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The \naim of our study was to assess effect of N-acetylcysteine (NAC) \non oxidative stress, inflammation, fluid requirement, multiple \norgan dysfunction (MOD) score and vasoactive drug requirement. \nIn this study 15 patients were on standard therapy, whereas for \nother 15 patients NAC was supplemented. Blood samples were taken \non admission and on the next five consecutive mornings. Levels \nof malondialdehyde, protein sulfhydril (PSH) groups, reduced \ngluthation (GSH), activity of myeloperoxidase, catalase and \nsuperoxide dismutase enzymes and induced free radical generating \ncapacity were measured as well as concentrations of TNF-alpha, \nIL-6, IL-8, and IL-10. MOD score, use of vasopressor agents and \nfluid utilisation were recorded daily. NAC treatment increased \nGSH level on days 4-5 (p<0.05) and PSH level on days 2-6 \n(p<0.05) compared to controls. Plasma IL-6 was lower on days 4-5 \n(p<0.05), IL-8 on days 4-6 (p<0.05) and IL-10 on days 4-6 \n(p<0.05) in NAC group. NAC group received less catecholamines \nthan controls (p<0.01) from day 4 without significant \ndifferences in MOD score. NAC treatment is associated with a \ndiminished oxidative stress reflected in preserved antioxidant \nlevels, lower inflammation mirrored in lower interleukin levels \nand less vasopressor requirement.", "subjects" : [ { "otype" : "Classification", "mtid" : 12548, "link" : "/api/classification/12548", "label" : "Egyéb orvostudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2012, "packet" : "609816", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-03-05", "oaFree" : false, "citationCount" : 62, "citationCountUnpublished" : 0, "citationCountWoOther" : 62, "independentCitCountWoOther" : 58, "nationalOriginCitationCount" : 5, "foreignEditionCitationCount" : 60, "doiCitationCount" : 57, "wosCitationCount" : 57, "scopusCitationCount" : 59, "wosScopusCitationCount" : 60, "wosScopusCitationCountWoOther" : 60, "wosScopusIndependentCitationCount" : 57, "wosScopusIndependentCitationCountWoOther" : 57, "independentCitationCount" : 58, "selfCitationCount" : 4, "unhandledCitationCount" : 0, "citingPubCount" : 62, "independentCitingPubCount" : 58, "citingPubCountWoOther" : 62, "independentCitingPubCountWoOther" : 58, "unhandledCitingPubCount" : 0, "citedPubCount" : 8, "citedCount" : 8, "ratings" : [ { "otype" : "SjrRating", "mtid" : 5661951, "link" : "/api/sjrrating/5661951", "label" : "sjr:Q1 (2012) Scopus - Critical Care and Intensive Care Medicine BURNS 0305-4179 1879-1409", "listPos" : 22, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2706, "link" : "/api/classificationexternal/2706", "label" : "Scopus - Critical Care and Intensive Care Medicine", "published" : true, "oldId" : 2706, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "oldId" : 5661951, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : true, "inSelectedPubs" : "10006373,10018162", "userChangeableUntil" : "2014-02-27T12:24:17.000+0000", "publishDate" : "2012-06-20T06:41:21.000+0000", "directInstitutesForSort" : "Aneszteziológiai és Intenzív Terápiás Intézet (PTE / ÁOK); Sebészeti Oktató és Kutató Intézet (PTE / ÁOK)", "ownerAuthorCount" : 7, "ownerInstituteCount" : 19, "directInstituteCount" : 2, "authorCount" : 8, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/1836428", "label" : "Csontos C et al. 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