  - Wéber, Edit
AU  - Hetényi, Anasztázia
AU  - Zupkó, István
AU  - Hsieh, TJ
TI  - In vitro Anti‐diabetic Activity and Chemical Characterization of an Apolar Fraction of Morus alba Leaf Water Extract
JF  - PHYTOTHERAPY RESEARCH
J2  - PHYTOTHER RES
VL  - 27
PY  - 2013
IS  - 6
SP  - 847
EP  - 851
PG  - 5
SN  - 0951-418X
DO  - 10.1002/ptr.4803
UR  - https://m2.mtmt.hu/api/publication/2102858
ID  - 2102858
N1  - Funding Agency and Grant Number: Hungarian National Research Fund [OTKA PD75383]; New Hungary Development Plan [TAMOP-4.2.1/B-09/1/KONV-2010-0005]; Baross Gabor Program [MFB-00339/2010]; National Science Council of Taiwan [NSC 982314B037011MY3]\n Funding text: This work was carried out within the framework of COST Action CM0804, Chemical Biology with Natural Products. The project was supported by the Hungarian National Research Fund (OTKA PD75383), the New Hungary Development Plan (TAMOP-4.2.1/B-09/1/KONV-2010-0005), the Baross Gabor Program (MFB-00339/2010) and by the grant from the National Science Council of Taiwan (NSC 982314B037011MY3).\n
AB  - The tea from the white mulberry (Morus alba L.) leaf is a worldwide known traditional medicine of type II diabetes. Here, we report the investigation of the dichloromethane-soluble fraction obtained in a 0.24% m/m yield from the hot water extract of mulberry leaves. A significant, dose-dependent activity was found by means of the 24-h glucose consumption of fully differentiated adipocytes both in the absence and presence of insulin. The fraction was characterized by HPLC-DAD, GC-MS and GC-FID. The main constituent (40.3% by means of GC-FID) was isolated and identified as loliolide by EIMS, HRESIMS and NMR spectroscopy. In the active fraction benzyl alcohol, ethyl benzoate, t-cinnamic acid, p-hydroxyacetophenone, t-coniferyl alcohol and synapil alcohol were also identified by GC-MS and quantified by GC-FID (0.7, 1.3, 1.5, 2.9, 7.5 and 2.6%, respectively). Copyright (c) 2012 John Wiley & Sons, Ltd.
LA  - English
DB  - MTMT
ER  -