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First Department of Medicine, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary
Department of Obstetrics and Gynecology, Postgraduate Medical School, Budapest, Hungary
Biometrical and Clinico-Epidemiological Unit, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary
Cited By :5
Export Date: 13 February 2021
CODEN: CTIND
Correspondence Address: Zséli, J.; First Department of Medicine, Korányi S. 2/a, Budapest, H-1083, Hungary
Chemicals/CAS: alkaline phosphatase, 9001-78-9; ethinylestradiol, 57-63-6; norethisterone, 68-22-4; osteocalcin, 136461-80-8; Alkaline Phosphatase, EC 3.1.3.1; Calcium, 7440-70-2; Estrogens; Minerals; Osteocalcin, 104982-03-8; Phosphorus, 7723-14-0; Progestational Hormones
First Department of Medicine, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary
Department of Obstetrics and Gynecology, Postgraduate Medical School, Budapest, Hungary
Biometrical and Clinico-Epidemiological Unit, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary
Cited By :5
Export Date: 26 May 2021
CODEN: CTIND
Correspondence Address: Zséli, J.; First Department of Medicine, Korányi S. 2/a, Budapest, H-1083, Hungary
Chemicals/CAS: alkaline phosphatase, 9001-78-9; ethinylestradiol, 57-63-6; norethisterone, 68-22-4; osteocalcin, 136461-80-8; Alkaline Phosphatase, EC 3.1.3.1; Calcium, 7440-70-2; Estrogens; Minerals; Osteocalcin, 104982-03-8; Phosphorus, 7723-14-0; Progestational Hormones
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Osteoporosis is one of the most common complications of streak gonad syndrome (SGS), however its pathogenesis is still unclear. Bone Gla protein (BGP) has been found to be a serum marker of bone turnover in various metabolic disease states. In the present study serum BGP and alkaline phosphatase (AP) were measured in 13 osteoporotic patients with SGS and in 56 healthy women. Mean (±SD) serum BGP levels were normal (7.5 ± 2.0 ng/ml) in seven patients who had been on estrogen-progestin replacement therapy and became significantly elevated (P < 0.001) 2 and 3 months after discontinuation of the treatment (15.3 ± 2.3 and 13.2 ± 1.0 ng/ml, respectively). Mean (±SD) serum AP (207 ± 65 U/l) showed significant increases (P < 0.05) 2 months after withdrawal of hormonal substitution (287 ± 74 U/l). Mean (±SD) serum BGP (15.4 ± 3.5) and AP (287 ± 49) levels were significantly higher (P < 0.001 and < 0.05, respectively) in six patients with SGS who had not been on hormonal substitution. These findings are consistent with those obtained in postmenopausal women suffering from ''high remodelling osteoporosis'' and suggest that bone turnover in osteoporotic patients with SGS is increased and the skeletal loss is a consequence of accelerated bone loss rather than decreased bone formation.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Zseli, J </span> <span class="author-type"> </span> ; <span class="author-name" mtid="1394753"> <a href="/gui2/?type=authors&mode=browse&sel=1394753" target="_blank">Bosze, P</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10012016"> <a href="/gui2/?type=authors&mode=browse&sel=10012016" target="_blank">Lakatos, P</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Vargha, P </span> <span class="author-type"> </span> ; <span class="author-name" > Tarjan, G </span> <span class="author-type"> </span> ; <span class="author-name" > Kollin, E </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10024005"> <a href="/gui2/?type=authors&mode=browse&sel=10024005" target="_blank">Horvath, C</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Laszlo, J </span> <span class="author-type"> </span> ; <span class="author-name" > Hollo, I </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1802383" mtid="1802383" target="_blank">Serum bone GLA protein in streak gonad syndrome</a></div> <div class="pub-info"> <span class="journal-title">CALCIFIED TISSUE INTERNATIONAL</span> <span class="journal-volume">48</span> : <span class="journal-issue">6</span> <span class="page"> pp. 387-391. , 5 p. </span> <span class="year">(1991)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1007/BF02556451" target="_blank" href="https://doi.org/10.1007/BF02556451"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1991FK72600003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1991FK72600003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0025814554" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0025814554"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="2070273" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2070273&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:1802383 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 5 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt: 5 | WoS/Scopus jelölt: 5 | DOI jelölt: 4 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Belgyógyászati Klinika</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1802383" target="_blank">Serum bone GLA protein in streak gonad syndrome</a></div> <div> <span class="journal-title">CALCIFIED TISSUE INTERNATIONAL</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0171-967X">0171-967X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1432-0827">1432-0827</a>)</span>:
<span class="journal-volume">48</span> <span class="journal-issue">6</span>
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pp 387-391
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<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span>
| Független: 5
| Függő: 0
| Nem jelölt: 0
| WoS jelölt: 3
| Scopus jelölt: 5
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<a target="_blank" href="/api/publication?cond=citations.related;eq;1802383&sort=publishedYear,desc&sort=title">
Idézett közlemények száma: 5
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 1802383</span>
| <span class="status-data status-VALIDATED"> Egyeztetett
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<span class="oldId">Régi azonosító: 1802383</span> |
Forrás Idéző
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
)
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<div class="lastModified">Utolsó módosítás: 2018.10.09. 11:59 Szuper Admin (admin)
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<div class="lockedBy">Ideiglenesen zárolva 2021.10.23. 03:13 MTMT API (MTMT API user, admin) Reményiné Kállai Zsuzsanna (MTMT ellenőrzés admin5)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: First Department of Medicine, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary
Department of Obstetrics and Gynecology, Postgraduate Medical School, Budapest, Hungary
Biometrical and Clinico-Epidemiological Unit, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary
C...</pre>
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