{ "labelLang" : "hun", "responseDate" : "2024-03-29 06:26", "paging" : { "last" : true, "first" : true, "totalPages" : 1, "totalElements" : 1, "totalUncutElements" : 1, "totalEstimatedElements" : 1, "size" : 100, "number" : 1, "numberOfElements" : 1, "sort" : [ { "direction" : "DESC", "property" : "publishedYear", "ascending" : false }, { "direction" : "ASC", "property" : "firstAuthor", "ascending" : true }, { "direction" : "ASC", "property" : "title", "ascending" : true } ] }, "content" : [ { "otype" : "JournalArticle", "mtid" : 2568539, "status" : "ADMIN_APPROVED", "published" : true, "unhandledTickets" : 0, "oldTimestamp" : "2015-03-17T11:34:47.000+0000", "deleted" : false, "oldId" : 2568539, "lastRefresh" : "2024-02-17T09:09:05.289+0000", "lastModified" : "2015-03-17T11:34:47.000+0000", "created" : "2014-04-04T19:09:01.000+0000", "creator" : { "otype" : "Author", "mtid" : 10001523, "link" : "/api/author/10001523", "label" : "Molnár Ildikó (Klinikai endokrinológia)", "familyName" : "Molnár", "givenName" : "Ildikó", "duplumRole" : "DUPLUM", "published" : true, "oldId" : 10001523, "snippet" : true }, "lastDuplumOK" : "2018-10-20T15:56:24.828+0000", "lastDuplumSearch" : "2018-10-20T15:56:24.828+0000", "adminApproved" : "2015-03-12T11:39:45.000+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10003141, "link" : "/api/admin/10003141", "label" : "Aggod Zsuzsa (MTMT 2-3, admin)", "familyName" : "Aggod", "givenName" : "Zsuzsa", "published" : true, "oldId" : 10003141, "snippet" : true }, "core" : true, "citation" : false, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 18, "link" : "/api/subtype/18", "label" : "Rövid közlemény (Folyóiratcikk)", "name" : "Rövid közlemény", "nameEng" : "Note, Short, Rapid communications", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 103, "published" : true, "oldId" : 18, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Molnar, I", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 5072026, "link" : "/api/authorship/5072026", "label" : "Molnar, I [Molnár, Ildikó (Klinikai endokrin...), szerző]", "listPosition" : 1, "share" : 0.5, "first" : true, "last" : false, "author" : { "otype" : "Author", "mtid" : 10001523, "link" : "/api/author/10001523", "label" : "Molnár Ildikó (Klinikai endokrinológia)", "familyName" : "Molnár", "givenName" : "Ildikó", "duplumRole" : "DUPLUM", "published" : true, "oldId" : 10001523, "snippet" : true }, "familyName" : "Molnar", "givenName" : "I", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 19575637, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 5072027, "link" : "/api/authorship/5072027", "label" : "Balazs, C", "listPosition" : 2, "share" : 0.5, "first" : false, "last" : true, "familyName" : "Balazs", "givenName" : "C", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 19575636, "snippet" : true } ], "title" : "TSH binding site structures in human eye muscle fractions identified by using covalent-crosslinking", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 792706, "link" : "/api/publicationidentifier/792706", "label" : "WoS: A1992JA82900010", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "A1992JA82900010", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/A1992JA82900010", "published" : false, "oldId" : 1097745, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 792707, "link" : "/api/publicationidentifier/792707", "label" : "Scopus: 0026695978", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "oaFree" : false, "validState" : "NO", "idValue" : "0026695978", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0026695978", "published" : false, "oldId" : 1101366, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 792708, "link" : "/api/publicationidentifier/792708", "label" : "PubMed: 1421036", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "oaFree" : false, "validState" : "NO", "idValue" : "1421036", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1421036&dopt=Abstract", "published" : false, "oldId" : 667023, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 732, "link" : "/api/journal/732", "label" : "BIOMEDICINE & PHARMACOTHERAPY 0753-3322 1950-6007", "pIssn" : "0753-3322", "eIssn" : "1950-6007", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 732, "snippet" : true }, "volume" : "46", "issue" : "2-3", "firstPage" : "121", "lastPage" : "125", "firstPageOrInternalIdForSort" : "121", "pageLength" : 5, "publishedYear" : 1992, "abstractText" : "125I-labelled human TSH was crosslinked to the human thyroid and extraocular eye muscle membrane and cytosol fractions (which were obtained by centrifugation). Studying crosslinking of 125I-labelled TSH to the thyroid fractions, TSH binding sites' structures were demonstrated on the eye muscle membranes and in the cytosol fractions. The binding of 125I-labelled TSH was inhibited by the addition of 120 mIU/mL of unlabelled TSH (and not with 12 mIU/mL) which confirmed the presence of TSH binding sites structures (MW about 66,000 Da) on the eye muscle membrane and in its cytosol. Adding purified IgG fractions from the sera from controls and Graves' disease (with high titer of antibodies against TSH receptor) to the thyroid and eye muscle membranes and cytosol fractions, the binding of 125I-labelled human TSH was inhibited by molecular weight of about 66,000 Da in the cytosol fractions. The affinity constant of the binding sites in the human eye muscle cytosol and the number of TSH receptors were found to be 146 x 10(9) M-1 and 9.8 x 10(10) molecules/mg/mL by Scatchard analysis, respectively.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12548, "link" : "/api/classification/12548", "label" : "Egyéb orvostudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 65, "link" : "/api/keyword/65", "label" : "Humans", "published" : true, "oldId" : 65, "snippet" : true }, { "otype" : "Keyword", "mtid" : 14602, "link" : "/api/keyword/14602", "label" : "Cross-Linking Reagents", "published" : true, "oldId" : 14602, "snippet" : true }, { "otype" : "Keyword", "mtid" : 20643, "link" : "/api/keyword/20643", "label" : "Radioligand Assay", "published" : true, "oldId" : 20643, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1160191, "link" : "/api/keyword/1160191", "label" : "Cytosol/chemistry/metabolism", "published" : true, "oldId" : 1160191, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1310633, "link" : "/api/keyword/1310633", "label" : "Thyroid Gland/chemistry", "published" : true, "oldId" : 1310633, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1310634, "link" : "/api/keyword/1310634", "label" : "Receptors, Thyrotropin/*analysis/metabolism/ultrastructure", "published" : true, "oldId" : 1310634, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1310635, "link" : "/api/keyword/1310635", "label" : "Oculomotor Muscles/*chemistry", "published" : true, "oldId" : 1310635, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1310636, "link" : "/api/keyword/1310636", "label" : "Muscles/*chemistry/cytology/metabolism", "published" : true, "oldId" : 1310636, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1310637, "link" : "/api/keyword/1310637", "label" : "Graves Disease/metabolism", "published" : true, "oldId" : 1310637, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2014, "packet" : "csomagMI (Molnár Ildikó (Immunológia); 2014.04.04. 20:15:47)", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-02-17", "oaFree" : false, "oaByAuthor" : { "otype" : "Author", "mtid" : 10001523, "link" : "/api/author/10001523", "label" : "Molnár Ildikó (Klinikai endokrinológia)", "familyName" : "Molnár", "givenName" : "Ildikó", "duplumRole" : "DUPLUM", "published" : true, "oldId" : 10001523, "snippet" : true }, "citationCount" : 5, "citationCountUnpublished" : 0, "citationCountWoOther" : 5, "independentCitCountWoOther" : 5, "nationalOriginCitationCount" : 1, "foreignEditionCitationCount" : 5, "doiCitationCount" : 4, "wosCitationCount" : 5, "scopusCitationCount" : 4, "wosScopusCitationCount" : 5, "wosScopusCitationCountWoOther" : 5, "wosScopusIndependentCitationCount" : 5, "wosScopusIndependentCitationCountWoOther" : 5, "independentCitationCount" : 5, "selfCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 5, "independentCitingPubCount" : 5, "citingPubCountWoOther" : 5, "independentCitingPubCountWoOther" : 5, "unhandledCitingPubCount" : 0, "citedPubCount" : 0, "citedCount" : 0, "hasCitationDuplums" : false, "userChangeableUntil" : "2015-03-12T11:39:45.000+0000", "publishDate" : "2014-04-05T09:40:34.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 1, "ownerInstituteCount" : 3, "directInstituteCount" : 0, "authorCount" : 2, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/2568539", "label" : "Molnar I et al. TSH binding site structures in human eye muscle fractions identified by using covalent-crosslinking. (1992) BIOMEDICINE & PHARMACOTHERAPY 0753-3322 1950-6007 46 2-3 121-125", "template" : "