TY - JOUR AU - Kurucz, Judit Éva AU - Váczi, Balázs AU - Márkus, Róbert AU - Laurinyecz, Barbara AU - Vilmos, Péter AU - Zsámboki, János AU - Csorba, Kinga AU - Gateff, E AU - Hultmark, D AU - Andó, István TI - Definition of Drosophila hemocyte subsets by cell-type specific antigens JF - ACTA BIOLOGICA HUNGARICA (1983-2018) J2 - ACTA BIOL HUNG VL - 58 PY - 2007 IS - Suppl. 1 SP - 95 EP - 111 PG - 17 SN - 0236-5383 DO - 10.1556/ABiol.58.2007.Suppl.8 UR - https://m2.mtmt.hu/api/publication/1915261 ID - 1915261 AB - We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. Oil the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmalocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged ill four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocyles. LA - English DB - MTMT ER - TY - JOUR AU - Pacher, Pál AU - Beckman, JS AU - Liaudet, L TI - Nitric oxide and peroxynitrite in health and disease JF - PHYSIOLOGICAL REVIEWS J2 - PHYSIOL REV VL - 87 PY - 2007 IS - 1 SP - 315 EP - 424 PG - 110 SN - 0031-9333 DO - 10.1152/physrev.00029.2006 UR - https://m2.mtmt.hu/api/publication/2204617 ID - 2204617 N1 - Megjegyzés-24870197 Megjegyzés-22510925 Megjegyzés-20592716 PubMed ID: 17237348 Chemicals/CAS: endothelium derived relaxing factor, 90880-94-7; hydroxyl radical, 3352-57-6; nitric oxide, 10102-43-9; superoxide, 11062-77-4; Nitric Oxide, 10102-43-9; Peroxynitrous Acid, 14691-52-2 Cited By :3810 Export Date: 29 October 2020 CODEN: PHREA Correspondence Address: Pacher, P.; National Institutes of Health, NIAAA, Laboratory of Physiological Studies, 5625 Fishers Lane, Bethesda, MD 20892-9413, United States; email: pacher@mail.nih.gov Chemicals/CAS: endothelium derived relaxing factor, 90880-94-7; hydroxyl radical, 3352-57-6; nitric oxide, 10102-43-9; superoxide, 11062-77-4; Nitric Oxide, 10102-43-9; Peroxynitrous Acid, 14691-52-2 Cited By :3852 Export Date: 4 December 2020 CODEN: PHREA Correspondence Address: Pacher, P.; National Institutes of Health, NIAAA, Laboratory of Physiological Studies, 5625 Fishers Lane, Bethesda, MD 20892-9413, United States; email: pacher@mail.nih.gov Chemicals/CAS: endothelium derived relaxing factor, 90880-94-7; hydroxyl radical, 3352-57-6; nitric oxide, 10102-43-9; superoxide, 11062-77-4; Nitric Oxide, 10102-43-9; Peroxynitrous Acid, 14691-52-2 AB - The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide (NO) has stimulated an extraordinary impetus for scientific research in all the fields of biology and medicine. Since its early description as an endothelial-derived relaxing factor, NO has emerged as a fundamental signaling device regulating virtually every critical cellular function, as well as a potent mediator of cellular damage in a wide range of conditions. Recent evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled reaction between NO and another free radical, the superoxide anion. Peroxynitrite interacts with lipids, DNA, and proteins via direct oxidative reactions or via indirect, radical-mediated mechanisms. These reactions trigger cellular responses ranging from subtle modulations of cell signaling to overwhelming oxidative injury, committing cells to necrosis or apoptosis. In vivo, peroxynitrite generation represents a crucial pathogenic mechanism in conditions such as stroke, myocardial infarction, chronic heart failure, diabetes, circulatory shock, chronic inflammatory diseases, cancer, and neurodegenerative disorders. Hence, novel pharmacological strategies aimed at removing peroxynitrite might represent powerful therapeutic tools in the future. Evidence supporting these novel roles of NO and peroxynitrite is presented in detail in this review. LA - English DB - MTMT ER - TY - JOUR AU - Zettervall, CJ AU - Anderl, I AU - Williams, MJ AU - Palmer, R AU - Kurucz, Judit Éva AU - Andó, István AU - Hultmark, D TI - A directed screen for genes involved in Drosophila blood cell activation JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 101 PY - 2004 IS - 39 SP - 14192 EP - 14197 PG - 6 SN - 0027-8424 DO - 10.1073/pnas.0403789101 UR - https://m2.mtmt.hu/api/publication/1913536 ID - 1913536 LA - English DB - MTMT ER - TY - JOUR AU - Asha, H AU - Nagy, István AU - Kovacs, G AU - Stetson, D AU - Andó, István AU - Dearolf, CR TI - Analysis of Ras-induced overproliferation in Drosophila hemocytes JF - GENETICS J2 - GENETICS VL - 163 PY - 2003 SP - 203 EP - 215 PG - 13 SN - 0016-6731 UR - https://m2.mtmt.hu/api/publication/1912854 ID - 1912854 LA - English DB - MTMT ER - TY - JOUR AU - Kurucz, Judit Éva AU - Zettervall, CJ AU - Sinka, Rita AU - Vilmos, Péter AU - Pivarcsi, A AU - Ekengren, S AU - Hegedűs, Zoltán AU - Andó, István AU - Hultmark, D TI - Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 100 PY - 2003 IS - 5 SP - 2622 EP - 2627 PG - 6 SN - 0027-8424 DO - 10.1073/pnas.0436940100 UR - https://m2.mtmt.hu/api/publication/1912851 ID - 1912851 LA - English DB - MTMT ER -