TY - JOUR AU - Lamsa, Karri AU - Heeroma, JH AU - Somogyi, Péter Pál AU - Rusakov, DA AU - Kullmann, DM TI - Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit. JF - SCIENCE J2 - SCIENCE VL - 315 PY - 2007 IS - 5816 SP - 1262 EP - 1266 PG - 5 SN - 0036-8075 DO - 10.1126/science.1137450 UR - https://m2.mtmt.hu/api/publication/2086368 ID - 2086368 N1 - Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom Anatomical Neuropharmacology Unit, Medical Research Council, Oxford University, Mansfield Road, Oxford OX1 3HT, United Kingdom Cited By :151 Export Date: 12 March 2020 CODEN: SCIEA Correspondence Address: Kullmann, D.M.; Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom; email: d.kullmann@ion.ucl.ac.uk Chemicals/CAS: calcium ion, 14127-61-8; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermine, 71-44-3 Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom Anatomical Neuropharmacology Unit, Medical Research Council, Oxford University, Mansfield Road, Oxford OX1 3HT, United Kingdom Cited By :151 Export Date: 24 May 2020 CODEN: SCIEA Correspondence Address: Kullmann, D.M.; Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom; email: d.kullmann@ion.ucl.ac.uk Chemicals/CAS: calcium ion, 14127-61-8; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermine, 71-44-3 Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom Anatomical Neuropharmacology Unit, Medical Research Council, Oxford University, Mansfield Road, Oxford OX1 3HT, United Kingdom Cited By :164 Export Date: 1 April 2021 CODEN: SCIEA Correspondence Address: Kullmann, D.M.; Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom; email: d.kullmann@ion.ucl.ac.uk Chemicals/CAS: calcium ion, 14127-61-8; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermine, 71-44-3 Funding details: Medical Research Council, MRC, G0400627, G0501424, G0600368, MC_U138135973 Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom Anatomical Neuropharmacology Unit, Medical Research Council, Oxford University, Mansfield Road, Oxford OX1 3HT, United Kingdom Cited By :164 Export Date: 6 April 2021 CODEN: SCIEA Correspondence Address: Kullmann, D.M.; Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom; email: d.kullmann@ion.ucl.ac.uk Chemicals/CAS: calcium ion, 14127-61-8; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermine, 71-44-3 Funding details: Medical Research Council, MRC, G0400627, G0501424, G0600368, MC_U138135973 Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom Anatomical Neuropharmacology Unit, Medical Research Council, Oxford University, Mansfield Road, Oxford OX1 3HT, United Kingdom Cited By :164 Export Date: 20 April 2021 CODEN: SCIEA Correspondence Address: Kullmann, D.M.; Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom; email: d.kullmann@ion.ucl.ac.uk Chemicals/CAS: calcium ion, 14127-61-8; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermine, 71-44-3 Funding details: Medical Research Council, MRC, G0400627, G0501424, G0600368, MC_U138135973 AB - Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian":Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity. LA - English DB - MTMT ER - TY - JOUR AU - Vinet, J AU - Sík, Attila TI - Expression pattern of voltage-dependent calcium channel subunits in hippocampal inhibitory neurons in mice JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 143 PY - 2006 IS - 1 SP - 189 EP - 212 PG - 24 SN - 0306-4522 DO - 10.1016/j.neuroscience.2006.07.019 UR - https://m2.mtmt.hu/api/publication/3322306 ID - 3322306 LA - English DB - MTMT ER - TY - JOUR AU - Rózsa J., Balázs AU - Zelles, Tibor AU - Vizi, E. Szilveszter AU - Lendvai, Balázs TI - Distance-dependent scaling of calcium transients evoked by backpropagating spikes and synaptic activity in dendrites of hippocampal interneurons JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 24 PY - 2004 IS - 3 SP - 661 EP - 670 PG - 10 SN - 0270-6474 DO - 10.1523/JNEUROSCI.3906-03.2004 UR - https://m2.mtmt.hu/api/publication/109502 ID - 109502 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary Cited By :53 Export Date: 12 March 2020 CODEN: JNRSD Correspondence Address: Vizi, E.S.; Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: calcium ion, 14127-61-8; Calcium, 7440-70-2 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary Cited By :53 Export Date: 24 May 2020 CODEN: JNRSD Correspondence Address: Vizi, E.S.; Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: calcium ion, 14127-61-8; Calcium, 7440-70-2 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary Cited By :56 Export Date: 1 April 2021 CODEN: JNRSD Correspondence Address: Vizi, E.S.; Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: calcium ion, 14127-61-8; Calcium, 7440-70-2 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary Cited By :56 Export Date: 20 April 2021 CODEN: JNRSD Correspondence Address: Vizi, E.S.; Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: calcium ion, 14127-61-8; Calcium, 7440-70-2 LA - English DB - MTMT ER - TY - JOUR AU - Goldberg, JH AU - Tamás, Gábor AU - Yuste, R TI - Ca2+ imaging of mouse neocortical interneurone dendrites: Ia-type K+ channels control action potential backpropagation. JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 551 PY - 2003 IS - 1 SP - 49 EP - 65 PG - 17 SN - 0022-3751 DO - 10.1113/jphysiol.2003.042580 UR - https://m2.mtmt.hu/api/publication/1442916 ID - 1442916 AB - GABAergic interneurones are essential in cortical processing, yet the functional properties of their dendrites are still poorly understood. In this first study, we combined two-photon calcium imaging with whole-cell recording and anatomical reconstructions to examine the calcium dynamics during action potential (AP) backpropagation in three types of V1 supragranular interneurones: parvalbumin-positive fast spikers (FS), calretinin-positive irregular spikers (IS), and adapting cells (AD). Somatically generated APs actively backpropagated into the dendritic tree and evoked instantaneous calcium accumulations. Although voltage-gated calcium channels were expressed throughout the dendritic arbor, calcium signals during backpropagation of both single APs and AP trains were restricted to proximal dendrites. This spatial control of AP backpropagation was mediated by Ia-type potassium currents and could be mitigated by by previous synaptic activity. Further, we observed supralinear summation of calcium signals in synaptically activated dendritic compartments. Together, these findings indicate that in interneurons, dendritic AP propagation is synaptically regulated. We propose that interneurones have a perisomatic and a distal dendritic functional compartment, with different integrative functions. LA - English DB - MTMT ER - TY - JOUR AU - Luján, R AU - Nusser, Zoltán AU - Roberts, JDB AU - Shigemoto, R AU - Somogyi, Péter Pál TI - Perisynaptic location of metabotropic glutamate receptors mGluR5 on dendrites and dendritic spines in the rat hippocampus JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 8 PY - 1996 SP - 1488 EP - 1500 PG - 13 SN - 0953-816X DO - 10.1111/j.1460-9568.1996.tb01611.x UR - https://m2.mtmt.hu/api/publication/108777 ID - 108777 LA - English DB - MTMT ER -