TY - JOUR AU - Klausberger, T AU - Somogyi, Péter Pál TI - Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. JF - SCIENCE J2 - SCIENCE VL - 321 PY - 2008 IS - 5885 SP - 53 EP - 57 PG - 5 SN - 0036-8075 DO - 10.1126/science.1149381 UR - https://m2.mtmt.hu/api/publication/2086363 ID - 2086363 N1 - Megjegyzés-27028849 Megjegyzés-10324201 [273006] Megjegyzés-21921752 Z9: 231 WC: Multidisciplinary Sciences Cited By :1085 Export Date: 21 August 2019 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1106 Export Date: 14 November 2019 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1133 Export Date: 6 March 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1133 Export Date: 12 March 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1140 Export Date: 15 April 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1158 Export Date: 18 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1161 Export Date: 20 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1162 Export Date: 23 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1162 Export Date: 24 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1162 Export Date: 25 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1235 Export Date: 18 March 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1235 Export Date: 23 March 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1239 Export Date: 31 March 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1239 Export Date: 6 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1239 Export Date: 7 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1241 Export Date: 13 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1241 Export Date: 14 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1244 Export Date: 20 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1244 Export Date: 26 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1283 Export Date: 7 September 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 AB - In the cerebral cortex, diverse types of neurons form intricate circuits and cooperate in time for the processing and storage of information. Recent advances reveal a spatiotemporal division of labor in cortical circuits, as exemplified in the CA1 hippocampal area. In particular, distinct GABAergic (gamma- aminobutyric acid-releasing) cell types subdivide the surface of pyramidal cells and act in discrete time windows, either on the same or on different subcellular compartments. They also interact with glutamatergic pyramidal cell inputs in a domain- specific manner and support synaptic temporal dynamics, network oscillations, selection of cell assemblies, and the implementation of brain states. The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior. LA - English DB - MTMT ER - TY - JOUR AU - Huberfeld, G AU - Wittner, Lucia AU - Clemanceau, S AU - Baulac, M AU - Kaila, K AU - Miles, R AU - Rivera, C TI - Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 27 PY - 2007 IS - 37 SP - 9866 EP - 9873 PG - 8 SN - 0270-6474 DO - 10.1523/JNEUROSCI.2761-07.2007 UR - https://m2.mtmt.hu/api/publication/109665 ID - 109665 N1 - INSERM U739, Faculté de Médecine Pitié-Salpêtrière, CHU Pitié-Salpêtrière, 75013 Paris, France Epilepsy Unit, Faculté de Médecine Pitié-Salpêtrière, CHU Pitié-Salpêtrière, 75013 Paris, France Laboratoire de Neurophysiologie, Faculté de Médecine Pitié-Salpêtrière, CHU Pitié-Salpêtrière, 75013 Paris, France Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083, Budapest, Hungary Department of Biological and Environmental Sciences, University of Helsinki, FI-00014, Helsinki, Finland Neuroscience Center, University of Helsinki, FI-00014, Helsinki, Finland Institute of Biotechnology, University of Helsinki, FI-00014, Helsinki, Finland INSERM U739, Université Pierre et Marie Curie Paris 6, CHU Pitié-Salpêtrière, 105 Bd de l'Hôpital, 75013 Paris, France Cited By :461 Export Date: 22 June 2023 CODEN: JNRSD Correspondence Address: Huberfeld, G.; INSERM U739, 105 Bd de l'Hôpital, 75013 Paris, France; email: gilles.huberfeld@chups.jussieu.fr Molecular Sequence Numbers: GENBANK: NM_020708; Chemicals/CAS: biocytin, 576-19-2; bumetanide, 28395-03-1; Chlorides; Sodium-Potassium-Chloride Symporters; Symporters; gamma-Aminobutyric Acid, 56-12-2; potassium-chloride symporters; sodium-potassium-chloride cotransporter 1 protein LA - English DB - MTMT ER - TY - JOUR AU - Földy, Csaba AU - Neu, A AU - Jones, MV AU - Soltesz, Ivan TI - Presynaptic, activity-dependent modulation of cannabinoid type 1 receptor-mediated inhibition of GABA release JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 26 PY - 2006 IS - 5 SP - 1465 EP - 1469 PG - 5 SN - 0270-6474 DO - 10.1523/JNEUROSCI.4587-05.2006 UR - https://m2.mtmt.hu/api/publication/2833489 ID - 2833489 N1 - Megjegyzés-21899090 Z9: 42 AB - Endocannabinoid signaling couples activity-dependent rises in postsynaptic Ca2+ levels to decreased presynaptic GABA release. Here, we present evidence from paired recording experiments that cannabinoid-mediated inhibition of GABA release depends on the firing rates of the presynaptic interneurons. Low-frequency action potentials in post hoc identified cholecystokinin-positive CA1 basket cells elicited IPSCs in the postsynaptic pyramidal cells that, as expected, were fully abolished by the exogenous application of the cannabinoid receptor agonist WIN55,212-2 [R-(+)-(2,3-dihydro-5-methyl-3-[(4-morpholinyl) methyl]pyrol[1,2,3-de]-1,4-benzoxazin-6-yl)(1-naphthalenyl) methanone monomethanesulfonate] at 5 μM. However, the presynaptic basket cells recovered from the cannabinoid agonist-induced inhibition of GABA release when the presynaptic firing rate was increased to ≥20 Hz. Pharmacological experiments showed that the recovered transmission was exclusively dependent on presynaptic N-type Ca2+ channels. Furthermore, the increased presynaptic firing could also overcome even complete depolarization-induced suppression of inhibition, indicating that the magnitude of DSI markedly depends on the activity levels of basket cells. These results reveal a new locus of activity-dependent modulation for endocannabinoid signaling and suggest that endocannabinoid-mediated inhibition of GABA release may differ in distinct behavioral states. Copyright © 2006 Society for Neuroscience. LA - English DB - MTMT ER - TY - JOUR AU - Szabadics, János AU - Varga, Csaba AU - Molnár, Gábor AU - Oláh, Szabolcs AU - Barzó, Pál AU - Tamás, Gábor TI - Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits JF - SCIENCE J2 - SCIENCE VL - 311 PY - 2006 IS - 5758 SP - 233 EP - 235 PG - 3 SN - 0036-8075 DO - 10.1126/science.1121325 UR - https://m2.mtmt.hu/api/publication/1316696 ID - 1316696 N1 - * Megosztott szerzőség AB - Axons in the cerebral cortex receive synaptic input at the axon initial segment almost exclusively from gamma-aminobutyric acid-releasing (GABAergic) axo-axonic cells (AACs). The axon has the lowest threshold for action potential generation in neurons; thus, AACs are considered to be strategically placed inhibitory neurons controlling neuronal output. However, we found that AACs can depolarize pyramidal cells and can initiate stereotyped series of synaptic events in rat and human cortical networks because of a depolarized reversal potential for axonal relative to perisomatic GABAergic inputs. Excitation and signal propagation initiated by AACs is supported by the absence of the potassium chloride cotransporter 2 in the axon. LA - English DB - MTMT ER - TY - JOUR AU - Maglóczky, Zsófia AU - Freund, Tamás TI - Impaired and repaired inhibitory circuits in the epileptic human hippocampus JF - TRENDS IN NEUROSCIENCES J2 - TRENDS NEUROSCI VL - 28 PY - 2005 SP - 334 EP - 340 PG - 7 SN - 0166-2236 DO - 10.1016/j.tins.2005.04.002 UR - https://m2.mtmt.hu/api/publication/109599 ID - 109599 N1 - Megjegyzés-20620036 Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1; calbindin; Calcium-Binding Protein, Vitamin D-Dependent; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins Cited By :136 Export Date: 23 August 2019 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, 46820 Funding details: National Institutes of Health, MH54671 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :136 Export Date: 24 August 2019 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, 46820 Funding details: National Institutes of Health, MH54671 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :136 Export Date: 24 February 2020 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institutes of Health, NIH, MH54671 Funding details: 46820 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :137 Export Date: 12 March 2020 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institutes of Health, NIH, MH54671 Funding details: 46820 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :139 Export Date: 25 May 2020 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institutes of Health, NIH, MH54671 Funding details: 46820 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :139 Export Date: 28 May 2020 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institutes of Health, NIH, MH54671 Funding details: 46820 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :152 Export Date: 31 March 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :152 Export Date: 1 April 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :152 Export Date: 6 April 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :152 Export Date: 14 April 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :156 Export Date: 7 September 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. LA - English DB - MTMT ER - TY - JOUR AU - Wittner, Lucia AU - Erőss, Loránd AU - Czirják, Sándor AU - Halász, Péter AU - Freund, Tamás AU - Maglóczky, Zsófia TI - Surviving CA1 pyramidal cells receive intact perisomatic inhibitory input in the human epileptic hippocampus JF - BRAIN J2 - BRAIN VL - 128 PY - 2005 SP - 138 EP - 152 PG - 15 SN - 0006-8950 DO - 10.1093/brain/awh339 UR - https://m2.mtmt.hu/api/publication/109379 ID - 109379 LA - English DB - MTMT ER - TY - JOUR AU - Freund, Tamás TI - Interneuron diversity series: Rhythm and mood in perisomatic inhibition JF - TRENDS IN NEUROSCIENCES J2 - TRENDS NEUROSCI VL - 26 PY - 2003 SP - 489 EP - 495 PG - 7 SN - 0166-2236 DO - 10.1016/S0166-2236(03)00227-3 UR - https://m2.mtmt.hu/api/publication/109314 ID - 109314 N1 - Cited By :523 Export Date: 1 June 2023 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, PO Box 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; vasoactive intestinal polypeptide, 37221-79-7 Funding details: National Institutes of Health, NIH, MH 54671 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 Funding details: Hungarian Scientific Research Fund, OTKA, T 32251 Funding text 1: I am grateful to all members of my team for valuable contributions to the original studies that underlie this review, as well as for discussion and comments on the manuscript. The help of Gábor Nyiri, Ágnes Bodor and István Katona with the figures, and the assistance of Katalin Iványi and Katalin Lengyel in the preparation of the manuscript, is also acknowledged. My work is supported by the Howard Hughes Medical Institute (USA), NIH (MH 54671, NS30549), Philip Morris External Research Program and OTKA (T 32251) Hungary. LA - English DB - MTMT ER - TY - JOUR AU - Megías, M AU - Emri, Zsuzsa AU - Freund, Tamás AU - Gulyás, Attila TI - Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 102 PY - 2001 SP - 527 EP - 540 PG - 14 SN - 0306-4522 DO - 10.1016/S0306-4522(00)00496-6 UR - https://m2.mtmt.hu/api/publication/109048 ID - 109048 N1 - Cited By :705 Export Date: 18 July 2023 CODEN: NRSCD Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, P.O. Box, Budapest H-1450, Hungary; email: gulyas@koki.hu Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Funding details: National Institutes of Health, NIH, MH 54671 Funding details: Howard Hughes Medical Institute, HHMI Funding details: James S. McDonnell Foundation, JSMF Funding details: Hungarian Scientific Research Fund, OTKA, T23261 Funding text 1: We are grateful to Drs L. Acsády, K. Kaila and R. Miles for helpful discussions and comments on the manuscript, and to Mrs E. Borók, Mr G. Goda and Mrs E. Oswald for excellent technical assistance. This work was supported by the Howard Hughes Medical Institute; the McDonnell Foundation; NIH (MH 54671); FPI grants, Ministerio de Edución y Ciencia, Spain; and OTKA (Hungarian Scientific Research Found, T23261), Hungary. LA - English DB - MTMT ER - TY - JOUR AU - Papp, Edit AU - Leinekugel, X AU - Henze, DA AU - Lee, J AU - Buzsáki, György TI - The apical shaft of CA1 pyramidal cells is under GABAergic interneuronal control JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 102 PY - 2001 SP - 715 EP - 721 PG - 7 SN - 0306-4522 DO - 10.1016/S0306-4522(00)00584-4 UR - https://m2.mtmt.hu/api/publication/109558 ID - 109558 LA - English DB - MTMT ER - TY - JOUR AU - Maccaferri, G AU - Roberts, JD AU - Szűcs, Péter AU - Cottingham, CA AU - Somogyi, Péter Pál TI - Cell surface domain specific postsynaptic currents evoked by identified GABAergic neurones in rat hippocampus in vitro. JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 524 PY - 2000 IS - 1 SP - 91 EP - 116 PG - 26 SN - 0022-3751 DO - 10.1111/j.1469-7793.2000.t01-3-00091.x UR - https://m2.mtmt.hu/api/publication/2138095 ID - 2138095 N1 - Cited By :259 Export Date: 21 August 2019 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :261 Export Date: 6 March 2020 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :262 Export Date: 20 May 2020 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :262 Export Date: 24 May 2020 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :262 Export Date: 25 May 2020 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :270 Export Date: 23 March 2021 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :271 Export Date: 6 April 2021 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 Cited By :271 Export Date: 13 April 2021 Chemicals/CAS: Bicuculline, 485-49-4; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA-A; Somatostatin, 51110-01-1 AB - 1. Inhibitory postsynaptic currents (IPSCs) evoked in CA1 pyramidal cells (n = 46) by identified interneurones (n = 43) located in str. oriens were recorded in order to compare their functional properties and to determine the effect of synapse location on the apparent IPSC kinetics as recorded using somatic voltage clamp at -70 mV and nearly symmetrical [Cl-]. 2. Five types of visualised presynaptic interneurone, oriens-lacunosum moleculare (O-LMC), basket (BC), axo-axonic (AAC), bistratified (BiC) and oriens-bistratified (O-BiC) cells, were distinguished by immunocytochemistry and/or synapse location using light and electron microscopy. 3. Somatostatin immunoreactive O-LMCs, innervating the most distal dendritic shafts and spines, evoked the smallest amplitude (26 +/- 10 pA, s.e.m., n = 8) and slowest IPSCs (10-90 % rise time, 6.2 +/- 0.6 ms; decay, 20.8 +/- 1.7 ms, n = 8), with no paired-pulse modulation of the second IPSC (93 +/- 4 %) at 100 ms interspike interval. In contrast, parvalbumin-positive AACs evoked larger amplitude (308 +/- 103 pA, n = 7) and kinetically faster (rise time, 0.8 +/- 0.1 ms; decay 11.2 +/- 0.9 ms, n = 7) IPSCs showing paired-pulse depression (to 68 +/- 5 %, n = 6). Parvalbumin- or CCK-positive BCs (n = 9) terminating on soma/dendrites, BiCs (n = 4) and O-BiCs (n = 7) innervating dendrites evoked IPSCs with intermediate kinetic parameters. The properties of IPSCs and sensitivity to bicuculline indicated that they were mediated by GABAA receptors. 4. In three cases, kinetically complex, multiphasic IPSCs, evoked by an action potential in the recorded basket cells, suggested that coupled interneurones, possibly through electrotonic junctions, converged on the same postsynaptic neurone. 5. The population of O-BiCs (4 of 4 somatostatin positive) characterised in this study had horizontal dendrites restricted to str. oriens/alveus and innervated stratum radiatum and oriens. Other BiCs had radial dendrites as described earlier. The parameters of IPSCs evoked by BiCs and O-BiCs showed the largest cell to cell variation, and a single interneurone could evoke both small and slow as well as large and relatively fast IPSCs. 6. The kinetic properties of the somatically recorded postsynaptic current are correlated with the innervated cell surface domain. A significant correlation of rise and decay times for the overall population of unitary IPSCs suggests that electrotonic filtering of distal responses is a major factor for the location and cell type specific differences of unitary IPSCs, but molecular heterogeneity of postsynaptic GABAA receptors may also contribute to the observed kinetic differences. Furthermore, domain specific differences in the short-term plasticity of the postsynaptic response indicate a differentiation of interneurones in activity-dependent responses. LA - English DB - MTMT ER - TY - JOUR AU - Reyes, A AU - Lujan, R AU - Rozov, A AU - Burnashev, N AU - Somogyi, Péter Pál AU - Sakmann, B TI - Target-cell-specific facilitation and depression in neocortical circuits. JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 1 PY - 1998 IS - 4 SP - 279 EP - 285 PG - 7 SN - 1097-6256 UR - https://m2.mtmt.hu/api/publication/2138098 ID - 2138098 N1 - Megjegyzés-22898736 Megjegyzés-21894849 Z9: 326 AB - In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortical layer 2/3. We induced repetitive action potentials in pyramidal cells and recorded the evoked unitary excitatory (E)PSPs in two classes of GABAergic neurons. We observed facilitation of EPSPs in bitufted GABAergic interneurons, many of which expressed somatostatin immunoreactivity. EPSPs recorded from multipolar interneurons, however, showed depression. Some of these neurons were immunopositive for parvalbumin. Unitary inhibitory (I)PSPs evoked by repetitive stimulation of a bitufted neuron also showed a less pronounced but significant difference between the two target neurons. Facilitation and depression involve presynaptic mechanisms, and because a single neuron can express both behaviors simultaneously, we infer that local differences in the molecular structure of presynaptic nerve terminals are induced by retrograde signals from different classes of target neurons. Because bitufted and multipolar neurons both formed reciprocal inhibitory connections with pyramidal cells, the results imply that the balance of activation between two recurrent inhibitory pathways in the neocortex depends on the frequency of action potentials in pyramidal cells. LA - English DB - MTMT ER - TY - JOUR AU - Kaila, K AU - Lamsa, Karri AU - Smirnov, S AU - Taira, T AU - Voipio, J TI - Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient. JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 17 PY - 1997 IS - 20 SP - 7662 EP - 7672 PG - 11 SN - 0270-6474 UR - https://m2.mtmt.hu/api/publication/2966613 ID - 2966613 AB - Biphasic GABAA-mediated postsynaptic responses can be readily evoked in CA1 pyramidal neurons of rat hippocampal slices by high-frequency stimulus (HFS) trains in the presence of ionotropic glutamate receptor antagonists. In the present experiments with sharp microelectrodes, whole-cell techniques, and K+-selective microelectrodes, an HFS train (40 pulses at 100 Hz) applied in stratum radiatum close to the recording site evoked a brief hyperpolarizing IPSP (hIPSP), which turned into a prolonged (2-3 sec) depolarization (GABA-mediated depolarizing postsynaptic potential; GDPSP). The I-V relationships of the postsynaptic currents (hIPSC and GDPSC) had distinct characteristics: the hIPSC and the early GDPSC showed outward rectification, whereas the late GDPSC was reduced with positive voltage steps to zero or beyond (inward rectification), but often no clear reversal was seen. That two distinct currents contribute to the generation of the GDPSP was also evident from the finding that a second HFS train at peak or late GDPSP induced a prompt GABAA-mediated hyperpolarization. The GDPSP/C was dependent on the availability of bicarbonate, but not on interstitial or intrapyramidal carbonic anhydrase activity. The HFS train evoked a rapid GABAA-mediated bicarbonate-dependent increase in the extracellular K+ concentration ([K+]o), and the GDPSP followed the K+ transient in a sub-Nernstian manner. The spatial and pharmacological characteristics of the [K+]o shift indicated that it is generated by a local network of GABAergic interneurons. The brief ascending phase of the GDPSP is linked to a K+-dependent accumulation of intracellular Cl-. Thereafter, a nonsynaptic mechanism, a direct depolarizing effect of the [K+]o shift, is responsible for the most conspicuous characteristics of the GDPSP: its large amplitude and prolonged duration. LA - English DB - MTMT ER - TY - JOUR AU - Freund, Tamás AU - Buzsáki, György TI - Interneurons of the hippocampus JF - HIPPOCAMPUS J2 - HIPPOCAMPUS VL - 6 PY - 1996 SP - 347 EP - 470 PG - 124 SN - 1050-9631 DO - 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I UR - https://m2.mtmt.hu/api/publication/107931 ID - 107931 LA - English DB - MTMT ER - TY - JOUR AU - Miles, R AU - Tóth, Katalin AU - Gulyás, Attila AU - Hájos, Norbert AU - Freund, Tamás TI - Differences between somatic and dendritic inhibition in the hippocampus JF - NEURON J2 - NEURON VL - 16 PY - 1996 IS - 4 SP - 815 EP - 823 PG - 9 SN - 0896-6273 DO - 10.1016/S0896-6273(00)80101-4 UR - https://m2.mtmt.hu/api/publication/107721 ID - 107721 N1 - Megjegyzés-25002645 Megjegyzés-21894988 Z9: 477 Lab. de Neurobiologie Cellulaire, Institut Pasteur, 25 rue de Dr. Roux, 75724 Paris, France Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest, Hungary Cited By :713 Export Date: 24 March 2021 CODEN: NERNE Correspondence Address: Miles, R.; Lab. de Neurobiologie Cellulaire, 25 rue de Dr. Roux, 75724 Paris, France Chemicals/CAS: biocytin, 576-19-2 Funding details: European Science Foundation, ESF Funding details: Human Frontier Science Program, HFSP Funding details: Hungarian Scientific Research Fund, OTKA, T5532 Funding text 1: Correspondence should be addressed to R. M. This work was supported by the Human Science Frontier Program, the European Science Foundation, the Ministére de la Recherche et de la Technologie, and OTKA (T5532) Hungary. We thank B. Barbour for helpful comments and E. Borók, I. Weisz, and G. Terstyánszky for excellent technical assistance. Lab. de Neurobiologie Cellulaire, Institut Pasteur, 25 rue de Dr. Roux, 75724 Paris, France Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest, Hungary Cited By :714 Export Date: 6 April 2021 CODEN: NERNE Correspondence Address: Miles, R.; Lab. de Neurobiologie Cellulaire, 25 rue de Dr. Roux, 75724 Paris, France Chemicals/CAS: biocytin, 576-19-2 Funding details: European Science Foundation, ESF Funding details: Human Frontier Science Program, HFSP Funding details: Hungarian Scientific Research Fund, OTKA, T5532 Funding text 1: Correspondence should be addressed to R. M. This work was supported by the Human Science Frontier Program, the European Science Foundation, the Ministére de la Recherche et de la Technologie, and OTKA (T5532) Hungary. We thank B. Barbour for helpful comments and E. Borók, I. Weisz, and G. Terstyánszky for excellent technical assistance. LA - English DB - MTMT ER - TY - JOUR AU - COBB, SR AU - BUHL, EH AU - Halasy, Katalin AU - PAULSEN, O AU - Somogyi, Péter Pál TI - SYNCHRONIZATION OF NEURONAL-ACTIVITY IN HIPPOCAMPUS BY INDIVIDUAL GABAERGIC INTERNEURONS JF - NATURE J2 - NATURE VL - 378 PY - 1995 IS - 6552 SP - 75 EP - 78 PG - 4 SN - 0028-0836 DO - 10.1038/378075a0 UR - https://m2.mtmt.hu/api/publication/1661000 ID - 1661000 N1 - MRC Anatomical Neuropharmacology Unit, University Department of Pharmacology, Mansfield Road, Oxford, OX1 3TH, United Kingdom Department of Zoology & Cell Biology, Jozsef Attila University, Szeged, H-6722, Hungary Cited By :1114 Export Date: 6 April 2021 Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; gamma-Aminobutyric Acid, 56-12-2; Receptors, GABA-A AB - SYNCHRONIZATION Of neuronal activity is fundamental in the operation of cortical networks(1). With respect to an ongoing synchronized oscillation, the precise timing of action potentials is an attractive candidate mechanism for information coding(2-5) Networks of inhibitory interneurons have been proposed to have a role in entraining cortical, synchronized 40-Hz activity(6,7). Here we demonstrate that individual GABAergic interneurons(8) can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at theta frequencies (4-7 Hz). The efficiency of this entrainment is due to interaction of GABA(A)-receptor-mediated hyperpolarizing synaptic events with intrinsic oscillatory mechanisms tuned to this frequency range in pyramidal cells. Moreover, this GABAergic mechanism is sufficient to synchronize the firing of pyramidal cells. Thus, owing to the divergence of each GABAergic interneuron(9,10), more than a thousand pyramidal cells may share a common temporal reference established by an individual interneuron. LA - English DB - MTMT ER - TY - JOUR AU - BUHL, EH AU - Halasy, Katalin AU - Somogyi, Péter Pál TI - DIVERSE SOURCES OF HIPPOCAMPAL UNITARY INHIBITORY POSTSYNAPTIC POTENTIALS AND THE NUMBER OF SYNAPTIC RELEASE SITES JF - NATURE J2 - NATURE VL - 368 PY - 1994 IS - 6474 SP - 823 EP - 828 PG - 6 SN - 0028-0836 DO - 10.1038/368823a0 UR - https://m2.mtmt.hu/api/publication/1660995 ID - 1660995 N1 - Medical Research Council, Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford 0X1 3TH, United Kingdom Department of Zoology, Jozsef Attila University, Szeged, Hungary Cited By :569 Export Date: 6 April 2021 Correspondence Address: Buhl, E.H.; Medical Research Council, Mansfield Road, Oxford 0X1 3TH, United Kingdom Chemicals/CAS: Receptors, GABA-A AB - Dual intracellular recordings from microscopically identified neurons in the hippocampus reveal that the synaptic terminals of three morphologically distinct types of interneuron act through GABA(A) receptors. Each type of interneuron forms up to 12 synaptic contacts with a postsynaptic principal neuron, but each interneuron innervates a different domain of the surface of the postsynaptic neuron. Different kinetics of the postsynaptic effects, together with the strategic placement of synapses, indicate that these GABAergic interneurons serve distinct functions in the cortical network. LA - English DB - MTMT ER - TY - JOUR AU - Gulyás, Attila AU - Miles, R AU - Hájos, Norbert AU - Freund, Tamás TI - Precision and variability in postsynaptic target selection of inhibitory cells in the hippocampal CA3 region JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 5 PY - 1993 IS - 12 SP - 1729 EP - 1751 PG - 23 SN - 0953-816X DO - 10.1111/j.1460-9568.1993.tb00240.x UR - https://m2.mtmt.hu/api/publication/107599 ID - 107599 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, Budapest, H-1450, Hungary Laboratoire de Neurobiologie Cellulaire, Institut Pasteur, INSERM U261, 25 Rue de Dr Roux, Paris, 75264, France Cited By :180 Export Date: 6 April 2021 Correspondence Address: Freund, T.F. Chemicals/CAS: biocytin, 576-19-2; Lysine, 56-87-1 Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, Budapest, H-1450, Hungary Laboratoire de Neurobiologie Cellulaire, Institut Pasteur, INSERM U261, 25 Rue de Dr Roux, Paris, 75264, France Cited By :180 Export Date: 7 April 2021 Correspondence Address: Freund, T.F. Chemicals/CAS: biocytin, 576-19-2; Lysine, 56-87-1 LA - English DB - MTMT ER - TY - JOUR AU - Han, ZS AU - Buhl, EH AU - Lőrinczi, Zoltán AU - Somogyi, Péter Pál TI - A high degree of spatial selectivity in the axonal and dendritic domains of physiologically identified local-circuit neurons in the dentate gyrus of the rat hippocampus. A High Degree of Spatial Selectivity in the Axonal and Dendritic Domains of Physiologically Identified Local‐circuit Neurons in the Dentate Gyms of the Rat Hippocampus JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 5 PY - 1993 IS - 5 SP - 395 EP - 410 PG - 16 SN - 0953-816X DO - 10.1111/j.1460-9568.1993.tb00507.x UR - https://m2.mtmt.hu/api/publication/2138105 ID - 2138105 N1 - Medical Research Council, Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford, OX1 3TH, United Kingdom Department of Anatomy, University of Medicine and Pharmacy, Tirgu Mures, 4300, Romania Cited By :341 Export Date: 3 August 2023 Correspondence Address: Somogyi, P. Chemicals/CAS: biocytin, 576-19-2; Lysine, 56-87-1 AB - The axonal and dendritic domains of neurons with extensive, locally arborizing axons were delineated in the dentate gyrus of the rat hippocampus. In horizontally cut slice preparations neurons were briefly recorded and subsequently filled with biocytin when one or several of the following physiological properties were observed: (i) high-amplitude short-latency spike afterhyperpolarization; (ii) lack of spike frequency adaptation; (iii) high firing rate in response to depolarizing current. In a sample of 14 neurons, sufficient dendritic and/or axonal detail was recovered to identify them as non-principal cells, i.e. non-granule, non-mossy cells. Five distinct types of cells were recognized, based on the spatial distribution of dendrites, presumably reflecting the availability of afferents, and on the basis of the highly selective distribution of their axon terminals, indicating synaptic target selectivity. They are: (1) the hilar cell forming a dense axonal plexus in the commissural and association pathway terminal field (HICAP cell; horizontal axon extent 1.6 mm) in the inner one-third of the molecular layer, and having dendrites extending from the hilus to the top of the molecular layer; (2) the hilar cell with its axon ramifying in the perforant path terminal field (HIPP cell, horizontal axon extent 2.0 mm) in the outer two-thirds of the molecular layer, whereas its spiny dendrites were restricted to the hilus; (3) the molecular layer cell with its dendritic and axonal domains confined to the perforant path terminal zone (MOPP cell, horizontal extent of axon 2.0 mm); (4) the dentate basket cell (horizontal axon extent 0.9 mm) had most of its axon concentrated in the granule cell layer, the remainder being localized in the inner molecular layer and hilus; (5) the hilar chandelier cell, or axo-axonic cell (horizontal axon extent 1.1 mm), densely innervating the granule cell layer with fascicles of radially oriented terminal rows, and also forming an extensive plexus in the hilus. The three cell types having their somata in the hilus projected to granule cells at the same septo-temporal level where their cell bodies were located. The results demonstrate that there is a spatially selective innervation of the granule cells by at least five distinct types of dentate neurons, which terminate in several instances in mutually exclusive domains. Their dendrites may have access to all (HICAP cell) or only a few (e.g. HIPP and MOPP cell) of the hippocampal afferents. This arrangement provides a framework for independent interaction between the output of local circuit neurons and subsets of excitatory afferents providing input to principal cells. LA - English DB - MTMT ER -