TY - JOUR AU - Schuster, Ildikó AU - Lázár, László AU - Fülöp, Ferenc TI - Convenient Synthesis of 1,2,3,4-Tetrahydroisoquinoline-1-carboxylic Acid Derivatives via Isocyanide-Based, Three-Component Reactions JF - SYNTHETIC COMMUNICATIONS J2 - SYNTHETIC COMMUN VL - 40 PY - 2010 IS - 16 SP - 2488 EP - 2498 PG - 11 SN - 0039-7911 DO - 10.1080/00397910903277920 UR - https://m2.mtmt.hu/api/publication/1366571 ID - 1366571 N1 - Megjegyzés-21039019 FU: Hungarian Scientific Research Foundation [OTKA K 075433] FX: The authors thank the Hungarian Scientific Research Foundation (Grant : No. OTKA K 075433) for financial support. WoS:hiba:000280389500017 2019-03-02 08:50 cikkazonosító nem egyezik AB - The three-component reactions of 3,4-dihydroisoquinolines, isocyanides, and benzyl chloroformate furnished 2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamides in moderate to good yields. Hydrogenolysis or selective hydrolysis of the benzyloxycarbonyl group provided 1,2,3,4-tetrahydroisoquinoline-1-carboxamides, further hydrolysis of which resulted in the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids. LA - English DB - MTMT ER - TY - JOUR AU - Schuster, Ildikó AU - Sztojkov-Ivanov, Anita AU - Lázár, László AU - Fülöp, Ferenc TI - Synthesis of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid Derivatives Via Ugi Reactions JF - LETTERS IN ORGANIC CHEMISTRY J2 - LETT ORG CHEM VL - 4 PY - 2007 IS - 2 SP - 102 EP - 108 PG - 7 SN - 1570-1786 DO - 10.2174/157017807780414226 UR - https://m2.mtmt.hu/api/publication/1083281 ID - 1083281 N1 - Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary. AB - The three-component Ugi reactions of 3,4-dihydroisoquinolines, isocyanides and acids furnished 2-acyl-N-substituted-1,2,3,4-tetrahydroisoquinoline-1-carboxamides in moderate to good yields. Chiral, nonracemic acids induced only poor diastercoselectivities in the condensations. Hydrolysis of the Ugi carboxamides gave the corresponding 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids, which due to their ready ability to undergo racemization, were obtained as racemic mixtures or with low enantiomeric excesses. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Béla Ernő AU - Bodnár, Ibolya AU - Homicskó, KG AU - Fülöp, Ferenc AU - Fekete, Márton AU - Nagy, M. György TI - Physiological role of salsolinol: Its hypophyseotrophic function in the regulation of pituitary prolactin secretion JF - NEUROTOXICOLOGY AND TERATOLOGY J2 - NEUROTOXICOL TERATOL VL - 24 PY - 2002 SP - 655 EP - 666 PG - 12 SN - 0892-0362 DO - 10.1016/S0892-0362(02)00216-7 UR - https://m2.mtmt.hu/api/publication/154023 ID - 154023 N1 - Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Semmelweis University, Tuzoltó u. 58, Budapest H-1094, Hungary Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :52 Export Date: 14 July 2023 CODEN: NETEE Correspondence Address: Nagy, G.M.; Neuroendocrine Research Laboratory, Tuzoltó u. 58, Budapest, H-1094, Hungary; email: nagy-gm@ana2.sote.hu Chemicals/CAS: Dopamine, 51-61-6; Isoquinolines; Prolactin, 9002-62-4; salsolinol, 525-72-4 Funding details: ETT 277/2001 Funding text 1: This work was sponsored by the Hungarian National Research Grant (OTKA 030748 to G.M.N.) and by the Research Grant of the Hungarian Ministry of Public Health (ETT 277/2001 to G.M.N.). The PhD Program of the Semmelweis University has also supported this work (to B.E.T., I.B., and K.G.H.). K.G. Homicskó was a recipient of a 2000 Summer Research Fellowship of the US Endocrine Society. LA - English DB - MTMT ER -