@article{MTMT:247847,
	title = {Differential distribution of NCX1 contributes to spine-dendrite compartmentalization in CA1 pyramidal cells},
	url = {https://m2.mtmt.hu/api/publication/247847},
	author = {Lőrincz, Andrea and Rózsa J., Balázs and Katona, Gergely and Vizi, E. Szilveszter and Tamás, Gábor},
	doi = {10.1073/pnas.0605412104},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {104},
	unique-id = {247847},
	issn = {0027-8424},
	abstract = {Compartmentalization of Ca(2+) between dendritic spines and shafts is governed by diffusion barriers and a range of Ca(2+) extrusion mechanisms. The distinct contribution of different Ca(2+) clearance systems to Ca(2+) compartmentalization in dendritic spines versus shafts remains elusive. We applied a combination of ultrastructural and functional imaging methods to assess the subcellular distribution and role of NCX1 in rat CA1 pyramidal cells. Quantitative electron microscopic analysis of preembedding immunogold reactions revealed uniform densities of NCX1 along the shafts of apical and basal dendrites, but densities in dendritic shafts were approximately seven times higher than in dendritic spines. In line with these results, two-photon imaging of synaptically activated Ca(2+) transients during NCX blockade showed preferential action localized to the dendritic shafts for NCXs in regulating spine-dendrite coupling.},
	year = {2007},
	eissn = {1091-6490},
	pages = {1033-1038},
	orcid-numbers = {Rózsa J., Balázs/0000-0003-1427-7003; Katona, Gergely/0000-0002-4173-0355; Vizi, E. Szilveszter/0000-0002-9557-4597; Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:1442913,
	title = {Calcium microdomains in aspiny dendrites.},
	url = {https://m2.mtmt.hu/api/publication/1442913},
	author = {Goldberg, JH and Tamás, Gábor and Aronov, D and Yuste, R},
	doi = {10.1016/S0896-6273(03)00714-1},
	journal-iso = {NEURON},
	journal = {NEURON},
	volume = {40},
	unique-id = {1442913},
	issn = {0896-6273},
	abstract = {Dendritic spines receive excitatory synapses and serve as calcium compartments, which appear to be necessary for input-specific synaptic plasticity. Dendrites of GABAergic interneurons have few or no spines and thus do not possess a clear morphological basis for synapse-specific compartmentalization. We demonstrate using two-photon calcium imaging that activation of single synapses on aspiny dendrites of neocortical fast spiking (FS) interneurons creates highly localized calcium microdomains, often restricted to less than 1 microm of dendritic space. We confirm using ultrastructural reconstruction of imaged dendrites the absence of any morphological basis for this compartmentalization and show that it is dependent on the fast kinetics of calcium-permeable (CP) AMPA receptors and fast local extrusion via the Na+/Ca2+ exchanger. Because aspiny dendrites throughout the CNS express CP-AMPA receptors, we propose that CP-AMPA receptors mediate a spine-free mechanism of input-specific calcium compartmentalization.},
	keywords = {Animals; MICE; Excitatory Postsynaptic Potentials/physiology; Microscopy, Electron; Mice, Inbred C57BL; Interneurons/*physiology/ultrastructure; Action Potentials/physiology; Models, Neurological; Indicators and Reagents; Synaptic Transmission/physiology; Cell Compartmentation/physiology; Calcium Signaling/*physiology; Synaptic Membranes/physiology/ultrastructure; Sodium-Calcium Exchanger/physiology; Receptors, AMPA/*physiology; Neocortex/*physiology/ultrastructure; Fluorescent Dyes/diagnostic use; Calcium/metabolism/physiology; Dendrites/*physiology/ultrastructure},
	year = {2003},
	eissn = {1097-4199},
	pages = {807-821},
	orcid-numbers = {Tamás, Gábor/0000-0002-7905-6001}
}