TY - JOUR AU - Spiess, E AU - Bestvater, F AU - Heckel-Pompey, A AU - Tóth, Katalin AU - Hacker, M AU - Stobrawa, G AU - Feurer, T AU - Wotzlaw, C AU - Berchner-Pfannschmidt, U AU - Porwol, T AU - Acker, H TI - Two-photon excitation and emission spectra of the green fluorescent protein variants ECFP, EGFP and EYFP JF - JOURNAL OF MICROSCOPY-OXFORD J2 - J MICROSC-OXFORD VL - 217 PY - 2005 IS - 3 SP - 200 EP - 204 PG - 5 SN - 0022-2720 DO - 10.1111/j.1365-2818.2005.01437.x UR - https://m2.mtmt.hu/api/publication/3391890 ID - 3391890 LA - English DB - MTMT ER - TY - JOUR AU - Hirase, H AU - Qian, L AU - Barthó, Péter AU - Buzsáki, György TI - Calcium dynamics of cortical astrocytic networks in vivo JF - PLOS BIOLOGY J2 - PLOS BIOL VL - 2 PY - 2004 SP - 494 EP - 499 PG - 6 SN - 1544-9173 DO - 10.1371/journal.pbio.0020096 UR - https://m2.mtmt.hu/api/publication/109457 ID - 109457 N1 - Export Date: 27 January 2024; CODEN: PBLIB LA - English DB - MTMT ER - TY - JOUR AU - Rózsa J., Balázs AU - Zelles, Tibor AU - Vizi, E. Szilveszter AU - Lendvai, Balázs TI - Distance-dependent scaling of calcium transients evoked by backpropagating spikes and synaptic activity in dendrites of hippocampal interneurons JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 24 PY - 2004 IS - 3 SP - 661 EP - 670 PG - 10 SN - 0270-6474 DO - 10.1523/JNEUROSCI.3906-03.2004 UR - https://m2.mtmt.hu/api/publication/109502 ID - 109502 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary Cited By :53 Export Date: 12 March 2020 CODEN: JNRSD Correspondence Address: Vizi, E.S.; Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: calcium ion, 14127-61-8; Calcium, 7440-70-2 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary Cited By :53 Export Date: 24 May 2020 CODEN: JNRSD Correspondence Address: Vizi, E.S.; Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: calcium ion, 14127-61-8; Calcium, 7440-70-2 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary Cited By :56 Export Date: 1 April 2021 CODEN: JNRSD Correspondence Address: Vizi, E.S.; Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: calcium ion, 14127-61-8; Calcium, 7440-70-2 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary Cited By :56 Export Date: 20 April 2021 CODEN: JNRSD Correspondence Address: Vizi, E.S.; Institute of Experimental Medicine, Szigony u. 43, H-1083 Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: calcium ion, 14127-61-8; Calcium, 7440-70-2 LA - English DB - MTMT ER - TY - JOUR AU - Andrásfalvy, Bertalan AU - Smith, MA AU - Borchardt, T AU - Sprengel, R AU - Magee, JC TI - Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient mice JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 552 PY - 2003 IS - Pt 1 SP - 35 EP - 45 PG - 11 SN - 0022-3751 DO - 10.1113/jphysiol.2003.045575 UR - https://m2.mtmt.hu/api/publication/1616468 ID - 1616468 AB - Neurons of the central nervous system (CNS) exhibit a variety of forms of synaptic plasticity, including associative long-term potentiation and depression (LTP/D), homeostatic activity-dependent scaling and distance-dependent scaling. Regulation of synaptic neurotransmitter receptors is currently thought to be a common mechanism amongst many of these forms of plasticity. In fact, glutamate receptor 1 (GluR1 or GluRA) subunits containing L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors have been shown to be required for several forms of hippocampal LTP and a particular hippocampal-dependent learning task. Because of this importance in associative plasticity, we sought to examine the role of these receptors in other forms of synaptic plasticity in the hippocampus. To do so, we recorded from the apical dendrites of hippocampal CA1 pyramidal neurons in mice lacking the GluR1 subunit (GluR1 -/-). Here we report data from outside-out patches that indicate GluR1-containing receptors are essential to the extrasynaptic population of AMPA receptors, as this pool was nearly empty in the GluR1 -/- mice. Additionally, these receptors appear to be a significant component of the synaptic glutamate receptor pool because the amplitude of spontaneous synaptic currents recorded at the site of input and synaptic AMPA receptor currents evoked by focal glutamate uncaging were both substantially reduced in these mice. Interestingly, the impact on synaptic weight was greatest at distant synapses such that the normal distance-dependent synaptic scaling used by these cells to counter dendritic attenuation was lacking in GluR1 -/- mice. Together the data suggest that the highly regulated movement of GluR1-containing AMPA receptors between extrasynaptic and synaptic receptor pools is critically involved in establishing two functionally diverse forms of synaptic plasticity: LTP and distance-dependent scaling. LA - English DB - MTMT ER - TY - JOUR AU - Goldberg, JH AU - Tamás, Gábor AU - Aronov, D AU - Yuste, R TI - Calcium microdomains in aspiny dendrites. JF - NEURON J2 - NEURON VL - 40 PY - 2003 IS - 4 SP - 807 EP - 821 PG - 15 SN - 0896-6273 DO - 10.1016/S0896-6273(03)00714-1 UR - https://m2.mtmt.hu/api/publication/1442913 ID - 1442913 AB - Dendritic spines receive excitatory synapses and serve as calcium compartments, which appear to be necessary for input-specific synaptic plasticity. Dendrites of GABAergic interneurons have few or no spines and thus do not possess a clear morphological basis for synapse-specific compartmentalization. We demonstrate using two-photon calcium imaging that activation of single synapses on aspiny dendrites of neocortical fast spiking (FS) interneurons creates highly localized calcium microdomains, often restricted to less than 1 microm of dendritic space. We confirm using ultrastructural reconstruction of imaged dendrites the absence of any morphological basis for this compartmentalization and show that it is dependent on the fast kinetics of calcium-permeable (CP) AMPA receptors and fast local extrusion via the Na+/Ca2+ exchanger. Because aspiny dendrites throughout the CNS express CP-AMPA receptors, we propose that CP-AMPA receptors mediate a spine-free mechanism of input-specific calcium compartmentalization. LA - English DB - MTMT ER - TY - JOUR AU - Lendvai, Balázs AU - Stern, EA AU - Chen, B AU - Svoboda, K TI - Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo JF - NATURE J2 - NATURE VL - 404 PY - 2000 IS - 6780 SP - 876 EP - 881 PG - 6 SN - 0028-0836 DO - 10.1038/35009107 UR - https://m2.mtmt.hu/api/publication/108830 ID - 108830 LA - English DB - MTMT ER -