TY  - JOUR
AU  - Csontos, Csaba
AU  - Rézmán, Barbara
AU  - Földi, Viktor Péter
AU  - Bogár, Lajos
AU  - Drenkovics, L
AU  - Rőth, Erzsébet
AU  - Wéber, György
AU  - Lantos, János
TI  - Effect of N-acetylcysteine treatment on oxidative stress and inflammation after severe burn.
JF  - BURNS
J2  - BURNS
VL  - 38
PY  - 2012
IS  - 3
SP  - 428
EP  - 437
PG  - 10
SN  - 0305-4179
DO  - 10.1016/j.burns.2011.09.011
UR  - https://m2.mtmt.hu/api/publication/1836428
ID  - 1836428
N1  - Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of Pécs, Akác u 1, Pécs 7632, Hungary            
            Department of Surgical Research and Techniques, Faculty of Medicine, University of Pécs, Hungary            
            Cited By :59            
            Export Date: 13 November 2023            
            CODEN: BURND            
            Correspondence Address: Csontos, C.; Department of Anaesthesia and Intensive Care, Akác u 1, Pécs 7632, Hungary; email: csaba.csontos@gmail.com
AB  - Oxidative stress and inflammation generate edema in burns. The 
aim of our study was to assess effect of N-acetylcysteine (NAC) 
on oxidative stress, inflammation, fluid requirement, multiple 
organ dysfunction (MOD) score and vasoactive drug requirement. 
In this study 15 patients were on standard therapy, whereas for 
other 15 patients NAC was supplemented. Blood samples were taken 
on admission and on the next five consecutive mornings. Levels 
of malondialdehyde, protein sulfhydril (PSH) groups, reduced 
gluthation (GSH), activity of myeloperoxidase, catalase and 
superoxide dismutase enzymes and induced free radical generating 
capacity were measured as well as concentrations of TNF-alpha, 
IL-6, IL-8, and IL-10. MOD score, use of vasopressor agents and 
fluid utilisation were recorded daily. NAC treatment increased 
GSH level on days 4-5 (p<0.05) and PSH level on days 2-6 
(p<0.05) compared to controls. Plasma IL-6 was lower on days 4-5 
(p<0.05), IL-8 on days 4-6 (p<0.05) and IL-10 on days 4-6 
(p<0.05) in NAC group. NAC group received less catecholamines 
than controls (p<0.01) from day 4 without significant 
differences in MOD score. NAC treatment is associated with a 
diminished oxidative stress reflected in preserved antioxidant 
levels, lower inflammation mirrored in lower interleukin levels 
and less vasopressor requirement.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Pásztiné Gere, Erzsébet
AU  - Jakus, Judit
TI  - The effect of N-acetylcysteine on amphetamine-mediated dopamine release in rat brain striatal slices by ion-pair reversed-phase high performance liquid chromatography
JF  - BIOMEDICAL CHROMATOGRAPHY
J2  - BIOMED CHROMATOGR
VL  - 23
PY  - 2009
IS  - 6
SP  - 658
EP  - 664
PG  - 7
SN  - 0269-3879
DO  - 10.1002/bmc.1171
UR  - https://m2.mtmt.hu/api/publication/113092
ID  - 113092
N1  - [038/2009]
MTA KK
LA  - English
DB  - MTMT
ER  -