TY  - JOUR
AU  - Lovey, K
AU  - Fodor, János
AU  - Major, Tibor
AU  - Szabo, E
AU  - Orosz, Zsolt
AU  - Sulyok, Z
AU  - Jánváry, Zsolt Levente
AU  - Fröhlich, Georgina
AU  - Kásler, Miklós
AU  - Polgár, Csaba
TI  - Fat necrosis after partial-breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy--4-year results of a randomized trial.
JF  - INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
J2  - INT J RADIAT ONCOL
VL  - 69
PY  - 2007
IS  - 3
SP  - 724
EP  - 731
PG  - 8
SN  - 0360-3016
DO  - 10.1016/j.ijrobp.2007.03.055
UR  - https://m2.mtmt.hu/api/publication/1118079
ID  - 1118079
N1  - Megjegyzés-20317363
Cited By (since 1996): 1
AB  - PURPOSE: To examine the incidence and clinical relevance of fat necrosis after
accelerated partial-breast irradiation (PBI) using interstitial high-dose-rate
brachytherapy (HDR-BT) in comparison with partial-breast electron irradiation
(ELE) and whole-breast irradiation (WBI). METHODS AND MATERIALS: Between 1998 and
2004, 258 early-stage breast cancer patients were randomized to receive 50 Gy WBI
(n = 130) or PBI (n = 128). The latter consisted of either 7 x 5.2 Gy HDR-BT (n =
88) or 50 Gy ELE (n = 40). The incidence of fat necrosis, its impact on cosmetic 
outcome, accompanying radiologic features, and clinical symptoms were evaluated. 
RESULTS: The 4-year actuarial rate of fat necrosis was 31.1% for all patients,
and 31.9%, 36.5%, and 17.7% after WBI, HDR-BT and ELE, respectively
(p(WBI/HDR-BT) = 0.26; p(WBI/ELE) = 0.11; p(ELE/HDR-BT) = 0.025). The respective 
rate of asymptomatic fat necrosis was 20.2%, 25.3%, and 10% of patients. The
incidence of symptomatic fat necrosis was not significantly different after WBI
(8.5%), HDR-BT (11.4%), and ELE (7.5%). Symptomatic fat necrosis was
significantly associated with a worse cosmetic outcome, whereas asymptomatic fat 
necrosis was not. Fat necrosis was detectable with mammography and/or ultrasound 
in each case. Additional imaging examinations were required in 21% of cases and
aspiration cytology in 42%. CONCLUSIONS: Asymptomatic fat necrosis is a common
adverse event of breast-conserving therapy, having no significant clinical
relevance in the majority of the cases. The incidence of both symptomatic and
asymptomatic fat necrosis is similar after conventional WBI and accelerated
partial-breast HDR-BT.
LA  - English
DB  - MTMT
ER  -