@article{MTMT:109502,
	title = {Distance-dependent scaling of calcium transients evoked by backpropagating spikes and synaptic activity in dendrites of hippocampal interneurons},
	url = {https://m2.mtmt.hu/api/publication/109502},
	author = {Rózsa J., Balázs and Zelles, Tibor and Vizi, E. Szilveszter and Lendvai, Balázs},
	doi = {10.1523/JNEUROSCI.3906-03.2004},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {24},
	unique-id = {109502},
	issn = {0270-6474},
	year = {2004},
	eissn = {1529-2401},
	pages = {661-670},
	orcid-numbers = {Zelles, Tibor/0000-0002-0357-0469; Vizi, E. Szilveszter/0000-0002-9557-4597}
}

@article{MTMT:1442914,
	title = {Ca2+ imaging of mouse neocortical interneurone dendrites: contribution of Ca2+-permeable AMPA and NMDA receptors to subthreshold Ca2+dynamics.},
	url = {https://m2.mtmt.hu/api/publication/1442914},
	author = {Goldberg, JH and Yuste, R and Tamás, Gábor},
	doi = {10.1113/jphysiol.2003.042598},
	journal-iso = {J PHYSIOL-LONDON},
	journal = {JOURNAL OF PHYSIOLOGY-LONDON},
	volume = {551},
	unique-id = {1442914},
	issn = {0022-3751},
	abstract = {In this second study, we have combined two-photon calcium imaging with whole-cell recording and anatomic reconstructions to directly characterize synaptically evoked calcium signals in three types of mouse V1 supragranular interneurones: parvalbumin-positive fast spikers (FS), calretinin-positive irregular spikers (IS), and adapting cells (AD). We observed that subthreshold synaptic activation evoked calcium signals locally restricted to individual dendritic compartments. These signals were mediated by NMDA receptors (NMDARs) in AD and IS cells, whereas in FS cells, calcium-permeable AMPA receptors (CP-AMPARs) provided an additional and kinetically distinct influx. Furthermore, even a single, subthreshold synaptic activation evoked a larger dendritic calcium influx than backpropagating action potentials. Our results demonstrate that NMDARs dominate subthreshold calcium dynamics in interneurones and reveal the functional contribution of CP-AMPARs to a specific subclass of cortical interneurone. These data highlight different strategies in dendritic signal processing by distinct classes of interneurones.},
	keywords = {Animals; MICE; KINETICS; Excitatory Postsynaptic Potentials/physiology; Electric Stimulation; Mice, Inbred C57BL; Synapses/physiology; Reaction Time; Action Potentials; Receptors, N-Methyl-D-Aspartate/*physiology; Calcium/*metabolism; Dendrites/*metabolism; Interneurons/*metabolism; Differential Threshold; Calcium Signaling; Receptors, Neurotransmitter/physiology; Neocortex/cytology/*metabolism; Receptors, AMPA/*physiology},
	year = {2003},
	eissn = {1469-7793},
	pages = {67-78},
	orcid-numbers = {Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:1442916,
	title = {Ca2+ imaging of mouse neocortical interneurone dendrites: Ia-type K+ channels control action potential backpropagation.},
	url = {https://m2.mtmt.hu/api/publication/1442916},
	author = {Goldberg, JH and Tamás, Gábor and Yuste, R},
	doi = {10.1113/jphysiol.2003.042580},
	journal-iso = {J PHYSIOL-LONDON},
	journal = {JOURNAL OF PHYSIOLOGY-LONDON},
	volume = {551},
	unique-id = {1442916},
	issn = {0022-3751},
	abstract = {GABAergic interneurones are essential in cortical processing, yet the functional properties of their dendrites are still poorly understood. In this first study, we combined two-photon calcium imaging with whole-cell recording and anatomical reconstructions to examine the calcium dynamics during action potential (AP) backpropagation in three types of V1 supragranular interneurones: parvalbumin-positive fast spikers (FS), calretinin-positive irregular spikers (IS), and adapting cells (AD). Somatically generated APs actively backpropagated into the dendritic tree and evoked instantaneous calcium accumulations. Although voltage-gated calcium channels were expressed throughout the dendritic arbor, calcium signals during backpropagation of both single APs and AP trains were restricted to proximal dendrites. This spatial control of AP backpropagation was mediated by Ia-type potassium currents and could be mitigated by by previous synaptic activity. Further, we observed supralinear summation of calcium signals in synaptically activated dendritic compartments. Together, these findings indicate that in interneurons, dendritic AP propagation is synaptically regulated. We propose that interneurones have a perisomatic and a distal dendritic functional compartment, with different integrative functions.},
	keywords = {Animals; MICE; Excitatory Postsynaptic Potentials/physiology; Mice, Inbred C57BL; Synapses/physiology; electric conductivity; Action Potentials; Visual Cortex/cytology/metabolism; Potassium Channels/*physiology; Interneurons/classification/*metabolism; Dendrites/*metabolism/physiology; Calcium Channels/physiology; Calcium/*metabolism/physiology; Neocortex/cytology/*metabolism},
	year = {2003},
	eissn = {1469-7793},
	pages = {49-65},
	orcid-numbers = {Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:1442913,
	title = {Calcium microdomains in aspiny dendrites.},
	url = {https://m2.mtmt.hu/api/publication/1442913},
	author = {Goldberg, JH and Tamás, Gábor and Aronov, D and Yuste, R},
	doi = {10.1016/S0896-6273(03)00714-1},
	journal-iso = {NEURON},
	journal = {NEURON},
	volume = {40},
	unique-id = {1442913},
	issn = {0896-6273},
	abstract = {Dendritic spines receive excitatory synapses and serve as calcium compartments, which appear to be necessary for input-specific synaptic plasticity. Dendrites of GABAergic interneurons have few or no spines and thus do not possess a clear morphological basis for synapse-specific compartmentalization. We demonstrate using two-photon calcium imaging that activation of single synapses on aspiny dendrites of neocortical fast spiking (FS) interneurons creates highly localized calcium microdomains, often restricted to less than 1 microm of dendritic space. We confirm using ultrastructural reconstruction of imaged dendrites the absence of any morphological basis for this compartmentalization and show that it is dependent on the fast kinetics of calcium-permeable (CP) AMPA receptors and fast local extrusion via the Na+/Ca2+ exchanger. Because aspiny dendrites throughout the CNS express CP-AMPA receptors, we propose that CP-AMPA receptors mediate a spine-free mechanism of input-specific calcium compartmentalization.},
	keywords = {Animals; MICE; Excitatory Postsynaptic Potentials/physiology; Microscopy, Electron; Mice, Inbred C57BL; Interneurons/*physiology/ultrastructure; Action Potentials/physiology; Models, Neurological; Indicators and Reagents; Synaptic Transmission/physiology; Cell Compartmentation/physiology; Calcium Signaling/*physiology; Synaptic Membranes/physiology/ultrastructure; Sodium-Calcium Exchanger/physiology; Receptors, AMPA/*physiology; Neocortex/*physiology/ultrastructure; Fluorescent Dyes/diagnostic use; Calcium/metabolism/physiology; Dendrites/*physiology/ultrastructure},
	year = {2003},
	eissn = {1097-4199},
	pages = {807-821},
	orcid-numbers = {Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:2138098,
	title = {Target-cell-specific facilitation and depression in neocortical circuits.},
	url = {https://m2.mtmt.hu/api/publication/2138098},
	author = {Reyes, A and Lujan, R and Rozov, A and Burnashev, N and Somogyi, Péter Pál and Sakmann, B},
	journal-iso = {NAT NEUROSCI},
	journal = {NATURE NEUROSCIENCE},
	volume = {1},
	unique-id = {2138098},
	issn = {1097-6256},
	abstract = {In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortical layer 2/3. We induced repetitive action potentials in pyramidal cells and recorded the evoked unitary excitatory (E)PSPs in two classes of GABAergic neurons. We observed facilitation of EPSPs in bitufted GABAergic interneurons, many of which expressed somatostatin immunoreactivity. EPSPs recorded from multipolar interneurons, however, showed depression. Some of these neurons were immunopositive for parvalbumin. Unitary inhibitory (I)PSPs evoked by repetitive stimulation of a bitufted neuron also showed a less pronounced but significant difference between the two target neurons. Facilitation and depression involve presynaptic mechanisms, and because a single neuron can express both behaviors simultaneously, we infer that local differences in the molecular structure of presynaptic nerve terminals are induced by retrograde signals from different classes of target neurons. Because bitufted and multipolar neurons both formed reciprocal inhibitory connections with pyramidal cells, the results imply that the balance of activation between two recurrent inhibitory pathways in the neocortex depends on the frequency of action potentials in pyramidal cells.},
	keywords = {Animals; RATS; Excitatory Postsynaptic Potentials/physiology; Pyramidal Cells/physiology; Electric Stimulation; Neural Pathways/cytology/physiology; Action Potentials/physiology; Synapses/physiology; Electrophysiology; Neural Inhibition/physiology; gamma-Aminobutyric Acid/physiology; Neocortex/cytology/*physiology; Neurons/physiology; Somatostatin/metabolism; Interneurons/metabolism/physiology},
	year = {1998},
	eissn = {1546-1726},
	pages = {279-285}
}

@article{MTMT:1660995,
	title = {DIVERSE SOURCES OF HIPPOCAMPAL UNITARY INHIBITORY POSTSYNAPTIC POTENTIALS AND THE NUMBER OF SYNAPTIC RELEASE SITES},
	url = {https://m2.mtmt.hu/api/publication/1660995},
	author = {BUHL, EH and Halasy, Katalin and Somogyi, Péter Pál},
	doi = {10.1038/368823a0},
	journal-iso = {NATURE},
	journal = {NATURE},
	volume = {368},
	unique-id = {1660995},
	issn = {0028-0836},
	abstract = {Dual intracellular recordings from microscopically identified neurons in the hippocampus reveal that the synaptic terminals of three morphologically distinct types of interneuron act through GABA(A) receptors. Each type of interneuron forms up to 12 synaptic contacts with a postsynaptic principal neuron, but each interneuron innervates a different domain of the surface of the postsynaptic neuron. Different kinetics of the postsynaptic effects, together with the strategic placement of synapses, indicate that these GABAergic interneurons serve distinct functions in the cortical network.},
	year = {1994},
	eissn = {1476-4687},
	pages = {823-828}
}